Astrocytes and gliotransmitters: New players in the treatment of major depression?

Current Drug Targets

Volumn 14, Issue 11, 2013, Pages 1295-1307

  Etiévant, Adeline ^a,b   Lambás Señas, Laura ^a,b   Scarna, Hélène ^a,b   Lucas, Guillaume ^a,b   Haddjeri, Nasser ^a,b  

^a STEM CELL AND BRAIN RESEARCH INSTITUTE   (France)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Antidepressants; Astrocytes; DBS; Gliotransmission; Tripartite synapse

Indexed keywords

4 AMINOBUTYRIC ACID; ANTIDEPRESSANT AGENT; AQUAPORIN 4; DOPAMINE; ELONGATION FACTOR 1ALPHA; FLUOXETINE; G PROTEIN COUPLED RECEPTOR; GLIOTRANSMITTER; GLUTAMIC ACID; HISTAMINE; IMIPRAMINE; MONOAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER; NORADRENALIN; PAROXETINE; SEROTONIN; SEROTONIN UPTAKE INHIBITOR; TRANYLCYPROMINE; UNCLASSIFIED DRUG; VIMENTIN;

ACTION POTENTIAL; ASTROCYTE; BRAIN FUNCTION; CELL COMMUNICATION; DENTATE GYRUS; FORCED SWIMMING TEST; HIPPOCAMPUS; HUMAN; IMMUNOREACTIVITY; MAJOR DEPRESSION; NEUROBIOLOGY; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; REVIEW; SYNAPSE; TRIPARTITE SYNAPSE;

ANIMALS; ANTIDEPRESSIVE AGENTS; ASTROCYTES; DEEP BRAIN STIMULATION; DEPRESSIVE DISORDER, MAJOR; HUMANS; NEURONS; NEUROTRANSMITTER AGENTS; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 84887983444     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/13894501113149990197     Document Type: Review

References (198)

1. Kessler RC, Berglund P, Demler O, et al. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 2003; 289(23): 3095-105.
2. Berton O, Nestler EJ. New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 2006; 7(2): 137-51.
3. Rajkowska G, Miguel-Hidalgo JJ. Gliogenesis and glial pathology in depression. CNS Neurol Disord Drug Targets 2007; 6(3): 219-33.
4. Cotter DR, Pariante CM, Everall IP. Glial cell abnormalities in major psychiatric disorders: the evidence and implications. Brain Res Bull 2001; 55(5): 585-95.
5. Frank MG. Astroglial regulation of sleep homeostasis. Curr Opin Neurobiol 2013; Epub ahead of print.
6. Ingiosi AM, Opp MR, Krueger JM. Sleep and immune function: glial contributions and consequences of aging. Curr Opin Neurobiol 2013; Epub ahead of print.
7. Pereira A, Jr., Furlan FA. Astrocytes and human cognition: modeling information integration and modulation of neuronal activity. Prog Neurobiol 2010; 92(3): 405-20.
8. Mitterauer BJ. Where and how could intentional programs be generated in the brain? A hypothetical model based on glial-neuronal interactions. Biosystems 2007; 88(1-2): 101-12.
9. Robertson JM. The Astrocentric Hypothesis: proposed role of astrocytes in consciousness and memory formation. J Physiol Paris 2002; 96(3-4): 251-5.
10. Cotter D, Mackay D, Landau S, et al. Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder. Arch Gen Psychiatry 2001; 58(6): 545-53.
11. Ongur D, Drevets WC, Price JL. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci U S A 1998; 95(22): 13290-5.
12. Rajkowska G, Miguel-Hidalgo JJ, Wei J, et al. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biol Psychiatry 1999; 45(9): 1085-98.
13. Cotter D, Mackay D, Chana G, et al. Reduced neuronal size and glial cell density in area 9 of the dorsolateral prefrontal cortex in subjects with major depressive disorder. Cereb Cortex 2002; 12(4): 386-94.
14. Johnston-Wilson NL, Sims CD, Hofmann JP, et al. Diseasespecific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium. Mol Psychiatry 2000; 5(2): 142-9.
15. Miguel-Hidalgo JJ, Baucom C, Dilley G, et al. Glial fibrillary acidic protein immunoreactivity in the prefrontal cortex distinguishes younger from older adults in major depressive disorder. Biol Psychiatry 2000; 48(8): 861-73.
16. Si X, Miguel-Hidalgo JJ, O'Dwyer G, et al. Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depression. Neuropsychopharmacology 2004; 29(11): 2088-96.
17. Choudary PV, Molnar M, Evans SJ, et al. Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci U S A 2005; 102(43): 15653-8.
