Diverse roles for MAPK signaling in Circadian clocks

Advances in Genetics

Volumn 84, Issue , 2013, Pages 1-39

  Goldsmith, Charles S ^a   Bell Pedersen, Deborah ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Circadian rhythm; ERK; Fibroblasts; JNK; MTOR; OS 2; P38; SCN; Stress response; Suprachiasmatic nucleus

Indexed keywords

ANIMAL; ARTICLE; CIRCADIAN RHYTHM; ERK; FIBROBLAST; HUMAN; JNK; MTOR; OS-2; P38; PHYSIOLOGY; SCN; SIGNAL TRANSDUCTION; STRESS; SUPRACHIASMATIC NUCLEUS;

CIRCADIAN RHYTHM; ERK; FIBROBLASTS; JNK; MTOR; OS-2; P38; SCN; STRESS RESPONSE; SUPRACHIASMATIC NUCLEUS;

ANIMALS; CIRCADIAN CLOCKS; HUMANS; MAP KINASE SIGNALING SYSTEM; SUPRACHIASMATIC NUCLEUS;

EID: 84887959208     PISSN: 00652660     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-407703-4.00001-3     Document Type: Chapter

References (130)

1. Akashi M., Hayasaka N., Yamazaki S., Node K. Mitogen-activated protein kinase is a functional component of the autonomous circadian system in the suprachiasmatic nucleus. The Journal of Neuroscience 2008, 28(18):4619-4623. 10.1523/JNEUROSCI.3410-07.2008.
2. Akashi M., Nishida E. Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock. Genes & Development 2000, 14(6):645-649. 10.1101/gad.14.6.645.
3. Anjum R., Blenis J. The RSK family of kinases: Emerging roles in cellular signalling. Nature Reviews. Molecular Cell Biology 2008, 9(10):747-758. 10.1038/nrm2509.
4. Antoun G., Cannon P.B., Cheng H.-Y.M. Regulation of MAPK/ERK signaling and photic entrainment of the suprachiasmatic nucleus circadian clock by Raf kinase inhibitor protein. The Journal of Neuroscience 2012, 32(14):4867-4877. 10.1523/jneurosci.5650-11.2012.
5. Arthur J., Fong A.L., Dwyer J.M., Davare M., Reese E., Obrietan K. Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins. The Journal of Neuroscience 2004, 24(18):4324-4332. 10.1523/jneurosci.5227-03.2004.
6. Bagley M.C., Davis T., Dix M.C., Rokicki M.J., Kipling D. Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells. Bioorganic & Medicinal Chemistry Letters 2007, 17(18):5107-5110. 10.1016/j.bmcl.2007.07.016.
7. Bain J., McLauchlan H., Elliott M., Cohen P. The specificities of protein kinase inhibitors: An update. Biochemical Journal 2003, 371(Pt 1):199-204. 10.1042/BJ20021535.
8. Balsalobre A., Marcacci L., Schibler U. Multiple signaling pathways elicit circadian gene expression in cultured rat-1 fibroblasts. Current Biology 2000, 10(20):1291-1294. 10.1016/S0960-9822(00)00758-2.
9. Barr R.K., Bogoyevitch M.A. The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs). The International Journal of Biochemistry & Cell Biology 2001, 33(11):1047-1063. 10.1016/S1357-2725(01)00093-0.
10. Bell-Pedersen D., Cassone V.M., Earnest D.J., Golden S.S., Hardin P.E., Thomas T.L. Circadian rhythms from multiple oscillators: Lessons from diverse organisms. Nature Reviews. Genetics 2005, 6(7):544-556. 10.1038/nrg1633.
11. Bennett L.D., Beremand P., Thomas T.L., Bell-Pedersen D. Circadian activation of the mitogen-activated protein kinase MAK-1 facilitates rhythms in clock-controlled genes in Neurospora crassa. Eukaryotic Cell 2013, 12(1):59-69. 10.1128/ec.00207-12.
12. Bennett B.L., Sasaki D.T., Murray B.W., O'Leary E.C., Sakata S.T., Xu W. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proceedings of the National Academy of Sciences of the United States of America 2001, 98(24):13681-13686. 10.1073/pnas.251194298.
