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Volumn 8, Issue 6, 1998, Pages 783-790

New developments in understanding the etiology of Parkinson's disease and in its treatment

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; CARBIDOPA; CLOZAPINE; FLUOXETINE; LEVODOPA; PROPRANOLOL DERIVATIVE; SELEGILINE;

EID: 0031701839     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(98)80122-0     Document Type: Article
Times cited : (89)

References (68)
  • 1
    • 0021057103 scopus 로고
    • Three-dimensional computer reconstruction of midbrain dopaminergic neuronal populations: From mouse to man
    • German DC, Schlusselberg DS, Woodward DJ. Three-dimensional computer reconstruction of midbrain dopaminergic neuronal populations: from mouse to man. J Neural Transm. 57:1983;243-254.
    • (1983) J Neural Transm , vol.57 , pp. 243-254
    • German, D.C.1    Schlusselberg, D.S.2    Woodward, D.J.3
  • 2
    • 0031898760 scopus 로고    scopus 로고
    • Programmed cell death and Parkinson's disease
    • (suppl 1)
    • Burke RE. Programmed cell death and Parkinson's disease. Mov Disord. 13:1998;17-23. (suppl 1).
    • (1998) Mov Disord , vol.13 , pp. 17-23
    • Burke, R.E.1
  • 3
    • 0032510758 scopus 로고    scopus 로고
    • Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
    • Offen D, Beart PM, Cheung NS, Pascoe CJ, Hochman A, Gorodin S, Melamed E, Bernard R, Bernard O. Transgenic mice expressing human Bcl-2 in their neurons are resistant to 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity. Proc Natl Acad Sci USA. 95:1998;5789-5794.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5789-5794
    • Offen, D.1    Beart, P.M.2    Cheung, N.S.3    Pascoe, C.J.4    Hochman, A.5    Gorodin, S.6    Melamed, E.7    Bernard, R.8    Bernard, O.9
  • 4
    • 0031947244 scopus 로고    scopus 로고
    • Iron metabolism and Parkinson's disease
    • (suppl 1)
    • Hirsch EC, Faucheux BA. Iron metabolism and Parkinson's disease. Mov Disord. 13:1998;39-45. (suppl 1).
    • (1998) Mov Disord , vol.13 , pp. 39-45
    • Hirsch, E.C.1    Faucheux, B.A.2
  • 5
    • 0031899172 scopus 로고    scopus 로고
    • Oxidative mechanisms in nigral cell death in Parkinson's disease
    • (suppl 1)
    • Jenner P. Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov Disord. 13:1998;24-34. (suppl 1).
    • (1998) Mov Disord , vol.13 , pp. 24-34
    • Jenner, P.1
  • 6
    • 0031455029 scopus 로고    scopus 로고
    • Pathogenesis of Parkinson's disease
    • Schapira AH. Pathogenesis of Parkinson's disease. Baillieres Clin Neurol. 6:1997;15-36.
    • (1997) Baillieres Clin Neurol , vol.6 , pp. 15-36
    • Schapira, A.H.1
  • 7
    • 0031959882 scopus 로고    scopus 로고
    • The neurotoxin 1-methyl-4-phenylpyridinium is sequestered within neurons that contain the vesicular monoamine transporter
    • Speciale SG, Liang CL, Sonsalla PK, Edwards RH, German DC. The neurotoxin 1-methyl-4-phenylpyridinium is sequestered within neurons that contain the vesicular monoamine transporter. Neuroscience. 84:1998;1177-1185.
    • (1998) Neuroscience , vol.84 , pp. 1177-1185
    • Speciale, S.G.1    Liang, C.L.2    Sonsalla, P.K.3    Edwards, R.H.4    German, D.C.5
  • 8
    • 0031979752 scopus 로고    scopus 로고
    • Hypothesis: The role of dopaminergic transporters in selective vulnerability of cells in Parkinson's disease
    • Uhl GR. Hypothesis: the role of dopaminergic transporters in selective vulnerability of cells in Parkinson's disease. Ann Neurol. 43:1998;555-560.
    • (1998) Ann Neurol , vol.43 , pp. 555-560
    • Uhl, G.R.1
  • 10
    • 0028583129 scopus 로고
    • Does the calcium binding protein calretinin protect dopaminergic neurons against degeneration in Parkinson's disease?
    • Mouatt-Prigent A, Agid Y, Hirsch EC. Does the calcium binding protein calretinin protect dopaminergic neurons against degeneration in Parkinson's disease? Brain Res. 666:1994;62-70.
