메뉴 건너뛰기




Volumn 143, Issue 11, 2013, Pages 1799-1807

Fish oil alleviates activation of the hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaned piglets after a lipopolysaccharide challenge

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CLUSTER DIFFERENTIATION FACTOR 14; CORN OIL; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLOOXYGENASE 2; DOCOSAHEXAENOIC ACID; HYDROCORTISONE; ICOSAPENTAENOIC ACID; INTERLEUKIN RECEPTOR ASSOCIATED KINASE 1; LIPOPOLYSACCHARIDE; MELANOCORTIN RECEPTOR; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 2; MYELOID DIFFERENTIATION FACTOR 88; NUCLEAR FACTOR KAPPA LIGHT CHAIN ENHANCER OF ACTIVATED B CELLS P65; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN; OMEGA 3 FATTY ACID; PENTOBARBITAL; PROOPIOMELANOCORTIN; PROTEIN; STEROIDOGENIC ACUTE REGULATORY PROTEIN; STEROIDOGENIC ACUTE REGULATORY PROTEIN 4; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; FISH OIL; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE;

EID: 84886813202     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.113.179960     Document Type: Article
Times cited : (22)

References (47)
  • 1
    • 0036230531 scopus 로고    scopus 로고
    • Minireview: neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules
    • Chesnokova V, Melmed S. Minireview: neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules. Endocrinology. 2002;143:1571-4.
    • (2002) Endocrinology. , vol.143 , pp. 1571-1574
    • Chesnokova, V.1    Melmed, S.2
  • 2
    • 34848912561 scopus 로고    scopus 로고
    • Adipocytes, myofibers, and cytokine biology: new horizons in the regulation of growth and body composition
    • Jacobi SK, Gabler NK, Ajuwon KM, Davis JE, Spurlock ME. Adipocytes, myofibers, and cytokine biology: new horizons in the regulation of growth and body composition. J Anim Sci. 2006;84: Suppl:E140-9.
    • (2006) J Anim Sci. , vol.84 , Issue.SUPPL.
    • Jacobi, S.K.1    Gabler, N.K.2    Ajuwon, K.M.3    Davis, J.E.4    Spurlock, M.E.5
  • 3
    • 79954613032 scopus 로고    scopus 로고
    • Cytokines mediated inflammation and decreased neurogenesis in animal models of depression
    • Song C, Wang H. Cytokines mediated inflammation and decreased neurogenesis in animal models of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35:760-8.
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry. , vol.35 , pp. 760-768
    • Song, C.1    Wang, H.2
  • 4
    • 0036889766 scopus 로고    scopus 로고
    • Cytokines and neuroimmune- endocrine interactions: a role for the hypothalamic-pituitaryadrenal revolving axis
    • Haddad JJ, Saadé NE, Safieh-Garabedian B. Cytokines and neuroimmune- endocrine interactions: a role for the hypothalamic-pituitaryadrenal revolving axis. J Neuroimmunol. 2002;133:1-19.
    • (2002) J Neuroimmunol. , vol.133 , pp. 1-19
    • Haddad, J.J.1    Saadé, N.E.2    Safieh-Garabedian, B.3
  • 5
    • 31844432926 scopus 로고    scopus 로고
    • The HPA and immune axes in stress: the involvement of the serotonergic system
    • Leonard BE. The HPA and immune axes in stress: the involvement of the serotonergic system. Eur Psychiatry. 2005;20: Suppl 3:S302-6.
    • (2005) Eur Psychiatry. , vol.20 , Issue.SUPPL. 3
    • Leonard, B.E.1
  • 6
    • 77549088368 scopus 로고    scopus 로고
    • Up-regulated expression of peroxisome proliferatoractivated receptor g in the hypothalamic-pituitary-adrenal axis of weaned pigs after Escherichia coli lipopolysaccharide challenge
    • Liu YL, Shi JX, Lu J, Che ZQ, Zhu HL, Hou YQ, Yin YL, Zhao SJ, Ding BY, Liu HM. Up-regulated expression of peroxisome proliferatoractivated receptor g in the hypothalamic-pituitary-adrenal axis of weaned pigs after Escherichia coli lipopolysaccharide challenge. Vet J. 2010;184:230-5.