18. Czeh B, Simon M, Schmelting B, et al. Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment. Neuropsychopharmacology 2006; 31(8): 1616-26.
19. Czeh B, Muller-Keuker JI, Rygula R, et al. Chronic social stress inhibits cell proliferation in the adult medial prefrontal cortex: hemispheric asymmetry and reversal by fluoxetine treatment. Neuropsychopharmacology 2007; 32(7): 1490-503.
20. Banasr M, Valentine GW, Li XY, et al. Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat. Biol Psychiatry 2007; 62(5): 496-504.
21. Sun JD, Liu Y, Yuan YH, et al. Gap junction dysfunction in the prefrontal cortex induces depressive-like behaviors in rats. Neuropsychopharmacology 2012; 37(5): 1305-20.
22. Banasr M, Duman RS. Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors. Biol Psychiatry 2008; 64(10): 863-70.
23. Scemes E, Dermietzel R, Spray DC. Calcium waves between astrocytes from Cx43 knockout mice. Glia 1998; 24(1): 65-73.
24. Dere E, Zlomuzica A. The role of gap junctions in the brain in health and disease. Neurosci Biobehav Rev 2012; 36(1): 206-17.
25. Frisch C, Theis M, De Souza Silva MA, et al. Mice with astrocytedirected inactivation of connexin43 exhibit increased exploratory behaviour, impaired motor capacities, and changes in brain acetylcholine levels. Eur J Neurosci 2003; 18(8): 2313-8.
26. Irwin LN. Gene expression in the hippocampus of behaviorally stimulated rats: analysis by DNA microarray. Brain Res Mol Brain Res 2001; 96(1-2): 163-9.
27. Gray JA, McNaughton N. The Neuropsychology of Anxiety: Oxford Univ. Press; 2000.
28. Muscat R, Papp M, Willner P. Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline. Psychopharmacology (Berl) 1992; 109(4): 433-8.
29. Nedergaard M, Ransom B, Goldman SA. New roles for astrocytes: redefining the functional architecture of the brain. Trends Neurosci 2003; 26(10): 523-30.
30. Bass NH, Hess HH, Pope A, et al. Quantitative cytoarchitectonic distribution of neurons, glia, and DNa in rat cerebral cortex. J Comp Neurol 1971; 143(4): 481-90.
31. Bushong EA, Martone ME, Jones YZ, et al. Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains. J Neurosci 2002; 22(1): 183-92.
32. Halassa MM, Haydon PG. Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annu Rev Physiol 2010; 72: 335-55.
33. Giaume C, Koulakoff A, Roux L, et al. Astroglial networks: a step further in neuroglial and gliovascular interactions. Nat Rev Neurosci 2010; 11(2): 87-99.
34. Ventura R, Harris KM. Three-dimensional relationships between hippocampal synapses and astrocytes. J Neurosci 1999; 19(16): 6897-906.
35. Oberheim NA, Wang X, Goldman S, et al. Astrocytic complexity distinguishes the human brain. Trends Neurosci 2006; 29(10): 547-53.
36. Kimelberg HK, Nedergaard M. Functions of astrocytes and their potential as therapeutic targets. Neurotherapeutics 2010; 7(4): 338-53.
37. Laping NJ, Teter B, Nichols NR, et al. Glial fibrillary acidic protein: regulation by hormones, cytokines, and growth factors. Brain Pathol 1994; 4(3): 259-75.
38. Magistretti PJ. Neuron-glia metabolic coupling and plasticity. J Exp Biol 2006; 209(Pt 12): 2304-11.
39. Magistretti PJ, Pellerin L, Rothman DL, et al. Energy on demand. Science 1999; 283(5401): 496-7.
40. Barres BA. Glial ion channels. Curr Opin Neurobiol 1991; 1(3): 354-9.
41. Sontheimer H. Voltage-dependent ion channels in glial cells. Glia 1994; 11(2): 156-72.
42. Volterra A, Meldolesi J. Astrocytes, from brain glue to communication elements: the revolution continues. Nat Rev Neurosci 2005; 6(8): 626-40.
43. Murphy S, Pearce B. Functional receptors for neurotransmitters on astroglial cells. Neuroscience 1987; 22(2): 381-94.
44. Porter JT, McCarthy KD. Astrocytic neurotransmitter receptors in situ and in vivo. Prog Neurobiol 1997; 51(4): 439-55.
45. Cornell-Bell AH, Finkbeiner SM, Cooper MS, et al. Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling. Science 1990; 247(4941): 470-3.