    • (1994) Brain Res , vol.666 , pp. 62-70
    • Mouatt-Prigent, A.1    Agid, Y.2    Hirsch, E.C.3
  • 11
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the α-synuclein gene identified in families with Parkinson's disease
    • of outstanding interest. The authors report the first mutation identified in families with Parkinson's disease. Understanding the molecular pathogenesis of the α-synuclein mutation will provide important insights into the etiology of genetic and so-called sporadic causes of PD.
    • Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, et al. Mutation in the α-synuclein gene identified in families with Parkinson's disease. of outstanding interest Science. 276:1997;2045-2047 The authors report the first mutation identified in families with Parkinson's disease. Understanding the molecular pathogenesis of the α-synuclein mutation will provide important insights into the etiology of genetic and so-called sporadic causes of PD.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1    Lavedan, C.2    Leroy, E.3    Ide, S.E.4    Dehejia, A.5    Dutra, A.6    Pike, B.7    Root, H.8    Rubenstein, J.9    Boyer, R.10
  • 12
    • 0030882856 scopus 로고    scopus 로고
    • Alpha-synuclein in Lewy bodies
    • of outstanding interest. α-Synuclein is a major component of Lewy bodies in PD and in Diffuse Lewy Body disease. This finding provides an important clue to the pathogenesis of PD. The role of synuclein aggregates in neuronal cell death is not yet known.
    • Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. Alpha-synuclein in Lewy bodies. of outstanding interest Nature. 388:1997;839-840 α-Synuclein is a major component of Lewy bodies in PD and in Diffuse Lewy Body disease. This finding provides an important clue to the pathogenesis of PD. The role of synuclein aggregates in neuronal cell death is not yet known.
    • (1997) Nature , vol.388 , pp. 839-840
    • Spillantini, M.G.1    Schmidt, M.L.2    Lee, V.M.3    Trojanowski, J.Q.4    Jakes, R.5    Goedert, M.6
  • 13
    • 0032499264 scopus 로고    scopus 로고
    • Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
    • of outstanding interest. The authors report the identification of a mutation in the parkin gene that causes autosomal recessive parkinsonism. This paper provides an important window into a distinct form of parkinsonism with a different molecular pathogenesis.
    • Kitada T, Asakawa S, Hattori N, Matsumine H, Yamamura Y, Minoshima S, Yokochi M, Mizuno Y, Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. of outstanding interest Nature. 392:1998;605-608 The authors report the identification of a mutation in the parkin gene that causes autosomal recessive parkinsonism. This paper provides an important window into a distinct form of parkinsonism with a different molecular pathogenesis.
    • (1998) Nature , vol.392 , pp. 605-608
    • Kitada, T.1    Asakawa, S.2    Hattori, N.3    Matsumine, H.4    Yamamura, Y.5    Minoshima, S.6    Yokochi, M.7    Mizuno, Y.8    Shimizu, N.9
  • 14
    • 0031952660 scopus 로고    scopus 로고
    • Models of basal ganglia function and pathophysiology of movement disorders
    • Wichmann T, DeLong MR. Models of basal ganglia function and pathophysiology of movement disorders. Neurosurg Clin N Am. 9:1998;223-236.
    • (1998) Neurosurg Clin N Am , vol.9 , pp. 223-236
    • Wichmann, T.1    Delong, M.R.2
  • 16
    • 0030294556 scopus 로고    scopus 로고
    • The basal ganglia: Focused selection and inhibition of competing motor programs
    • Mink JW. The basal ganglia: focused selection and inhibition of competing motor programs. Prog Neurobiol. 50:1996;381-425.
    • (1996) Prog Neurobiol , vol.50 , pp. 381-425
    • Mink, J.W.1
  • 17
    • 0031892576 scopus 로고    scopus 로고
    • Neuronal circuitry and synaptic connectivity of the basal ganglia
    • of special interest. An excellent summary of our current understanding of the basal ganglia circuitry, including newly described pathways.
    • Smith Y, Shink E, Sidibe M. Neuronal circuitry and synaptic connectivity of the basal ganglia. of special interest Neurosurg Clin N Am. 9:1998;203-222 An excellent summary of our current understanding of the basal ganglia circuitry, including newly described pathways.
    • (1998) Neurosurg Clin N Am , vol.9 , pp. 203-222
    • Smith, Y.1    Shink, E.2    Sidibe, M.3
  • 18
    • 0013583334 scopus 로고    scopus 로고
    • Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates
    • Bergman H, Feingold A, Nini A, Raz A, Slovin H, Abeles M, Vaadia E. Physiological aspects of information processing in the basal ganglia of normal and parkinsonian primates. Trends Neurosci. 21:1998;32-38.
