Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxygenation

Journal of Nutritional Biochemistry

Volumn 24, Issue 12, 2013, Pages 2152-2157

  Cabrerizo, Susana ^a   De La Cruz, José Pedro ^a   López Villodres, Juan Antonio ^a   Muñoz Marín, Javier ^a   Guerrero, Ana ^a   Reyes, José Julio ^a   Labajos, María Teresa ^b   González Correa, José Antonio ^a  

^a Laboratorio de Investigaciones Antitrombóticas e Isquemia Tisular LIAIT   (Spain)

^b UNIVERSITY OF MÁLAGA   (Spain)

Author keywords

Hydroxytyrosol; Hypoxia reoxygenation; Inflammation; Neuroprotection; Oxidative stress

Indexed keywords

GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; HYDROXYTYROSOL; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; NEUROPROTECTIVE AGENT; NITRIC OXIDE; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN HYPOXIA; BRAIN SLICE; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; ENZYME ACTIVITY; EX VIVO STUDY; LIPID PEROXIDATION; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL; RAT; REOXYGENATION;

GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; GSH; GSHPX; GSHTF; GSSG; HT; HYDROXYTYROSOL; HYPOXIA-REOXYGENATION; IL-1Β; INFLAMMATION; INTERLEUKIN 1Β; LACTATE DEHYDROGENASE; LDH; MALONDIALDEHYDE; MDA; NEUROPROTECTION; NITRITES + NITRATES; NO(-)(2) + NO(-)(3); OXIDATIVE STRESS; OXIDIZED GLUTATHIONE; PGE(2); PROSTAGLANDIN E(2); REDUCED GLUTATHIONE; TBARS; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

ADMINISTRATION, ORAL; ANIMALS; ANOXIA; BRAIN; DINOPROSTONE; GLUTATHIONE; INFLAMMATION; INTERLEUKIN-1BETA; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; MALE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PHENYLETHYL ALCOHOL; POLYPHENOLS; RATS; RATS, WISTAR; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84887545246     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2013.08.007     Document Type: Article

References (45)

