DNA released by leukemic cells contributes to the disruption of the bone marrow microenvironment

Oncogene

Volumn 32, Issue 44, 2013, Pages 5201-5209

  Dvorakova M ^a   Karafiat V ^a   Pajer, P ^a   Kluzakova E ^b   Jarkovska K ^c   Pekova S ^d   Krutilkova L ^d   Dvorak M ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF ANIMAL PHYSIOLOGY AND GENETICS   (Czech Republic)

^d Laboratory for Molecular Diagnostics   (Czech Republic)

Author keywords

acute leukemia; cell death; DNA damage response; extracellular DNA; extracellular nucleosomes; tumor microenvironment

Indexed keywords

CASPASE 3; CELL NUCLEUS DNA; CYTOTOXIC AGENT; DNA; DNA FRAGMENT; HISTONE H2AX; SINGLE STRANDED DNA;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; BONE MARROW MICROENVIRONMENT; CELL DEATH; CELL KILLING; CELL STRAIN 3T3; CELL VIABILITY; CHICKEN; CHROMATIN; CORRELATION ANALYSIS; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; EMBRYO; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; LEUKEMIA CELL; MAMMAL CELL; MASS SPECTROMETRY; MICROENVIRONMENT; NONHUMAN; NUCLEOSOME; ONCOGENE MYB; PRIORITY JOURNAL; STROMA CELL; TUMOR CELL; TUMOR GROWTH; TUMOR MICROENVIRONMENT; WILD TYPE;

ANIMALS; APOPTOSIS; BONE MARROW; BONE MARROW NEOPLASMS; CELL LINE, TUMOR; CELL NUCLEUS; CHICK EMBRYO; CHICKENS; DISEASE PROGRESSION; DNA; DNA DAMAGE; DNA REPAIR; HISTONES; HUMANS; LEUKEMIA, MYELOID, ACUTE; NEOPLASM TRANSPLANTATION; NUCLEOSOMES; STROMAL CELLS; TUMOR MICROENVIRONMENT;

EID: 84887085890     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2012.553     Document Type: Article

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