Enantioselective Analysis of Ritalinic Acids in Biological Samples by Using a Protein-Based Chiral Stationary Phase

Pharmaceutical Research

Volumn 20, Issue 11, 2003, Pages 1881-1884

  Zhang, Jianhua ^a,b   Deng, Yulin ^a   Fang, Jim ^b   McKay, Gordon ^b  

^a BEIJING INSTITUTE OF TECHNOLOGY   (China)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Chiral separation; HPLC; Methylphenidate; Ritalinic acid

Indexed keywords

ACETIC ACID; DIMETHYLOCTYLAMINE; ESTERASE; METHYLPHENIDATE; OCTYLAMINE; OROSOMUCOID; RITALINIC ACID; UNCLASSIFIED DRUG;

ACIDITY; ANALYTIC METHOD; ARTICLE; CHIRAL CHROMATOGRAPHY; CONTROLLED STUDY; DATA ANALYSIS; DOG; DRUG CLEARANCE; DRUG METABOLISM; ENANTIOMER; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIVER; NONHUMAN; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SAMPLING; SEPARATION TECHNIQUE; VALIDATION PROCESS;

ANIMALS; BUFFERS; CARBOXYLESTERASE; CATALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; HUMANS; HYDROLYSIS; METHYLPHENIDATE; PLASMA; PROTEINS; SOLUTIONS; STEREOISOMERISM;

EID: 0344945686     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000003389.77585.be     Document Type: Article

References (14)

1. 11C] d-threo and l-threo-methylphenidate in the human and baboon brain. Psychopharmy 131:71-78 (1997).
2. N. R. Srinivas, J. W. Hubbard, G. Mckay, E. M. Hawes, and K. K. Midha. In vitro hydrolysis of RR, SS-threo-Methylphenidate by blood esterases-differential and enantioselective interspecies variability. Chirality 3:99-103 (1991).
3. N. R. Srinivas, J. W. Hubbard, E. D. Korchinski, and K. K. Midha. Enantioselective pharmacokinetics of dl-threo-Methylphenidate in humans. Pharm. Res. 10:14-21 (1993).
4. J. W. Hubbard, N. R. Srinivas, D. Quinn, and K. K. Midha. Enantioselective aspects of the disposition of d l-threo-Methylphenidate after the administration of a sustained-release formulation to children with attention deficit-hyperactivity disorder. J. Pharm. Sci. 78:944-947 (1989).
5. T. Aoyoma, H. Kotaki, Y. Honda, and F. Nakagawa. Kinetic analysis of enantiomers of threo-methylphenidate and its metabolite in two healthy subjects after oral administration as determined by a gas chromatographic-mass spectrometric method. J. Pharm. Sci. 79:465-469 (1990).
6. K. S. Patrick, R. W. Caldwell, R. M. Ferris, and G. R. Breese. Pharmacology of the enantiomers of threo-methylphenidate. J. Pharmacol. Exp. Ther. 241:152-158 (1987).
7. H. Egger, F. Bartlett, R. Drefuss, and J. Karliner. Metabolism of methylphenidate in dog and rat. J. Drug Metab. Dispos. 9:415-423 (1981).
8. N. R. Srinivas, J. W. Hubbard, and K. K. Midha. Enantioselective gas chromatographic assay with electron capture detection for dl-Ritalinic Acid in plasma. J. Chromagr. Biomed. Appl. 530:327-336 (1990).
9. A. Solans, M. Carnicero, and R. De-La-Torre, J. Segura. Simultaneous detection of methylphenidate and its main metabolite, ritalinic acid, in doping control. J. Chromatogr. B Biomed. Appl. 658:380-384 (1994).
10. S. J. Soldin, B. M. Hill, Y. M. Chan, J. M. Swanson, and J. G. Hill. A liquid-chromatographic analysis for Ritalinic acid [α-Phenyl-α- (piperdyl) acetic acid] in serum. Clin. Chem. 25:51-54 (1979).
11. A. Takashi. Chiral separation of pharmaceuticals possessing a carboxyl moiety. J. Chromatogr. B. 717:295-311 (1998).
12. J. Iredale, A. F. Aubry, and I. W. Wainer. The effects of pH and alcoholic organic modifiers on the direct separation of some acidic, basic and neutral compounds on a commercially available ovomucoid column. Chromatographia 31:329-334 (1991).
13. Y. Deng, W. Maruyama, M. Kawai, P. Doster, and M. Naoi. Enantioseparation of Biologically Active compounds by HPLC. In: Naoi M., Parvez H., Acworth I.N., Parvez P.S., Matson D. (eds.), Progress in HPLC-HPCE. VSP, Utrecht, 1996 Vol. 6. pp.301-350.
14. V. P. Shah, K. K. Midha, J. W. Findly, H. M. Hill, J. D. Hulse, I. J. McGilveray, G. McKay, K. J. Miller, R. N. Patnaik, M. L. Powell, A. Tonelli, C. T. Viswanathan, and A. Yacobi. Bioanalytical method validation-a revisit with a decade of progress. Pharm. Res. 17:1551-1557 (2000).