1. Lee O.H., Lee B.Y. Antioxidant and antimicrobial activities of individual and combined phenolics in Olea europaea leaf extract. Bioresour Technol 2010, 101:3751-3754.
2. Nenadis N., Wang L.F., Tsimidou M.Z., Zhang H.Y. Radical scavenging potential of phenolic compounds encountered in O. europaea products as indicated by calculation of bond dissociation enthalpy and ionization potential values. J Agric Food Chem 2005, 53:295-299.
3. Capozzi F., Piperno A., Uccella N. Oleuropein site selective hydrolysis by technomimetic nuclear magnetic resonance experiments. J Agric Food Chem 2000, 48:1623-1629.
4. Briante R., La Cara F., Febbraio F., Barone R., Piccialli G., Carolla R., et al. Hydrolysis of oleuropein by recombinant beta-glycosidase from hyperthermophilic archaeon Sulfolobus solfataricus immobilised on chitosan matrix. J Biotechnol 2000, 77:275-286.
5. de Lorgeril M., Salen P. Mediterranean diet in secondary prevention of CHD. Public Health Nutr 2011, 14:2333-2337.
6. Gardener H., Wright C.B., Gu Y., Demmer R.T., Boden-Albala B., Elkind M.S., et al. Mediterranean-style diet and risk of ischemic stroke, myocardial infarction, and vascular death: the Northern Manhattan Study. Am J Clin Nutr 2011, 94:1458-1464.
7. Demetriou C.A., Hadjisavvas A., Loizidou M.A., Loucaides G., Neophytou I., Sieri S., et al. The Mediterranean dietary pattern and breast cancer risk in Greek-Cypriot women: a case-control study. BMC Cancer 2012, 12:113-125.
8. Kyrø C., Skeie G., Loft S., Overvad K., Christensen J., Tjønneland A., et al. Adherence to a healthy Nordic food index is associated with a lower incidence of colorectal cancer in women: The Diet, Cancer and Health cohort study. Br J Nutr 2012, 10.1017/S0007114512002085.
9. Martínez-González M.A., Guillén-Grima F., De Irala J., Ruíz-Canela M., Bes-Rastrollo M., Beunza J.J., et al. The Mediterranean diet is associated with a reduction in premature mortality among middle-aged adults. J Nutr 2012, 142:1672-1678.
10. Mitjavila M.T., Fandos M., Salas-Salvadó J., Covas M.I., Borrego S., Estruch R., et al. The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial. Clin Nutr 2012, 10.1016/j.clnu.2012.08.002.
11. Visioli F., Bernardini E. Extra virgin olive oil's polyphenols: biological activities. Curr Pharm Des 2011, 17:786-804.
12. Demarin V., Lisak M., Morović S. Mediterranean diet in healthy lifestyle and prevention of stroke. Acta Clin Croat 2011, 50:67-77.
13. Kastorini C.M., Milionis H.J., Ioannidi A., Kalantzi K., Nikolaou V., Vemmos K.N., et al. Adherence to the Mediterranean diet in relation to acute coronary syndrome or stroke nonfatal events: a comparative analysis of a case/case-control study. Am Heart J 2011, 162:717-724.
14. De La Cruz J.P., Del Río S., Arrebola M.M., López-Villodres J.A., Jebrouni N., González-Correa J.A. Effect of virgin olive oil plus acetylsalicylic acid on brain slices damage after hypoxia-reoxygenation in rats with type 1-like diabetes mellitus. Neurosci Lett 2010, 471:89-93.
15. González-Correa J.A., Muñoz-Marín J., Arrebola M.M., Guerrero A., Narbona F., López-Villodres J.A., et al. Dietary virgin olive oil reduces oxidative stress and cellular damage in rat brain slices subjected to hypoxia-reoxygenation. Lipids 2007, 42:921-929.
16. Schaffer S., Podstawa M., Visioli F., Bogani P., Müller W.E., Eckert G.P. Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo. J Agric Food Chem 2007, 55:5043-5049.
17. González-Correa J.A., Navas M.D., Lopez-Villodres J.A., Trujillo M., Espartero J.L., De La Cruz J.P. Neuroprotective effect of hydroxytyrosol and hydroxytyrosol acetate in rat brain slices subjected to hypoxia-reoxygenation. Neurosci Lett 2008, 446:143-146.
18. González-Correa J.A., Arrebola M.M., Cansino A.L., Muñoz-Marín J., Ruiz-Villafranca D., Guerrero A., et al. Effects of hypoxia reoxygenation in brain slices from rats with type 1-like diabetes mellitus. Diabetes Metab Res Rev 2006, 22:390-400.
19. De La Cruz J.P., Carrasco T., Ortega G., Sanchez de la Cuesta F. Inhibition of ferrous-induced lipid peroxidation by pyrimido-pyrimidine derivatives in human liver membranes. Lipids 1992, 27:192-194.
20. Hissin P.J., Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 1976, 74:214-226.
21. Flohé L., Gunzler W.A. Assays of glutathione peroxidase. Meth Enzymol. 1985, 105:114-121.
22. Warholm M., Guthenberg C., Von Bahr Mannervik B. Glutathione transferases from human liver. Meth Enzymol 1985, 113:449-503.
