Transforming Growth Factor-β and All-Trans Retinoic Acid Generate Ex Vivo Transgenic Regulatory T Cells With Intestinal Homing Receptors

Transplantation Proceedings

Volumn 41, Issue 6, 2009, Pages 2670-2672

  Moore, C ^a,b   Sauma, D ^a   Morales, J ^c   Bono, M R ^a   Rosemblatt, M ^a,b,d   Fierro, J A ^c  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSIDAD ANDRÉS BELLO   (Chile)

^c CLÍNICA LAS CONDES   (Chile)

^d Fundacion Ciencia para la Vida   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4BETA7 INTEGRIN; CHEMOKINE RECEPTOR CCR9; HOMING RECEPTOR; INTEGRIN; RETINOIC ACID; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; COCULTURE; CONTROLLED STUDY; DENDRITIC CELL; DRUG POTENTIATION; EX VIVO STUDY; FEMALE; LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN CELL;

ANIMALS; ANTIGENS, CD11C; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; MICE; MICE, INBRED BALB C; MICE, INBRED STRAINS; RECEPTORS, LYMPHOCYTE HOMING; SELF TOLERANCE; SPLEEN; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; TRETINOIN;

EID: 68949217711     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2009.06.130     Document Type: Article

References (4)

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2. Yamazaki S., Bonito A.J., Spisek R., et al. Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors. Blood 110 (2007) 4293
3. Benson M.J., Pino-Lagos K., Rosemblatt M., et al. All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med 204 (2007) 1765
4. Iwata M., Hirakiyama A., Eshima Y., et al. Retinoic acid imprints gut-homing specificity on T cells. Immunity 21 (2004) 527