Rapid synthesis of VX-745: p38 MAP kinase inhibition in Werner syndrome cells

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 18, 2007, Pages 5107-5110

  Bagley, Mark C ^a   Davis, Terence ^a   Dix, Matthew C ^a   Rokicki, Michal J ^a   Kipling, David ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Heterocycles; Microwaves; p38 MAPK; Palladium; Ullmann coupling; VX 745; Werner syndrome

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 5 (2,6 DICHLOROPHENYL) 2 (2,4 DIFLUOROPHENYLTHIO)PYRIMIDO[1,6 B]PYRIDAZIN 6 ONE; ANISOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE P38;

ARTICLE; CELL CULTURE; CELL STRAIN; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PROTEIN PHOSPHORYLATION; WERNER SYNDROME;

BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; PYRIDAZINES; PYRIMIDINES; WERNER SYNDROME;

EID: 34547882369     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.07.016     Document Type: Article

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