46. Parpura V, Basarsky TA, Liu F, et al. Glutamate-mediated astrocyte-neuron signalling. Nature 1994; 369(6483): 744-7.
47. Nedergaard M. Direct signaling from astrocytes to neurons in cultures of mammalian brain cells. Science 1994; 263(5154): 1768-71.
48. Agulhon C, Petravicz J, McMullen AB, et al. What is the role of astrocyte calcium in neurophysiology? Neuron 2008; 59(6): 932-46.
49. Perea G, Araque A. Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes. J Neurosci 2005; 25(9): 2192-203.
50. Rothstein JD, Martin L, Levey AI, et al. Localization of neuronal and glial glutamate transporters. Neuron 1994; 13(3): 713-25.
51. Wu Q, Wada M, Shimada A, et al. Functional characterization of Zn2(+)-sensitive GABA transporter expressed in primary cultures of astrocytes from rat cerebral cortex. Brain Res 2006; 1075(1): 100-9.
52. Bal N, Figueras G, Vilaro MT, et al. Antidepressant drugs inhibit a glial 5-hydroxytryptamine transporter in rat brain. Eur J Neurosci 1997; 9(8): 1728-38.
53. Takeda H, Inazu M, Matsumiya T. Astroglial dopamine transport is mediated by norepinephrine transporter. Naunyn Schmiedebergs Arch Pharmacol 2002; 366(6): 620-3.
54. Inazu M, Takeda H, Matsumiya T. Expression and functional characterization of the extraneuronal monoamine transporter in normal human astrocytes. J Neurochem 2003; 84(1): 43-52.
55. Fitzgerald LW, Kaplinsky L, Kimelberg HK. Serotonin metabolism by monoamine oxidase in rat primary astrocyte cultures. J Neurochem 1990; 55(6): 2008-14.
56. Levitt P, Pintar JE, Breakefield XO. Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons. Proc Natl Acad Sci U S A 1982; 79(20): 6385-9.
57. Westlund KN, Denney RM, Rose RM, et al. Localization of distinct monoamine oxidase A and monoamine oxidase B cell populations in human brainstem. Neuroscience 1988; 25(2): 439-56.
58. Araque A, Parpura V, Sanzgiri RP, et al. Tripartite synapses: glia, the unacknowledged partner. Trends Neurosci 1999; 22(5): 208-15.
59. Sasaki T, Kuga N, Namiki S, et al. Locally synchronized astrocytes. Cereb Cortex 2011; 21(8): 1889-900.
60. Araque A, Carmignoto G, Haydon PG. Dynamic signaling between astrocytes and neurons. Annu Rev Physiol 2001; 63: 795-813.
61. Bezzi P, Domercq M, Vesce S, et al. Neuron-astrocyte cross-talk during synaptic transmission: physiological and neuropathological implications. Prog Brain Res 2001; 132: 255-65.
62. Perea G, Navarrete M, Araque A. Tripartite synapses: astrocytes process and control synaptic information. Trends Neurosci 2009; 32(8): 421-31.
63. Santello M, Cali C, Bezzi P. Gliotransmission and the tripartite synapse. Adv Exp Med Biol 2012; 970: 307-31.
64. Rose CR, Blum R, Pichler B, et al. Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature 2003; 426(6962): 74-8.
65. Zhang JM, Wang HK, Ye CQ, et al. ATP released by astrocytes mediates glutamatergic activity-dependent heterosynaptic suppression. Neuron 2003; 40(5): 971-82.
66. Fields RD, Stevens B. ATP: an extracellular signaling molecule between neurons and glia. Trends Neurosci 2000; 23(12): 625-33.
67. Snyder SH, Kim PM. D-amino acids as putative neurotransmitters: focus on D-serine. Neurochem Res 2000; 25(5): 553-60.
68. Araque A, Parpura V, Sanzgiri RP, et al. Glutamate-dependent astrocyte modulation of synaptic transmission between cultured hippocampal neurons. Eur J Neurosci 1998; 10(6): 2129-42.
69. Fellin T, Pascual O, Gobbo S, et al. Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. Neuron 2004; 43(5): 729-43.
70. Angulo MC, Kozlov AS, Charpak S, et al. Glutamate released from glial cells synchronizes neuronal activity in the hippocampus. J Neurosci 2004; 24(31): 6920-7.
71. Pascual O, Casper KB, Kubera C, et al. Astrocytic purinergic signaling coordinates synaptic networks. Science 2005; 310(5745): 113-6.
