1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 23, 2013, Pages 7435-7452

  Koch, Pierre ^a   Akkari, Rhalid ^a   Brunschweiger, Andreas ^a   Borrmann, Thomas ^a   Schlenk, Miriam ^a   Küppers, Petra ^a   Köse, Meryem ^a   Radjainia, Hamid ^a   Hockemeyer, Jörg ^a   Drabczyńska, Anna ^b   Kieć Kononowicz, Katarzyna ^b   Müller, Christa E ^a  

^a UNIVERSITY OF BONN   (Germany)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Adenosine A 2A receptor antagonists; Adenosine A1 receptor antagonists; Alzheimer's disease; Anellated xanthines; Caffeine derivatives; Monoamine oxidase B inhibitors; Parkinson's disease; Synthesis; Tetrahydropyrimido 2,1 f purinediones; Tricyclic compounds

Indexed keywords

1 METHYL 3 PROPARGYLTETRAHYDROPYRIMIDO[1,2 F]PURINEDIONE DERIVATIVE; 1,3 DIETHYLTETRAHYDROPYRIMIDO[1,2 F]PURINEDIONE DERIVATIVE; 1,3 DIMETHYLTETRAHYDROPYRIMIDO[1,2 F]PURINEDIONE DERIVATIVE; 1,3 DIPROPYLTETRAHYDROPYRIMIDO[1,2 F]PURINEDIONE DERIVATIVE; 9 (3,4 DICHLOROBENZYL) 1,3 DIMETHYL 6,7,8,9 TETRAHYDROPYRIMIDO[1,2 F]PURINE 2,4 (1H,3H)DIONE; 9 BENZYL 1 METHYL 3 PROPARGYL 6,7,8,9 TETRAHYDROPYRIMIDO[1,2 F]PURINE 2,4(1H,3H)DIONE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR ANTAGONIST; ADENOSINE RECEPTOR; AMINE OXIDASE (FLAVIN CONTAINING); AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; MONOAMINE OXIDASE B INHIBITOR; TETRAHYDROPYRIMIDO[1,2 F]PURINE 2,4 DIONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHO CELL; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; IC 50; LIGAND BINDING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADENOSINE A(1) RECEPTOR ANTAGONISTS; ADENOSINE A(2A) RECEPTOR ANTAGONISTS; ALZHEIMER'S DISEASE; ANELLATED XANTHINES; CAFFEINE DERIVATIVES; MONOAMINE OXIDASE B INHIBITORS; PARKINSON'S DISEASE; SYNTHESIS; TETRAHYDROPYRIMIDO[2,1-F]PURINEDIONES; TRICYCLIC COMPOUNDS;

ADENOSINE A1 RECEPTOR ANTAGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; CAFFEINE; CHO CELLS; CRICETULUS; HUMANS; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; NEURODEGENERATIVE DISEASES; PURINERGIC P1 RECEPTOR ANTAGONISTS; PURINES; XANTHINES;

EID: 84886946282     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.09.044     Document Type: Article

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