    • (1998) Trends Neurosci , vol.21 , pp. 32-38
    • Bergman, H.1    Feingold, A.2    Nini, A.3    Raz, A.4    Slovin, H.5    Abeles, M.6    Vaadia, E.7
  • 19
    • 0030853296 scopus 로고    scopus 로고
    • Effects of apomorphine on globus pallidus neurons in parkinsonian patients
    • of special interest. Single-unit recordings in PD patients reveals that apomorphine reduces GPi but increases GPe, firing rates. The findings suggest that, as in parkinsonian non-human primates, GPi is overactive in PD patients, that dopamine agonists reduce this excessive activity, and that reductions in GPi firing are associated with improvements in akinesia and rigidity.
    • Hutchison WD, Levy R, Dostrovsky JO, Lozano AM, Lang AE. Effects of apomorphine on globus pallidus neurons in parkinsonian patients. of special interest Ann Neurol. 42:1997;767-775 Single-unit recordings in PD patients reveals that apomorphine reduces GPi but increases GPe, firing rates. The findings suggest that, as in parkinsonian non-human primates, GPi is overactive in PD patients, that dopamine agonists reduce this excessive activity, and that reductions in GPi firing are associated with improvements in akinesia and rigidity.
    • (1997) Ann Neurol , vol.42 , pp. 767-775
    • Hutchison, W.D.1    Levy, R.2    Dostrovsky, J.O.3    Lozano, A.M.4    Lang, A.E.5
  • 21
    • 0028021805 scopus 로고
    • The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism
    • Bergman H, Wichmann T, Karmon B, DeLong MR. The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism. J Neurophysiol. 72:1994;507-520.
    • (1994) J Neurophysiol , vol.72 , pp. 507-520
    • Bergman, H.1    Wichmann, T.2    Karmon, B.3    Delong, M.R.4
  • 23
    • 0027530638 scopus 로고
    • Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease
    • Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med. 328:1993;176-183.
    • (1993) N Engl J Med , vol.328 , pp. 176-183
  • 24
    • 9044226896 scopus 로고    scopus 로고
    • Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP patients requiring levodopa
    • Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP patients requiring levodopa. Ann Neurol. 39:1996;37-45.
    • (1996) Ann Neurol , vol.39 , pp. 37-45
  • 25
    • 0031037786 scopus 로고    scopus 로고
    • L-(-)-desmethylselegiline, a metabolite of selegiline [L-(-)-deprenyl], protects mesencephalic dopamine neurons from excitotoxicity in vitro
    • Mytilineou C, Radcliffe PM, Olanow CW. L-(-)-desmethylselegiline, a metabolite of selegiline [L-(-)-deprenyl], protects mesencephalic dopamine neurons from excitotoxicity in vitro. J Neurochem. 68:1997;434-436.
    • (1997) J Neurochem , vol.68 , pp. 434-436
    • Mytilineou, C.1    Radcliffe, P.M.2    Olanow, C.W.3
  • 26
    • 9044227267 scopus 로고
    • Comparison of therapeutic effects and mortality data of levodopa and levodopa combined with selegiline in patients with early, mild Parkinson's disease. Parkinson's Disease Research Group of the United Kingdom
    • Lees AJ. Comparison of therapeutic effects and mortality data of levodopa and levodopa combined with selegiline in patients with early, mild Parkinson's disease. Parkinson's Disease Research Group of the United Kingdom. BMJ. 311:1995;1602-1607.
    • (1995) BMJ , vol.311 , pp. 1602-1607
    • Lees, A.J.1
  • 27
    • 0031893241 scopus 로고    scopus 로고
    • Mortality in DATATOP: A multicenter trial in early Parkinson's disease
    • of special interest. The Parkinson study group evaluated the mortality of the DATATOP cohort so as to provide further data to compare to the worrisome results of a UK study [26] finding a significantly increased mortality rate in combined treatments of selegiline and levodopa. This study did not find that the combination of selegiline and levodopa is associated with an increase in mortality in PD patients; however, this study used a different population of patients from the UK study [26].
    • Mortality in DATATOP: a multicenter trial in early Parkinson's disease. of special interest Ann Neurol. 43:1998;318-325 The Parkinson study group evaluated the mortality of the DATATOP cohort so as to provide further data to compare to the worrisome results of a UK study [26] finding a significantly increased mortality rate in combined treatments of selegiline and levodopa. This study did not find that the combination of selegiline and levodopa is associated with an increase in mortality in PD patients; however, this study used a different population of patients from the UK study [26].