13. Bogoyevitch M.A. The isoform-specific functions of the c-Jun N-terminal Kinases (JNKs): Differences revealed by gene targeting. Bioessays 2006, 28(9):923-934. 10.1002/bies.20458.
14. Boivin D.B., James F.O., Wu A., Cho-Park P.F., Xiong H., Sun Z.S. Circadian clock genes oscillate in human peripheral blood mononuclear cells. Blood 2003, 102(12):4143-4145. 10.1182/blood-2003-03-0779.
15. Bozek K., Rosahl A.L., Gaub S., Lorenzen S., Herzel H. Circadian transcription in liver. Biosystems 2010, 102(1):61-69. 10.1016/j.biosystems.2010.07.010.
16. Bray M.S., Shaw C.A., Moore M.W.S., Garcia R.A.P., Zanquetta M.M., Durgan D.J. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. American Journal of Physiology - Heart and Circulatory Physiology 2008, 294(2):H1036-H1047. 10.1152/ajpheart.01291.2007.
17. Butcher G.Q., Doner J., Dziema H., Collamore M., Burgoon P.W., Obrietan K. The p42/44 mitogen-activated protein kinase pathway couples photic input to circadian clock entrainment. The Journal of Biological Chemistry 2002, 277(33):29519-29525. 10.1074/jbc.M203301200.
18. Butcher G.Q., Lee B., Cheng H.Y., Obrietan K. Light stimulates MSK1 activation in the suprachiasmatic nucleus via a PACAP-ERK/MAP kinase-dependent mechanism. The Journal of Neuroscience 2005, 25(22):5305-5313. 10.1523/JNEUROSCI.4361-04.2005.
19. Butcher G.Q., Lee B., Hsieh F., Obrietan K. Light- and clock-dependent regulation of ribosomal S6 kinase activity in the suprachiasmatic nucleus. European Journal of Neuroscience 2004, 19(4):907-915. 10.1111/j.0953-816X.2004.03155.x.
20. Cahill G.M. Clock mechanisms in zebrafish. Cell and Tissue Research 2002, 309(1):27-34. 10.1007/s00441-002-0570-7.
21. Cao R., Anderson F.E., Jung Y.J., Dziema H., Obrietan K. Circadian regulation of mammalian target of rapamycin signaling in the mouse suprachiasmatic nucleus. Neuroscience 2011, 181:79-88. 10.1016/j.neuroscience.2011.03.005.
22. Cao R., Butcher G.Q., Karelina K., Arthur J.S., Obrietan K. Mitogen- and stress-activated protein kinase 1 modulates photic entrainment of the suprachiasmatic circadian clock. European Journal of Neuroscience 2013, 37(1):130-140. 10.1111/ejn.12028.
23. Cao R., Lee B., Cho H.Y., Saklayen S., Obrietan K. Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock. Molecular and Cellular Neuroscience 2008, 38(3):312-324. 10.1016/j.mcn.2008.03.005.
24. Cao R., Li A., Cho H.Y., Lee B., Obrietan K. Mammalian target of rapamycin signaling modulates photic entrainment of the suprachiasmatic circadian clock. The Journal of Neuroscience 2010, 30(18):6302-6314. 10.1523/JNEUROSCI.5482-09.2010.
25. Cermakian N., Pando M.P., Thompson C.L., Pinchak A.B., Selby C.P., Gutierrez L. Light induction of a vertebrate clock gene involves signaling through blue-light receptors and MAP kinases. Current Biology 2002, 12(10):844-848. 10.1016/S0960-9822(02)00835-7.
26. Chansard M., Molyneux P., Nomura K., Harrington M.E., Fukuhara C. c-Jun N-terminal kinase inhibitor SP600125 modulates the period of mammalian circadian rhythms. Neuroscience 2007, 145(3):812-823. 10.1016/j.neuroscience.2006.12.037.
27. Chen C.-H., DeMay B.S., Gladfelter A.S., Dunlap J.C., Loros J.J. Physical interaction between VIVID and white collar complex regulates photoadaptation in Neurospora. Proceedings of the National Academy of Sciences of the United States of America 2010, 107(38):16715-16720. 10.1073/pnas.1011190107.
