Inhibition of the Mitotic Exit Network in Response to Damaged Telomeres

PLoS Genetics

Volumn 9, Issue 10, 2013, Pages

  Valerio Santiago, Mauricio ^a   de los Santos Velázquez, Ana Isabel ^a   Monje Casas, Fernando ^a  

^a UNIVERSITY OF SEVILLE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE; FUNGAL PROTEIN; PROTEIN BFA1; PROTEIN BUB2; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; DNA DAMAGE; FUNGAL CELL; G2 PHASE CELL CYCLE CHECKPOINT; METAPHASE; MITOSIS; NONHUMAN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; SPINDLE CELL; TELOMERE;

CELL CYCLE; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CHECKPOINT KINASE 2; CYTOSKELETAL PROTEINS; DNA DAMAGE; G2 PHASE CELL CYCLE CHECKPOINTS; MITOSIS; PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SPINDLE APPARATUS; TELOMERE;

EID: 84887273210     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003859     Document Type: Article

References (51)

1. Harrison JC, Haber JE, (2006) Surviving the breakup: the DNA damage checkpoint. Annu Rev Genet 40: 209-235.
2. Musacchio A, Salmon ED, (2007) The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8: 379-393.
3. Pereira G, Yamashita YM, (2011) Fly meets yeast: checking the correct orientation of cell division. Trends Cell Biol 21: 526-533.
4. Hu F, Wang Y, Liu D, Li Y, Qin J, et al. (2001) Regulation of the Bub2/Bfa1 GAP complex by Cdc5 and cell cycle checkpoints. Cell 107: 655-665.
5. Stegmeier F, Amon A, (2004) Closing mitosis: the functions of the Cdc14 phosphatase and its regulation. Annu Rev Genet 38: 203-232.
6. Shou W, Seol JH, Shevchenko A, Baskerville C, Moazed D, et al. (1999) Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97: 233-244.
7. Visintin R, Hwang ES, Amon A, (1999) Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus. Nature 398: 818-823.
8. Geymonat M, Spanos A, Walker PA, Johnston LH, Sedgwick SG, (2003) In vitro regulation of budding yeast Bfa1/Bub2 GAP activity by Cdc5. J Biol Chem 278: 14591-14594.
9. Lee SE, Frenz LM, Wells NJ, Johnson AL, Johnston LH, (2001) Order of function of the budding-yeast mitotic exit-network proteins Tem1, Cdc15, Mob1, Dbf2, and Cdc5. Curr Biol 11: 784-788.
10. Rock JM, Amon A, (2011) Cdc15 integrates Tem1 GTPase-mediated spatial signals with Polo kinase-mediated temporal cues to activate mitotic exit. Genes Dev 25: 1943-1954.
11. D'Aquino KE, Monje-Casas F, Paulson J, Reiser V, Charles GM, et al. (2005) The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell 19: 223-234.
12. Pereira G, Schiebel E, (2005) Kin4 kinase delays mitotic exit in response to spindle alignment defects. Mol Cell 19: 209-221.
13. Caydasi AK, Pereira G, (2009) Spindle alignment regulates the dynamic association of checkpoint proteins with yeast spindle pole bodies. Dev Cell 16: 146-156.
14. Pereira G, Hofken T, Grindlay J, Manson C, Schiebel E, (2000) The Bub2p spindle checkpoint links nuclear migration with mitotic exit. Mol Cell 6: 1-10.
15. Valerio-Santiago M, Monje-Casas F, (2011) Tem1 localization to the spindle pole bodies is essential for mitotic exit and impairs spindle checkpoint function. J Cell Biol 192: 599-614.
16. Agarwal R, Tang Z, Yu H, Cohen-Fix O, (2003) Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. J Biol Chem 278: 45027-45033.
17. Liang F, Wang Y, (2007) DNA damage checkpoints inhibit mitotic exit by two different mechanisms. Mol Cell Biol 27: 5067-5078.
18. Cheng L, Hunke L, Hardy CF, (1998) Cell cycle regulation of the Saccharomyces cerevisiae polo-like kinase cdc5p. Mol Cell Biol 18: 7360-7370.
19. Zhang T, Nirantar S, Lim HH, Sinha I, Surana U, (2009) DNA damage checkpoint maintains CDH1 in an active state to inhibit anaphase progression. Dev Cell 17: 541-551.
20. Wang Y, Hu F, Elledge SJ, (2000) The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit. Curr Biol 10: 1379-1382.
21. Lin JJ, Zakian VA, (1996) The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo. Proc Natl Acad Sci U S A 93: 13760-13765.
22. Pennock E, Buckley K, Lundblad V, (2001) Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104: 387-396.
23. Nugent CI, Hughes TR, Lue NF, Lundblad V, (1996) Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274: 249-252.