    • (1998) Ann Neurol , vol.43 , pp. 318-325
  • 28
    • 0031899713 scopus 로고    scopus 로고
    • Levodopa: Is toxicity a myth?
    • of special interest. This is an excellent review of the issues related to levodopa toxicity, which concludes that there is no clinical or experimental evidence to support the concern that levodopa is toxic to dopaminergic neurons.
    • Agid Y. Levodopa: is toxicity a myth? of special interest Neurology. 50:1998;858-863 This is an excellent review of the issues related to levodopa toxicity, which concludes that there is no clinical or experimental evidence to support the concern that levodopa is toxic to dopaminergic neurons.
    • (1998) Neurology , vol.50 , pp. 858-863
    • Agid, Y.1
  • 29
    • 0031968959 scopus 로고    scopus 로고
    • Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions
    • of outstanding interest. An important study that evaluates the effects of levodopa in rats with partial and severe nigrostriatal lesions. In the rats with partial lesions, levodopa has a trophic rather than a toxic effect on the remaining dopaminergic neurons.
    • Murer MG, Dziewczapolski G, Menalled LB, Garcia MC, Agid Y, Gershanik O, Raisman-Vozari R. Chronic levodopa is not toxic for remaining dopamine neurons, but instead promotes their recovery, in rats with moderate nigrostriatal lesions. of outstanding interest Ann Neurol. 43:1998;561-575 An important study that evaluates the effects of levodopa in rats with partial and severe nigrostriatal lesions. In the rats with partial lesions, levodopa has a trophic rather than a toxic effect on the remaining dopaminergic neurons.
    • (1998) Ann Neurol , vol.43 , pp. 561-575
    • Murer, M.G.1    Dziewczapolski, G.2    Menalled, L.B.3    Garcia, M.C.4    Agid, Y.5    Gershanik, O.6    Raisman-Vozari, R.7
  • 30
    • 0030784938 scopus 로고    scopus 로고
    • Motor complications of chronic levodopa therapy in Parkinson's disease
    • of special interest. A good, up-to-date review of the frequency of levodopa complications in a large clinical population of PD patients.
    • Miyawaki E, Lyons K, Pahwa R, Troster AI, Hubble J, Smith D, Busenbark K, McGuire D, Michalek D, Koller WC. Motor complications of chronic levodopa therapy in Parkinson's disease. of special interest Clin Neuropharmacol. 20:1997;523-530 A good, up-to-date review of the frequency of levodopa complications in a large clinical population of PD patients.
    • (1997) Clin Neuropharmacol , vol.20 , pp. 523-530
    • Miyawaki, E.1    Lyons, K.2    Pahwa, R.3    Troster, A.I.4    Hubble, J.5    Smith, D.6    Busenbark, K.7    McGuire, D.8    Michalek, D.9    Koller, W.C.10
  • 31
    • 0029689447 scopus 로고    scopus 로고
    • Contribution of dopaminergic and glutamatergic mechanisms to the pathogenesis of motor response complications in Parkinson's disease
    • Chase TN, Engber TM, Mouradian MM. Contribution of dopaminergic and glutamatergic mechanisms to the pathogenesis of motor response complications in Parkinson's disease. Adv Neurol. 69:1996;497-501.
    • (1996) Adv Neurol , vol.69 , pp. 497-501
    • Chase, T.N.1    Engber, T.M.2    Mouradian, M.M.3
  • 34
    • 0030869562 scopus 로고    scopus 로고
    • Efficacy of pramipexole, a novel dopamine agonist, as monotherapy in mild to moderate Parkinson's disease
    • The Pramipexole Study Group
    • Shannon KM, Bennett JPJ, Friedman JH. Efficacy of pramipexole, a novel dopamine agonist, as monotherapy in mild to moderate Parkinson's disease. The Pramipexole Study Group Neurology. 49:1997;724-728.
    • (1997) Neurology , vol.49 , pp. 724-728
    • Shannon, K.M.1    Bennett, J.P.J.2    Friedman, J.H.3
  • 35
    • 0031026244 scopus 로고    scopus 로고
    • Cabergoline in the treatment of early Parkinson's disease: Results of the first year of treatment in a double-blind comparison of cabergoline and levodopa
    • Rinne UK, Bracco F, Chouza C, Dupont E, Gershanik O, Masso JFM, Montastruc JL, Marsden CD, Dubini A, Orlando N, et al. Cabergoline in the treatment of early Parkinson's disease: results of the first year of treatment in a double-blind comparison of cabergoline and levodopa. Neurology. 48:1997;363-368.