23. Albarracin S.L., Stab B., Casas Z., Sutachan J.J., Samudio I., Gonzalez J., et al. Effects of natural antioxidants in neurodegenerative disease. Nutr Neurosci 2012, 15:1-9.
24. Craggs L., Kalaria R.N. Revisiting dietary antioxidants, neurodegeneration and dementia. Neuroreport 2011, 22:1-3.
25. Lin B. Polyphenols and neuroprotection against ischemia and neurodegeneration. Mini Rev Med Chem 2011, 11:1222-1238.
26. Sahota P., Savitz S.I. Investigational therapies for ischemic stroke: neuroprotection and neurorecovery. Neurotherapeutics 2011, 8:434-451.
27. Raederstorff D. Antioxidant activity of olive polyphenols in humans: a review. Int J Vitam Nutr Res 2009, 79:152-165.
28. Schaffer S., Müller W.E., Eckert G.P. Cytoprotective effects of olive mill wastewater extract and its main constituent hydroxytyrosol in PC12 cells. Pharmacol Res 2010, 62:322-327.
29. Olmez I., Ozyurt H. Reactive oxygen species and ischemic cerebrovascular disease. Neurochem Int 2012, 60:208-212.
30. Sims N.R., Nilsson M., Muyderman H. Mitochondrial glutathione: a modulator of brain cell death. J Bioenerg Biomembr 2004, 36:329-333.
31. Zou X., Feng Z., Li Y., Wang Y., Wertz K., Weber P., et al. Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62/SQSTM1 pathways. J Nutr Biochem 2011, 23:994-1006.
32. Fabiani R., Sepporta M.V., Rosignoli P., De Bartolomeo A., Crescimanno M., Morozzi G. Anti-proliferative and pro-apoptotic activities of hydroxytyrosol on different tumour cells: the role of extracellular production of hydrogen peroxide. Eur J Nutr 2012, 51:455-464.
33. O'Dowd Y., Driss F., Dang P.M., Elbim C., Gougerot-Pocidalo M.A., Pasquier C., et al. Antioxidant effect of hydroxytyrosol, a polyphenol from olive oil: scavenging of hydrogen peroxide but not superoxide anion produced by human neutrophils. Biochem Pharmacol 2004, 68:2003-2008.
34. Zrelli H., Matsuoka M., Kitazaki S., Araki M., Kusunoki M., Zarrouk M., et al. Hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction. J Agric Food Chem 2011, 59:4473-4482.
35. Guo Z.H., Li F., Wang W.Z. The mechanisms of brain ischemic insult and potential protective interventions. Neurosci Bull 2009, 25:139-152.
36. López-Villodres J.A., De La Cruz J.P., Muñoz-Marin J., Guerrero A., Reyes J.J., González-Correa J.A. Lack of enantiomeric influence on the brain cytoprotective effect of ibuprofen and flurbiprofen. Naunyn Schmiedebergs Arch Pharmacol. 2011, 384:177-183.
37. López-Villodres J.A., De La Cruz J.P., Muñoz-Marin J., Guerrero A., Reyes J.J., González-Correa J.A. Cytoprotective effect of nonsteroidal antiinflammatory drugs in rat brain slices subjected to reoxygenation after oxygen-glucose deprivation. Eur J Pharm Sci 2012, 45:624-631.
38. Richard N., Arnold S., Hoeller U., Kilpert C., Wertz K., Schwager J. Hydroxytyrosol is the major anti-inflammatory compound in aqueous olive extracts and impairs cytokine and chemokine production in macrophages. Planta Med 2011, 77:1890-1897.
39. Zhang X., Cao J., Zhong L. Hydroxytyrosol inhibits pro-inflammatory cytokines, iNOS, and COX-2 expression in human monocytic cells. Naunyn Schmiedebergs Arch Pharmacol 2009, 379:581-586.
40. Reyes J.J., De La Cruz J.P., Muñoz-Marin J., Guerrero A., Lopez-Villodres J.A., Madrona A., et al. Antiplatelet effect of new lipophilic hydroxytyrosol alkyl ether derivatives in human blood. Eur J Nutr 2012, 10.1007/s00394-012-0361-1.
41. Sánchez-Fidalgo S., Sánchez de Ibargüen L., Cárdeno A., Alarcón de la Lastra C. Influence of extra virgin olive oil diet enriched with hydroxytyrosol in a chronic DSS colitis model. Eur J Nutr 2012, 51:497-506.
42. Fitó M., de la Torre R., Farré-Albaladejo M., Khymenetz O., Marrugat J., Covas M.I. Bioavailability and antioxidant effects of olive oil phenolic compounds in humans: a review. Ann Ist Super Sanita 2007, 43:375-381.
43. Serra A., Rubió L., Borràs X., Macià A., Romero M.P., Motilva M.J. Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake. Mol Nutr Food Res 2012, 56:486-496.
44. Magrone T., Marzulli G., Jirillo E. Immunopathogenesis of neurodegenerative diseases: current therapeutic models of neuroprotection with special reference to natural products. Curr Pharm Des 2012, 18:34-42.
45. Slemmer J.E., Shacka J.J., Sweeney M.I., Weber J.T. Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging. Curr Med Chem 2008, 15:404-414.