The Bfa1/Bub2 GAP complex comprises a universal checkpoint required to prevent mitotic exit

Current Biology

Volumn 10, Issue 21, 2000, Pages 1379-1382

  Wang, Yanchang ^a   Hu, Fenghua ^a   Elledge, Stephen J ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0034597552     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00779-X     Document Type: Article

References (20)

1. Regulation of the APC and the exit from mitosis
2. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation
3. A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in budding yeast
4. Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2
5. Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage
6. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint
7. The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo
8. Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
9. Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms
10. RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast
11. Bifurcation of the mitotic checkpoint pathway in budding yeast
12. The yeast dynactin complex is involved in partitioning the mitotic spindle between mother and daughter cells during anaphase B
13. The JNM1 gene in the yeast Saccharomyces cerevisiae is required for nuclear migration and spindle orientation during the mitotic cell cycle
14. A yeast actin-related protein homologous to that in vertebrate dynactin complex is important for spindle orientation and nuclear migration
15. A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein
16. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex
17. Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus
18. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5
19. A mechanism for coupling exit from mitosis to partitioning of the nucleus
20. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae