Human monocytoid cells as a model to study Toll-like receptor-mediated activation

Journal of Immunological Methods

Volumn 313, Issue 1-2, 2006, Pages 1-10

  Remer, Katharina A ^a   Brcic, Marija ^a   Sauter, Kay Sara ^a   Jungi, Thomas W ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

CD14; Monocytoid cells; THP 1; TLR; TLR agonists; TNF

Indexed keywords

AMINO ACID DERIVATIVE; ANTIBODY; CALCITRIOL; CD14 ANTIGEN; FLAGELLIN; LIGAND; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; LYSINE DERIVATIVE; MESSENGER RNA; PEPTIDOGLYCAN; PROTEIN ANTIBODY; SERINE DERIVATIVE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR;

ANTIBODY SPECIFICITY; ARTICLE; BINDING SITE; CELL ACTIVATION; CELL LINE; CELL SURFACE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD14; CALCITRIOL; CELL LINE; CYSTEINE; FLAGELLIN; GENE EXPRESSION; HUMANS; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; LIPOPROTEINS; MONOCYTES; PEPTIDOGLYCAN; POLY I-C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TEICHOIC ACIDS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 5; TOLL-LIKE RECEPTOR 9; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33745685155     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2005.07.026     Document Type: Article

References (38)

1. Akira S., and Hemmi H. Recognition of pathogen-associated molecular patterns by TLR family. Immunol. Lett. 85 (2003) 85
2. Akira S., Takeda K., and Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2 (2001) 675
3. Alexopoulou L., Holt A.C., Medzhitov R., and Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 (2001) 732
4. Bauer S., Kirschning C.J., Hacker H., Redecke V., Hausmann S., Akira S., Wagner H., and Lipford G.B. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 9237
5. Beutler B. Innate immunity: an overview. Mol. Immunol. 40 (2004) 845
6. Cleveland M.G., Gorham J.D., Murphy T.L., Tuomanen E., and Murphy K.M. Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway. Infect. Immun. 64 (1996) 1906
7. Ellingsen E., Morath S., Flo T., Schromm A., Hartung T., Thiemermann C., Espevik T., Golenbock D., Foster D., Solberg R., Aasen A., and Wang J. Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14. Med. Sci. Monit. 8 (2002) BR149
8. Eperon S., and Jungi T.W. The use of human monocytoid lines as indicators of endotoxin. J. Immunol. Methods 194 (1996) 121
9. Eperon S., De Groote D., Werner Felmayer G., and Jungi T.W. Human monocytoid cell lines as indicators of endotoxin. Comparison with rabbit pyrogen and Limulus amoebocyte lysate assay. J. Immunol. Methods 207 (1997) 135
10. Flo T.H., Halaas O., Lien E., Ryan L., Teti G., Golenbock D.T., Sundan A., and Espevik T. Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. J. Immunol. 164 (2000) 2064
11. Franchini M., Schweizer M., Matzener P., Magkouras I., Sauter K.S., Mirkovitch J., Peterhans E., and Jungi T.W. Evidence for dissociation of TLR mRNA expression and TLR agonist-mediated functions in bovine macrophages. Vet. Immunol. Immunopathol. 110 (2006) 37
12. Gantner B.N., Simmons R.M., Canavera S.J., Akira S., and Underhill D.M. Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2. J. Exp. Med. 197 (2003) 1107
13. Hattor Y., Kasai K., Akimoto K., and Thiemermann C. Induction of NO synthesis by lipoteichoic acid from Staphylococcus aureus in J774 macrophages: involvement of a CD14-dependent pathway. Biochem. Biophys. Res. Commun. 233 (1997) 375
14. Hayashi F., Smith K.D., Ozinsky A., Hawn T.R., Yi E.C., Goodlett D.R., Eng J.K., Akira S., Underhill D.M., and Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410 (2001) 1099
15. Heinz S., Haehnel V., Karaghiosoff M., Schwarzfischer L., Muller M., Krause S.W., and Rehli M. Species-specific regulation of Toll-like receptor 3 genes in men and mice. J. Biol. Chem. 278 (2003) 21502