72. Newman EA. Glial cell inhibition of neurons by release of ATP. J Neurosci 2003; 23(5): 1659-66.
73. Mothet JP, Pollegioni L, Ouanounou G, et al. Glutamate receptor activation triggers a calcium-dependent and SNARE proteindependent release of the gliotransmitter D-serine. Proc Natl Acad Sci U S A 2005; 102(15): 5606-11.
74. Miyazaki J, Nakanishi S, Jingami H. Expression and characterization of a glycine-binding fragment of the N-methyl-D-aspartate receptor subunit NR1. Biochem J 1999; 340 (Pt 3): 687-92.
75. Johnson JW, Ascher P. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 1987; 325(6104): 529-31.
76. Kleckner NW, Dingledine R. Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes. Science 1988; 241(4867): 835-7.
77. Panatier A, Theodosis DT, Mothet JP, et al. Glia-derived D-serine controls NMDA receptor activity and synaptic memory. Cell 2006; 125(4): 775-84.
78. Mothet JP, Parent AT, Wolosker H, et al. D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A 2000; 97(9): 4926-31.
79. Wolosker H. NMDA receptor regulation by D-serine: new findings and perspectives. Mol Neurobiol 2007; 36(2): 152-64.
80. Ben Achour S, Pascual O. Astrocyte-neuron communication: functional consequences. Neurochem Res 2012; 37(11): 2464-73.
81. Schildkraut JJ. The catecholamine hypothesis of affective disorders: a review of supporting evidence. Am J Psychiatry 1965; 122(5): 509-22.
82. Nestler EJ, Barrot M, DiLeone RJ, et al. Neurobiology of depression. Neuron 2002; 34(1): 13-25.
83. Czeh B, Di Benedetto B. Antidepressants act directly on astrocytes: Evidences and functional consequences. Eur Neuropsychopharmacol 2013; 23(3):171-85
84. Sillaber I, Panhuysen M, Henniger MS, et al. Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine. Psychopharmacology (Berl) 2008; 200(4): 557-72.
85. Conti B, Maier R, Barr AM, et al. Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine. Mol Psychiatry 2007; 12(2): 167-89.
86. Kragh J, Bolwig TG, Woldbye DP, et al. Electroconvulsive shock and lidocaine-induced seizures in the rat activate astrocytes as measured by glial fibrillary acidic protein. Biol Psychiatry 1993; 33(11-12): 794-800.
87. Dwork AJ, Arango V, Underwood M, et al. Absence of histological lesions in primate models of ECT and magnetic seizure therapy. Am J Psychiatry 2004; 161(3): 576-8.
88. Liu Q, Li B, Zhu HY, et al. Clomipramine treatment reversed the glial pathology in a chronic unpredictable stress-induced rat model of depression. Eur Neuropsychopharmacol 2009; 19(11): 796-805.
89. Schafer BW, Heizmann CW. The S100 family of EF-hand calciumbinding proteins: functions and pathology. Trends Biochem Sci 1996; 21(4): 134-40.
90. Arolt V, Peters M, Erfurth A, et al. S100B and response to treatment in major depression: a pilot study. Eur Neuropsychopharmacol 2003; 13(4): 235-9.
91. Uher T, Bob P. Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders. Neurosci Lett 2012; 529(2): 139-43.
92. Manev R, Uz T, Manev H. Fluoxetine increases the content of neurotrophic protein S100beta in the rat hippocampus. Eur J Pharmacol 2001; 420(2-3): R1-2.
93. Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 2001; 33(7): 637-68.
94. Tramontina AC, Tramontina F, Bobermin LD, et al. Secretion of S100B, an astrocyte-derived neurotrophic protein, is stimulated by fluoxetine via a mechanism independent of serotonin. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32(6): 1580-3.
95. Schipke CG, Heuser I, Peters O. Antidepressants act on glial cells: SSRIs and serotonin elicit astrocyte calcium signaling in the mouse prefrontal cortex. J Psychiatr Res 2011; 45(2): 242-8.
96. Whitaker-Azmitia PM, Clarke C, Azmitia EC. Localization of 5-HT1A receptors to astroglial cells in adult rats: implications for neuronal-glial interactions and psychoactive drug mechanism of action. Synapse 1993; 14(3): 201-5.
97. Barnes NM, Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 1999; 38(8): 1083-152.
98. Shimizu M, Nishida A, Zensho H, et al. Chronic antidepressant exposure enhances 5-hydroxytryptamine7 receptor-mediated cyclic adenosine monophosphate accumulation in rat frontocortical astrocytes. J Pharmacol Exp Ther 1996; 279(3): 1551-8.
99. Zhang S, Li B, Lovatt D, et al. 5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'. Neuron Glia Biol 2010; 6(2): 113-25.
