General anesthetics and β-amyloid protein

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 47, Issue , 2013, Pages 140-146

  Xie, Zhongcong ^a   Xu, Zhipeng ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Amyloid protein; General anesthetics; Neurotoxicity

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; DESFLURANE; INHALATION ANESTHETIC AGENT; ISOFLURANE; NITROUS OXIDE; PROPOFOL; SEVOFLURANE;

ALZHEIMER DISEASE; ANESTHESIA; DEMENTIA; GENERAL ANESTHESIA; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PATHOGENESIS; REVIEW; SURGICAL PATIENT;

99-RESIDUE MEMBRANE-ASSOCIATED C-TERMINUS FRAGMENT; AD; ADENOSINE-5'-TRIPHOSPHATE; AICD; ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEIN; ANTERIOR PHARYNX-DEFECTIVE 1; APH-1; APP; APP-C-TERMINAL FRAGMENT; APP-C83; APP-C99; APP-CTF; ATP; AΒ; BACE; BACE CLEAVAGE OF APP; CAD; CARBOBENZOXY-VALYL -ALANYL-ASPARTYL-[OMETHYL]- FLUROMETHYLKETONE; CARBOXYL-TERMINUS FRAGMENT OF 83 AMINO ACIDS; CORONARY ARTERY DISEASE; DAPT; GENERAL ANESTHETICS; IDE; INSULIN DEGRADING ENZYME; N-[N-(3,5-DIFLUOROPHENACETYL)-L-ALANYL]-(S)-PHENYLGLYCINE T-BUTYL ESTER; NEUROTOXICITY; PEN-2; PRESENILIN ENHANCER 2; TNF-Α; TUMOR NECROSIS FACTOR-Α; WILD-TYPE; WT; Z-VAD; Α-APPS; Α-SECRETASE CLEAVAGE OF APP; Β-AMYLOID PRECURSOR PROTEIN INTRACELLULAR DOMAIN; Β-AMYLOID PROTEIN; Β-APPS; Β-SITE APP-CLEAVING ENZYME;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANESTHETICS, GENERAL; HUMANS;

EID: 84887171866     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2012.08.002     Document Type: Review

References (85)

