The blood brain barrier and the role of cytokines in neuropsychiatry

Psychiatry

Volumn 6, Issue 11, 2009, Pages 18-22

  Yarlagadda, Atmaram ^a   Alfson, Elizabeth ^a   Clayton, Anita H ^b  

^a University of Virginia ^*

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Blood brain barrier; Cytokine; Neuropsychiatry; Neurotransmission

Indexed keywords

CYTOKINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HAPTOGLOBIN; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANXIETY DISORDER; BIPOLAR DISORDER; BLOOD BRAIN BARRIER; DECREASED APPETITE; DELIRIUM; DEMENTIA; EPILEPSY; FATIGUE; FEVER; HEADACHE; HUMAN; LIBIDO DISORDER; MAJOR DEPRESSION; NEUROPSYCHIATRY; PATHOPHYSIOLOGY; REVIEW; SCHIZOPHRENIA; SLEEP; SYMPTOM;

EID: 77649225653     PISSN: 15505952     EISSN: 15555194     Source Type: Journal    
DOI: None     Document Type: Review

References (26)

1. Kronfol Z, Remick DG. Cytokines and the brain: implications for clinical psychiatry. Am J Psychiatry. 2000;157(5):683-694.
2. Dermietzel R, Spray DC, Nedergaard M. Blood-Brain Interface: From ontogeny to Artificial Barriers. Weinhein, Germany:WILEY-VCH VerlagGmbh & Co.;2006
3. Dantzer R, Kelley KW. Twenty years of research on cytokine-induced sickness behavior. Brain Behav Immun. 2007;21(2):153-160. Epub 2006 Nov 7.
4. Gutierrez EG, Banks WA, Kastin AJ. Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. J Neuroimmunol. 1993;47(2):169-176.
5. Pan W, Xiang S, Tu H, Kastin A. Cytokines Interact with the Blood-brain-barrier. In: Dermietzel R, Spray D, Nedergaard M (ed)s. Blood-Brain Interface: From ontogeny to Artificial Barriers. Weinhein, Germany: WILEY-VCH VerlagGmbh & Co;2006:247-258.
6. Breder CD, Dinarello CA, Saper CB. Interleukin-1 immunoreactive innervation of the human hypothalamus. Science. 1988;240(4850):321-324.
7. Aubert A, Vega C, Dantzer R, Goodall G. Pyrogens specifically disrupt the acquisition of a task involving cognitive processing in the rat. Brain Behav Immun. 1995;9(2):129-148.
8. Maes M. A review on the acute phase response in major depression. Rev Neurosci. 1993;4(4):407-416.
9. Brambilla F, Perna G, Bellodi L, et al. Plasma interleukin-1 beta and tumor necrosis factor concentrations in obsessive-compulsive disorders. Biol Psychiatry. 1997;42(11):976-981.
10. Brambilla F, Bellodi L, Perna G, et al. Plasma interleukin-1 beta concentrations in panic disorder. Psychiatry Res. 1994;54(2):135-142.
11. Brietzke E, Stertz L, Fernandes BS, et al. Comparison of cytokine levels in depressed, manic and euthymic patients with bipolar disorder. J Affect Disord. 2009;116(3):214-217. Epub 2009 Feb 28.
12. Ganguli R, Rabin BS, Kelly RH, et al. Clinical and laboratory evidence of autoimmunity in acute schizophrenia. Ann NY Acad Sci. 1987;496:676-685.
13. Asuni C, Stochino ME, Cherchi A, et al. Migraine and tumour necrosis factor gene polymorphism. An association study in a Sardinian sample. J Neurol. 2009;256(2):194-197. Epub 2009 Mar 1.
14. Marchi N, Angelov L, Masaryk T, et al. Seizure-promoting effect of blood-brain barrier disruption. Epilepsia. 2007;48(4):732-742. Epub 2007 Feb 23.
15. Aisen PS, Davis KL. Inflammatory mechanisms in Alzheimer's disease: implications for therapy. Am J Psychiatry. 1994;151(8):1105-1113.
16. Adamis D, Lunn M, Martin FC, et al. Cytokines and IGF-I in delirious and nondelirious acutely ill older medical inpatients. Age Ageing. 2009;38(3):326-332; discussion 251. Epub 2009 Mar 5.
17. Dusheiko G. Side effects of alpha interferon in chronic hepatitis C. Hepatology. 1997;26(3 Suppl 1):112S-121S.
18. Banks WA. Blood-brain barrier transport of cytokines: a mechanism for neuropathology. Curr Pharm Des. 2005;11(8):973-984.
19. Griffin WS, Stanley LC, Ling C, et al. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci U S A. 1989;86(19):7611-7615.
20. Yarlagadda A, Helvink B, Chou C, et al. Glutamic acid decarboxylase (GAD) antibodies in tardive dyskinesia (TD) as compared to patients with schizophrenia without TD and normal controls. Schizophr Res. 2008;105(1-3):287-8. Epub 2008 Aug 16.
21. Lohmann T, Londei M, Hawa M, Leslie RD. Humoral and cellular autoimmune responses in stiff person syndrome. Ann N Y Acad Sci. 2003;998:215-222.
22. Hägg S, Rosenius S, Spigset O. Long-term combination treatment with clozapine and filgrastim in patients with clozapine-induced agranulocytosis. Int Clin Psychopharmacol. 2003;18(3):173-174.
23. Levenson JL, Fallon HJ. Fluoxetine treatment of depression caused by interferonalpha. Am J Gastroenterol. 1993;88(5):760-761.
24. Yarlagadda A. Role of calcium regulation in pathophysiology model of schizophrenia and possible interventions. Med Hypotheses. 2002;58(2):182-186.
25. Lidow MS. Calcium signaling dysfunction in schizophrenia: a unifying approach. Brain Res Brain Res Rev. 2003;43(1):70-84.
26. Nelson TJ, Quattrone A, Kim J, et al. Calcium-regulated GTPase activity in the calcium-binding protein calexcitin. Comp Biochem Physiol B Biochem Mol Biol. 2003;135(4):627-638.