    • (2010) Vet J. , vol.184 , pp. 230-235
    • Liu, Y.L.1    Shi, J.X.2    Lu, J.3    Che, Z.Q.4    Zhu, H.L.5    Hou, Y.Q.6    Yin, Y.L.7    Zhao, S.J.8    Ding, B.Y.9    Liu, H.M.10
  • 7
    • 54549108771 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
    • Calder PC. Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. Mol Nutr Food Res. 2008;52:885-97.
    • (2008) Mol Nutr Food Res. , vol.52 , pp. 885-897
    • Calder, P.C.1
  • 8
    • 71449118574 scopus 로고    scopus 로고
    • Fatty acids and immune function: relevance to inflammatory bowel diseases
    • Calder PC. Fatty acids and immune function: relevance to inflammatory bowel diseases. Int Rev Immunol. 2009;28:506-34.
    • (2009) Int Rev Immunol. , vol.28 , pp. 506-534
    • Calder, P.C.1
  • 9
    • 80055019374 scopus 로고    scopus 로고
    • Fatty acids and inflammation: the cutting edge between food and pharma
    • Calder PC. Fatty acids and inflammation: the cutting edge between food and pharma. Eur J Pharmacol. 2011;668: Suppl 1:S50-8.
    • (2011) Eur J Pharmacol. , vol.668 , Issue.SUPPL. 1
    • Calder, P.C.1
  • 10
    • 1542442160 scopus 로고    scopus 로고
    • Effects of fish oil supplementation on the performance and the immunological, adrenal, and somatotropic responses of weaned pigs after an Escherichia coli lipopolysaccharide challenge
    • Liu YL, Li DF, Gong LM, Yi GF, Gaines AM, Carroll JA. Effects of fish oil supplementation on the performance and the immunological, adrenal, and somatotropic responses of weaned pigs after an Escherichia coli lipopolysaccharide challenge. J Anim Sci. 2003;81:2758-65.
    • (2003) J Anim Sci. , vol.81 , pp. 2758-2765
    • Liu, Y.L.1    Li, D.F.2    Gong, L.M.3    Yi, G.F.4    Gaines, A.M.5    Carroll, J.A.6
  • 11
    • 79952022410 scopus 로고    scopus 로고
    • Omega-3 fatty acid and inflammatory processes
    • Calder PC. Omega-3 fatty acid and inflammatory processes. Nutrients. 2010;2:355-74.
    • (2010) Nutrients. , vol.2 , pp. 355-374
    • Calder, P.C.1
  • 13
    • 33846640524 scopus 로고    scopus 로고
    • Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers
    • Michaeli B, Berger MM, Revelly JP, Tappy L, Chioléro R. Effects of fish oil on the neuro-endocrine responses to an endotoxin challenge in healthy volunteers. Clin Nutr. 2007;26:70-7.
    • (2007) Clin Nutr. , vol.26 , pp. 70-77
    • Michaeli, B.1    Berger, M.M.2    Revelly, J.P.3    Tappy, L.4    Chioléro, R.5
  • 14
    • 36649010031 scopus 로고    scopus 로고
    • Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies
    • Calon F, Cole G. Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. Prostaglandins Leukot Essent Fatty Acids. 2007;77:287-93.
    • (2007) Prostaglandins Leukot Essent Fatty Acids. , vol.77 , pp. 287-293
    • Calon, F.1    Cole, G.2
  • 15
    • 0344738574 scopus 로고    scopus 로고
    • Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression
    • Logan AC. Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression. Altern Med Rev. 2003;8:410-25.
    • (2003) Altern Med Rev. , vol.8 , pp. 410-425
    • Logan, A.C.1
  • 16
    • 71749121383 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids and anxiety disorders
    • Ross BM. Omega-3 polyunsaturated fatty acids and anxiety disorders. Prostaglandins Leukot Essent Fatty Acids. 2009;81:309-12.
    • (2009) Prostaglandins Leukot Essent Fatty Acids. , vol.81 , pp. 309-312
    • Ross, B.M.1
  • 17
    • 69949105213 scopus 로고    scopus 로고
    • Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders
    • Fukata M, Vamadevan AS, Abreu MT. Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders. Semin Immunol. 2009;21:242-53.
    • (2009) Semin Immunol. , vol.21 , pp. 242-253
    • Fukata, M.1    Vamadevan, A.S.2    Abreu, M.T.3
  • 18
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell. 2010;140:805-20.
