Site-specific recognition of a 70-base-pair element containing d(GA)n repeats mediates bithoraxoid polycomb group response element-dependent silencing

Molecular and Cellular Biology

Volumn 21, Issue 14, 2001, Pages 4528-4543

  Hodgson, J W ^a   Argiropoulos, B ^a   Brock, H W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BASE PAIRING; DNA BINDING; DNA FLANKING REGION; DNA RESPONSIVE ELEMENT; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE LOCUS; GENE MUTATION; GENE REPRESSION; GENE SILENCING; MOLECULAR RECOGNITION; PHENOTYPE; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; BASE PAIRING; BASE SEQUENCE; CELL EXTRACTS; CELL LINE; CELL NUCLEUS; DINUCLEOTIDE REPEATS; DNA, COMPLEMENTARY; DROSOPHILA; DROSOPHILA PROTEINS; GENE SILENCING; GENES, INSECT; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; RESPONSE ELEMENTS;

EID: 0034953140     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.14.4528-4543.2001     Document Type: Article

References (67)

1. The molecular basis for metameric pattern in the Drosophila embryo
2. Molecular genetics of the Bithorax complex in Drosophila melanogaster
3. Multiple isoforms of GAGA factor, a critical component of chromatin structure
4. The GAGA factor is required in the early Drosophila embryo not only for transcriptional regulation but also for nuclear division
5. Transcription factors that activate the Ultrabithorax promotor in developmentally staged extracts
6. The Drosophila Polycomb Group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1
7. Silencers in Abdominal-B, a homeotic Drosophila gene
8. A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression
9. Discrete Polycomb-binding sites in each parasegmental domain of the bithorax complex
10. Imaginal disc silencers from Ultrabithorax: Evidence for Polycomb response elements
11. The polyhomeotic gene of Drosophila encodes a chromatin protein that shares polytene chromosome binding sites with Polycomb
12. The bithorax complex
13. Maternal and zygotic requirement for polyhomeotic, a genetically complex locus required for normal expression of segmental identity and cuticular development
14. Modularity in promoters and enhancers
15. The N-terminal POZ domain of GAGA mediates the formation of oligomers that bind DNA with high affinity and specificity
16. The GAGA factor of Drosophila interacts with SAP18, a Sin3-associated polypeptide
17. The trithorax-like gene encodes the Drosophila GAGA factor
18. Polyhomeotic regulatory sequences induce development regulator-dependent variegation and targeted P-element insertions in Drosophila
19. Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster
20. The DNA-binding Polycomb group protein Pleiohomeotic mediates silencing of a Drosophila homeotic gene
21. A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: Application to components of the Escherichia coli lactose operon regulatory system
22. Identification of Polycomb and trithorax group responsive elements in the regulatory region of the Drosophila homeotic gene Sex combs reduced
23. A Polycomb and GAGA dependent silencer adjoin the Fab-7 boundary in the Drosophila bithorax complex
24. Characterization of Drosophila transcription factors that activate the tandem promoters of the alcohol dehydrogenase gene
25. The polyhomeotic locus of Drosophila melanogaster is transcriptionally and post-transcriptionally regulated during embryogenesis
26. Structure of a Polycomb response element and in vitro binding of Polycomb group complexes containing GAGA factor
27. The Drosophila pipsqueak gene encodes a nuclear BTB-domain-containing protein required early in oogenesis
28. The GAGA factor of Drosophila binds triple-stranded DNA
29. Unusual properties of regulatory DNA from the Drosophila engrailed gene: Three "pairing-sensitive" sites within a 1.6kb region
30. A fragment of the engrailed regulatory DNA can mediate transvection of the white gene in Drosophila
31. Co-operative DNA binding by GAGA transcription factor requires the conserved BTB/POZ domain and reorganizes promoter topology
32. Transcriptional activation of Drosophila homeotic genes from distant regulatory elements
33. Sequence-specific transcriptional antirepression of the Drosophila Kruppel gene by the GAGA factor
34. The Drosophila Polycomb group protein Psc contacts ph and Pc through specific conserved domains
35. The Pipsqueak protein of Drosophila melanogaster binds to GAGA sequences through a novel DNA-binding domain
36. Interactions of the Polycomb group of genes with homeotic loci of Drosophila
37. A conserved sequence motif in Polycomb-response elements
38. Long range repression conferring boundaries of Ultrabithorax expression in the Drosophila embryo
39. Chromatin remodeling mediated by Drosophila GAGA factor and ISWI activates fushi tarazu gene transcription in vitro
40. The binding of Trithorax and Polycomb proteins to the bithorax complex: Dynamic changes during early Drosophila embryogenesis
41. A Drosophila RNA polymerase II transcription factor contains a promoter-region-specific DNA-binding activity
42. A domain shared by the Polycomb group proteins Scm and ph mediates heterotypic and homotypic interactions
43. Vectors for P-mediated transformation in Drosophila
44. Distinct parasegmental and imaginal enhancers and the establishment of the expression pattern of the Ubx gene
45. White gene expression, repressive chromatin domains, and homeotic gene regulation in Drosophila
46. Hunchback-independent silencing of late Ubx enhancers by a Polycomb Group Response Element
47. Recruitment of components of Polycomb Group chromatin complexes in Drosophila
48. Transposon-induced rearrangements in the duplicated locus ph of Drosophila melanogaster can create new chimeric genes functionally identical to wild-type
49. Stabilization of chromatin structure by PRC1, a Polycomb complex
50. Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene
51. Pipsqueak, an early acting member of the posterior group of genes, affects vasa level and germ cell-somatic cell interaction in the developing egg chamber
52. Chromatin insulator elements block the silencing of a target gene by the Drosophila Polycomb Response Element (PRE) but allow trans interactions between PREs on different chromosomes
53. Locking in stable states of gene expression: Transcriptional control during Drosophila development
54. Ten different Polycomb group genes are required for spatial control of the abd-A and Abd-B homeotic products
55. Elements of the Drosophila bithorax complex that mediate repression by Polycomb group products
56. Comparison of germ-line mosaics of genes in the Polycomb group of Drosophila melanogaster
57. A-tract bending: Insights into experimental structures by computational models
58. Altered distribution of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila
59. Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression
60. The Polycomb group protein complex of Drosophila melanogaster has different compositions at different target genes
61. The Drosophila Polycomb Group proteins ESC and E(Z) are present in a complex containing the histone-binding protein p55 and the histone deacetylase RPD3
62. Trithorax- and Polycomb-group response elements within an Ultrabithorax transcription maintenance unit consist of closely situated but separable sequences
63. ATP-dependent nucleosome disruption at a heat-shock promoter mediated by binding of GAGA transcription factor
64. Pipsqueak encodes a novel nuclear protein required downstream of seven-up for the development of photoreceptors R3 and R4
65. GAGA factor binding of DNA via a single trinucleotide sequence element
66. DNA distortion and multimerization: Novel functions of the glutamine-rich domain of GAGA factor
67. Direct interaction of the Polycomb protein with Antennapedia regulatory sequences in polytene chromosomes of Drosophila melanogaster