Prediction and experimental validation of enzyme substrate specificity in protein structures

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 45, 2013, Pages

  Amin, Shivas R ^a,b   Erdin, Serkan ^a   Ward, R Matthew ^a   Lua, Rhonald C ^a   Lichtarge, Olivier ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ST THOMAS   (United States)

Author keywords

Evolutionary trace; Function annotation; Protein function; Structural motif

Indexed keywords

CARBOXYLESTERASE;

ARTICLE; BIOCATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; EXPERIMENTAL STUDY; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STRUCTURAL GENOMICS; STRUCTURAL HOMOLOGY;

EVOLUTIONARY TRACE; FUNCTION ANNOTATION; PROTEIN FUNCTION; STRUCTURAL MOTIF;

CLONING, MOLECULAR; COMPUTATIONAL BIOLOGY; DNA PRIMERS; ENZYMES; EVOLUTION, MOLECULAR; MOLECULAR SEQUENCE ANNOTATION; PROTEOMICS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 84887309484     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1305162110     Document Type: Article

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