An Angiotensin II type 1 receptor activation switch patch revealed through Evolutionary Trace analysis

Biochemical Pharmacology

Volumn 80, Issue 1, 2010, Pages 86-94

  Bonde, Marie Mi ^a,b   Yao, Rong ^c   Ma, Jian Nong ^d   Madabushi, Srinivasan ^c,g   Haunsø, Stig ^a   Burstein, Ethan S ^d   Whistler, Jennifer L ^e   Sheikh, Søren P ^f   Lichtarge, Olivier ^c   Hansen, Jakob Lerche ^a,b  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d ACADIA PHARMACEUTICALS INC   (United States)

^e UNIVERSITY OF CALIFORNIA SAN FRANCISCO   (United States)

^f ODENSE UNIVERSITY HOSPITAL   (Denmark)

^g ZS Associates   (United States)

Author keywords

7TM receptor; Angiotensin; Constitutive activity; Evolutionary Trace; GPCR

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR; MUTANT PROTEIN;

ALPHA HELIX; ARTICLE; BINDING AFFINITY; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; EVOLUTIONARY TRACE ANALYSIS; GENE MUTATION; HUMAN; HUMAN CELL; HYPOTHESIS; INTERNALIZATION; LIGAND BINDING; MATHEMATICAL ANALYSIS; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

ANGIOTENSIN II; ANIMALS; CYTOPLASM; EVOLUTION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 77952290328     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.03.006     Document Type: Article

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