Effect of D-amino acid substitution on the stability, the secondary structure, and the activity of membrane-active peptide

Biochemical Pharmacology

Volumn 58, Issue 11, 1999, Pages 1775-1780

  Hong, Sung Yu ^a   Oh, Jong Eun ^a   Lee, Keun Hyeung ^a  

^a Mogam Biotechnology Research Institute   (South Korea)

Author keywords

helical structure; Antimicrobial peptide; Cleavage site; Diastereomer; Enantiomer; Serum protease; Stability

Indexed keywords

AMINO ACID; ANTIINFECTIVE AGENT;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; DIASTEREOISOMER; DRUG SYNTHESIS; ENANTIOMER; LIPID MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIFUNGAL AGENTS; CANDIDA; CELL MEMBRANE; CIRCULAR DICHROISM; DRUG STABILITY; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0344418718     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00259-2     Document Type: Article

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