    • (2010) Cell. , vol.140 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 21
    • 58149111250 scopus 로고    scopus 로고
    • Animal models to study neonatal nutrition in humans
    • Puiman P, Stoll B. Animal models to study neonatal nutrition in humans. Curr Opin Clin Nutr Metab Care. 2008;11:601-6.
    • (2008) Curr Opin Clin Nutr Metab Care. , vol.11 , pp. 601-606
    • Puiman, P.1    Stoll, B.2
  • 23
    • 84869129239 scopus 로고    scopus 로고
    • Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge
    • Liu Y, Chen F, Odle J, Lin X, Jacobi SK, Zhu H, Wu Z, Hou Y. Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge. J Nutr. 2012;142:2017- 24.
    • (2012) J Nutr. , vol.142 , pp. 2017-2024
    • Liu, Y.1    Chen, F.2    Odle, J.3    Lin, X.4    Jacobi, S.K.5    Zhu, H.6    Wu, Z.7    Hou, Y.8
  • 24
    • 66149165911 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma potentiates pro-inflammatory cytokine production, and adrenal and somatotropic changes of weaned pigs after Escherichia coli lipopolysaccharide challenge
    • Liu Y, Shi J, Lu J, Meng G, Zhu H, Hou Y, Yin Y, Zhao S, Ding B. Activation of peroxisome proliferator-activated receptor-gamma potentiates pro-inflammatory cytokine production, and adrenal and somatotropic changes of weaned pigs after Escherichia coli lipopolysaccharide challenge. Innate Immun. 2009;15:169-78.
    • (2009) Innate Immun. , vol.15 , pp. 169-178
    • Liu, Y.1    Shi, J.2    Lu, J.3    Meng, G.4    Zhu, H.5    Hou, Y.6    Yin, Y.7    Zhao, S.8    Ding, B.9
  • 25
    • 44249120525 scopus 로고    scopus 로고
    • Increased expression of the peroxisome proliferator-activated receptor gamma in the immune system of weaned pigs after Escherichia coli lipopolysaccharide injection
    • Liu Y, Lu J, Shi J, Hou Y, Zhu H, Zhao S, Liu H, Ding B, Yin Y, Yi G. Increased expression of the peroxisome proliferator-activated receptor gamma in the immune system of weaned pigs after Escherichia coli lipopolysaccharide injection. Vet Immunol Immunopathol. 2008;124: 82-92.
    • (2008) Vet Immunol Immunopathol. , vol.124 , pp. 82-92
    • Liu, Y.1    Lu, J.2    Shi, J.3    Hou, Y.4    Zhu, H.5    Zhao, S.6    Liu, H.7    Ding, B.8    Yin, Y.9    Yi, G.10
  • 26
    • 0034909630 scopus 로고    scopus 로고
    • Effect of repeated lipopolysaccharide administration on tissue cytokine expression and hypothalamic-pituitary-adrenal axis activity in rats
    • Grinevich V, Ma XM, Herman JP, Jezova D, Akmayev I, Aguilera G. Effect of repeated lipopolysaccharide administration on tissue cytokine expression and hypothalamic-pituitary-adrenal axis activity in rats. J Neuroendocrinol. 2001;13:711-23.
    • (2001) J Neuroendocrinol. , vol.13 , pp. 711-723
    • Grinevich, V.1    Ma, X.M.2    Herman, J.P.3    Jezova, D.4    Akmayev, I.5    Aguilera, G.6
  • 27
    • 19444365791 scopus 로고    scopus 로고
    • Endogenous opioids and attenuated hypothalamic-pituitary-adrenal axis responses to immune challenge in pregnant rats
    • Brunton PJ, Meddle SL, Ma S, Ochedalski T, Douglas AJ, Russell JA. Endogenous opioids and attenuated hypothalamic-pituitary-adrenal axis responses to immune challenge in pregnant rats. J Neurosci. 2005;25:5117-26.
    • (2005) J Neurosci. , vol.25 , pp. 5117-5126
    • Brunton, P.J.1    Meddle, S.L.2    Ma, S.3    Ochedalski, T.4    Douglas, A.J.5    Russell, J.A.6
  • 28
    • 0036138758 scopus 로고    scopus 로고
    • Dietary polyunsaturated fatty acids improve histological and biochemical alterations in rats with experimental ulcerative colitis
    • Nieto N, Torres MI, Ríos A, Gil A. Dietary polyunsaturated fatty acids improve histological and biochemical alterations in rats with experimental ulcerative colitis. J Nutr. 2002;132:11-9.
