Inhibition of Growth by Pro-Inflammatory Cytokines: An Integrated View

Journal of Animal Science

Volumn 75, Issue 5, 1997, Pages 1244-1255

  Johnson, Rodney W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Central Nervous System; Cytokines; Food Intake; Growth; Metabolism; Stress

Indexed keywords

ANIMALIA;

CYTOKINE; HYDROCORTISONE; INTERLEUKIN 1; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ACUTE PHASE RESPONSE; ANIMAL; BLOOD; BRAIN; BRAIN LEVEL; CHEMISTRY; ENERGY METABOLISM; GROWTH; IMMUNE SYSTEM; METABOLISM; NEUROSECRETION; PHYSIOLOGY; REVIEW; UREA NITROGEN BLOOD LEVEL;

ACUTE-PHASE REACTION; ANIMALS; BLOOD UREA NITROGEN; BRAIN; BRAIN CHEMISTRY; CYTOKINES; ENERGY METABOLISM; GROWTH; HYDROCORTISONE; IMMUNE SYSTEM; INTERLEUKIN-1; INTERLEUKIN-6; NEUROSECRETORY SYSTEMS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031134814     PISSN: 00218812     EISSN: None     Source Type: Journal    
DOI: 10.2527/1997.7551244x     Document Type: Article

References (122)

1. Adams, F., J. R. Quesada, and J. U. Gutterman. 1984. Neuropsychiatric manifestations of human leukocyte interferon therapy in patients with cancer. J. Am. Med. Assoc. 252:938-941.
2. Andus, T., J. Bauer, and W. Gerok. 1991. Effects of cytokines on the liver. Hepatology 13:364-375.
3. Arend, W. P. 1991. Interleukin-1 receptor antagonist. J. Clin. Invest. 88:1445-1451.
4. Ayala, J. M., T. Yamin, L. A. Egger, J. Chin, M. J. Kostura, and D. K. Miller. 1994. IL-1β converting enzyme is present in monocytic cells as an inactive 45-kDa precursor. J. Immunol. 53: 2592-2599.
5. Ban, E., F. Haour, and R. Lenstra. 1992. Brain interleukin 1 gene expression induced by peripheral lipopolysaccharide administration. Cytokine 4:48-54.
6. Ban, E., G. Milon, N. Prudhomme, G. Fillion, and F. Haour. 1991. Receptors for interleukin-1 (α and β) in mouse brain: mapping and neuronal localization in hippocampus. Neuroscience 43: 21-30.
7. Banks, W. A., A. J. Kastin, and E. G. Gutierrez. 1993. Interleukin-1α in blood has direct access to cortical brain cells. Neurosci. Lett. 163:41-44.
8. Banks, W. A., and A. J. Kastin. 1992. The interleukins-1α, -1β and -2 do not acutely disrupt the murine blood-brain barrier. Int. J. Immunopharmacol. 14:629-636.
9. Banks, W. A., A. J. Kastin, and E. G. Gutierrez. 1994. Penetration of interleukin-6 across the murine blood-brain barrier. Neurosci. Lett. 179:53-56.
10. Banks, W. A., L. Ortiz, S. R. Plotkin, and A. J. Kastin. 1991. Human interleukin (IL) 1α, murine IL-1α and murine IL-1β are transported from blood to brain in the mouse by a shared saturable mechanism. J. Pharmacol. Exp. Ther. 259:988-996.
11. Benveniste, E. N. 1992. Inflammatory cytokines within the central nervous system: Sources, function, and mechanism of action. Am. J. Physiol. 263:C1-C16.
12. Berkenbosch, F. J. van Oers, A. Del Rey, F. Tilders, and H. Besedovsky. 1987. Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science (Wash DC) 238:524-526.
13. Beutler, B., and A. Cerami. 1989. The biology of cachectin/TNF - a primary mediator of the host response. Annu. Rev. Immunol. 7: 625-655.
14. Binns, R. M., S. T. Licence, F. B. Peter, and W.P.H. Duffus. 1992. Active lymphocyte traffic induced in the periphery by cytokines and phytohemagglutin: Three different mechanisms? Eur. J. Immunol. 22:2195-2203.