28. Cheng H.-Y.M., Dziema H., Papp J., Mathur D.P., Koletar M., Ralph M.R. The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. The Journal of Neuroscience 2006, 26(50):12984-12995. 10.1523/jneurosci.4253-06.2006.
29. Cheng H.-Y.M., Obrietan K., Cain S.W., Lee B.Y., Agostino P.V., Joza N.A. Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron 2004, 43(5):715-728. 10.1016/j.neuron.2004.08.021.
30. Cheng H.-Y.M., Papp J.W., Varlamova O., Dziema H., Russell B., Curfman J.P. microRNA modulation of circadian-clock period and entrainment. Neuron 2007, 54(5):813-829. 10.1016/j.neuron.2007.05.017.
31. Chik C.L., Mackova M., Price D., Ho A.K. Adrenergic regulation and diurnal rhythm of p38 mitogen-activated protein kinase phosphorylation in the rat pineal gland. Endocrinology 2004, 145(11):5194-5201. 10.1210/en.2004-0864.
32. Coogan A.N., Piggins H.D. Circadian and photic regulation of phosphorylation of ERK1/2 and Elk-1 in the suprachiasmatic nuclei of the syrian hamster. The Journal of Neuroscience 2003, 23(7):3085-3093.
33. Coogan A.N., Piggins H.D. MAP kinases in the mammalian circadian system-Key regulators of clock function. Journal of Neurochemistry 2004, 90(4):769-775. 10.1111/j.1471-4159.2004.02554.x.
34. Cuenda A., Rousseau S. p38 MAP-Kinases pathway regulation, function and role in human diseases. Biochimica et Biophysica Acta-Molecular Cell Research 2007, 1773(8):1358-1375. 10.1016/j.bbamcr.2007.03.010.
35. Daan S., Pittendrigh C.S. A functional analysis of circadian pacemakers in nocturnal rodents. IV. Entrainment: Pacemaker as clock. Journal of Comparative Physiology 1976, 106:253-266.
36. Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S. Mutations of the BRAF gene in human cancer. Nature 2002, 417(6892):949-954. 10.1038/nature00766.
37. Davis S., Vanhoutte P., Pagès C., Caboche J., Laroche S. The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. The Journal of Neuroscience 2000, 20(12):4563-4572.
38. de Paula R.M., Lamb T.M., Bennett L., Bell-Pedersen D. A connection between MAPK pathways and circadian clocks. Cell Cycle 2008, 7(17):2630-2634.
39. Dibner C., Schibler U., Albrecht U. The mammalian circadian timing system: Organization and coordination of central and peripheral clocks. Annual Review of Physiology 2010, 72:517-549. 10.1146/annurev-physiol-021909-135821.
40. Dunlap J.C. Molecular bases for circadian clocks. Cell 1999, 96(2):271-290. 10.1016/S0092-8674(00)80566-8.
41. Dunlap J.C., Loros J.J., Liu Y., Crosthwaite S.K. Eukaryotic circadian systems: Cycles in common. Genes to Cells 1999, 4(1):1-10. 10.1046/j.1365-2443.1999.00239.x.
42. Dziema H., Oatis B., Butcher G.Q., Yates R., Hoyt K.R., Obrietan K. The ERK/MAP kinase pathway couples light to immediate-early gene expression in the suprachiasmatic nucleus. European Journal of Neuroscience 2003, 17(8):1617-1627. 10.1046/j.1460-9568.2003.02592.x.
43. Dziema H., Obrietan K. PACAP potentiates L-type calcium channel conductance in suprachiasmatic nucleus neurons by activating the MAPK pathway. Journal of Neurophysiology 2002, 88(3):1374-1386.
44. Eckel-Mahan K.L., Phan T., Han S., Wang H., Chan G.C.K., Scheiner Z.S. Circadian oscillation of hippocampal MAPK activity and cAMP: Implications for memory persistence. Nature Neuroscience 2008, 11(9):1074-1082. 10.1038/nn.2174.
45. Fabian M.A., Biggs W.H., Treiber D.K., Atteridge C.E., Azimioara M.D., Benedetti M.G. A small molecule-kinase interaction map for clinical kinase inhibitors. Nature Biotechnology 2005, 23(3):329-336. 10.1038/nbt1068.