    • (2002) J Nutr. , vol.132 , pp. 11-19
    • Nieto, N.1    Torres, M.I.2    Ríos, A.3    Gil, A.4
  • 29
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and 2-DDCT method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and 2-DDCT method. Methods. 2001;25:402-8.
    • (2001) Methods. , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 30
    • 84881356916 scopus 로고    scopus 로고
    • Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4 and NOD signaling in weaning piglets after LPS challenge
    • Liu Y, Chen F, Odle J, Lin X, Zhu H, Shi H, Hou Y, Yin J. Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4 and NOD signaling in weaning piglets after LPS challenge. J Nutr. 2013;143:1331-9.
    • (2013) J Nutr. , vol.143 , pp. 1331-1339
    • Liu, Y.1    Chen, F.2    Odle, J.3    Lin, X.4    Zhu, H.5    Shi, H.6    Hou, Y.7    Yin, J.8
  • 31
    • 84861960992 scopus 로고    scopus 로고
    • Long term adequate polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice
    • Moranis A, Delpech JC, De Smedt-Peyrusse V, Aubert A, Guesnet P, Lavialle M, Joffre C, Layé S. Long term adequate polyunsaturated fatty acid diet protects from depressive-like behavior but not from working memory disruption and brain cytokine expression in aged mice. Brain Behav Immun. 2012;26:721-31.
    • (2012) Brain Behav Immun. , vol.26 , pp. 721-731
    • Moranis, A.1    Delpech, J.C.2    De Smedt-Peyrusse, V.3    Aubert, A.4    Guesnet, P.5    Lavialle, M.6    Joffre, C.7    Layé, S.8
  • 32
    • 72049083989 scopus 로고    scopus 로고
    • Minimal penetration of lipopolysaccharide across the murine blood-brain barrier
    • Banks WA, Robinson SM. Minimal penetration of lipopolysaccharide across the murine blood-brain barrier. Brain Behav Immun. 2010;24:102-9.
    • (2010) Brain Behav Immun. , vol.24 , pp. 102-109
    • Banks, W.A.1    Robinson, S.M.2
  • 33
    • 84880447788 scopus 로고    scopus 로고
    • Innate immune regulation by toll-like receptors in the brain
    • Mallard C. Innate immune regulation by toll-like receptors in the brain. ISRN Neurol. 2012;2012:701950.
    • (2012) ISRN Neurol. , vol.2012 , pp. 701950
    • Mallard, C.1
  • 34
    • 45949087450 scopus 로고    scopus 로고
    • Integrating the immune system with the regulation of growth and efficiency
    • Gabler NK, Spurlock ME. Integrating the immune system with the regulation of growth and efficiency. J Anim Sci. 2008;86: Suppl 14:E64-74.
    • (2008) J Anim Sci. , vol.86 , Issue.SUPPL. 14
    • Gabler, N.K.1    Spurlock, M.E.2
  • 35
    • 51149094970 scopus 로고    scopus 로고
    • Effects of Achyranthes bidentata polysaccharide on growth performance, immunological, adrenal, and somatotropic responses of weaned pigs challenged with Escherichia coli lipopolysaccharide
    • Guo GL, Liu YL, Fan W, Han J, Hou YQ, Yin YL, Zhu HL, Ding BY, Shi JX, Lu J, et al. Effects of Achyranthes bidentata polysaccharide on growth performance, immunological, adrenal, and somatotropic responses of weaned pigs challenged with Escherichia coli lipopolysaccharide. Asian-Aust J Anim Sci. 2008;21:1189-95.
    • (2008) Asian-Aust J Anim Sci. , vol.21 , pp. 1189-1195
    • Guo, G.L.1    Liu, Y.L.2    Fan, W.3    Han, J.4    Hou, Y.Q.5    Yin, Y.L.6    Zhu, H.L.7    Ding, B.Y.8    Shi, J.X.9    Lu, J.10
  • 36
    • 77649225653 scopus 로고    scopus 로고
    • The blood brain barrier and the role of cytokines in neuropsychiatry
    • Yarlagadda A, Alfson E, Clayton AH. The blood brain barrier and the role of cytokines in neuropsychiatry. Psychiatry (Edgmont). 2009;6:18-22.