15. Black, R. A., S. A. Kronheim, and P. R. Sleath. 1989. Activation of interleukin-1β by a co-induced protease. FEBS Lett. 247: 386-390.
16. Blalock, J. E. 1994a. The syntax of immune-neuroendocrine communication. Immunol. Today 15:504-511.
17. Blalock, J. E. 1994b. The immune system. Our sixth sense. Immunologist 2:8-15.
18. Blatteis, C. M. 1992. The OVLT: The interface between the brain and circulating pyrogens? In: T. Bartfai and D. Ottoson (Ed.) Neuroimmunology of Fever. p. 167. Pergamon, Oxford, U.K.
19. Blecha, F. 1990. New approaches to increasing immunity in food animals. Vet. Med. 85:1241-1250.
20. Blecha, F. 1991. Cytokines: Application in domestic food animals. J. Dairy Sci. 74:328-339.
21. Blecha, F., D. N. Reddy, C. G. Chitko-McKown, D. S. McVey, M. M. Chengappa, R. D. Goodband, and J. L. Nelssen. 1995. Influence of recombinant bovine interleukin-1β and interleukin-2 in pigs vaccinated and challenged with Streptococcus suis. Vet. Immunol. Immunopathol. 44:329-346.
22. Bluthé, R. M., M. Pawloski, S. Suarez, P. Parnet, Q. Pittman, K. W. Kelley, and R. Dantzer. 1994a. Synergy between tumor necrosis factor α and interleukin-1 in the induction of sickness behavior in mice. Psychoneuroendocrinology 19:197-207.
23. Bluthé, R. M., V. Walter, P. Parnet, S. Layé, J. Lestage, D. Verrier, S. Poole, B. E. Stenning, K. W. Kelley, and R. Dantzer. 1994b. Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism. C. R. Acad. Sci. Sec. III Sci. Vie 317:499-503.
24. Breder, C. D., and C. B. Saper. 1996. Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide. Brain Res. 713:64-69.
25. Carter, D. B., M. R. Deibel, C. J. Dunn, C. S. Tomich, A. L. Laborde, J. L. Slightom, A. E. Berger, M. J. Bienkowski, F. F. Sun, R. N. McEwan, P. K. Harris, A. W. Yem, G. A. Waszak, J. G. Chosay, L. C. Sieu, M. M. Hardee, H. A. Zurcher-Neely, I. M. Reardon, R. L. Heinrikson, S. E. Truesdell, J. A. Shelly, T. E. Eessalu, B. M. Taylor, and D. E. Tracey. 1990. Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature (Lond.) 344:633-638.
26. Cheng, B., S. Christakos, and M. P. Mattson. 1994. Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron 12: 139-153.
27. Coates, M. E., R. Fuller, G. F. Harrison, M. Lev, and S. F. Suffolk. 1963. A comparison of the growth of chicks in the Gustafsson germ-free apparatus and in conventional environment, with and without dietary supplements of penicillin. Br. J. Nutr. 17: 141-150.
28. Cromwell, G. L. 1991. Antimicrobial agents. In: E. R. Miller, D. E. Ullrey, and A. J. Lewis (Ed.) Swine Nutrition. pp 297-314 Butterworth-Heinemann, Boston, MA.
29. Dantzer, R. 1994. How do cytokines say hello to the brain? Neural versus humoral mediation. Eur. Cytokine Netw. 5:271-273.
30. De Simoni, M. G., R. Del Bo, A. De Luigi, S. Simard, and G. Forloni. 1995. Central endotoxin induces different patterns of interleukin (IL)-1β and IL-6 messenger ribonucleic acid expression and IL-6 secretion in the brain and periphery. Endocrinology 136:897-902.
31. De Simoni, M. G., M. Sironi, A. D. Luigi, A. Manfridi, A. Mantovani, and P. Ghezzi. 1990. Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6. J. Exp. Med. 171:1773-1778.
