CD8+CD122+ regulatory T cells (Tregs) and CD4 + Tregs cooperatively prevent and cure CD4+ cell-induced colitis

Journal of Immunology

Volumn 186, Issue 1, 2011, Pages 41-52

  Tri Endharti, Agustina ^a,c   Okuno, Yusuke ^a   Shi, Zhe ^c   Misawa, Nobuaki ^a   Toyokuni, Shinya ^a   Ito, Masafumi ^b   Isobe, Ken Ichi ^a   Suzuki, Haruhiko ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPANESE RED CROSS NAGOYA FIRST HOSPITAL   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD45RB ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR BETA; TRANSCRIPTION FACTOR FOXP3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ CD45RB LOW REGULATORY T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ CD122+ REGULATORY T LYMPHOCYTE; COLITIS; CONTROLLED STUDY; HOMEOSTASIS; LYMPHOCYTE COUNT; LYMPHOCYTE TRANSFER; MESENTERY LYMPH NODE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN CELL; STRAIN DIFFERENCE; SURVIVAL RATE; T LYMPHOCYTE ACTIVATION; THERAPY EFFECT; WEIGHT CHANGE;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD45; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELLS, CULTURED; COCULTURE TECHNIQUES; COLITIS; DISEASE MODELS, ANIMAL; INTERLEUKIN-10; INTERLEUKIN-2 RECEPTOR BETA SUBUNIT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; T-LYMPHOCYTES, REGULATORY;

EID: 79251534981     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000800     Document Type: Article

References (42)

1. Groux, H., and F. Powrie. 1999. Regulatory T cells and inflammatory bowel disease. Immunol. Today 20: 442-445.
2. Singh, B., S. Read, C. Asseman, V. Malmström, C. Mottet, L. A. Stephens, R. Stepankova, H. Tlaskalova, and F. Powrie. 2001. Control of intestinal in- flammation by regulatory T cells. Immunol. Rev. 182: 190-200.
3. Allez, M., and L. Mayer. 2004. Regulatory T cells: peace keepers in the gut. Inflamm. Bowel Dis. 10: 666-676.
4. Huibregtse, I. L., A. U. van Lent, and S. J. van Deventer. 2007. Immunopathogenesis of IBD: insufficient suppressor function in the gut? Gut 56: 584-592.
5. Elson, C. O., Y. Cong, V. J. McCracken, R. A. Dimmitt, R. G. Lorenz, and C. T. Weaver. 2005. Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota. Immunol. Rev. 206: 260-276.
6. Coombes, J. L., N. J. Robinson, K. J. Maloy, H. H. Uhlig, and F. Powrie. 2005. Regulatory T cells and intestinal homeostasis. Immunol. Rev. 204: 184-194.
7. high T lymphocytes into nude mice. Inflamm. Bowel Dis. 12: 89-99.
8. +T lymphocytes during progression of HIV infection. J. Immunol. 158: 464-474.
9. + regulatory T cells in ulcerative colitis. Inflamm. Bowel Dis. 13: 191-199.
10. + regulatory T cells during recovery from colitis via Fas/Fas ligand-induced death. J. Immunol. 180: 8316-8326.
11. + regulatory T cells. J. Immunol. 170: 3939-3943.
12. + regulatory T cells cure murine colitis: the role of IL-10, TGF-β, and CTLA4. J. Immunol. 171: 5012-5017.
13. + regulatory T cells impaired for intestinal homing can prevent colitis. J. Immunol. 174: 7487-7491.
14. Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic selftolerance. Cell 101: 455-458.
15. Vlad, G., R. Cortesini, and N. Suciu-Foca. 2005. License to heal: bidirectional interaction of antigen-specific regulatory T cells and tolerogenic APC. J. Immunol. 174: 5907-5914. (Pubitemid 40663774)
16. - T cells in an autoimmune disease model. J. Clin. Invest. 112: 1037-1048.
17. Sakaguchi, S., T. Yamaguchi, T. Nomura, and M. Ono. 2008. Regulatory T cells and immune tolerance. Cell 133: 775-787.
18. + Treg-mediated suppression. Trends Immunol. 29: 337-342.
19. + regulatory T cells in the maintenance of T cell homeostasis. J. Exp. Med. 200: 1123-1134.
20. + regulatory T cells in the recovery from experimental autoimmune encephalomyelitis. J. Immunol. 180: 825-832.
21. + regulatory T cells recognize activated T cells via conventional MHC class I-αbTCR interaction and become IL-10-producing active regulatory cells. Int. Immunol. 20: 937-947.
22. -/- mice, which can be abrogated by anti-CXCL10 antibody inhibition. J. Interferon Cytokine Res. 28: 31-43.
23. Ameho, C. K., A. A. Adjei, E. K. Harrison, K. Takeshita, T. Morioka, Y. Arakaki, E. Ito, I. Suzuki, A. D. Kulkarni, A. Kawajiri, and S. Yamamoto. 1997. Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor α production in trinitrobenzene sulphonic acid induced colitis. Gut 41: 487-493.
24. - cells leads to rapid colitis: an improved model for pharmacologic testing. Int. Immunopharmacol. 6: 1341-1354.
25. Olsen, C. H. 2003. Review of the use of statistics in infection and immunity. Infect. Immun. 71: 6689-6692.
26. + T cells. J. Immunol. 175: 7093-7097.
27. +CD8αα T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease. Proc. Natl. Acad. Sci. USA 100: 5324-5329.
28. -regulatory T lymphocytes prevent experimental inflammatory bowel disease in mice. Gastroenterology 131: 1775-1785.
29. + regulatory T lymphocytes: the new era. Hum. Immunol. 69: 708-714.
30. +CD28 regulatory cells in suppressing myasthenia gravis-associated responses by a dual altered peptide ligand. Proc. Natl. Acad. Sci. USA 104: 17459-17464.
31. -/- mice. J. Immunol. 171: 1401-1406.
32. + T cells in the control of inflammation. J. Immunol. 171: 5018-5026.
33. + T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J. Immunol. 166: 3008-3018.
34. Ikenoue, Y., T. Tagami, and M. Murata. 2005. Development and validation of a novel IL-10 deficient cell transfer model for colitis. Int. Immunopharmacol. 5: 993-1006.
35. Autenrieth, I. B., N. Bucheler, E. Bohn, G. Heinze, and I. Horak. 1997. Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation. Gut 41: 793-800.
36. Asseman, C., S. Mauze, M. W. Leach, R. L. Coffman, and F. Powrie. 1999. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J. Exp. Med. 190: 995-1004.
37. + T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp. Med. 197: 111-119.
38. + regulatory T cells and IL-10. J. Immunol. 171: 971-978.
39. + regulatory T cells is not essential for suppression of intestinal inflammation. Eur. J. Immunol. 35: 2886-2895.
40. + regulatory T cells can mediate suppressor function in the absence of transforming growth factor β1 production and responsiveness. J. Exp. Med. 196: 237-246.
41. + T cells. J. Exp. Med. 183: 2669-2674.
42. + Treg. Eur. J. Immunol. 39: 2106-2119.