    • (1997) Neurology , vol.48 , pp. 363-368
    • Rinne, U.K.1    Bracco, F.2    Chouza, C.3    Dupont, E.4    Gershanik, O.5    Masso, J.F.M.6    Montastruc, J.L.7    Marsden, C.D.8    Dubini, A.9    Orlando, N.10
  • 36
    • 0031028464 scopus 로고    scopus 로고
    • Tolcapone improves motor function and reduces levodopa requirement in patients with Parkinson's disease experiencing motor fluctuations: A multicenter, double-blind, randomized, placebo-controlled trial
    • Tolcapone Fluctuator Study Group I
    • Kurth MC, Adler CH, Hilaire MS, Singer C, Waters C, Lewitt P, Chernik DA, Dorflinger EE, Yoo K. Tolcapone improves motor function and reduces levodopa requirement in patients with Parkinson's disease experiencing motor fluctuations: a multicenter, double-blind, randomized, placebo-controlled trial. Tolcapone Fluctuator Study Group I Neurology. 48:1997;81-87.
    • (1997) Neurology , vol.48 , pp. 81-87
    • Kurth, M.C.1    Adler, C.H.2    Hilaire, M.S.3    Singer, C.4    Waters, C.5    Lewitt, P.6    Chernik, D.A.7    Dorflinger, E.E.8    Yoo, K.9
  • 37
    • 0030778373 scopus 로고    scopus 로고
    • Entacapone improves motor fluctuations in levodopa-treated Parkinson's disease patients
    • Entacapone improves motor fluctuations in levodopa-treated Parkinson's disease patients. Ann Neurol. 42:1997;747-755.
    • (1997) Ann Neurol , vol.42 , pp. 747-755
  • 38
    • 0029884740 scopus 로고    scopus 로고
    • Improvement of levodopa-induced dyskinesia by propranolol in Parkinson's disease
    • Carpentier AF, Bonnet AM, Vidalhet M, Agid Y. Improvement of levodopa-induced dyskinesia by propranolol in Parkinson's disease. Neurology. 46:1996;1548-1551.
    • (1996) Neurology , vol.46 , pp. 1548-1551
    • Carpentier, A.F.1    Bonnet, A.M.2    Vidalhet, M.3    Agid, Y.4
  • 39
    • 0029431964 scopus 로고
    • Levodopa-induced dyskinesias are improved by fluoxetine
    • Durif F, Vidailhet M, Bonnet AM, Blin J, Agid Y. Levodopa-induced dyskinesias are improved by fluoxetine. Neurology. 45:1995;1855-1858.
    • (1995) Neurology , vol.45 , pp. 1855-1858
    • Durif, F.1    Vidailhet, M.2    Bonnet, A.M.3    Blin, J.4    Agid, Y.5
  • 41
    • 0006647256 scopus 로고    scopus 로고
    • Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease
    • of special interest. The authors describe a new use for an old, and usually well tolerated, drug, amantadine. Its antidyskinetic effect may be related to its anti-NMDA effects, which may also underlie its overall anti-Parkinson effects.
    • Verhagen ML, Del DP, Van DM, Fang J, Mouradian MM, Chase TN. Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease. of special interest Neurology. 50:1998;1323-1326 The authors describe a new use for an old, and usually well tolerated, drug, amantadine. Its antidyskinetic effect may be related to its anti-NMDA effects, which may also underlie its overall anti-Parkinson effects.
    • (1998) Neurology , vol.50 , pp. 1323-1326
    • Verhagen, M.L.1    Del, D.P.2    Van, D.M.3    Fang, J.4    Mouradian, M.M.5    Chase, T.N.6
  • 42
    • 0030819935 scopus 로고    scopus 로고
    • The emerging role of clozapine in the treatment of movement disorders
    • Factor SA, Friedman JH. The emerging role of clozapine in the treatment of movement disorders. Mov Disord. 12:1997;483-496.
    • (1997) Mov Disord , vol.12 , pp. 483-496
    • Factor, S.A.1    Friedman, J.H.2
  • 43
    • 0029845563 scopus 로고    scopus 로고
    • Olanzapine in the treatment of dopaminomimetic psychosis in patients with Parkinson's disease
    • Wolters EC, Jansen ENH, Tuynman-Qua HG, Bergmans PLM. Olanzapine in the treatment of dopaminomimetic psychosis in patients with Parkinson's disease. Neurology. 47:1996;1085-1087.