    • (2009) Psychiatry (Edgmont). , vol.6 , pp. 18-22
    • Yarlagadda, A.1    Alfson, E.2    Clayton, A.H.3
  • 39
    • 0031134814 scopus 로고    scopus 로고
    • Inhibition of growth by pro-inflammatory cytokines: an integrated view
    • Johnson RW. Inhibition of growth by pro-inflammatory cytokines: an integrated view. J Anim Sci. 1997;75:1244-55.
    • (1997) J Anim Sci. , vol.75 , pp. 1244-1255
    • Johnson, R.W.1
  • 40
    • 80053900477 scopus 로고    scopus 로고
    • Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: multiplex quantification with path analysis
    • Erickson MA, Banks WA. Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: multiplex quantification with path analysis. Brain Behav Immun. 2011;25:1637-48.
    • (2011) Brain Behav Immun. , vol.25 , pp. 1637-1648
    • Erickson, M.A.1    Banks, W.A.2
  • 42
    • 41749120975 scopus 로고    scopus 로고
    • Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization
    • De Smedt-Peyrusse V, Sargueil F, Moranis A, Harizi H, Mongrand S, Layé S. Docosahexaenoic acid prevents lipopolysaccharide-induced cytokine production in microglial cells by inhibiting lipopolysaccharide receptor presentation but not its membrane subdomain localization. J Neurochem. 2008;105:296-307.
    • (2008) J Neurochem. , vol.105 , pp. 296-307
    • De Smedt-Peyrusse, V.1    Sargueil, F.2    Moranis, A.3    Harizi, H.4    Mongrand, S.5    Layé, S.6
  • 43
    • 78651292670 scopus 로고    scopus 로고
    • Docosahexaenoic acid suppresses neuroinflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: implications of antidepressant effects for v-3 fatty acids
    • Lu DY, Tsao YY, Leung YM, Su KP. Docosahexaenoic acid suppresses neuroinflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: implications of antidepressant effects for v-3 fatty acids. Neuropsychopharmacology. 2010;35:2238-48.
    • (2010) Neuropsychopharmacology. , vol.35 , pp. 2238-2248
    • Lu, D.Y.1    Tsao, Y.Y.2    Leung, Y.M.3    Su, K.P.4
  • 45
    • 70350482557 scopus 로고    scopus 로고
    • Fatty acids modulate toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner
    • Wong SW, Kwon MJ, Choi AM, Kim HP, Nakahira K, Hwang DH. Fatty acids modulate toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J Biol Chem. 2009;284:27384-92.
    • (2009) J Biol Chem. , vol.284 , pp. 27384-27392
    • Wong, S.W.1    Kwon, M.J.2    Choi, A.M.3    Kim, H.P.4    Nakahira, K.5    Hwang, D.H.6
  • 46
    • 34249716382 scopus 로고    scopus 로고
    • Differential modulation of Nods signaling pathways by fatty acids in human colonic epithelial HCT116 cells
    • Zhao L, Kwon MJ, Huang S, Lee JY, Fukase K, Inohara N, Hwang DH. Differential modulation of Nods signaling pathways by fatty acids in human colonic epithelial HCT116 cells. J Biol Chem. 2007;282: 11618-28.
    • (2007) J Biol Chem. , vol.282 , pp. 11618-11628
    • Zhao, L.1    Kwon, M.J.2    Huang, S.3    Lee, J.Y.4    Fukase, K.5    Inohara, N.6    Hwang, D.H.7
  • 47
    • 0037444368 scopus 로고    scopus 로고
    • Kinetics of lipopolysaccharide-induced transcription factor activation/inactivation and relation to proinflammatory gene expression in the murine spleen
    • Zhou HR, Islam Z, Pestka JJ. Kinetics of lipopolysaccharide-induced transcription factor activation/inactivation and relation to proinflammatory gene expression in the murine spleen. Toxicol Appl Pharmacol. 2003;187:147-61.
    • (2003) Toxicol Appl Pharmacol. , vol.187 , pp. 147-161
    • Zhou, H.R.1    Islam, Z.2    Pestka, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.