46. Fu L., Lee C.C. The circadian clock: Pacemaker and tumour suppressor. Nature Reviews. Cancer 2003, 3(5):350-361. 10.1038/nrc1072.
47. Gazel A., Banno T., Walsh R., Blumenberg M. Inhibition of JNK promotes differentiation of epidermal keratinocytes. The Journal of Biological Chemistry 2006, 281(29):20530-20541. 10.1074/jbc.M602712200.
48. Gazel A., Nijhawan R.I., Walsh R., Blumenberg M. Transcriptional profiling defines the roles of ERK and p38 kinases in epidermal keratinocytes. Journal of Cellular Physiology 2008, 215(2):292-308. 10.1002/jcp.21394.
49. Ginty D.D., Kornhauser J.M., Thompson M.A., Bading H., Mayo K.E., Takahashi J.S. Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. Science 1993, 260(5105):238-241. 10.1126/science.8097062.
50. Golden S.S., Ishiura M., Johnson C.H., Kondo T. Cyanobacterial circadian rhythms. Annual Review of Plant Biology 1997, 48(1):327-354. 10.1146/annurev.arplant.48.1.327.
51. Hagiwara D., Asano Y., Marui J., Yoshimi A., Mizuno T., Abe K. Transcriptional profiling for Aspergillus nidulans HogA MAPK signaling pathway in response to fludioxonil and osmotic stress. Fungal Genetics and Biology 2009, 46(11):868-878. 10.1016/j.fgb.2009.07.003.
52. Hainich E.C., Pizzio G.A., Golombek D.A. Constitutive activation of the ERK-MAPK pathway in the suprachiasmatic nuclei inhibits circadian resetting. FEBS Letters 2006, 580(28-29):6665-6668. 10.1016/j.febslet.2006.11.019.
53. Han J., Sun P. The pathways to tumor suppression via route p38. Trends in Biochemical Sciences 2007, 32(8):364-371. 10.1016/j.tibs.2007.06.007.
54. Hardin P.E. The circadian timekeeping system of Drosophila. Current Biology 2005, 15(17):R714-R722. 10.1016/j.cub.2005.08.019.
55. Hasegawa M., Cahill G.M. Regulation of the circadian oscillator in Xenopus retinal photoreceptors by protein kinases sensitive to the stress-activated protein kinase inhibitor, SB 203580. The Journal of Biological Chemistry 2004, 279(21):22738-22746. 10.1074/jbc.M401389200.
56. Hayashi Y., Sanada K., Fukada Y. Circadian and photic regulation of MAP kinase by Ras- and protein phosphatase-dependent pathways in the chick pineal gland. FEBS Letters 2001, 491(1-2):71-75. 10.1016/S0014-5793(01)02153-6.
57. Hayashi Y., Sanada K., Hirota T., Shimizu F., Fukada Y. p38 mitogen-activated protein kinase regulates oscillation of chick pineal circadian clock. The Journal of Biological Chemistry 2003, 278(27):25166-25171. 10.1074/jbc.M212726200.
58. Hess J., Angel P., Schorpp-Kistner M. AP-1 subunits: Quarrel and harmony among siblings. Journal of Cell Science 2004, 117(25):5965-5973. 10.1242/jcs.01589.
59. Ho A.K., Mackova M., Price L., Chik C.L. Diurnal variation in p42/44 mitogen-activated protein kinase in the rat pineal gland. Molecular and Cellular Endocrinology 2003, 208(1-2):23-30. 10.1016/S0303-7207(03)00260-0.
60. Johnson C.H., Elliott J.A., Foster R. Entrainment of circadian programs. Chronobiology International 2003, 20(5):741-774. 10.1081/cbi-120024211.
61. Johnson G.L., Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002, 298(5600):1911-1912. 10.1126/science.1072682.
62. Karmarkar S.W., Bottum K.M., Krager S.L., Tischkau S.A. ERK/MAPK is essential for endogenous neuroprotection in SCN2.2 cells. PLoS One 2011, 6(8):e23493. 10.1371/journal.pone.0023493.
63. Keller M., Mazuch J., Abraham U., Eom G.D., Herzog E.D., Volk H.-D. A circadian clock in macrophages controls inflammatory immune responses. Proceedings of the National Academy of Sciences of the United States of America 2009, 106(50):21407-21412. 10.1073/pnas.0906361106.