    • (1996) Neurology , vol.47 , pp. 1085-1087
    • Wolters, E.C.1    Jansen, E.N.H.2    Tuynman-Qua, H.G.3    Bergmans, P.L.M.4
  • 45
    • 0028324501 scopus 로고
    • N-0923, a selective dopamine D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease
    • Belluzzi JD, Domino EF, May JM, Bankiewicz KS, McAfee DA. N-0923, a selective dopamine D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease. Mov Disord. 9:1994;147-154.
    • (1994) Mov Disord , vol.9 , pp. 147-154
    • Belluzzi, J.D.1    Domino, E.F.2    May, J.M.3    Bankiewicz, K.S.4    McAfee, D.A.5
  • 46
    • 0030611334 scopus 로고    scopus 로고
    • Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson's disease
    • Richardson PJ, Kase H, Jenner PG. Adenosine A2A receptor antagonists as new agents for the treatment of Parkinson's disease. Trends Pharmacol Sci. 18:1997;338-344.
    • (1997) Trends Pharmacol Sci , vol.18 , pp. 338-344
    • Richardson, P.J.1    Kase, H.2    Jenner, P.G.3
  • 47
    • 0031951172 scopus 로고    scopus 로고
    • Kappa-opioid receptor agonists increase locomotor activity in the monoamine-depleted rat model of parkinsonism
    • Hughes NR, McKnight AT, Woodruff GN, Hill MP, Crossman AR, Brotchie JM. Kappa-opioid receptor agonists increase locomotor activity in the monoamine-depleted rat model of parkinsonism. Mov Disord. 13:1998;228-233.
    • (1998) Mov Disord , vol.13 , pp. 228-233
    • Hughes, N.R.1    McKnight, A.T.2    Woodruff, G.N.3    Hill, M.P.4    Crossman, A.R.5    Brotchie, J.M.6
  • 48
    • 0031225736 scopus 로고    scopus 로고
    • Improved therapies for Parkinson's disease: Life beyond dopamine D2/D3 receptor agonists
    • of special interest. An excellent survey of some new pharmacological avenues being explored for the future treatment of Parkinson's disease.
    • Williams M, Wright S, Lloyd GK. Improved therapies for Parkinson's disease: life beyond dopamine D2/D3 receptor agonists. of special interest Trends Pharmacol Sci. 18:1997;307-310 An excellent survey of some new pharmacological avenues being explored for the future treatment of Parkinson's disease.
    • (1997) Trends Pharmacol Sci , vol.18 , pp. 307-310
    • Williams, M.1    Wright, S.2    Lloyd, G.K.3
  • 49
    • 0029665122 scopus 로고    scopus 로고
    • Levodopa-induced dyskinesias improved by a glutamate antagonist in Parkinsonian monkeys
    • Papa SM, Chase TN. Levodopa-induced dyskinesias improved by a glutamate antagonist in Parkinsonian monkeys. Ann Neurol. 39:1996;574-578.
    • (1996) Ann Neurol , vol.39 , pp. 574-578
    • Papa, S.M.1    Chase, T.N.2
  • 50
    • 12644257556 scopus 로고    scopus 로고
    • Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models
    • of outstanding interest. The identification of neurotrophic immunophilins is potentially one of the most important new developments in the field of treatment of neurodegenerative diseases. The authors demonstrate the protective and regenerative effects of neurotrophic immunophilin ligands in culture and in animal models of PD.
    • Steiner JP, Hamilton GS, Ross DT, Valentine HL, Guo HZ, Connolly MA, Liang S, Ramsey C, Li JHJ, Huang W, et al. Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. of outstanding interest Proc Natl Acad Sci USA. 94:1997;2019-2024 The identification of neurotrophic immunophilins is potentially one of the most important new developments in the field of treatment of neurodegenerative diseases. The authors demonstrate the protective and regenerative effects of neurotrophic immunophilin ligands in culture and in animal models of PD.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2019-2024
    • Steiner, J.P.1    Hamilton, G.S.2    Ross, D.T.3    Valentine, H.L.4    Guo, H.Z.5    Connolly, M.A.6    Liang, S.7    Ramsey, C.8    Li, J.H.J.9    Huang, W.10
  • 52
    • 0030987501 scopus 로고    scopus 로고
    • High frequency stimulation of the globus pallidus internalis in Parkinson's disease: A study of seven cases
    • of special interest. Reports that stimulation of GPi produces striking improvements in the major signs of PD.
