Short Antibacterial Peptides with Significantly Reduced Hemolytic Activity can be Identified by a Systematic L -to- D Exchange Scan of their Amino Acid Residues

ACS Combinatorial Science

Volumn 15, Issue 11, 2013, Pages 585-592

  Albada, H Bauke ^a   Prochnow, Pascal ^a   Bobersky, Sandra ^a   Langklotz, Sina ^a   Bandow, Julia E ^a   Metzler Nolte, Nils ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

antibacterial peptides; hemolysis; L to D substitution scan; lipidated peptide; MRSA

Indexed keywords

AMINO ACID; ANTIINFECTIVE AGENT; PEPTIDE;

ACINETOBACTER BAUMANNII; BACILLUS SUBTILIS; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ERYTHROCYTE; ESCHERICHIA COLI; GROWTH, DEVELOPMENT AND AGING; HEMOLYSIS; HUMAN; MICROBIAL SENSITIVITY TEST; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACINETOBACTER BAUMANNII; AMINO ACIDS; ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; ESCHERICHIA COLI; HEMOLYSIS; HUMANS; MICROBIAL SENSITIVITY TESTS; PEPTIDES; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84887597873     PISSN: 21568952     EISSN: 21568944     Source Type: Journal    
DOI: 10.1021/co400072q     Document Type: Article

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