Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 4, 2012, Pages 1739-1742

  Song, Bo ^a   Xiao, Tong ^a   Qi, Xiaolu ^a   Li, Ling Na ^a   Qin, Kuiyou ^a   Nian, Siyun ^a   Hu, Guo Xin ^a   Yu, Yinfei ^a   Liang, Guang ^a   Ye, Faqing ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Inhibitory effect; Monoamine oxidase B inhibitors; Neuroportective effect; Parkinson's disease; Xanthine derivative

Indexed keywords

8 (BENZAMIDO)PHENYL XANTHINE DERIVATIVE; MONOAMINE OXIDASE B INHIBITOR; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ARTICLE; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; INHIBITION KINETICS;

EID: 84862799939     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.094     Document Type: Article

References (16)

1. Royal College of Physicians, Parkinson's Disease, London, 2006, pp 59-100.
2. Di Monte, D. A.; DeLanney, L. E.; Irwin, I. Brain Res. 1996, 738, 55.
3. Finberg, J. P.; Wang, J.; Bankiewicz, K.; Harvey-White, J.; Kopin, I. J.; Goldstein, D. S. J. Neural. Transm. Suppl. 1998, 52, 282.
4. Shoulson, I.; Oakes, D.; Fahn, S., et al Ann. Neurol. 2002, 51, 607.
5. Petzer, Jacobus P.; Castagnoli, Neal, Jr.; Schwarzschild, Michael A.; Chen, Jiang-Fan; Cornelis J. Neurotherapeutics 2009, 6, 145.
6. den Berg, Deidre'van; Zoellner, Kevin R.; Modupe; Ogunrombi, O. Bioorg. Med. Chem. 2007, 15, 3693.
7. Petzer, J. P.; Steyn, S.; Castagnoli, K. P.; Chen, J. F.; Schwarzschild, M. A.; Van der Schyf, C. J.; Castagnoli, N., Jr. Bioorg. Med. Chem. 2003, 11, 1299.
8. Castagnoli, N.; Petzer, J. P.; Steyn, S.; Castagnoli, K.; Chen, J. F.; Schwarzschild, M. A.; Van der Schyf, C. J. Neurol. 2003, 61, S63.
9. Petzer, Jacobus P.; Steyn, Salome; Castagnoli, KayP; Chen, Jiang-Fan; Schwarzschild, Michael A.; Van der Schyf, Cornelis J.; Castagnoli, Neal Bioorg. Med. Chem. 2003, 11, 1302.
10. Kalla, Rao V.; Elzein, Elfatih; Perry, Thao; Li, Xiaofen; Palle, Venkata; Varkhedkar, Vaibhav; Gimbel, Arthur; Maa, Tennig; Zeng, Dewan; Zablocki, Jeff J. Med. Chem. 2006, 49, 3684.
11. Kmil, M. Biochem. Pharmaco1. 1965, 14, 1685.
12. Pretorius, Judey; malan, Sarel F.; Castagnoli, Neal Bioorg. Med. Chem. 2008, 16, 8679.
13. Sonsalla, Patricia K.; Wong, Lai-Yoong; Winnik, Bozena; Buckley, Brian Exp. Neurol. 2010, 221, 330.
14. Gnerre, C.; Catto, M.; Leonetti, F.; Weber, P.; Carrupt, P. A.; Altomare, C.; Carotti, A.; Testa, B. J. Med. Chem. 2000, 43, 4747.
15. Lange, K. H.; Riederer, P.; Youdim, M. B. Clin. Pharmacol. Ther. 1994, 56, 734.
16. Chen, Jiang-Fan; Steyn, Salome; Staal, Roland; Petzer, Jacobus P.; Xu, Kui; Van der Schyf, Cornelis J.; Castagnoli, Kay; Sonsalla, Patricia K.; Castagnoli, Neal, Jr.; Schwarzschild, Michael A. J. Biol. Chem. 2002, 39, 36041.