Silver(I)-Promoted conversion of thioamides to amidines: Divergent synthesis of a key series of vancomycin aglycon residue 4 amidines that clarify binding behavior to model ligands

Journal of the American Chemical Society

Volumn 134, Issue 21, 2012, Pages 8790-8793

  Okano, Akinori ^a   James, Robert C ^a   Pierce, Joshua G ^a   Xie, Jian ^a   Boger, Dale L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMICROBIAL PROPERTY; BINDING BEHAVIORS; DIVERGENT SYNTHESIS; PEPTIDOGLYCAN PRECURSORS; THIOAMIDES; VANCOMYCIN;

SILVER COMPOUNDS;

LIGANDS;

AMIDINE; PEPTIDOGLYCAN; SILVER; THIOAMIDE; VANCOMYCIN;

ARTICLE; BINDING AFFINITY; BIOTRANSFORMATION; DRUG BINDING; DRUG SYNTHESIS; LIGAND BINDING; MINIMUM INHIBITORY CONCENTRATION; SUBSTITUTION REACTION;

AMIDINES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CATALYSIS; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS FAECALIS; LIGANDS; PEPTIDOGLYCAN; SILVER; THIOAMIDES; VANCOMYCIN;

EID: 84861621100     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja302808p     Document Type: Article

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