32. Denbow, M. D. 1989. Peripheral and central control of food intake. Poult. Sci. 68:938-947.
33. Dinarello, C. A. 1988. Biology of interleukin-1. FASEB J. 2:108-115.
34. Dinarello, C. A. 1991. Interleukin-1 and interleukin-1 antagonism. Blood 77:1627-1652.
35. Dinarello, C. A. 1996. Biological basis for interleukin-1 in disease. Blood 87:2095-2146.
36. Ebisui, O., J. Fukata, N. Murakami, H. Kobayashi, H. Segawa, S. Muro, I. Hanaoka, Y. Naito, Y. Masui, Y. Ohmoto, H. Imura, and K. Nakao. 1994. Effect of IL-1 receptor antagonist and antiserum to TNF-α on LPS-induced plasma ACTH and corticosterone rise in rats. Am. J. Physiol. 266:E986-E992.
37. Eisenberg, S. P., R. J. Evans, W. P. Arend, E. Verderber, M. T. Brewer, C. H. Hannum, and R. C. Thompson. 1990. Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature (Lond.) 343:341-346.
38. Farrar, W. L., P. L. Kilian, M. R. Ruff, J. M. Hill, and C. B. Pert. 1987. Visualization and characterization of interleukin 1 receptors in brain. J. Immunol. 139:459-463.
39. Feingold, K. R., and C. Grunfeld. 1987. Tumor necrosis factor alpha stimulates hepatic lipogenesis in the rat in vivo. J. Clin. Invest. 193:318-325.
40. Fent, K., and G. Zbinden. 1987. Toxicity of interferon and interleukin. Trends Pharmacol. Sci. 8:100-105.
41. Finck, B. N., R. Dantzer, K. W. Kelley, J. Woods, and R. W. Johnson. 1997. Central lipopolysaccharide elevates plasma interleukin-6 concentration by an α-adrenoreceptor-mediated mechanism. Am. J. Physiol. (In press).
42. Fontana, A., S. Bodmer, and K. Frei. 1987. Immunoregulatory factors secreted by astrocytes and glioblastoma cells. Lymphokines 14:91-121.
43. Frei, K., D. Nadal, P. Ralph, and A. Fontana. 1991. Cytokines in Inflammatory Brain Diseases. Cellular and Cytokine Networks in Tissue Immunity. pp 91-98. Wiley-Liss, New York.
44. Grunfeld, C., and K. R. Feingold. 1991. Tumor necrosis factor, cytokines, and hyperlipidemia of infection. Trends Endocrinol. Metab. 2:213-219.
45. Grunfeld, C., R. Gulli, A. H. Moser, L. A. Gavin, and K. R. Feingold. 1989. Effects of tumor necrosis factor administration in vivo on lipoprotein lipase activity in various tissues of the rat. J. Lipid Res. 30:579-585.
46. Grunfeld, C., and M. A. Palladino. 1990. Tumor necrosis factor: Immunologic, antitumor, metabolic, and cardiovascular activities. Adv. Intern. Med. 35:45-72.
47. Gutierrez, E. G., W. A. Banks, and A. J. Kastin. 1993. Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. J. Neuroimmunol. 47:169-176.
48. Haour, F. G., E. M. Ban, G. M. Milon, D. Baran, and G. M. Fillion. 1991. Brain interleukin 1 receptors: Characterization and modulation after lipopolysaccharide injection. Prog. NeuroEndocrinImmunol. 3:196-204.
49. Hill, D. C., H. D. Branion, S. J. Slinger, and G. W. Anderson. 1952. Influence of environment on the growth response of chicks to penicillin. Poultry Sci. 32:464-466.
50. Hill, M. R., and R. E. McCallum. 1992. Identification of tumor necrosis factor as a transcriptional regulator of the phosphoenolpyruvate carboxykinase gene following endotoxin treatment in mice. Infect. Immunol. 60:4040-4050.
51. Hopkins, S. J., and N. J. Rothwell. 1995. Cytokines and the nervous system I: Expression and recognition. Trends Neurosci. 18: 83-88.
52. Jewell, D. E., D. D. Jones, R. J. Martin, A. Prestwood, and G. J. Hausman. 1988. Sera from pigs infected with Sarcocytis suicanis and cachectin decrease preadipocyte differentiation in primary cell culture. J. Anim. Sci. 66:2992-2999.
53. Jirillo, E., V. Covelli, A. B. Maffione, B. Greco, S. Pece, D. Fumarola, S. Antonaci, and C. De Simone. 1994. Endotoxins, cytokines, and neuroimmune networks with special reference to HIV infection. Ann. N.Y. Acad. Sci. 741:174-184.
