Regulation of G-protein signaling by RKTG via sequestration of the Gβγ subunit to the Golgi apparatus

Molecular and Cellular Biology

Volumn 30, Issue 1, 2010, Pages 78-90

  Jiang, Yuhui ^a   Xie, Xiaoduo ^a   Zhang, Yixuan ^a   Luo, Xiaolin ^a   Wang, Xiao ^a   Fan, Fengjuan ^a   Zheng, Dawei ^a   Wang, Zhenzhen ^a   Chen, Yan ^a  

^a Chinese Academy of Sciences   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; LIGAND; MEMBRANE PROTEIN; PROTEIN KINASE B; RAF PROTEIN;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DESENSITIZATION; DOWN REGULATION; EMBRYO; FEMALE; GOLGI COMPLEX; HUMAN; HUMAN CELL; INTERNALIZATION; INTRACELLULAR SPACE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; G-PROTEIN-COUPLED RECEPTOR KINASES; GENE SILENCING; GOLGI APPARATUS; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MEMBRANE PROTEINS; MICE; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ADRENERGIC, BETA-2; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 73549119237     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01038-09     Document Type: Article

References (34)

1. Akgoz, M., V. Kalyanaraman, and N. Gautam. 2006. G protein betagamma complex translocation from plasma membrane to Golgi complex is influenced by receptor gamma subunit interaction. Cell Signal. 18:1758-1768.
2. Akgoz, M., V. Kalyanaraman, and N. Gautam. 2004. Receptor-mediated reversible translocation of the G protein betagamma complex from the plasma membrane to the Golgi complex. J. Biol. Chem. 279:51541-51544.
3. Azpiazu, I., M. Akgoz, V. Kalyanaraman, and N. Gautam. 2006. G protein betagamma11 complex translocation is induced by Gi, Gq and Gs coupling receptors and is regulated by the alpha subunit type. Cell Signal. 18:1190-1200.
4. Benovic, J. L., R. H. Strasser, M. G. Caron, and R. J. Lefkowitz. 1986. Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Proc. Natl. Acad. Sci. U. S. A. 83:2797-2801.
5. Bommakanti, R. K., S. Vinayak, and W. F. Simonds. 2000. Dual regulation of Akt/protein kinase B by heterotrimeric G protein subunits. J. Biol. Chem. 275:38870-38876.
6. Chang, J. D., G. K. Sukhova, P. Libby, E. Schvartz, A. H. Lichtenstein, S. J. Field, C. Kennedy, S. Madhavarapu, J. Luo, D. Wu, and L. C. Cantley. 2007. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc. Natl. Acad. Sci. U. S. A. 104:8077-8082.
7. Chen, S., E. J. Dell, F. Lin, J. Sai, and H. E. Hamm. 2004. RACK1 regulates specific functions of Gbetagamma. J. Biol. Chem. 279:17861- 17868.
8. Daaka, Y., J. A. Pitcher, M. Richardson, R. H. Stoffel, J. D. Robishaw, and R. J. Lefkowitz. 1997. Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases. Proc. Natl. Acad. Sci. U. S. A. 94:2180-2185.
9. DebBurman, S. K., J. Ptasienski, J. L. Benovic, and M. M. Hosey. 1996. G protein-coupled receptor kinase GRK2 is a phospholipid-dependent enzyme that can be conditionally activated by G protein betagamma subunits. J. Biol. Chem. 271:22552-22562.
10. Dingus, J., C. A. Wells, L. Campbell, J. H. Cleator, K. Robinson, and J. D. Hildebrandt. 2005. G Protein betagamma dimer formation: Gbeta and Ggamma differentially determine efficiency of in vitro dimer formation. Biochemistry 44:11882-11890.
11. Fan, F., L. Feng, J. He, X. Wang, X. Jiang, Y. Zhang, Z. Wang, and Y. Chen. 2008. RKTG sequesters B-Raf to the Golgi apparatus and inhibits the proliferation and tumorigenicity of human malignant melanoma cells. Carcinogenesis 29:1157-1163.
12. Feng, L., X. Xie, Q. Ding, X. Luo, J. He, F. Fan, W. Liu, Z. Wang, and Y. Chen. 2007. Spatial regulation of Raf kinase signaling by RKTG. Proc. Natl. Acad. Sci. U. S. A. 104:14348-14353.
13. Garcia-Regalado, A., M. L. Guzman-Hernandez, I. Ramirez-Rangel, E. Robles-Molina, T. Balla, J. Vazquez-Prado, and G. Reyes-Cruz. 2008. G proteincoupled receptor-promoted trafficking of Gbeta1gamma2 leads to AKT activation at endosomes via a mechanism mediated by Gbeta1gamma2-Rab11a interaction. Mol. Biol. Cell 19:4188-4200.
