Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes

Nature Medicine

Volumn 19, Issue 10, 2013, Pages 1325-1330

  Taniguchi, Cullen M ^a   Finger, Elizabeth C ^a   Krieg, Adam J ^b   Wu, Colleen ^a   Diep, Anh N ^a   Lagory, Edward L ^a   Wei, Kevin ^c   McGinnis, Lisa M ^c   Yuan, Jenny ^c   Kuo, Calvin J ^c   Giaccia, Amato J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; ISOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; PROLYL HYDROXYLASE DOMAIN CONTAINING PROTEIN ISOFORM 2; PROLYL HYDROXYLASE DOMAIN CONTAINING PROTEIN ISOFORM 3; PROTEIN KINASE B; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; EGLN3 PROTEIN, HUMAN; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE SILENCING; GENETIC TRANSCRIPTION; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HYPOXIA; INSULIN SENSITIVITY; KNOCKOUT GENE; LIPID METABOLISM; LIVER METABOLISM; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; ANIMAL; ANOXIA; EXPERIMENTAL DIABETES MELLITUS; GENETICS; KNOCKOUT MOUSE; LIVER; METABOLISM;

ANIMALS; ANOXIA; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR-PROLINE DIOXYGENASES; INSULIN; LIPID METABOLISM; LIVER; MICE; MICE, KNOCKOUT; SIGNAL TRANSDUCTION;

EID: 84887473989     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.3294     Document Type: Article

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