Mitochondrial targeting of the electrophilic lipid 15-deoxy-Δ12,14- prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms

Biochemical Journal

Volumn 426, Issue 1, 2010, Pages 31-41

  Diers, Anne R ^a,b   Higdon, Ashlee N ^a,b   Ricart, Karina C ^a,b   Johnson, Michelle S ^a,b   Agarwal, Anupam ^a,c   Kalyanaraman, Balaraman ^d   Landar, Aimee ^a,b   Darley Usmar, Victor M ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c University of Alabama at Birmingham   (United States)

^d FREE RADICAL RESEARCH CENTER   (United States)

Author keywords

15 deoxy 12,14 prostaglandin J2; Apoptosis; Haem(heme); Mitochondrion; Redox signalling; Thiol

Indexed keywords

APOPTOSIS; APOPTOTIC; APOPTOTIC CELL DEATH; BIOLOGICAL EFFECTS; CELL SIGNALLING; CELLULAR RESPONSE; CYTOPROTECTIVE EFFECTS; CYTOSOLS; ELECTROPHILES; ELECTROPHILIC LIPIDS; GLUTATHIONES; HIGH DOSE; MITOCHONDRIAL MEMBRANES; OXYGENASES; PHARMACOPHORES; PROTEOMES; REDOX SIGNALLING; SIGNALLING PROTEINS; THERAPEUTIC POTENTIALS;

BIOCHEMISTRY; BIOLOGICAL RADIATION EFFECTS; CELL MEMBRANES; GENE EXPRESSION; HEMOGLOBIN; PORPHYRINS;

CELL DEATH;

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEME OXYGENASE 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; METHYLTRIPHENYLPHOSPHONIUM; PROCASPASE 9; PROSTAGLANDIN E2; TRANSCRIPTION FACTOR NRF2; 15 DEOXYPROSTAGLANDIN J2; 15-DEOXYPROSTAGLANDIN J2; DRUG DERIVATIVE; KEAP1 PROTEIN, HUMAN; PROSTAGLANDIN D2; SIGNAL PEPTIDE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LIPOPHILICITY; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UPREGULATION; CELL LINE; CELL SURVIVAL; DRUG EFFECT; GENETICS; METABOLISM; TUMOR CELL LINE; WESTERN BLOTTING;

VASCONCELLEA CANDICANS;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; GLUTATHIONE; HEME OXYGENASE-1; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATION-REDUCTION; PROSTAGLANDIN D2; SIGNAL TRANSDUCTION;

EID: 76549096602     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091293     Document Type: Article

References (5)

1. Smith, R. A. J., Porteous, C. M., Coulter, C. V. and Murphy, M. P. (1999) Selective targeting of an antioxidant to mitochondria. Euro. J. Biochem. 263, 709-716
2. 2. Prostaglandins Other Lipid Mediat. 62, 15-21
3. Rasmussen, H. N., Andersen, A. J. and Rasmussen, U. F. (1997) Optimization of preparation of mitochondria from 25-100 mg skeletal muscle. Anal. Biochem. 252, 153-159
4. Shepherd, D., Garland, P. B. and John, M. L. (1969) Citrate synthase from rat liver: [EC 4.1.3.7 Citrate oxaloacetage-lyase (CoA-acetylating)]. In Methods in Enzymology (Estabrook, R. W. and Pullman, M. E., eds), pp. 11-16, Academic Press
5. Wharton, D. C., Tzagoloff, A. and Ronald, W. E. and Pullman, M. E. (1967) Cytochrome oxidase from beef heart mitochondria. In Methods in Enzymology (Lowenstein, J.M., ed.), pp. 245-250, Academic Press