Chipping away at γ-H2AX foci

Cell Cycle

Volumn 8, Issue 20, 2009, Pages 3285-3290

  Savic, Velibor ^a   Sanborn, Keri B ^a   Orange, Jordan S ^a,b   Bassing, Craig H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Chromatin; Chromatin immunoprecipitation; H2AX; Immunofluorescence; Phosphorylation

Indexed keywords

ATM PROTEIN; ENDONUCLEASE; HISTONE GAMMA H2AX; HISTONE H2AX; IMMUNOGLOBULIN KAPPA CHAIN; NUCLEAR PROTEIN; PROTEIN MDC1; RAG1 PROTEIN; RAG2 PROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; IMMUNOFLUORESCENCE; MICROSCOPY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOSOME; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVIEW;

MAMMALIA;

EID: 70350236888     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.20.9719     Document Type: Review

References (17)

1. Kinner A, Wu W, Staudt C, Iliakis G. Gamma- H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res 2008; 36:5678-5694
2. Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, et al. H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell 2003; 114:371-383 (Pubitemid 36962935)
3. Bassing CH, Suh H, Ferguson DO, Chua KF, Manis J, Eckersdorff M, et al. Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell 2003; 114:359-370 (Pubitemid 36962934)
4. Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 1999; 146:905-916 (Pubitemid 29430435)
5. Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998; 273:5858-5868
6. Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, et al. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell 2006; 21:187-200. (Pubitemid 43099935)
7. Stucki M, Jackson SP. gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair 2006; 5:534-543
8. Haber JE. Mating-type gene switching in Saccharomyces cerevisiae. Annu Rev Genet 1998; 32:561-599
9. Unal E, Arbel-Eden A, Sattler U, Shroff R, Lichten M, Haber JE, et al. DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol Cell 2004; 16:991-1002. (Pubitemid 40018408)
10. Shroff R, Arbel-Eden A, Pilch D, Ira G, Bonner WM, Petrini JH, et al. Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr Biol 2004; 14:1703-1711 (Pubitemid 39301159)
11. Downs JA, Lowndes NF, Jackson SP. A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature 2000; 408:1001-1004
12. Bewersdorf J, Bennett BT, Knight KL. H2AX chromatin structures and their response to DNA damage revealed by 4Pi microscopy. Proc Natl Acad Sci USA 2006; 103:18137-18142 (Pubitemid 44871625)
13. Bassing CH, Swat W, Alt FW. The mechanism and regulation of chromosomal V(D)J recombination. Cell 2002; 109:45-55.
14. Chen HT, Bhandoola A, Difilippantonio MJ, Zhu J, Brown MJ, Tai X, et al. Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX. Science 2000; 290:1962-1965
15. Savic V, Yin B, Maas NL, Bredemeyer AL, Carpenter AC, Helmink BA, et al. Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol Cell 2009; 34:298-310.
16. Orange JS, Harris KE, Andzelm MM, Valter MM, Geha RS, Strominger JL. The mature activating natural killer cell immunologic synapse is formed in distinct stages. Proc Natl Acad Sci USA 2003; 100:14151-14156
17. Banerjee PP, Pandey R, Zheng R, Suhoski MM, Monaco-Shawver L, Orange JS. Cdc42-interacting protein-4 functionally links actin and microtubule networks at the cytolytic NK cell immunological synapse. J Exp Med 2007; 204:2305-2320 (Pubitemid 47529318)