54. Johnson, R. W., S. E. Curtis, R. Dantzer, J. M. Bahr, and K. W. Kelley. 1993a. Sickness behavior in birds caused by peripheral or central injection of endotoxin. Physiol. Behav. 53:343-348.
55. Johnson, R. W., S. E. Curtis, R. Dantzer, and K. W. Kelley. 1993b. Central and peripheral prostaglandins are involved in sickness behavior in birds. Physiol. Behav. 53:127-131.
56. Johnson, R. W., G. Gheusi, S. Segreti, R. Dantzer, and K. W. Kelley. 1997. C3H/HeJ mice are refractory to lipopolysaccharide in the brain. Brain Res. (In press).
57. Johnson, R. W., M. J. Propes, and Y. Shavit. 1996. Corticosterone modulates the behavioral and metabolic effects of lipopolysaccharide. Am. J. Physiol. 270:R192-R198.
58. Johnson, R. W., and E. von Borell. 1994. Lipopolysaccharide-induced sickness behavior in pigs is inhibited by pretreatment with indomethacin. J. Anim. Sci. 72:309-314.
59. Johnson, R. W., E. H. von Borrell, L. L. Anderson, L. D. Kojic, and J. E. Cunnick. 1994. Intracerebroventricular injection of corticotropin-releasing hormone in the pig: Acute effects on behavior, adrenocorticotropin secretion, and immune suppression. Endocrinology 135:642-648.
60. Kakucska, I., Y. Qi, B. D. Clark, and R. M. Lechan. 1993. Endotoxin-induced corticortropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is mediated centrally by interleukin-1. Endocrinology 133:815-821.
61. Katsuura, G., A. Arimura, K. Koves, and P. E. Gottschall. 1990. Involvement of organum vasculosum of lamina terminalis and preoptic area in interleukin 1β-induced ACTH release. Am. J. Physiol. 258:E163-E171.
62. Keelan, E. T., S. T. Licence, A. M. Peters, R. M. Binns, and D. O. Haskard. 1994. Characterization of E-selectin expression in vivo with use of radiolabeled monoclonal antibody. Am. J. Physiol. 266:H279-H290.
63. Kelley, K. W., R. W. Johnson, and R. Dantzer. 1994. Immunology discovers physiology. Vet. Immunol. Immunopathol. 43: 157-165.
64. Kent, S., R. M. Bluthé, K. W. Kelley, and R. Dantzer. 1992. Sickness behavior as a new target for drug development. Trends Pharmacol. Sci. 131:24-28.
65. Kinouchi, K., G. Brown, G. Pasternak, and D. B. Donner. 1991. Identification and characterization of receptors for tumor necrosis factor-α in the brain. Biochem. Biophys. Res. Commun. 181:1532-1538.
66. Klasing, K. C. 1984. Effect of inflammatory agents and interleukin 1 on iron and zinc metabolism. Am. J. Physiol. 247:R901-R904.
67. Klasing, K. C. 1988. Nutritional aspects of leukocytic cytokines. J. Nutr. 118:1436-1446.
68. Klasing, K. C., and D. M. Barnes. 1988. Decreased amino acid requirements of growing chicks due to immunologic stress. J. Nutr. 118:1158-1164.
69. Klasing, K. C., and B. J. Johnstone. 1991. Monokines in growth and development. Poult. Sci. 70:1781-1789.
70. Klasing, K. C., D. E. Laurin, R. K. Peng, and D. M. Fry. 1987. Immunologically mediated growth depression in chicks: Influence of feed intake, corticosterone and interleukin-1. J. Nutr. 117:1629-1637.
71. Kluger, M. J. 1991. Fever: Role of pyrogens and cryogens. Physiol. Rev. 71:93-127.
72. Kroemer, G., I. M. de Alborán, J. A. Gonzalo, and C. Martínez. 1993. Immunoregulation by cytokines. Crit. Rev. Immunol. 13: 163-191.
73. Kyriakis, S. C., and G. Andersson. 1989. Wasting pig syndrome (WPS) in weaners-treatment with amperozide. J. Vet. Pharmacol. Ther. 12:232.
