Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells

Genetics

Volumn 195, Issue 3, 2013, Pages 757-767

  Sajesh, Babu V ^a   Bailey, Melanie ^b   Lichtensztejn, Zelda ^a   Hieter, Philip ^b   McManus, Kirk J ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHOXYESTRADIOL; COPPER ZINC SUPEROXIDE DISMUTASE; DIMETHYL SULFOXIDE; DNA; DOUBLE STRANDED DNA; RAD54 PROTEIN; RAD54B PROTEIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; STAUROSPORINE; TETRATHIOMOLYBDATE AMMONIUM; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ASSAY; BUDDING; CANCER CELL CULTURE; CELL TYPE; CELLS; CHROMOSOMAL INSTABILITY; COLORECTAL CANCER; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; ENZYME INHIBITION; FUNGAL GENE; GENE SILENCING; GENE TARGETING; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; LETHAL GENE; LETHALITY; MAMMAL CELL; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN TARGETING; RAD54B GENE; SOMATIC MUTATION;

COLORECTAL CANCER; RAD54B; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE 1; SYNTHETIC LETHALITY;

APOPTOSIS; CHROMOSOMAL INSTABILITY; COLORECTAL NEOPLASMS; DNA BREAKS, DOUBLE-STRANDED; DNA HELICASES; ESTRADIOL; GENES, FUNGAL; GENES, LETHAL; HCT116 CELLS; HUMANS; MOLYBDENUM; MUTATION; NUCLEAR PROTEINS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SACCHAROMYCES CEREVISIAE; SUPEROXIDE DISMUTASE;

EID: 84887088428     PISSN: 00166731     EISSN: 19432631     Source Type: Journal    
DOI: 10.1534/genetics.113.156836     Document Type: Article

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