64. Kloss B., Price J.L., Saez L., Blau J., Rothenfluh A., Wesley C.S. The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Ie{open}. Cell 1998, 94(1):97-107. 10.1016/S0092-8674(00)81225-8.
65. Ko G.Y.P., Ko M.L., Dryer S.E. Circadian regulation of cGMP-gated cationic channels of chick retinal cones: Erk MAP kinase and Ca2+/calmodulin-dependent protein kinase II. Neuron 2001, 29(1):255-266. 10.1016/S0896-6273(01)00195-7.
66. Ko M.L., Shi L., Ko G.Y. Circadian controls outweigh acute illumination effects on the activity of extracellular signal-regulated kinase (ERK) in the retina. Neuroscience Letters 2009, 451(1):74-78. 10.1016/j.neulet.2008.12.025.
67. Ko M.L., Shi L., Tsai J.-Y., Young M.E., Neuendorff N., Earnest D.J. Cardiac-specific mutation of clock alters the quantitative measurements of physical activities without changing behavioral circadian rhythms. Journal of Biological Rhythms 2011, 26(5):412-422. 10.1177/0748730411414170.
68. Ko C.H., Takahashi J.S. Molecular components of the mammalian circadian clock. Human Molecular Genetics 2006, 15(suppl 2):R271-R277. 10.1093/hmg/ddl207.
69. Koike N., Yoo S.-H., Huang H.-C., Kumar V., Lee C., Kim T.-K. Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science 2012, 338(6105):349-354. 10.1126/science.1226339.
70. Kolch W. Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nature Reviews. Molecular Cell Biology 2005, 6(11):827-837. 10.1038/nrm1743.
71. Lamb T.M., Finch K.E., Bell-Pedersen D. The Neurospora crassa OS MAPK pathway-activated transcription factor ASL-1 contributes to circadian rhythms in pathway responsive clock-controlled genes. Fungal Genetics and Biology 2012, 49(2):180-188. 10.1016/j.fgb.2011.12.006.
72. Lamb T.M., Goldsmith C.S., Bennett L., Finch K.E., Bell-Pedersen D. Direct transcriptional control of a p38 MAPK pathway by the circadian clock in Neurospora crassa. PLoS One 2011, 6(11):e27149. 10.1371/journal.pone.0027149.
73. Lee K., Dunlap J.C., Loros J.J. Interconnected feedback loops in the Neurospora circadian system. Science 2000, 289(5476):107-110.
74. Lee H.S., Nelms J.L., Nguyen M., Silver R., Lehman M.N. The eye is necessary for a circadian rhythm in the suprachiasmatic nucleus. Nature Neuroscience 2003, 6(2):111-112. 10.1038/nn1006.
75. Lonze B.E., Ginty D.D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 2002, 35(4):605-623. 10.1016/s0896-6273(02)00828-0.
76. Louie K., Wilson M.A. Temporally structured replay of awake hippocampal ensemble activity during rapid eye movement sleep. Neuron 2001, 29(1):145-156. 10.1016/S0896-6273(01)00186-6.
77. Lowrey P.L., Shimomura K., Antoch M.P., Yamazaki S., Zemenides P.D., Ralph M.R. Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau. Science 2000, 288(5465):483-491. 10.1126/science.288.5465.483.
78. Luo J., Phan T.X., Yang Y., Garelick M.G., Storm D.R. Increases in cAMP, MAPK activity, and CREB phosphorylation during REM sleep: Implications for REM sleep and memory consolidation. The Journal of Neuroscience 2013, 33(15):6460-6468. 10.1523/jneurosci.5018-12.2013.
79. Menet J.S., Rodriguez J., Abruzzi K.C., Rosbash M. Nascent-seq reveals novel features of mouse circadian transcriptional regulation. eLife 2012, 1. 10.7554/eLife.00011.
80. Menger G.J., Allen G.C., Neuendorff N., Nahm S.S., Thomas T.L., Cassone V.M. Circadian profiling of the transcriptome in NIH/3T3 fibroblasts: Comparison with rhythmic gene expression in SCN2.2 cells and the rat SCN. Physiological Genomics 2007, 29(3):280-289. 10.1152/physiolgenomics.00199.2006.