    • Gross C, Rougier A, Guehl D, Boraud T, Julien J, Bioulac B. High frequency stimulation of the globus pallidus internalis in Parkinson's disease: a study of seven cases. of special interest J Neurosurg. 87:1997;491-498 Reports that stimulation of GPi produces striking improvements in the major signs of PD.
    • (1997) J Neurosurg , vol.87 , pp. 491-498
    • Gross, C.1    Rougier, A.2    Guehl, D.3    Boraud, T.4    Julien, J.5    Bioulac, B.6
  • 53
    • 0031566830 scopus 로고    scopus 로고
    • Chronic stimulation of subthalamic nucleus improves levodopa-induced dyskinesias in Parkinson's disease
    • of special interest. The authors report that chronic subthalamic stimulation has an unexpected anti-dyskinetic effect. The diminution in dyskinesias may be related to the important reduction in medications made possible by the anti-parkinsonian effect of the surgery.
    • Krack P, Limousin P, Benabid AL, Pollak P. Chronic stimulation of subthalamic nucleus improves levodopa-induced dyskinesias in Parkinson's disease. of special interest Lancet. 350:1997;1676 The authors report that chronic subthalamic stimulation has an unexpected anti-dyskinetic effect. The diminution in dyskinesias may be related to the important reduction in medications made possible by the anti-parkinsonian effect of the surgery.
    • (1997) Lancet , vol.350 , pp. 1676
    • Krack, P.1    Limousin, P.2    Benabid, A.L.3    Pollak, P.4
  • 54
    • 0030941260 scopus 로고    scopus 로고
    • Globus pallidus stimulation activates the cortical motor system during alleviation of parkinsonian symptoms
    • of special interest. Globus pallidus stimulation, like pallidotomy, activates the cortical supplementary motor area. This finding suggests that pallidal stimulation acts as a reversible pallidal lesion.
    • Davis KD, Taub E, Houser D, Lang AE, Dostrovsky JO, Tasker R, Lozano A. Globus pallidus stimulation activates the cortical motor system during alleviation of parkinsonian symptoms. of special interest Nat Med. 3:1997;671-674 Globus pallidus stimulation, like pallidotomy, activates the cortical supplementary motor area. This finding suggests that pallidal stimulation acts as a reversible pallidal lesion.
    • (1997) Nat Med , vol.3 , pp. 671-674
    • Davis, K.D.1    Taub, E.2    Houser, D.3    Lang, A.E.4    Dostrovsky, J.O.5    Tasker, R.6    Lozano, A.7
  • 55
    • 0031566831 scopus 로고    scopus 로고
    • Stimulation of subthalamic nucleus alleviates tremor in Parkinson's disease
    • of outstanding interest. STN stimulation produces striking improvements in parkinsonian signs, including tremor. This is the first paper to report the use of the STN nucleus as a surgical target for the treatment of PD tremor.
    • Krack P, Pollak P, Limousin P, Benazzouz A, Benabid AL. Stimulation of subthalamic nucleus alleviates tremor in Parkinson's disease. of outstanding interest Lancet. 350:1997;1675 STN stimulation produces striking improvements in parkinsonian signs, including tremor. This is the first paper to report the use of the STN nucleus as a surgical target for the treatment of PD tremor.
    • (1997) Lancet , vol.350 , pp. 1675
    • Krack, P.1    Pollak, P.2    Limousin, P.3    Benazzouz, A.4    Benabid, A.L.5
  • 56
    • 0030835608 scopus 로고    scopus 로고
    • High-frequency stimulation of the globus pallidus for the treatment of Parkinson's disease
    • of special interest. Reports that high-frequency GPi stimulation is an alternative to pallidotomy as a treatment of PD.
    • Pahwa R, Wilkinson S, Smith D, Lyons K, Miyawaki E, Koller WC. High-frequency stimulation of the globus pallidus for the treatment of Parkinson's disease. of special interest Neurology. 49:1997;249-253 Reports that high-frequency GPi stimulation is an alternative to pallidotomy as a treatment of PD.
    • (1997) Neurology , vol.49 , pp. 249-253
    • Pahwa, R.1    Wilkinson, S.2    Smith, D.3    Lyons, K.4    Miyawaki, E.5    Koller, W.C.6
  • 57
    • 0026536547 scopus 로고
    • Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease
    • Laitinen LV, Bergenheim AT, Hariz MI. Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease. J Neurosurg. 76:1992;53-61.
