PAQR3 has modulatory roles in obesity, energy metabolism, and leptin signaling

Endocrinology

Volumn 154, Issue 12, 2013, Pages 4525-4535

  Wang, Lingdi ^a   Wang, Xiao ^a   Li, Zhenghu ^a   Xia, Tingting ^a   Zhu, Lu ^a   Liu, Bin ^a   Zhang, Yongxian ^a   Xiao, Fei ^a   Pan, Yi ^a   Liu, Yong ^a   Guo, Feifan ^a   Chen, Yan ^a  

^a UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN RECEPTOR; CARBON DIOXIDE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; LEPTIN; LEPTIN RECEPTOR; LOW DENSITY LIPOPROTEIN; PAQR3 RECEPTOR; PROGESTERONE RECEPTOR; PYRUVIC ACID; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ANTIBODY; FAT INTAKE; RKTG PROTEIN, MOUSE; SIGNAL PEPTIDE;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY MASS; BODY WEIGHT; BROWN ADIPOSE TISSUE; CELL CULTURE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENERGY EXPENDITURE; ENERGY METABOLISM; FAT MASS; FATTY LIVER; FOOD INTAKE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GLUCONEOGENESIS; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HUMAN; HUMAN CELL; HYPOTHALAMUS; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN TOLERANCE TEST; LEAN BODY WEIGHT; LIPID DIET; LIPID STORAGE; LIPOPROTEIN BLOOD LEVEL; LOCOMOTION; METABOLIC RATE; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PHYSICAL ACTIVITY; PHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSIENT TRANSFECTION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; WHITE ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; DOSE RESPONSE; FAT INTAKE; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; KNOCKOUT MOUSE; METABOLISM;

ANIMALS; ANTIBODIES; DIETARY FATS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LEPTIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; SIGNAL TRANSDUCTION;

EID: 84888216790     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1633     Document Type: Article

References (41)

1. Després JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2006;444(7121):881-887.
2. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation. 2004;109(3): 433-438.
3. Katzmarzyk PT, Church TS, Janssen I, Ross R, Blair SN. Metabolic syndrome, obesity, and mortality: impact of cardiorespiratory fitness. Diabetes Care. 2005;28(2):391-397.
4. Rocha VZ, Libby P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol. 2009;6(6):399-409.
5. Ryan KK, Woods SC, Seeley RJ. Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity. Cell Metab. 2012;15(2):137-149.
6. Coppari R, Bjørbaek C. Leptin revisited: its mechanism of action and potential for treating diabetes. Nat Rev Drug Discov. 2012; 11(9):692-708.
7. Myers MG Jr, Leibel RL, Seeley RJ, Schwartz MW. Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab. 2010;21(11):643-651.
8. Tartaglia LA, Dembski M, Weng X, et al. Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995;83(7):1263- 1271.
9. Myers MG, Cowley MA, Münzberg H. Mechanisms of leptin action and leptin resistance. Annu Rev Physiol. 2008;70:537-556.
10. Bates SH, Myers MG Jr. The role of leptin receptor signaling in feeding and neuroendocrine function. Trends Endocrinol Metab. 2003;14(10):447-452.
11. Bjørbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res. 2004;59:305-331.
12. Farooqi IS, O'Rahilly S. Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr. 2009;89(3):980S-984S.
13. Yamauchi T, Kamon J, Ito Y, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003; 423(6941):762-769.
14. Feng L, Xie X, Ding Q, et al. Spatial regulation of Raf kinase signaling by RKTG. Proc Natl Acad Sci USA. 2007;104(36):14348- 14353.
15. Fan F, Feng L, He J, et al. RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells. Carcinogenesis. 2008;29(6):1157- 1163.
16. Jiang Y, Xie X, Zhang Y, et al. Regulation of G-protein signaling by RKTG via sequestration of the G βγ subunit to the Golgi apparatus. Mol Cell Biol. 2010;30(1):78-90.
17. Xie X, Zhang Y, Jiang Y, et al. Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse. Carcinogenesis. 2008;29(8):1632-1638.
18. Zhang Y, Jiang X, Qin X, et al. RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma. Oncogene. 2010; 29(39):5404-5415.
19. Jiang Y, Xie X, Li Z, et al. Functional cooperation of RKTG with p53 in tumorigenesis and epithelial-mesenchymal transition. Cancer Res. 2011;71(8):2959-2968.
20. Wang X, Li X, Fan F, et al. PAQR3 plays a suppressive role in the tumorigenesis of colorectal cancers. Carcinogenesis. 2012;33(11): 2228-2235.
21. Wang X, Wang L, Zhu L, et al. PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus. Diabetes. 2013;62(2):444-456.
22. Knight ZA, Gonzalez B, Feldman ME, et al. Apharmacological map of the PI3-K family defines a role for p110α in insulin signaling. Cell. 2006;125(4):733-747.
23. Yang L, Zhang Y, Wang L, et al. Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22. J Hepatol. 2010;53(2):339-347.
24. Yang G, Ge H, Boucher A, Yu X, Li C. Modulation of direct leptin signaling by soluble leptin receptor. Mol Endocrinol. 2004;18(6): 1354-1362.
25. Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404(6778): 661-671.
26. Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell. 2001;104(4):531-543.
27. Schwartz MW, Porte D Jr. Diabetes, obesity, and the brain. Science. 2005;307(5708):375-379.
28. Kleinridders A, Schenten D, Könner AC, et al. MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab. 2009;10(4):249- 259.
29. Zhang R, Dhillon H, Yin H, et al. Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology. 2008;149(11):5654-5661.
30. Mori H, Hanada R, Hanada T, et al. Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med. 2004;10(7):739-743.
31. Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjørbaek C, Flier JS. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med. 2004;10(7): 734-738.
32. Burguera B, Couce ME, Curran GL, et al. Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats. Diabetes. 2000;49(7):1219-1223.
33. Ozcan U, Yilmaz E, Ozcan L, et al. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science. 2006;313(5790):1137-1140.
34. Hosoi T, Sasaki M, Miyahara T, et al. Endoplasmic reticulum stress induces leptin resistance. Mol Pharmacol. 2008;74(6):1610-1619.
35. Ozcan L, Ergin AS, Lu A, et al. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab. 2009; 9(1):35-51.
36. Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity. Cell. 2008;135(1):61-73.
37. Bence KK, Delibegovic M, Xue B, et al. Neuronal PTP1B regulates body weight, adiposity and leptin action. Nat Med. 2006;12(8): 917-924.
38. Loh K, Fukushima A, Zhang X, et al. Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab. 2011; 14(5):684-699.
39. Yamauchi T, Nio Y, Maki T, et al. Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med. 2007;13(3):332-339.
40. Liu Y, Michael MD, Kash S, et al. Deficiency of adiponectin receptor 2 reduces diet-induced insulin resistance but promotes type 2 diabetes. Endocrinology. 2007;148(2):683-692.
41. Xu Y, Hill JW, Fukuda M, et al. PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab. 2010;12(1):88-95.