74. Layé, S., R. Bluthé, S. Kent, C. Combe, C. Médina, P. Parnet, K. Kelley, and R. Dantzer. 1995. Subdiaphragmatic vagotomy blocks induction of IL-1β mRNA in mice brain in response to peripheral LPS. Am. J. Physiol. 268:R1327-R1331.
75. Layé, S., P. Parnet, E. Goujon, and R. Dantzer. 1994. Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice. Mol. Brain Res. 27:157-162.
76. Liao, J., J. A. Keiser, W. E. Scales, S. L. Kunkel, and M. J. Kluger. 1995. Role of epinephrine in TNF and IL-6 production from isolated perfused rat liver. Am. J. Physiol. 268:R896-R901.
77. McCarthy, D. O., and J. M. Daun. 1992. The role of prostaglandins in interleukin-1 induced gastroparesis. Physiol. Behav. 52: 351-353
78. McHugh, K. J., S. M. Collins, and H. P. Weingarten. 1994. Central interleukin-1 receptors contribute to suppression of feeding after acute colitis in the rat. Am. J. Physiol. 266:R1659-R1663.
79. McMahan, C. J., J. L. Slack, B. Mosley, D. Cosman, S. D. Lupton, L. L. Brunton, C. E. Grubin, J. M. Wignall, N. A. Jenkins, C. I. Brannan, N. G. Copeland, K. Huebner, C. M. Croce, L. A. Cannizzarro, D. Benjamin, S. K. Dower, M. K. Spriggs, and J. E. Sims. 1991. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J. 10:2821-2832.
80. Megyeri, P., C. S. Abraham, P. Temesvari, J. Kovacs, T. Vas, and C. P. Speer. 1992. Recombinant human tumor necrosis factor α constricts pial arterioles and increases blood-brain barrier permeability in newborn piglets. Neurosci. Lett. 148:137-140.
81. Memon, R. A., K. R. Feingold, and C. Grunfeld. 1994. The effects of cytokines on intermediary metabolism. Endocrinologist 4: 59-63.
82. Miller D. K., J. M. Ayala, L. A. Egger, S. M. Raju, T. T. Yamin, G. J. Ding E. P. Gaffney, A. D. Howard, O. C. Palyha, A. M. Rolando, J. P. Salley, N. A. Thornberry, J. R. Weidner, J. H. Williams, K. T. Chapman, J. Jackson, M. J. Kostura, G. Limjueo, S. M. Molineaux, R. A. Mumford, and J. R. Calaycay. 1993. Purification and characterization of active human interleukin-1β-converting enzyme from THP.1 monocytic cells. J. Biol. Chem. 268:18062-18069.
83. Moltz, H. 1993. Fever: Causes and consequences. Neurosci. Biobehav. Rev. 17:237-269.
84. Morrow-Tesch, J., and G. Andersson. 1994. Immunological and hematological characterizations of the wasting pig syndrome. J. Anim. Sci. 72:976-983.
85. Mosley, B., D. L. Urdal, K. S. Prickett, A. Larsen, D. Cosman, P. J. Conlon, S. Gillis, and S. K. Dower. 1987. The interleukin-1 receptor binds the human interleukin-1α precursor but not the interleukin-1β precursor. J. Biol. Chem. 262:2941-2944.
86. Nam, M. J., C. Thore, and D. Busija. 1995. Rapid induction of prostaglandin synthesis in piglet astroglial cells by interleukin-1α. Brain Res. Bull. 36:215-218.
87. Navarra, R. A., S. Tsagarakis, M. S. Faria, L. H. Rees, G. M. Besser, and A. B. Grossman. 1991. Interleukins-1 and -6 stimulate the release of corticotropin-releasing hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway. Endocrinology 128:37-44.
88. Nonogaki, K., G. M. Fuller, N. L. Fuentes, A. H. Moser, I. Staprans, C. Grunfeld, and K. R. Feingold. 1995. Interleukin-6 stimulates hepatic triglyceride secretion in rats. Endocrinology 136: 2143-2149.