81. Mohawk J.A., Green C.B., Takahashi J.S. Central and peripheral circadian clocks in mammals. Annual Review of Neuroscience 2012, 35(1):445-462. 10.1146/annurev-neuro-060909-153128.
82. Morrison D.K., Davis R.J. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annual Review of Cell and Developmental Biology 2003, 19:91-118. 10.1146/annurev.cellbio.19.111401.091942.
83. Mrosovsky N. Locomotor activity and non-photic influences on circadian clocks. Biological Reviews 1996, 71(3):343-372. 10.1111/j.1469-185X.1996.tb01278.x.
84. Nakaya M., Sanada K., Fukada Y. Spatial and temporal regulation of mitogen-activated protein kinase phosphorylation in the mouse suprachiasmatic nucleus. Biochemical and Biophysical Research Communications 2003, 305(3):494-501. 10.1016/S0006-291X(03)00791-5.
85. Noguchi R., Banno S., Ichikawa R., Fukumori F., Ichiishi A., Kimura M. Identification of OS-2 MAP kinase-dependent genes induced in response to osmotic stress, antifungal agent fludioxonil, and heat shock in Neurospora crassa. Fungal Genetics and Biology 2007, 44(3):208-218. 10.1016/j.fgb.2006.08.003.
86. Obrietan K., Impey S., Smith D., Athos J., Storm D.R. Circadian regulation of cAMP response element-mediated gene expression in the suprachiasmatic nuclei. The Journal of Biological Chemistry 1999, 274(25):17748-17756. 10.1074/jbc.274.25.17748.
87. Obrietan K., Impey S., Storm D.R. Light and circadian rhythmicity regulate MAP kinase activation in the suprachiasmatic nuclei. Nature Neuroscience 1998, 1(8):693-700. 10.1038/3695.
88. O'Rourke S.M., Herskowitz I. The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae. Genes & Development 1998, 12(18):2874-2886. 10.1101/gad.12.18.2874.
89. Owens D.M., Keyse S.M. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 2007, 26(22):3203-3213. 10.1038/sj. Onc.1210412.
90. Petrzilka S., Taraborrelli C., Cavadini G., Fontana A., Birchler T. Clock gene modulation by TNF-alpha depends on calcium and p38 MAP kinase signaling. Journal of Biological Rhythms 2009, 24(4):283-294. 10.1177/0748730409336579.
91. Phan T.H., Chan G.C.-K., Sindreu C.B., Eckel-Mahan K.L., Storm D.R. The diurnal oscillation of MAP (mitogen-activated protein) kinase and adenylyl cyclase activities in the hippocampus depends on the suprachiasmatic nucleus. The Journal of Neuroscience 2011, 31(29):10640-10647. 10.1523/jneurosci.6535-10.2011.
92. Pizzio G.A., Hainich E.C., Ferreyra G.A., Coso O.A., Golombek D.A. Circadian and photic regulation of ERK, JNK and p38 in the hamster SCN. Neuroreport 2003, 14(11):1417-1419. 10.1097/01.wnr.0000082025.91120.69.
93. Plautz J.D., Kaneko M., Hall J.C., Kay S.A. Independent photoreceptive circadian clocks throughout Drosophila. Science 1997, 278(5343):1632-1635. 10.1126/science.278.5343.1632.
94. Poe G.R., Nitz D.A., McNaughton B.L., Barnes C.A. Experience-dependent phase-reversal of hippocampal neuron firing during REM sleep. Brain Research 2000, 855(1):176-180. 10.1016/S0006-8993(99)02310-0.
95. Pollard L.C., Choy E.H., Gonzalez J., Khoshaba B., Scott D.L. Fatigue in rheumatoid arthritis reflects pain, not disease activity. Rheumatology 2006, 45(7):885-889. 10.1093/rheumatology/kel021.
96. Price J.L., Blau J., Rothenfluh A., Abodeely M., Kloss B., Young M.W. Double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation. Cell 1998, 94(1):83-95. 10.1016/S0092-8674(00)81224-6.
97. Ramsey K.M., Yoshino J., Brace C.S., Abrassart D., Kobayashi Y., Marcheva B. Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. Science 2009, 324(5927):651-654. 10.1126/science.1171641.