100. Junker V, Becker A, Huhne R, et al. Stimulation of betaadrenoceptors activates astrocytes and provides neuroprotection. Eur J Pharmacol 2002; 446(1-3): 25-36.
101. Hosli E, Hosli L. Receptors for neurotransmitters on astrocytes in the mammalian central nervous system. Prog Neurobiol 1993; 40(4): 477-506.
102. Miyazaki I, Asanuma M, Diaz-Corrales FJ, et al. Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia. Brain Res 2004; 1029(1): 120-3.
103. Inazu M, Takeda H, Ikoshi H, et al. Pharmacological characterization and visualization of the glial serotonin transporter. Neurochem Int 2001; 39(1): 39-49.
104. Inazu M, Takeda H, Matsumiya T. Functional expression of the norepinephrine transporter in cultured rat astrocytes. J Neurochem 2003; 84(1): 136-44.
105. Schildkraut JJ, Mooney JJ. Toward a rapidly acting antidepressant: the normetanephrine and extraneuronal monoamine transporter (uptake 2) hypothesis. Am J Psychiatry 2004; 161(5): 909-11.
106. Sapena R, Morin D, Zini R, et al. Desipramine treatment differently down-regulates beta-adrenoceptors of freshly isolated neurons and astrocytes. Eur J Pharmacol 1996; 300(1-2): 159-62.
107. Mannisto PT, Kaakkola S. Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors. Pharmacol Rev 1999; 51(4): 593-628.
108. Benmansour S, Owens WA, Cecchi M, et al. Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter. J Neurosci 2002; 22(15): 6766-72.
109. Cao X, Li LP, Wang Q, et al. Astrocyte-derived ATP modulates depressive-like behaviors. Nat Med 2013; 19(6):773-7.
110. Hunter AM, Balleine BW, Minor TR. Helplessness and escape performance: glutamate-adenosine interactions in the frontal cortex. Behav Neurosci 2003; 117(1): 123-35.
111. Minor TR, Winslow JL, Chang WC. Stress and adenosine: II. Adenosine analogs mimic the effect of inescapable shock on shuttle-escape performance in rats. Behav Neurosci 1994; 108(2): 265-76.
112. Kulkarni SK, Mehta AK. Purine nucleoside--mediated immobility in mice: reversal by antidepressants. Psychopharmacology (Berl) 1985; 85(4): 460-3.
113. Cunha GM, Canas PM, Oliveira CR, et al. Increased density and synapto-protective effect of adenosine A2A receptors upon subchronic restraint stress. Neuroscience 2006; 141(4): 1775-81.
114. Kaster MP, Santos AR, Rodrigues AL. Involvement of 5-HT1A receptors in the antidepressant-like effect of adenosine in the mouse forced swimming test. Brain Res Bull 2005; 67(1-2): 53-61.
115. Kaster MP, Rosa AO, Rosso MM, et al. Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors. Neurosci Lett 2004; 355(1-2): 21-4.
116. Woodson JC, Minor TR, Job RF. Inhibition of adenosine deaminase by erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) mimics the effect of inescapable shock on escape learning in rats. Behav Neurosci 1998; 112(2): 399-409.
117. Elgun S, Keskinege A, Kumbasar H. Dipeptidyl peptidase IV and adenosine deaminase activity. Decrease in depression. Psychoneuroendocrinology 1999; 24(8): 823-32.
118. Herken H, Gurel A, Selek S, et al. Adenosine deaminase, nitric oxide, superoxide dismutase, and xanthine oxidase in patients with major depression: impact of antidepressant treatment. Arch Med Res 2007; 38(2): 247-52.
119. van Calker D, Biber K. The role of glial adenosine receptors in neural resilience and the neurobiology of mood disorders. Neurochem Res 2005; 30(10): 1205-17.
120. Hines DJ, Schmitt LI, Hines RM, et al. Antidepressant effects of sleep deprivation require astrocyte-dependent adenosine mediated signaling. Transl Psychiatry 2013; 3: e212.
121. Chau A, Rose JC, Koos BJ. Adenosine modulates corticotropin and cortisol release during hypoxia in fetal sheep. Am J Obstet Gynecol 1999; 180(5): 1272-7.
122. Scaccianoce S, Navarra D, Di Sciullo A, et al. Adenosine and pituitary-adrenocortical axis activity in the rat. Neuroendocrinology 1989; 50(4): 464-8.
123. Okada M, Nutt DJ, Murakami T, et al. Adenosine receptor subtypes modulate two major functional pathways for hippocampal serotonin release. J Neurosci 2001; 21(2): 628-40.