14. Guillermet-Guibert, J., K. Bjorklof, A. Salpekar, C. Gonella, F. Ramadani, A. Bilancio, S. Meek, A. J. Smith, K. Okkenhaug, and B. Vanhaesebroeck. stream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc. Natl. Acad. Sci. U. S. A. 105:8292-8297.
15. Haga, K., and T. Haga. 1992. Activation by G protein beta gamma subunits of agonist- or light-dependent phosphorylation of muscarinic acetylcholine receptors and rhodopsin. J. Biol. Chem. 267:2222-2227.
16. Hamm, H. E., and A. Gilchrist. 1996. Heterotrimeric G proteins. Curr. Opin. Cell Biol. 8:189-196.
17. Jia, S., Z. Liu, S. Zhang, P. Liu, L. Zhang, S. H. Lee, J. Zhang, S. Signoretti, M. Loda, T. M. Roberts, and J. J. Zhao. 2008. Essential roles of PI(3)Kp110beta in cell growth, metabolism and tumorigenesis. Nature 454:776-779.
18. Koch, W. J., J. Inglese, W. C. Stone, and R. J. Lefkowitz. 1993. The binding site for the beta gamma subunits of heterotrimeric G proteins on the betaadrenergic receptor kinase. J. Biol. Chem. 268:8256-8260.
19. Koch, W. J., H. A. Rockman, P. Samama, R. A. Hamilton, R. A. Bond, C. A. Milano, and R. J. Lefkowitz. 1995. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science 268: 1350-1353.
20. Lodowski, D. T., J. A. Pitcher, W. D. Capel, R. J. Lefkowitz, and J. J. Tesmer. 2003. Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. Science 300:1256-1262.
21. Luo, X., L. Feng, X. Jiang, F. Xiao, Z. Wang, G. S. Feng, and Y. Chen. 2008. Characterization of the topology and functional domains of RKTG. Biochem. J. 414:399-406.
22. Marrari, Y., M. Crouthamel, R. Irannejad, and P. B. Wedegaertner. 2007. Assembly and trafficking of heterotrimeric G proteins. Biochemistry 46: 7665-7677.
23. Murga, C., S. Fukuhara, and J. S. Gutkind. 2000. A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt. J. Biol. Chem. 275:12069-12073.
24. Murga, C., A. Ruiz-Gomez, I. Garcia-Higuera, C. M. Kim, J. L. Benovic, and F. Mayor, Jr. 1996. High affinity binding of beta-adrenergic receptor kinase to microsomal membranes. Modulation of the activity of bound kinase by heterotrimeric G protein activation. J. Biol. Chem. 271:985-994.
25. Neer, E. J. 1995. Heterotrimeric G proteins: organizers of transmembrane signals. Cell 80:249-257.
26. Pitcher, J. A., J. Inglese, J. B. Higgins, J. L. Arriza, P. J. Casey, C. Kim, J. L. Benovic, M. M. Kwatra, M. G. Caron, and R. J. Lefkowitz. 1992. Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. Science 257:1264-1267.
27. Qin, X. F., D. S. An, I. S. Chen, and D. Baltimore. 2003. Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc. Natl. Acad. Sci. U. S. A. 100:183-188.
28. Ruiz-Gomez, A., and F. Mayor, Jr. 1997. Beta-adrenergic receptor kinase (GRK2) colocalizes with beta-adrenergic receptors during agonist-induced receptor internalization. J. Biol. Chem. 272:9601-9604.
29. Saini, D. K., V. Kalyanaraman, M. Chisari, and N. Gautam. 2007. A family of G protein betagamma subunits translocate reversibly from the plasma membrane to endomembranes on receptor activation. J. Biol. Chem. 282: 24099-24108.
30. Smrcka, A. V. 2008. G protein betagamma subunits: central mediators of G protein-coupled receptor signaling. Cell Mol. Life Sci. 65:2191-2214.
31. Tang, Y. T., T. Hu, M. Arterburn, B. Boyle, J. M. Bright, P. C. Emtage, and W. D. Funk. 2005. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. J. Mol. Evol. 61:372-380.
32. Tesmer, V. M., T. Kawano, A. Shankaranarayanan, T. Kozasa, and J. J. Tesmer. 2005. Snapshot of activated G proteins at the membrane: the Galphaq-GRK2-Gbetagamma complex. Science 310:1686-1690.
33. Xie, X., Y. Zhang, Y. Jiang, W. Liu, H. Ma, Z. Wang, and Y. Chen. 2008. Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse. Carcinogenesis. 29:1632-1638.
34. Yamauchi, J., Y. Kaziro, and H. Itoh. 1997. C-terminal mutation of G protein beta subunit affects differentially extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways in human embryonal kidney 293 cells. J. Biol. Chem. 272:7602-7607.