D-amino acids as putative neurotransmitters: Focus on D-serine

Neurochemical Research

Volumn 25, Issue 5, 2000, Pages 553-560

  Snyder, Solomon H ^a   Kim, Paul M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Astrocytes; Bergmann glia; D aspartate; D serine; N methyl D aspartate (NMDA) receptor

Indexed keywords

DEXTRO AMINO ACID; DEXTRO SERINE;

ARTICLE; ASTROCYTE; GLIA; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; STEREOCHEMISTRY;

AMINO ACIDS; ANIMALS; ASTROCYTES; BRAIN; HUMANS; MAMMALS; NEUROTRANSMITTER AGENTS; SERINE; STEREOISOMERISM;

MAMMALIA;

EID: 0033932747     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007586314648     Document Type: Article

References (30)

1. Dunlop, D. S., Neidle, A., McHale, D., Dunlop, D. M., and Lajtha, A. 1986. The presence of free D-aspartic acid in rodents and man. Biochem. Biophys. Res. Commun. 141:27-32.
2. Hashimoto, A., Nishikawa, T., Oka, T., Takahashi, K. and Hayashi, T. 1992. Determination of free amino acid enantiomers in rat brain and serum by high-performance liquid chromatography after derivatization with N-tert.-butyloxycarbonyl-L-cysteine and o-phthaldialdehyde. J. Chromatogr. 582:41-8.
3. Hashimoto, A., Nishikawa, T., Hayashi, T., Fujii, N., Harada, K., Oka, T. and Takahashi, K. 1992. The presence of free D-serine in rat brain. FEBS Lett. 296:33-36.
4. Hashimoto, A. and Oka, T. 1997. Free D-aspartate and D-serine in the mammalian brain and periphery. Prog. Neurobiol. 52:325-53.
5. Hashimoto, A., Nishikawa, T., Oka, T. and Takahashi, K. 1993. Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging. J. Neurochem. 60:783-6.
6. Matsui, T., Sekiguchi, M., Hashimoto, A., Tomita, U., Nishikawa, T. and Wada, K. 1995. Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration. J. Neurochem. 65: 454-8.
7. Schell, M. J., Molliver, M. E. and Snyder, S. H. 1995. D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc. Natl. Acad. Sci. USA. 92:3948-52.
8. Krebs, H. A. 1935. CXCVII. Metabolism of amino acids. III. Deamination of amino acids. Biochem. J. 29:1620-1644.
9. Horiike, K., Tojo, H., Arai, R., Nozaki, M. and Maeda, T. 1994. D-amino-acid oxidase is confined to the lower brain stem and cerebellum in rat brain: regional differentiation of astrocytes. Brain Res. 652:297-303.
10. Hashimoto, A., Nishikawa, T., Konno, R., Niwa, A., Yasumura, Y., Oka, T. and Takahashi, K. 1993. Free D-serine, D-aspartate and D-alanine in central nervous system and serum in mutant mice lacking D-amino acid oxidase. Neurosci. Lett. 152:33-6.
11. Levison, S. W. and McCarthy, K. D. 1991. Culturing Nerve Cells. Pages 309-336 in Banner, G. K. and Goslin K. (eds), MIT Press, Cambridge.
12. Schell, M. J., Brady, R. O., Jr., Molliver, M. E. and Snyder, S. H. 1997. D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors. J. Neurosci. 17:1604-15.
13. Trombley, P. Q. and Shepherd, G. M. 1994. Glycine exerts potent inhibitory actions on mammalian olfactory bulb neurons. J. Neurophysiol. 71:761-7.
14. Hashimoto, A., Oka, T. and Nishikawa, T. 1995. Anatomical distribution and postnatal changes in endogenous free D-aspartate and D-serine in rat brain and periphery. Eur. J. Neurosci. 7: 1657-63.
15. Rossi, D. J. and Slater, N. T. 1993. The developmental onset of NMDA receptor-channel activity during neuronal migration. Neuropharmacology. 32:1239-48.
16. Komuro, H. and Rakic, P. 1993. Modulation of neuronal migration by NMDA receptors. Science. 260:95-7.
17. Garthwaite, J. and Brodbelt, A. R. 1989. Synaptic activation of N-methyl-D-aspartate and non-N-methyl-D- aspartate receptors in the mossy fibre pathway in adult and immature rat cerebellar slices. Neuroscience. 29:401-12.
18. Dunlop, D. S. and Neidle, A. 1997. The origin and turnover of D-serine in brain. Biochem. Biophys. Res. Commun. 235:26-30.
19. Uo, T., Yoshimura, T., Shimizu, S. and Esaki, N. 1998. Occurrence of pyridoxal 5′-phosphate-dependent serine racemase in silkworm, Bombyx mori. Biochem. Biophys. Res. Commun. 246:31-4.
20. Wolosker, H., Sheth, K. N., Takahashi, M., Mothet, J. P., Brady, R. O., Jr., Ferris, C. D. and Snyder, S. H. 1999. Purification of serine racemase: biosynthesis of the neuromodulator D-serine. Proc. Natl. Acad. Sci. U S A. 96:721-5.
21. Wolosker, H., Blackshaw, S., and Snyder, S. H. 1999. Serine racemase: A glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc. Natl. Acad. Sci. U S A. 96:13409-14.
22. Denu, J. M. and Fitzpatrick, P. F. 1994. pH and kinetic isotope effects on the oxidative half-reaction of D- amino-acid oxidase. J. Biol. Chem. 269:15054-9.
23. D'Aniello, A., Vetere, A. and Petrucelli, L. 1993. Further study on the specificity of D-amino acid oxidase and D- aspartate oxidase and time course for complete oxidation of D-amino acids. Comp. Biochem. Physiol. [B]. 105:731-4.
24. Mothet, J. P., Parent, A. T., Wolosker, H., Brady Jr., R. O., Linden, D. J., Ferris, C. D., Rogawski, M. A. and Snyder, S. H. 2000. D-Serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc. Natl. Acad. Sci. USA. 97:4926-4931, 2000.
25. Mothet, J. P., Brady, R. O., Wolosker, H., Molliver, M. E. and Snyder, S. H. 1998. Physiological relevance of endogenous D-serine in the activation of NMDA receptors in the cerebellum of young rats. Soc. Neurosci. 24:332.
26. Bredt, D. S. and Snyder, S. H. 1989. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc. Natl. Acad. Sci. USA. 86:9030-3.
27. Berger, A. J., Dieudonne, S. and Ascher, P. 1998. Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses. J. Neurophysiol. 80:3336-40.
28. Hashimoto, A., Oka, T. and Nishikawa, T. 1995. Extracellular concentration of endogenous free D-serine in the rat brain as revealed by in vivo microdialysis. Neuroscience. 66:635-43.
29. Hashimoto, A., Kumashiro, S., Nizhikawa, T., Oka, T., Takahashi, K., Mito, T., Takashima, S., Doi, N., Mizutani, Y., Yamazaki, T. and et al. 1993. Embryonic development and postnatal changes in free D-aspartate and D-serine in the human prefrontal cortex. J. Neurochem. 61:348-51.
30. Schell, M. J., Cooper, O. B. and Snyder, S. H. 1997. D-aspartate localizations imply neuronal and neuroendocrine roles. Proc. Natl. Acad. Sci. USA. 94:2013-8.