Growth receptor binding protein 10 inhibits glucose-stimulated insulin release from pancreatic β-cells associated with suppression of the insulin/insulin-like growth factor-1 signalling pathway

Clinical and Experimental Pharmacology and Physiology

Volumn 40, Issue 12, 2013, Pages 841-847

  Li, Ling ^a,b,c   Li, Xiaowen ^b,c   Zhu, Yunxia ^a,b,c   Zhang, Mingliang ^a,b,c   Yin, Dechao ^a,b,c   Lu, Junxi ^b,c   Liu, Feng ^d   Wang, Chen ^a,b,c   Jia, Weiping ^a,b,c  

^a SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c Shanghai Key Laboratory of Diabetes Mellitus   (China)

^d Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Akt; Extracellular signal regulated kinase; Growth receptor binding protein 10; Insulin secretion

Indexed keywords

BINDING PROTEIN; GLUCOSE; GROWTH RECEPTOR BINDING PROTEIN 10; INSULIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; PALMITIC ACID; SOMATOMEDIN C; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INSULIN RELEASE; LIPID DIET; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; SUGAR INTAKE; WESTERN BLOTTING;

AKT; EXTRACELLULAR SIGNAL-REGULATED KINASE; GROWTH RECEPTOR BINDING PROTEIN 10; INSULIN SECRETION;

ANIMALS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; DIET, HIGH-FAT; GLUCOSE; GRB10 ADAPTOR PROTEIN; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR I; INSULIN-SECRETING CELLS; INTERLEUKIN-1BETA; MALE; MAP KINASE SIGNALING SYSTEM; ORGAN SPECIFICITY; PALMITATES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84888047475     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/1440-1681.12160     Document Type: Article

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