98. Roberts C.J., Nelson B., Marton M.J., Stoughton R., Meyer M.R., Bennett H.A. Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles. Science 2000, 287(5454):873-880. 10.1126/science.287.5454.873.
99. Roenneberg T., Merrow M. Molecular circadian oscillators: An alternative hypothesis. Journal of Biological Rhythms 1998, 13(2):167-179. 10.1177/074873098129000011.
100. Roux P.P., Blenis J. ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions. Microbiology and Molecular Biology Reviews 2004, 68(2):320-344. 10.1128/mmbr.68.2.320-344.2004.
101. Sanada K., Harada Y., Sakai M., Todo T., Fukada Y. Serine phosphorylation of mCRY1 and mCRY2 by mitogen-activated protein kinase. Genes to Cells 2004, 9(8):697-708. 10.1111/j.1356-9597.2004.00758.x.
102. Sanada K., Hayashi Y., Harada Y., Okano T., Fukada Y. Role of circadian activation of mitogen-activated protein kinase in chick pineal clock oscillation. The Journal of Neuroscience 2000, 20(3):986-991.
103. Sanada K., Okano T., Fukada Y. Mitogen-activated protein kinase phosphorylates and negatively regulates basic helix-loop-helix-PAS transcription factor BMAL1. The Journal of Biological Chemistry 2002, 277(1):267-271. 10.1074/jbc.M107850200.
104. Schmidt T.M., Chen S.K., Hattar S. Intrinsically photosensitive retinal ganglion cells: Many subtypes, diverse functions. Trends in Neurosciences 2011, 34(11):572-580. 10.1016/j.tins.2011.07.001.
105. Schurov I.L., Hepworth T.J., Hastings M.H. Dopaminergic signalling in the rodent neonatal suprachiasmatic nucleus identifies a role for protein kinase A and mitogen-activated protein kinase in circadian entrainment. European Journal of Neuroscience 2002, 15(2):223-232. 10.1046/j.0953-816x.2001.01848.x.
106. Shimizu K., Okada M., Nagai K., Fukada Y. Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway. The Journal of Biological Chemistry 2003, 278(17):14920-14925. 10.1074/jbc.M213214200.
107. Shimizu K., Okada M., Takano A., Nagai K. SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus. FEBS Letters 1999, 458(3):363-369. 10.1016/S0014-5793(99)01190-4.
108. Shimizu K., Phan T., Mansuy I.M., Storm D.R. Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory. Cell 2007, 128(6):1219-1229. 10.1016/j.cell.2006.12.047.
109. Smith K.M., Sancar G., Dekhang R., Sullivan C.M., Li S., Tag A.G. Transcription factors in light and circadian clock signaling networks revealed by genomewide mapping of direct targets for Neurospora white collar complex. Eukaryotic Cell 2010, 9(10):1549-1556. 10.1128/ec.00154-10.
110. Spriggs D.R., Sherman M.L., Michie H., Arthur K.A., Imamura K., Wilmore D. Recombinant human tumor necrosis factor administered as a 24-hour intravenous infusion: A phase I and pharmacologic study. Journal of the National Cancer Institute 1988, 80(13):1039-1044. 10.1093/jnci/80.13.1039.
111. Storch K.-F., Lipan O., Leykin I., Viswanathan N., Davis F.C., Wong W.H. Extensive and divergent circadian gene expression in liver and heart. Nature 2002, 417(6884):78-83. 10.1038/nature744.
112. Tauber E., Last K.S., Olive P.J.W., Kyriacou C.P. Clock gene evolution and functional divergence. Journal of Biological Rhythms 2004, 19(5):445-458. 10.1177/0748730404268775.
113. Tischkau S.A., Mitchell J.W., Tyan S.-H., Buchanan G.F., Gillette M.U. Ca2+/cAMP response element-binding protein (CREB)-dependent activation of Per1 is required for light-induced signaling in the suprachiasmatic nucleus circadian clock. The Journal of Biological Chemistry 2003, 278(2):718-723. 10.1074/jbc.M209241200.
114. Tsuchiya Y., Minami I., Kadotani H., Todo T., Nishida E. Circadian clock-controlled diurnal oscillation of Ras/ERK signaling in mouse liver. Proceedings of the Japan Academy. Series B, Physical and Biological Sciences 2013, 89(1):59-65. 10.2183/pjab.89.59.