89. Parnet, P., S. Amindari, W. Wu, D. L. Brunke-Reese, E. Goujon, J. A. Weyhenmeyer, R. Dantzer, and K. W. Kelley. 1994. Expression of type I and type II interleukin-1 receptors in mouse brain. Mol. Brain Res. 27:63-70.
90. Peisen, J. N., K. J. McDonnell, S. E. Mulroney, and M.D. Lumpkin. 1995. Endotoxin-induced suppression of the somatotropic axis is mediated by interleukin-1β and corticotropin-releasing factor in the juvenile rat. Endocrinology 136:3378-3390.
91. Perlstein, R. S., M. H. Whitnall, J. S. Abrams, E. H. Mougey, and R. Neta. 1993 Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo. Endocrinology 132: 946-952.
92. Plata-Salamán, C. R., Y. Oomura, and Y. Kai. 1988. Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system. Brain Res. 448:106-114.
93. Renno, T., M. Krakowski, C. Piccirillo, J. Lin, and T. Owens. 1995. TNF-α expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. J. Immunol. 154:944-953.
94. Richards, C., J. Gauldie, and H. Baumann. 1991. Cytokine control of acute phase protein expression. Eur. Cytokine Netw. 2:89-98.
95. Rivier, C., R. Chizzonite, and W. Vale. 1989. In the mouse, the activation of the hypothalamic-pituitary-adrenal axis by a lipopolysaccharide (endotoxin) is mediated through interleukin-1. Endocrinology 125:2800-2805.
96. 2 synthesis by the stomach and retards gastric emptying. Life Sci. 48:123-134.
97. Roura, E., J. Homedes, and K. C. Klasing. 1992. Prevention of immunologic stress contributes to the growth-promoting ability of dietary antibiotics in chicks. J. Nutr. 122:2383-2390.
98. Saperas, E. S., H. Yang, C. Rivier, and Y. Taché. 1990. Central action of interleukin-1 to inhibit acid secretion in rats. Gastroenterology 99:1599-1606.
99. Schöbitz, B., G. Pezeshki, T. Pohl, U. Hemmann, P. C. Heinrich, F. Holsboer, and J.M.H.M. Reul. 1995. Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo. FASEB J. 9:659-664.
100. Segreti, J., G. Gheusi, R. Dantzer, K. W. Kelley, and R. W. Johnson. 1997. Defect in interleukin-1β secretion prevents sickness behavior in C3H/HeJ mice. Physiol. Behav. (In press).
101. Shi, J., R. D. Goodband, M. M. Chengappa, J. L. Nelssen, M. D. Tokach, D. S. McVey, and F. Blecha. 1994. Influence of interleukin-1 on neutrophil function and resistance to Streptococcus suis in neonatal pigs. J. Leukoc. Biol. 56:88-94.
102. Sims, J. E., C. J. March, D. Cosman, M. B. Widmer, R. MacDonald H., C. J. McMahan, C. E. Grubin, J. M. Wignall, J. L. Jackson, S. M. Call, D. Friend, A. R. Alpert, S. Gillis, D. L. Urdal, and S. K. Dower. 1988. DNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily. Science (Wash DC) 241:585-589.
103. Sonti, G. S., E. Ilyin, and C. R. Plata-Salamán. 1996. Anorexia induced by cytokine interactions at pathophysiological concentrations. Am. J. Physiol. R1394-R1402.
104. Spitzer, I. I., G. J. Bagby, K. Meszaros, and C. H. Lang. 1989. Altered control of carbohydrate metabolism in endotoxemia. Prog. Clin. Biol. Res. 286:145-165.
105. Stith, R. D., and L. A. Templer. 1994. Peripheral endocrine and metabolic responses to centrally administered interleukin-1. Neuroendocrinology 60:215-224.
106. Taché, Y., and E. Saperas. 1993. Central actions on interluekin 1 on gastrointestinal function. In: E. B. De Souza (Ed.) Neurobiology of Cytokines, Part B. pp 169-184. Academic Press, New York.
107. Takao, T., D. E. Tracey, and E. B. De Souza. 1990. Interleukin-1 receptors in mouse brain: Characterization and autoradiographic localization. Endocrinology 127:3070-3078.