16. Hoffmann S., Peterbauer A., Schindler S., Fennrich S., Poole S., Mistry Y., Montag-Lessing T., Spreitzer I., Loschner B., van Aaldelaren M., Bos R., Gommer M., Nibbeling R., Werner-Felmayer G., Loitzl P., Jungi T., Brcic M., Brugger P., Frey E., Bowe G., Casado J., Coecke S., de Lange J., Mogster B., Naess L.M., Aaberge I.S., Wendel A., and Hartung T. International validation of novel pyrogen tests based on human monocytoid cells. J. Immunol. Methods 298 (2005) 161
17. Janeway C.A.J. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol. Today 13 (1992) 11
18. Jungi T.W., Brcic M., and Eperon S. Human macrophages respond to LPS in a serum-independent, CD14-dependent manner. Immunol. Lett. 54 (1996) 37
19. Kadowaki N., Ho S., Antonenko S., Malefyt R.W., Kastelein R.A., Bazan F., and Liu Y.J. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194 (2001) 863
20. Kuhnert P., Schalch L., and Jungi T.W. Cytokine induction in human mononuclear cells stimulated by IgG-coated culture surfaces and by IgG for infusion. Clin. Immunol. Immunopathol. 57 (1990) 218
21. Mizel S.B., Honko A.N., Moors M.A., Smith P.S., and West A.P. Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes. J. Immunol. 170 (2003) 6217
22. Morath S., Geyer A., and Hartung T. Structure-function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus. J. Exp. Med. 193 (2001) 393
23. Murthy K.G., Deb A., Gonnesekera S., Szabo C., and Salzmnan A.L. Identification of conserved domains in Salmonella muenchen flagellin that are essential for its ability to activate TLR5 and to induce an inflammatory response in vitro. J. Biol. Chem. 279 (2005) 5667
24. Ozinsky A., Underhill D.M., Fontenot J.D., Hajjar A.M., Smith K.D., Wilson C.B., Schroeder L., and Aderem A. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 13766
25. Poltorak A., He X., Smirnova I., Liu M.Y., Huffel C.V., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., and Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 (1998) 2085
26. Poltorak A., Ricciardi-Castagnoli P., Citterio S., and Beutler B. Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 2163
27. Pugin J., Ulevitch R.J., and Tobias P.S. A critical role for monocytes and CD14 in endotoxin-induced endothelial cell activation. J. Exp. Med. 178 (1993) 2193
28. Schumann R.R., Rietschel E.T., and Loppnow H. The role of CD14 and lipopolysaccharide-binding protein (LBP) in the activation of different cell types by endotoxin. Med. Microbiol. Immunol. 183 (1994) 279
29. Schwandner R., Dziarski R., Wesche H., Rothe M., and Kirschning C.J. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 274 (1999) 17406
30. Shimazu R., Akashi S., Ogata H., Nagai Y., Fukudome K., Miyake K., and Kimoto M. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189 (1999) 1777
31. Simmons D.L., Tan S., Tenen D.G., Nicholson Weller A., and Seed B. Monocyte antigen CD14 is a phospholipid anchored membrane protein. Blood 73 (1989) 284
32. Siren J., Pirhonen J., Julkunen I., and Matikainen S. IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29. J. Immunol. 174 (2005) 1932
33. Takeda K., and Akira S. Microbial recognition by Toll-like receptors. J. Dermatol. Sci. 34 (2004) 73
34. Travassos L.H., Girardin S.E., Philpott D.J., Blanot D., Nahori M.A., Werts C., and Boneca I.G. Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep. 5 (2004) 1
35. Viriyakosol S., Tobias P.S., Kitchens R.L., and Kirkland T.N. MD-2 binds to bacterial lipopolysaccharide. J. Biol. Chem. 276 (2001) 38044
36. Wagner H. The immunobiology of the TLR9 subfamily. Trends Immunol. 25 (2004) 381
37. Werling D., Hope J.C., Howard C.J., and Jungi T.W. Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists. Immunology 111 (2004) 41
38. Wright S.D., Ramos R.A., Tobias P.S., Ulevitch R.J., and Mathison J.C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249 (1990) 1431