1. Affholter J.A., Hsieh C.L., Francke U., Roth R.A. Insulin-degrading enzyme: stable expression of the human complementary DNA, characterization of its protein product, and chromosomal mapping of the human and mouse genes. Mol Endocrinol 1990, 4:1125-1135.
2. Ashe K.H., Zahs K.R. Probing the biology of Alzheimer's disease in mice. Neuron 2010, 66:631-645.
3. Avidan M.S., Searleman A.C., Storandt M., Barnett K., Vannucci A., Saager L., et al. Long-term cognitive decline in older subjects was not attributable to noncardiac surgery or major illness. Anesthesiology 2009, 111:964-970.
4. Baranov D., Bickler P.E., Crosby G.J., Culley D.J., Eckenhoff M.F., Eckenhoff R.G., et al. Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease. Anesth Analg 2009, 108:1627-1630.
5. Bates K.A., Verdile G., Li Q.X., Ames D., Hudson P., Masters C.L., et al. Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests. Mol Psychiatry 2009, 14:469-486.
6. Bertram L., Tanzi R.E. Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses. Nat Rev Neurosci 2008, 9:768-778.
7. Bianchi S.L., Tran T., Liu C., Lin S., Li Y., Keller J.M., et al. Brain and behavior changes in 12-month-old Tg2576 and nontransgenic mice exposed to anesthetics. Neurobiol Aging 2008, 29:1002-1010.
8. Bohnen N., Warner M.A., Kokmen E., Kurland L.T. Early and midlife exposure to anesthesia and age of onset of Alzheimer's disease. Int J Neurosci 1994, 77:181-185.
9. Bohnen N.I., Warner M.A., Kokmen E., Beard C.M., Kurland L.T. Alzheimer's disease and cumulative exposure to anesthesia: a case-control study. J Am Geriatr Soc 1994, 42:198-201.
10. Bufill E., Bartes A., Moral A., Casadevall T., Codinachs M., Zapater E., et al. Genetic and environmental factors that may influence in the senile form of Alzheimer's disease: nested case control studies. Neurologia 2009, 24:108-112.
11. Buxton D.W. Crawford Williamson Long (1815-1879): the pioneer of anaesthesia and the first to suggest and employ ether inhalation during surgical operations. Proc R Soc Med 1912, 5:19-45.
12. de Klaver M.J., Manning L., Palmer L.A., Rich G.F. Isoflurane pretreatment inhibits cytokine-induced cell death in cultured rat smooth muscle cells and human endothelial cells. Anesthesiology 2002, 97:24-32.
13. De Strooper B. Aph-1, Pen-2, and nicastrin with presenilin generate an active gamma-secretase complex. Neuron 2003, 38:9-12.
14. Dong Y., Zhang G., Zhang B., Moir R.D., Xia W., Marcantonio E.R., et al. The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Arch Neurol 2009, 66:620-631.
15. Dong Y., Xu Z., Zhang Y., McAuliffe S., Wang H., Shen X., et al. RNA interference-mediated silencing of BACE and APP attenuates the isoflurane-induced caspase activation. Med Gas Res 2011, 1:5.
16. Eckenhoff R.G., Johansson J.S., Wei H., Carnini A., Kang B., Wei W., et al. Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity. Anesthesiology 2004, 101:703-709.
17. Eckman E.A., Eckman C.B. Abeta-degrading enzymes: modulators of Alzheimer's disease pathogenesis and targets for therapeutic intervention. Biochem Soc Trans 2005, 33:1101-1105.
18. Edbauer D., Winkler E., Regula J.T., Pesold B., Steiner H., Haass C. Reconstitution of gamma-secretase activity. Nat Cell Biol 2003, 5:486-488.
19. Esch F.S., Keim P.S., Beattie E.C., Blacher R.W., Culwell A.R., Oltersdorf T., et al. Cleavage of amyloid beta peptide during constitutive processing of its precursor. Science 1990, 248:1122-1124.
20. Francis R., McGrath G., Zhang J., Ruddy D.A., Sym M., Apfeld J., et al. Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 2002, 3:85-97.
21. Gasparini M., Vanacore N., Schiaffini C., Brusa L., Panella M., Talarico G., et al. A case-control study on Alzheimer's disease and exposure to anesthesia. Neurol Sci 2002, 23:11-14.
22. Glenner G.G., Wong C.W. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 1984, 122:1131-1135.
23. Glenner G.G., Wong C.W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984, 120:885-890.
24. Goate A., Chartier-Harlin M.C., Mullan M., Brown J., Crawford F., Fidani L., et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 1991, 349:704-706.
25. 2+ and mitogen-activated protein kinases. Anesthesiology 2005, 102:606-615.
26. Gu Y., Misonou H., Sato T., Dohmae N., Takio K., Ihara Y. Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch. J Biol Chem 2001, 276:35235-35238.
27. Harris R.A., Eger E.I. Alzheimer's disease and anesthesia: out of body, out of mind. . .or not?. Ann Neurol 2008, 64:595-597.
28. Higuchi M., Iwata N., Saido T.C. Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions. Biochim Biophys Acta 2005, 1751:60-67.
29. Hussain I., Powell D., Howlett D.R., Tew D.G., Meek T.D., Chapman C., et al. Identification of a novel aspartic protease (Asp 2) as beta-secretase. Mol Cell Neurosci 1999, 14:419-427.
