Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity

ACS Chemical Biology

Volumn 8, Issue 2, 2013, Pages 297-302

  Okamoto, Toru ^a,b   Zobel, Kerry ^c   Fedorova, Anna ^c   Quan, Clifford ^c   Yang, Hong ^a,b   Fairbrother, Wayne J ^c   Huang, David C S ^a,b   Smith, Brian J ^a,b,d   Deshayes, Kurt ^c   Czabotar, Peter E ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c GENENTECH INC   (United States)

^d LA TROBE UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BIMBH3 PEPTIDE; CYTOCHROME C; PEPTIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; UNCLASSIFIED DRUG; BAX PROTEIN (53-86); ONCOPROTEIN; PEPTIDE FRAGMENT;

ALPHA HELIX; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CIRCULAR DICHROISM; COVALENT BOND; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN MODIFICATION; PROTEIN TARGETING; SURVIVAL FACTOR; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; PROTEIN SECONDARY STRUCTURE;

ANIMALS; APOPTOSIS; HUMANS; MICE; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS;

EID: 84874027448     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb3005403     Document Type: Article

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