24. Lingner J, Cech TR, Hughes TR, Lundblad V, (1997) Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc Natl Acad Sci U S A 94: 11190-11195.
25. Weinert TA, Kiser GL, Hartwell LH, (1994) Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev 8: 652-665.
26. Sanchez Y, Bachant J, Wang H, Hu F, Liu D, et al. (1999) Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science 286: 1166-1171.
27. Zhao X, Muller EG, Rothstein R, (1998) A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol Cell 2: 329-340.
28. Dion V, Kalck V, Horigome C, Towbin BD, Gasser SM, (2012) Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery. Nat Cell Biol 14: 502-509.
29. Paulovich AG, Hartwell LH, (1995) A checkpoint regulates the rate of progression through S phase in S. cerevisiae in response to DNA damage. Cell 82: 841-847.
30. Visintin R, Amon A, (2001) Regulation of the mitotic exit protein kinases Cdc15 and Dbf2. Mol Biol Cell 12: 2961-2974.
31. Allen JB, Zhou Z, Siede W, Friedberg EC, Elledge SJ, (1994) The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev 8: 2401-2415.
32. Morin I, Ngo HP, Greenall A, Zubko MK, Morrice N, et al. (2008) Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response. EMBO J 27: 2400-2410.
33. Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, et al. (2007) A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol 14: 1261-1272.
34. Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, et al. (2003) The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell 115: 83-95.
35. Elia AE, Cantley LC, Yaffe MB, (2003) Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science 299: 1228-1231.
36. Bishop AC, Ubersax JA, Petsch DT, Matheos DP, Gray NS, et al. (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407: 395-401.
37. Kim J, Luo G, Bahk YY, Song K, (2012) Cdc5-dependent asymmetric localization of bfa1 fine-tunes timely mitotic exit. PLoS Genet 8: e1002450.
38. Lu Y, Cross FR, (2010) Periodic cyclin-Cdk activity entrains an autonomous Cdc14 release oscillator. Cell 141: 268-279.
39. Manzoni R, Montani F, Visintin C, Caudron F, Ciliberto A, et al. (2010) Oscillations in Cdc14 release and sequestration reveal a circuit underlying mitotic exit. J Cell Biol 190: 209-222.
40. Visintin R, Stegmeier F, Amon A, (2003) The role of the polo kinase Cdc5 in controlling Cdc14 localization. Mol Biol Cell 14: 4486-4498.
41. Lee SE, Jensen S, Frenz LM, Johnson AL, Fesquet D, et al. (2001) The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis. J Cell Sci 114: 2345-2354.
42. Myung K, Smith S, Kolodner RD, (2004) Mitotic checkpoint function in the formation of gross chromosomal rearrangements in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 101: 15980-15985.
43. Dewar JM, Lydall D, (2012) Similarities and differences between "uncapped" telomeres and DNA double-strand breaks. Chromosoma 121: 117-130.
44. Baker NM, Zeitlin SG, Shi LZ, Shah J, Berns MW, (2010) Chromosome tips damaged in anaphase inhibit cytokinesis. PLoS One 5: e12398.
45. Gruneberg U, Campbell K, Simpson C, Grindlay J, Schiebel E, (2000) Nud1p links astral microtubule organization and the control of exit from mitosis. EMBO J 19: 6475-6488.
46. Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, et al. (2010) CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation. PLoS Biol 8: e1000286.
47. Huang X, Tran T, Zhang L, Hatcher R, Zhang P, (2005) DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint. Proc Natl Acad Sci U S A 102: 1065-1070.
48. Anantha RW, Sokolova E, Borowiec JA, (2008) RPA phosphorylation facilitates mitotic exit in response to mitotic DNA damage. Proc Natl Acad Sci U S A 105: 12903-12908.
49. van Vugt MA, Smits VA, Klompmaker R, Medema RH, (2001) Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion. J Biol Chem 276: 41656-41660.
50. Smits VA, Klompmaker R, Arnaud L, Rijksen G, Nigg EA, et al. (2000) Polo-like kinase-1 is a target of the DNA damage checkpoint. Nat Cell Biol 2: 672-676.
51. Tsvetkov L, Xu X, Li J, Stern DF, (2003) Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody. J Biol Chem 278: 8468-8475.