30. Kanemitsu H., Tomiyama T., Mori H. Human neprilysin is capable of degrading amyloid beta peptide not only in the monomeric form but also the pathological oligomeric form. Neurosci Lett 2003, 350:113-116.
31. Kawaguchi M., Drummond J.C., Cole D.J., Kelly P.J., Spurlock M.P., Patel P.M. Effect of isoflurane on neuronal apoptosis in rats subjected to focal cerebral ischemia. Anesth Analg 2004, 98:798-805. table of contents.
32. Knopman D.S., Petersen R.C., Cha R.H., Edland S.D., Rocca W.A. Coronary artery bypass grafting is not a risk factor for dementia or Alzheimer disease. Neurology 2005, 65:986-990.
33. Lee T.A., Wolozin B., Weiss K.B., Bednar M.M. Assessment of the emergence of Alzheimer's disease following coronary artery bypass graft surgery or percutaneous transluminal coronary angioplasty. J Alzheimers Dis 2005, 7:319-324.
34. Lee J.J., Li L., Jung H.H., Zuo Z. Postconditioning with isoflurane reduced ischemia-induced brain injury in rats. Anesthesiology 2008, 108:1055-1062.
35. Li Y.M., Lai M.T., Xu M., Huang Q., DiMuzio-Mower J., Sardana M.K., et al. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci U S A 2000, 97:6138-6143.
36. Li L., Peng L., Zuo Z. Isoflurane preconditioning increases B-cell lymphoma-2 expression and reduces cytochrome c release from the mitochondria in the ischemic penumbra of rat brain. Eur J Pharmacol 2008, 586(1-3):106-113.
37. Liang G., Wang Q., Li Y., Kang B., Eckenhoff M.F., Eckenhoff R.G., et al. A presenilin-1 mutation renders neurons vulnerable to isoflurane toxicity. Anesth Analg 2008, 106:492-500. table of contents.
38. Loop T., Dovi-Akue D., Frick M., Roesslein M., Egger L., Humar M., et al. Volatile anesthetics induce caspase-dependent, mitochondria-mediated apoptosis in human T lymphocytes in vitro. Anesthesiology 2005, 102:1147-1157.
39. Lu Y., Wu X., Dong Y., Xu Z., Zhang Y., Xie Z. Anesthetic sevoflurane causes neurotoxicity differently in neonatal naive and Alzheimer disease transgenic mice. Anesthesiology 2010, 112:1404-1416.
40. Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A 1985, 82:4245-4249.
41. McDermott J.R., Gibson A.M. Degradation of Alzheimer's beta-amyloid protein by human and rat brain peptidases: involvement of insulin-degrading enzyme. Neurochem Res 1997, 22:49-56.
42. Miners J.S., Baig S., Palmer J., Palmer L.E., Kehoe P.G., Love S. Abeta-degrading enzymes in Alzheimer's disease. Brain Pathol 2008, 18:240-252.
43. Palotas M., Palotas A., Bjelik A., Pakaski M., Hugyecz M., Janka Z., et al. Effect of general anesthetics on amyloid precursor protein and mRNA levels in the rat brain. Neurochem Res 2005, 30:1021-1026.
44. Pan C., Xu Z., Dong Y., Zhang Y., Zhang J., McAuliffe S., et al. The potential dual effects of anesthetic isoflurane on hypoxia-induced caspase-3 activation and increases in beta-site amyloid precursor protein-cleaving enzyme levels. Anesth Analg 2011, 113:145-152.
45. Perez A., Morelli L., Cresto J.C., Castano E.M. Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains. Neurochem Res 2000, 25:247-255.
46. Perucho J., Rubio I., Casarejos M.J., Gomez A., Rodriguez-Navarro J.A., Solano R.M., et al. Anesthesia with isoflurane increases amyloid pathology in mice models of Alzheimer's disease. J Alzheimers Dis 2010, 19:1245-1257.
47. Qiu W.Q., Folstein M.F. Insulin, insulin-degrading enzyme and amyloid-beta peptide in Alzheimer's disease: review and hypothesis. Neurobiol Aging 2006, 27:190-198.
48. Qiu W.Q., Walsh D.M., Ye Z., Vekrellis K., Zhang J., Podlisny M.B., et al. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem 1998, 273:32730-32738.
49. Raphael J., Zuo Z., Abedat S., Beeri R., Gozal Y. Isoflurane preconditioning decreases myocardial infarction in rabbits via up-regulation of hypoxia inducible factor 1 that is mediated by mammalian target of rapamycin. Anesthesiology 2008, 108:415-425.
50. Sakono M., Zako T. Amyloid oligomers: formation and toxicity of Abeta oligomers. FEBS J 2010, 277:1348-1358.
51. Sastre M., Steiner H., Fuchs K., Capell A., Multhaup G., Condron M.M., et al. Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep 2001, 2:835-841.
52. Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001, 81:741-766.
53. Selkoe D.J., Podlisny M.B., Joachim C.L., Vickers E.A., Lee G., Fritz L.C., et al. Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proc Natl Acad Sci U S A 1988, 85:7341-7345.
54. Sinha S., Lieberburg I. Cellular mechanisms of beta-amyloid production and secretion. Proc Natl Acad Sci U S A 1999, 96:11049-11053.
55. Sisodia S.S., Koo E.H., Beyreuther K., Unterbeck A., Price D.L. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science 1990, 248:492-495.