124. Diogenes MJ, Fernandes CC, Sebastiao AM, et al. Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices. J Neurosci 2004; 24(12): 2905-13.
125. de Mendonca A, Ribeiro JA. Adenosine inhibits the NMDA receptor-mediated excitatory postsynaptic potential in the hippocampus. Brain Res 1993; 606(2): 351-6.
126. de Mendonca A, Ribeiro JA. Long-term potentiation observed upon blockade of adenosine A1 receptors in rat hippocampus is Nmethyl-D-aspartate receptor-dependent. Neurosci Lett 2000; 291(2): 81-4.
127. Kaster MP, Machado DG, Santos AR, et al. Involvement of NMDA receptors in the antidepressant-like action of adenosine. Pharmacol Rep 2012; 64(3): 706-13.
128. Krishnan V, Nestler EJ. Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry 2010; 167(11): 1305-20.
129. Sanacora G, Zarate CA, Krystal JH, et al. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nat Rev Drug Discov 2008; 7(5): 426-37.
130. Skolnick P, Layer RT, Popik P, et al. Adaptation of N-methyl-Daspartate (NMDA) receptors following antidepressant treatment: implications for the pharmacotherapy of depression. Pharmacopsychiatry 1996; 29(1): 23-6.
131. Li N, Lee B, Liu RJ, et al. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science 2010; 329(5994): 959-64.
132. Li N, Liu RJ, Dwyer JM, et al. Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biol Psychiatry 2011; 69(8): 754-61.
133. Berman RM, Cappiello A, Anand A, et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 2000; 47(4): 351-4.
134. Zarate CA, Jr., Singh JB, Carlson PJ, et al. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 2006; 63(8): 856-64.
135. Phelps LE, Brutsche N, Moral JR, et al. Family history of alcohol dependence and initial antidepressant response to an N-methyl-Daspartate antagonist. Biol Psychiatry 2009; 65(2): 181-4.
136. Malkesman O, Austin DR, Tragon T, et al. Acute d-serine treatment produces antidepressant-like effects in rodents. Int J Neuropsychopharmacol 2011; 12: 1-14.
137. Malkesman O, Austin DR, Tragon T, et al. Acute d-serine treatment produces antidepressant-like effects in rodents. Int J Neuropsychopharmacol 2012; 12: 1-14.
138. Monteggia LM, Gideons E, Kavalali ET. The Role of Eukaryotic Elongation Factor 2 Kinase in Rapid Antidepressant Action of Ketamine. Biol Psychiatry 2013; 73(12):1199-203.
139. Nosyreva E, Szabla K, Autry AE, et al. Acute suppression of spontaneous neurotransmission drives synaptic potentiation. J Neurosci 2013; 33(16): 6990-7002.
140. Papouin T, Ladepeche L, Ruel J, et al. Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists. Cell 2012; 150(3): 633-46.
141. Lehre KP, Levy LM, Ottersen OP, et al. Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations. J Neurosci 1995; 15(3 Pt 1): 1835-53.
142. Huang YH, Sinha SR, Tanaka K, et al. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci 2004; 24(19): 4551-9.
143. Banasr M, Chowdhury GM, Terwilliger R, et al. Glial pathology in an animal model of depression: reversal of stress-induced cellular, metabolic and behavioral deficits by the glutamate-modulating drug riluzole. Mol Psychiatry 2010; 15(5): 501-11.
144. Song H, Stevens CF, Gage FH. Astroglia induce neurogenesis from adult neural stem cells. Nature 2002; 417(6884): 39-44.
145. Lim DA, Alvarez-Buylla A. Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis. Proc Natl Acad Sci U S A 1999; 96(13): 7526-31.
146. Connor B, Dragunow M. The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Res Brain Res Rev 1998; 27(1): 1-39.
147. Karege F, Vaudan G, Schwald M, et al. Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Brain Res Mol Brain Res 2005; 136(1-2): 29-37.
148. Shirayama Y, Chen AC, Nakagawa S, et al. Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 2002; 22(8): 3251-61.
149. Duman RS, Monteggia LM. A neurotrophic model for stressrelated mood disorders. Biol Psychiatry 2006; 59(12): 1116-27.
150. Samuels BA, Hen R. Neurogenesis and affective disorders. Eur J Neurosci 2011; 33(6): 1152-9.
151. Nibuya M, Morinobu S, Duman RS. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neurosci 1995; 15(11): 7539-47.
152. Lee J, Duan W, Mattson MP. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. J Neurochem 2002; 82(6): 1367-75.
153. Santarelli L, Saxe M, Gross C, et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003; 301(5634): 805-9.
154. David DJ, Samuels BA, Rainer Q, et al. Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron 2009; 62(4): 479-93.
155. Prickaerts J, De Vry J, Boere J, et al. Differential BDNF responses of triple versus dual reuptake inhibition in neuronal and astrocytoma cells as well as in rat hippocampus and prefrontal cortex. J Mol Neurosci 2012; 48(1): 167-75.
