Human spastin has multiple microtubule-related functions

Journal of Neurochemistry

Volumn 95, Issue 5, 2005, Pages 1411-1420

  Salinas, Sara ^a   Carazo Salas, Rafael E ^a   Proukakis, Christos ^b   Cooper, J Mark ^b   Weston, Anne E ^a   Schiavo, Giampietro ^a   Warner, Thomas T ^b  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

ATPases associated with various cellular activities; Bundling; Hereditary spastic paraplegia; Microtubule severing; Spastin

Indexed keywords

ADENOSINE TRIPHOSPHATASE; PACLITAXEL; RECOMBINANT PROTEIN; SPASTIN;

ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CELL STRAIN HEK293; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVITY; GENE; GENE MUTATION; HELA CELL; HEREDITARY MOTOR SENSORY NEUROPATHY; HUMAN; HUMAN CELL; MICROTUBULE; MUSCLE WEAKNESS; PATHOGENESIS; PRIORITY JOURNAL; RNA TRANSLATION; SPASTICITY; SPG4 GENE;

EID: 28844436513     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03472.x     Document Type: Article

References (32)

1. Beetz C., Brodhun M., Moutzouris K., Kiehntopf M., Berndt A., Lehnert D., Deufel T., Bastmeyer M. and Schickel J. (2004) Identification of nuclear localisation sequences in spastin (SPG4) using a novel Tetra-GFP reporter system. Biochem. Biophys. Res. Commun. 318, 1079-1084.
2. Cairns N. J., Lee V. M. and Trojanowski J. Q. (2004) The cytoskeleton in neurodegenerative diseases. J. Pathol. 204, 438-449.
3. Charvin D., Cifuentes-Diaz C., Fonknechten N., Joshi V., Kazan J., Melki J. and Betuing S. (2003) Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protein localized in the nucleus. Hum. Mol. Genet. 12, 71-78.
4. Ciccarelli F. D., Proukakis C., Patel H., Cross H., Azam S., Patton M. A., Bork P. and Crosby A. H. (2003) The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia. Genomics 81, 437-441.
5. Claudiani P., Riano E., Errico A., Andolfi G. and Rugarli E. I. (2005) Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus. Exp. Cell Res. 309, 358-369.
6. Cleveland D. W., Hwo S. Y. and Kirschner M. W. (1977) Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J. Mol. Biol. 116, 207-225.
7. Crosby A. H. and Proukakis C. (2002) Is the transportation highway the right road for hereditary spastic paraplegia? Am. J. Hum. Genet. 71, 1009-1016.
8. Errico A., Ballabio A. and Rugarli E. I. (2002) Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics. Hum. Mol. Genet. 11, 153-163.
9. Errico A., Claudiani P., D'Addio M. and Rugarli E. I. (2004) Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon. Hum. Mol. Genet. 13, 2121-2132.
10. Evans K. J., Gomes E. R., Reisenweber S. M., Gundersen G. G. and Lauring B. P. (2005) Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing. J. Cell Biol. 168, 599-606.
11. Frickey T. and Lupas A. N. (2004) Phylogenetic analysis of AAA proteins. J. Struct. Biol. 146, 2-10.
12. Guzik B. W. and Goldstein L. S. (2004) Microtubule-dependent transport in neurons: steps towards an understanding of regulation, function and dysfunction. Curr. Opin. Cell Biol. 16, 443-450.
13. Hafezparast M., Klocke R., Ruhrberg C. et al. (2003) Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science 300, 808-812.
14. Hartman J. J. and Vale R. D. (1999) Microtubule disassembly by ATP-dependent oligomerization of the AAA enzyme katanin. Science 286, 782-785.
15. Hartman J. J., Mahr J., McNally K. et al. (1998) Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit. Cell 93, 277-287.
16. Kazan J., Fonknechten N., Mavel D. et al. (1999) Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia. Nat. Genet. 23, 296-303.
17. Holzbaur E. L. (2004) Motor neurons rely on motor proteins. Trends Cell Biol. 14, 233-240.
18. Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N. and Ohara O. (1999) Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6, 197-205.
19. LaMonte B. H., Wallace K. E., Holloway B. A., Shelly S. S., Ascano J., Tokito M., Van Winkle T., Rowland D. S. and Holzbaur E. L. (2002) Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. Neuron 34, 715-727.
20. McDermott C., White K., Bushby K. and Shaw P. (2000) Hereditary spastic paraparesis: a review of new developments. J. Neurol. Neurosurg. Psychiatry 69, 150-160.
21. McDermott C. J., Grierson A. J., Wood J. D., Bingley M., Wharton S. B., Bushby K. M. and Shaw P. J. (2003) Hereditary spastic paraparesis: disrupted intracellular transport associated with spastin mutation. Ann. Neurol. 54, 748-759.
22. McNally F. J. and Vale R. D. (1993) Identification of katanin, an ATPase that severs and disassembles stable microtubules. Cell 75, 419-429.
23. McNally K. P., Bazirgan O. A. and McNally F. J. (2000) Two domains of p80 katanin regulate microtubule severing and spindle pole targeting by p60 katanin. J. Cell Sci. 113, 1623-1633.
24. Puls I., Jonnakuty C., LaMonte B. H. et al. (2003) Mutant dynactin in motor neuron disease. Nat. Genet. 33, 455-456.
25. Reid E. (2003) Science in motion: common molecular pathological themes emerge in the hereditary spastic paraplegias. J. Med. Genet. 40, 81-86.
26. Reid E., Connell J., Edwards T. L., Duley S., Brown S. E. and Sanderson C. M. (2005) The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B. Hum. Mol. Genet. 14, 19-38.
27. Roll-Mecak A. and Vale R. D. (2005) The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules. Curr. Biol. 15, 650-655.
28. Sherwood N. T., Sun Q., Xue M., Zhang B. and Zinn K. (2004) Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function. PLoS Biol 2, e429.
29. Smith E., Meyerrose T. E., Kohler T. et al. (2005) Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo. Nucl. Acids Res. 33, 1298-1308.
30. Svenson I. K., Ashley-Koch A. E., Gaskell P. C. et al. (2001) Identification and expression analysis of spastin gene mutations in hereditary spastic paraplegia. Am. J. Hum Genet. 68, 1077-1085.
31. Trotta N., Orso G., Rossetto M. G., Daga A. and Broadie K. (2004) The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function. Curr. Biol. 14, 1135-1147.
32. Wittmann T, Boleti H., Antony C., Karsenti E. and Vernos I. (1998) Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein. J. Cell Biol. 143, 673-685.