56. Steiner H., Winkler E., Edbauer D., Prokop S., Basset G., Yamasaki A., et al. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. J Biol Chem 2002, 277:39062-39065.
57. Tang J.X., Baranov D., Hammond M., Shaw L.M., Eckenhoff M.F., Eckenhoff R.G. Human Alzheimer and inflammation biomarkers after anesthesia and surgery. Anesthesiology 2011, 115:727-732.
58. Tanzi R.E., Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 2005, 120:545-555.
59. Turner A.J., Tanzawa K. Mammalian membrane metallopeptidases: NEP, ECE, KELL, and PEX. FASEB J 1997, 11:355-364.
60. Turner A.J., Brown C.D., Carson J.A., Barnes K. The neprilysin family in health and disease. Adv Exp Med Biol 2000, 477:229-240.
61. Turner A.J., Isaac R.E., Coates D. The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function. Bioessays 2001, 23:261-269.
62. Tyther R., Fanning N., Halligan M., Wang J., Redmond H.P., Shorten G. The effect of the anaesthetic agent isoflurane on the rate of neutrophil apoptosis in vitro. Ir J Med Sci 2001, 170:41-44.
63. Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999, 286:735-741.
64. Wan Y., Xu J., Meng F., Bao Y., Ge Y., Lobo N., et al. Cognitive decline following major surgery is associated with gliosis, beta-amyloid accumulation, and tau phosphorylation in old mice. Crit Care Med 2010, 38(11):2190-2198.
65. Wang D.S., Dickson D.W., Malter J.S. Beta-amyloid degradation and Alzheimer's disease. J Biomed Biotechnol 2006, 2006:58406.
66. Wei H., Liang G., Yang H. Isoflurane preconditioning inhibited isoflurane-induced neurotoxicity. Neurosci Lett 2007, 425:59-62.
67. Wise-Faberowski L., Raizada M.K., Sumners C. Oxygen and glucose deprivation-induced neuronal apoptosis is attenuated by halothane and isoflurane. Anesth Analg 2001, 93:1281-1287.
68. Wise-Faberowski L., Aono M., Pearlstein R.D., Warner D.S. Apoptosis is not enhanced in primary mixed neuronal/glial cultures protected by isoflurane against N-methyl-d-aspartate excitotoxicity. Anesth Analg 2004, 99:1708-1714. table of contents.
69. Wolfe M.S. The secretases of Alzheimer's disease. Curr Top Dev Biol 2003, 54:233-261.
70. Xie Z., Dong Y., Maeda U., Alfille P., Culley D.J., Crosby G., et al. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology 2006, 104:988-994.
71. Xie Z., Dong Y., Maeda U., Moir R.D., Xia W., Culley D.J., et al. The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci 2007, 27:1247-1254.
72. Xie Z., Culley D.J., Dong Y., Zhang G., Zhang B., Moir R.D., et al. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol 2008, 64:618-627.
73. Xu X., Feng J., Zuo Z. Isoflurane preconditioning reduces the rat NR8383 macrophage injury induced by lipopolysaccharide and interferon gamma. Anesthesiology 2008, 108:643-650.
74. Xu Z., Dong Y., Wu X., Zhang J., McAuliffe S., Pan C., et al. The potential dual effects of anesthetic isoflurane on Abeta-induced apoptosis. Curr Alzheimer Res 2011, 8:741-752.
75. Yan R., Bienkowski M.J., Shuck M.E., Miao H., Tory M.C., Pauley A.M., et al. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 1999, 402:533-537.
76. Yu G., Nishimura M., Arawaka S., Levitan D., Zhang L., Tandon A., et al. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature 2000, 407:48-54.
77. Yu C., Kim S.H., Ikeuchi T., Xu H., Gasparini L., Wang R., et al. Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma-secretase processing of the APP and Notch1 transmembrane domains. J Biol Chem 2001, 276:43756-43760.
78. Zaugg M., Jamali N.Z., Lucchinetti E., Shafiq S.A., Siddiqui M.A. Norepinephrine-induced apoptosis is inhibited in adult rat ventricular myocytes exposed to volatile anesthetics. Anesthesiology 2000, 93:209-218.
79. Zhang B., Dong Y., Zhang G., Moir R.D., Xia W., Yue Y., et al. The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem 2008, 283:11866-11875.
80. Zhang G., Dong Y., Zhang B., Ichinose F., Wu X., Culley D.J., et al. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci 2008, 28:4551-4560.
81. Zhang Y., Dong Y., Wu X., Lu Y., Xu Z., Knapp A., et al. The mitochondrial pathway of anesthetic isoflurane-induced apoptosis. J Biol Chem 2010, 285:4025-4037.
82. Zhang Y., Zhen Y., Dong Y., Xu Z., Yue Y., Golde T.E., et al. Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and abeta oligomerization. PLoS One 2011, 6:e27019.
83. Zhang B., Tian M., Zhen Y., Yue Y., Sherman J., Zheng H., et al. The effects of isoflurane and desflurane on cognitive function in humans. Anesth Analg 2012, 114:410-415.
84. Zhang Y., Xu Z., Wang H., Dong Y., Shi H.N., Culley D.J., et al. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol 2012, 71:687-698.
85. Zhen Y., Dong Y., Wu X., Xu Z., Lu Y., Zhang Y., et al. Nitrous oxide plus isoflurane induces apoptosis and increases beta-amyloid protein levels. Anesthesiology 2009, 111:741-752.