156. Allaman I, Fiumelli H, Magistretti PJ, et al. Fluoxetine regulates the expression of neurotrophic/growth factors and glucose metabolism in astrocytes. Psychopharmacology (Berl) 2011; 216(1): 75-84.
157. Kittel-Schneider S, Kenis G, Schek J, et al. Expression of monoamine transporters, nitric oxide synthase 3, and neurotrophin genes in antidepressant-stimulated astrocytes. Front Psychiatry 2012; 3: 33.
158. Angelucci F, Croce N, Spalletta G, et al. Paroxetine rapidly modulates the expression of brain-derived neurotrophic factor mRNA and protein in a human glioblastoma-astrocytoma cell line. Pharmacology 87(1-2): 5-10.
159. Hisaoka K, Nishida A, Koda T, et al. Antidepressant drug treatments induce glial cell line-derived neurotrophic factor (GDNF) synthesis and release in rat C6 glioblastoma cells. J Neurochem 2001; 79(1): 25-34.
160. Kajitani N, Hisaoka-Nakashima K, Morioka N, et al. Antidepressant acts on astrocytes leading to an increase in the expression of neurotrophic/growth factors: differential regulation of FGF-2 by noradrenaline. PLoS One 2012; 7(12): e51197.
161. Hisaoka K, Nishida A, Takebayashi M, et al. Serotonin increases glial cell line-derived neurotrophic factor release in rat C6 glioblastoma cells. Brain Res 2004; 1002(1-2): 167-70.
162. Ohta K, Kuno S, Mizuta I, et al. Effects of dopamine agonists bromocriptine, pergolide, cabergoline, and SKF-38393 on GDNF, NGF, and BDNF synthesis in cultured mouse astrocytes. Life Sci 2003; 73(5): 617-26.
163. Inoue S, Susukida M, Ikeda K, et al. Dopaminergic transmitter upregulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) synthesis in mouse astrocytes in culture. Biochem Biophys Res Commun 1997; 238(2): 468-72.
164. Quesseveur G, David DJ, Gaillard MC, et al. BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities. Transl Psychiatry 2013; 3: e253.
165. Cao X, Li LP, Qin XH, et al. Astrocytic ATP release regulates the proliferation of neural stem cells in the adult hippocampus. Stem Cells 2013; Epub ahead of print.
166. Lie DC, Colamarino SA, Song HJ, et al. Wnt signalling regulates adult hippocampal neurogenesis. Nature 2005; 437(7063): 1370-5.
167. Lin JH, Takano T, Arcuino G, et al. Purinergic signaling regulates neural progenitor cell expansion and neurogenesis. Dev Biol 2007; 302(1): 356-66.
168. Suyama S, Sunabori T, Kanki H, et al. Purinergic signaling promotes proliferation of adult mouse subventricular zone cells. J Neurosci 2012; 32(27): 9238-47.
169. Benabid AL, Pollak P, Louveau A, et al. Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease. Appl Neurophysiol 1987; 50(1-6): 344-6.
170. Mayberg HS, Lozano AM, Voon V, et al. Deep brain stimulation for treatment-resistant depression. Neuron 2005; 45(5): 651-60.
171. Kennedy SH, Giacobbe P, Rizvi SJ, et al. Deep Brain Stimulation for Treatment-Resistant Depression: Follow-Up After 3 to 6 Years. Am J Psychiatry 2011; 168(5):502-10.
172. Lozano AM, Dostrovsky J, Chen R, et al. Deep brain stimulation for Parkinson's disease: disrupting the disruption. Lancet Neurol 2002; 1(4): 225-31.
173. Montgomery EB, Jr., Gale JT. Mechanisms of action of deep brain stimulation(DBS). Neurosci Biobehav Rev 2008; 32(3): 388-407.
174. Vitek JL. Mechanisms of deep brain stimulation: excitation or inhibition. Mov Disord 2002; 17 Suppl 3: S69-72.
175. Gubellini P, Salin P, Kerkerian-Le Goff L, et al. Deep brain stimulation in neurological diseases and experimental models: from molecule to complex behavior. Prog Neurobiol 2009; 89(1): 79-123.
176. McIntyre CC, Savasta M, Kerkerian-Le Goff L, et al. Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both. Clin Neurophysiol 2004; 115(6): 1239-48.