    • (1992) J Neurosurg , vol.76 , pp. 53-61
    • Laitinen, L.V.1    Bergenheim, A.T.2    Hariz, M.I.3
  • 58
    • 0030922767 scopus 로고    scopus 로고
    • Posteroventral medial pallidotomy in advanced Parkinson's disease
    • of special interest. Reports the results of a large trial of microelectrode-guided unilateral pallidotomy showing improvements in the major manifestations of PD and increased independence in patients with advanced PD.
    • Lang AE, Lozano AM, Montgomery E, Duff J, Tasker R, Hutchison W. Posteroventral medial pallidotomy in advanced Parkinson's disease. of special interest N Engl J Med. 337:1997;1036-1042 Reports the results of a large trial of microelectrode-guided unilateral pallidotomy showing improvements in the major manifestations of PD and increased independence in patients with advanced PD.
    • (1997) N Engl J Med , vol.337 , pp. 1036-1042
    • Lang, A.E.1    Lozano, A.M.2    Montgomery, E.3    Duff, J.4    Tasker, R.5    Hutchison, W.6
  • 59
    • 0031006158 scopus 로고    scopus 로고
    • Efficacy, stability and predictors of outcome of pallidotomy for Parkinson's disease - Six-month follow-up with additional 1-year observations
    • of special interest. The authors report good clinical benefits using (non-microelectrode recording guided) unilateral pallidotomy. This surgical technique, which does not rely on a detailed physiologic localization of the sensorimotor territory of GPi, can also produce substantial motor improvements.
    • Kishore A, Turnbull IM, Snow BJ, De La Fuente-Fernandez R, Schulzer M, Mak E, Yardley S, Calne DB. Efficacy, stability and predictors of outcome of pallidotomy for Parkinson's disease - six-month follow-up with additional 1-year observations. of special interest Brain. 120:1997;729-737 The authors report good clinical benefits using (non-microelectrode recording guided) unilateral pallidotomy. This surgical technique, which does not rely on a detailed physiologic localization of the sensorimotor territory of GPi, can also produce substantial motor improvements.
    • (1997) Brain , vol.120 , pp. 729-737
    • Kishore, A.1    Turnbull, I.M.2    Snow, B.J.3    De La Fuente-Fernandez, R.4    Schulzer, M.5    Mak, E.6    Yardley, S.7    Calne, D.B.8
  • 63
    • 0028868574 scopus 로고
    • Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres
    • Isacson O, Deacon TW, Pakzaban P, Galpern WR, Dinsmore J, Burns LH. Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres. Nat Med. 1:1995;1189-1194.
    • (1995) Nat Med , vol.1 , pp. 1189-1194
    • Isacson, O.1    Deacon, T.W.2    Pakzaban, P.3    Galpern, W.R.4    Dinsmore, J.5    Burns, L.H.6
  • 64
    • 85046166537 scopus 로고    scopus 로고
    • Neuronal xenotransplantation in Parkinson's disease
    • Schumacher JM, Isacson O. Neuronal xenotransplantation in Parkinson's disease. Nat Med. 3:1997;474-475.
    • (1997) Nat Med , vol.3 , pp. 474-475
    • Schumacher, J.M.1    Isacson, O.2
  • 66
    • 0032005461 scopus 로고    scopus 로고
    • Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates
    • Espejo EF, Montoro RJ, Armengol JA, Lopez-Barneo J. Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates. Neuron. 20:1998;197-206.
    • (1998) Neuron , vol.20 , pp. 197-206
    • Espejo, E.F.1    Montoro, R.J.2    Armengol, J.A.3    Lopez-Barneo, J.4
  • 67
    • 0031936437 scopus 로고    scopus 로고
    • Implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor improve survival, growth, and function of fetal dopaminergic grafts
    • Sautter J, Tseng JL, Braguglia D, Aebischer P, Spenger C, Seiler RW, Widmer HR, Zurn AD. Implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor improve survival, growth, and function of fetal dopaminergic grafts. Exp Neurol. 149:1998;230-236.
    • (1998) Exp Neurol , vol.149 , pp. 230-236
    • Sautter, J.1    Tseng, J.L.2    Braguglia, D.3    Aebischer, P.4    Spenger, C.5    Seiler, R.W.6    Widmer, H.R.7    Zurn, A.D.8
  • 68
    • 0031945063 scopus 로고    scopus 로고
    • Gene therapy for Parkinson's disease: Neurobiologic issues and new developments in gene transfer methodologies
    • of special interest
    • Kang UJ. Gene therapy for Parkinson's disease: neurobiologic issues and new developments in gene transfer methodologies. of special interest Mov Disord. 1998; An excellent review of gene therapy techniques in animal models of PD.
    • (1998) Mov Disord
    • Kang, U.J.1


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