115. Uchida Y., Osaki T., Yamasaki T., Shimomura T., Hata S., Horikawa K. Involvement of stress kinase mitogen-activated protein kinase kinase 7 in regulation of mammalian circadian clock. The Journal of Biological Chemistry 2012, 287(11):8318-8326. 10.1074/jbc.M111.308908.
116. Vanhoutte P., Barnier J.-V., Guibert B., Pagès C., Besson M.-J., Hipskind R.A. Glutamate induces phosphorylation of Elk-1 and CREB, along with c-fos activation, via an extracellular signal-regulated kinase-dependent pathway in brain slices. Molecular and Cellular Biology 1999, 19(1):136-146.
117. Vgontzas A.N., Zoumakis E., Lin H.-M., Bixler E.O., Trakada G., Chrousos G.P. Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-α antagonist. The Journal of Clinical Endocrinology and Metabolism 2004, 89(9):4409-4413. 10.1210/jc.2003-031929.
118. Vitalini M.W., de Paula R.M., Goldsmith C.S., Jones C.A., Borkovich K.A., Bell-Pedersen D. Circadian rhythmicity mediated by temporal regulation of the activity of p38 MAPK. Proceedings of the National Academy of Sciences of the United States of America 2007, 104(46):18223-18228. 10.1073/pnas.0704900104.
119. Vitalini M.W., de Paula R.M., Park W.D., Bell-Pedersen D. The rhythms of life: Circadian output pathways in Neurospora. Journal of Biological Rhythms 2006, 21(6):432-444. 10.1177/0748730406294396.
120. Vollmers C., Schmitz R.J., Nathanson J., Yeo G., Ecker J.R., Panda S. Circadian oscillations of protein-coding and regulatory RNAs in a highly dynamic mammalian liver epigenome. Cell Metabolism 2012, 16(6):833-845. 10.1016/j.cmet.2012.11.004.
121. Wang G.K., Sehgal A. Signaling components that drive circadian rhythms. Current Opinion in Neurobiology 2002, 12(3):331-338. 10.1016/S0959-4388(02)00324-0.
122. Watanabe S., Yamashita K., Ochiai N., Fukumori F., Ichiishi A., Kimura M. OS-2 mitogen activated protein kinase regulates the clock-controlled gene ccg-1 in Neurospora crassa. Bioscience, Biotechnology, and Biochemistry 2007, 71(11):2856-2859. 10.1271/bbb.70410.
123. Weber F., Hung H.C., Maurer C., Kay S.A. Second messenger and Ras/MAPK signalling pathways regulate CLOCK/CYCLE-dependent transcription. Journal of Neurochemistry 2006, 98(1):248-257. 10.1111/j.1471-4159.2006.03865.x.
124. Whitmarsh A.J., Davis R.J. Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals. Trends in Biochemical Sciences 1998, 23(12):481-485. 10.1016/S0968-0004(98)01309-7.
125. Williams J.A., Su H.S., Bernards A., Field J., Sehgal A. A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK. Science 2001, 293(5538):2251-2256. 10.1126/science.1063097.
126. Xing J., Ginty D.D., Greenberg M.E. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 1996, 273(5277):959-963. 10.1126/science.273.5277.959.
127. Yadav G., Straume M., Heath J., Zatz M. Are changes in MAPK/ERK necessary or sufficient for entrainment in chick pineal cells?. The Journal of Neuroscience 2003, 23(31):10021-10031.
128. Yagita K., Yamanaka I., Koinuma S., Shigeyoshi Y., Uchiyama Y. Mini screening of kinase inhibitors affecting period-length of mammalian cellular circadian clock. Acta Histochemica et Cytochemica 2009, 42(3):89-93. 10.1267/ahc.09015.
129. Yoshitane H., Honma S., Imamura K., Nakajima H., Nishide S.Y., Ono D. JNK regulates the photic response of the mammalian circadian clock. EMBO Reports 2012, 13(5):455-461. 10.1038/embor.2012.37.
130. Zarubin T., Han J. Activation and signaling of the p38 MAP kinase pathway. Cell Research 2005, 15(1):11-18.