Correlated evolutionary pressure at interacting transcription factors and DNA response elements can guide the rational engineering of DNA binding specificity

Journal of Molecular Biology

Volumn 350, Issue 3, 2005, Pages 402-415

  Raviscioni, Michele ^a,b,c   Gu, Peili ^c   Sattar, Minawar ^c   Cooney, Austin J ^c   Lichtarge, Olivier ^a,c  

^a W M Keck Center for Computational and Structural Biology   (United States)

^b UNIVERSITY OF MILAN   (Italy)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Evolutionary trace; Gene expression; Nuclear receptors; Protein engineering; Protein DNA interaction

Indexed keywords

AMINO ACID; DNA BASE; HELIX LOOP HELIX PROTEIN; HOMEODOMAIN PROTEIN; HORMONE RECEPTOR; LIVER RECEPTOR HOMOLOG 1; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BASE PAIRING; CORRELATION ANALYSIS; DNA BINDING; DNA RESPONSIVE ELEMENT; ENTROPY; MATHEMATICAL ANALYSIS; MOLECULAR EVOLUTION; PREDICTION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN ENGINEERING; PROTEIN FAMILY;

EID: 20444462091     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.04.054     Document Type: Article

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