177. Vedam-Mai V, van Battum EY, Kamphuis W, et al. Deep brain stimulation and the role of astrocytes. Mol Psychiatry 2012; 17(2):124-31.
178. Takano T, Tian GF, Peng W, et al. Astrocyte-mediated control of cerebral blood flow. Nat Neurosci 2006; 9(2): 260-7.
179. Zonta M, Angulo MC, Gobbo S, et al. Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat Neurosci 2003; 6(1): 43-50.
180. Kefalopoulou Z, Paschali A, Markaki E, et al. Regional cerebral blood flow changes induced by deep brain stimulation in secondary dystonia. Acta Neurochir (Wien) 2010; 152(6): 1007-14.
181. Perlmutter JS, Mink JW, Bastian AJ, et al. Blood flow responses to deep brain stimulation of thalamus. Neurology 2002; 58(9): 1388-94.
182. Bekar L, Libionka W, Tian GF, et al. Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor. Nat Med 2008; 14(1): 75-80.
183. Tawfik VL, Chang SY, Hitti FL, et al. Deep brain stimulation results in local glutamate and adenosine release: investigation into the role of astrocytes. Neurosurgery 2010; 67(2): 367-75.
184. Jansson L, Wennstrom M, Johanson A, et al. Glial cell activation in response to electroconvulsive seizures. Prog Neuropsychopharmacol Biol Psychiatry 2009; 33(7): 1119-28.
185. Steward O. Electroconvulsive seizures upregulate astroglial gene expression selectively in the dentate gyrus. Brain Res Mol Brain Res 1994; 25(3-4): 217-24.
186. Ongur D, Pohlman J, Dow AL, et al. Electroconvulsive seizures stimulate glial proliferation and reduce expression of Sprouty2 within the prefrontal cortex of rats. Biol Psychiatry 2007; 62(5): 505-12.
187. Wennstrom M, Hellsten J, Ekdahl CT, et al. Electroconvulsive seizures induce proliferation of NG2-expressing glial cells in adult rat hippocampus. Biol Psychiatry 2003; 54(10): 1015-24.
188. Wennstrom M, Hellsten J, Tingstrom A. Electroconvulsive seizures induce proliferation of NG2-expressing glial cells in adult rat amygdala. Biol Psychiatry 2004; 55(5): 464-71.
189. Nemeroff CB, Mayberg HS, Krahl SE, et al. VNS therapy in treatment-resistant depression: clinical evidence and putative neurobiological mechanisms. Neuropsychopharmacology 2006; 31(7): 1345-55.
190. McDougal DH, Hermann GE, Rogers RC. Vagal afferent stimulation activates astrocytes in the nucleus of the solitary tract via AMPA receptors: evidence of an atypical neural-glial interaction in the brainstem. J Neurosci 2011; 31(39): 14037-45.
191. Fujiki M, Steward O. High frequency transcranial magnetic stimulation mimics the effects of ECS in upregulating astroglial gene expression in the murine CNS. Brain Res Mol Brain Res 1997; 44(2): 301-8.
192. Kozlov AS, Angulo MC, Audinat E, et al. Target cell-specific modulation of neuronal activity by astrocytes. Proc Natl Acad Sci U S A 2006; 103(26): 10058-63.
193. Chang SY, Shon YM, Agnesi F, et al. Microthalamotomy effect during deep brain stimulation: potential involvement of adenosine and glutamate efflux. Conf Proc IEEE Eng Med Biol Soc 2009; 2009: 3294-7.
194. Morishita T, Foote KD, Wu SS, et al. Brain penetration effects of microelectrodes and deep brain stimulation leads in ventral intermediate nucleus stimulation for essential tremor. J Neurosurg 2010; 112(3): 491-6.
195. Mann JM, Foote KD, Garvan CW, et al. Brain penetration effects of microelectrodes and DBS leads in STN or GPi. J Neurol Neurosurg Psychiatry 2009; 80(7): 794-7.
196. Perez-Caballero L, Perez-Egea R, Romero-Grimaldi C, et al. Early responses to deep brain stimulation in depression are modulated by anti-inflammatory drugs. Mol Psychiatry 2013.
197. Etiévant A, Oosterhof CA, Bétry C, et al. Glial modulation of medial prefrontal cortex deep brain stimulation. In: European Neuropsychopharmacology; 2011. p. S16-S17.
198. Hamani C, Machado DC, Hipolide DC, et al. Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Role of Serotonin and Brain Derived Neurotrophic Factor. Biol Psychiatry 2012; 71(1): 30-5.