108. Tchelingerian, J. L., J. Quinonero, J. Booss, and C. Jacque C. 1993. Localization of TNFα and IL-1α immunoreactivities in striatal neurons after surgical injury to the hippocampus. Neuron 10: 213-224.
109. Terao, A., M. Oikawa, and M. Saito. 1994. Tissue-specific increase in norepinephrine turnover by central interleukin-1, but not by interleukin-6, in rats. Am. J. Physiol. 266:R400-R404.
110. Thornberry, N. A., H. G. Bull, J. R. Calaycay, K. T. Chapman, A. D. Howard, M. J. Kostura, D. K. Miller, S. M. Molineaux, J. R. Weidner, J. Aunins, K. O. Elliston, J. M. Ayala, F. J. Casano, J. Chin, G. J. Ding, L. A. Egger, E. P. Gaffney, G. Limjuco, O. C. Paylha, S. M. Raju, A. M. Rolando, J. P. Salley, T. T. Yamin, T. D. Lee, J. E. Shively, M MacCross, R. A. Mumford, J. A. Schmidt, and M. J. Tocci. 1992. A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature (Lond.) 356:768-774.
111. van der Meer, M.J.M., C.G.J. Sweep, G. J. Pesman, G. F. Borm, and A.R.M.M. Hermus. 1995. Synergism between IL-1β and TNF-α on the activity of the pituitary-adrenal axis and on food intake of rats. Am. J. Physiol. 268:E551-E557.
112. Vriend, C. Y., L. Zuo, D. G. Dyck, D. M. Nance, and A. H. Greenberg. 1993. Central administration of interleukin-1β increases norepinephrine turnover in the spleen. Brain Res. Bull. 31: 39-42.
113. Warren, E. J., B. N. Finck, S. Arkins, K. W. Kelley, R. W. Scamurra, M. P. Murtaugh, and R. W. Johnson. 1997. Coincidental changes in behavior and plasma cortisol in unrestrained pigs following intracerebroventricular injection of tumor necrosis factor-α. Endocrinology (In press).
114. Watkins, L. R., E. P. Wiertelak, L. E. Goehler, K. Mooney-Heiberger, J. Martinez, L. Furness, K. P. Smith, and S. F. Maier. 1994a. Neurocircuitry of illness-induced hyperalgesia. Brain Res. 639: 283-299.
115. Watkins, L. R., E. P. Wiertelak, L. E. Goehler, K. P. Smith, D. Martin, and S. F. Maier. 1994b. Characterization of cytokine-induced hyperalgesia. Brain Res. 654:15-26.
116. Webel, D., B. N. Finck, D. Baker, and R. W. Johnson. 1997. Time course of increased plasma cytokines, cortisol, and urea nitrogen in pigs following intraperitoneal injection of lipopolysaccharide. J. Anim. Sci. (In press).
117. Weingarten, H. P. 1995. Cytokines and food intake: The relevance of the immune system to the student of ingestive behavior. Neurosci. Biobehav. Rev. 20:163-170.
118. Williams, N. H., T. S. Stahly, and D. R. Zimmerman. 1993. Impact of immune system activation and dietary amino acid regimen on nitrogen retention of pigs. J. Anim. Sci. 71(Suppl. 1):171 (Abstr.).
119. Woolley, S. T., A. Whyte, S. T. Licence, D. O. Haskard, F.B.P. Wooding, and R. M. Binns. 1995. Differences in E-selectin expression and leucocyte infiltration induced by inflammatory agents in a novel subcutaneous sponge matrix model. Immunol. 84:55-63.
120. Yang, Z. J., M. Koskeki, M. Meguid, J. R. Gleason, and D. Debonis. 1994. Synergistic effect of rhTNF-α and rhIL-1α in inducing anorexia in rats. Am. J. Physiol. 267:R1056-R1064.
121. Zamir, O., P. O. Hasselgren, D. Allmen, and J. E. Fischer. 1993. In vivo administration of interleukin-1α induces muscle proteolysis in normal and adrenalectomized rats. Metabolism 42: 204-208.
122. Zamir, O., P. O. Hasselgren, S. L. Kunkel, J. Frederick, T. Higashiguchi, and J. E. Fischer. 1992. Evidence that tumor necrosis factor participates in the regulation of muscle proteolysis during sepsis. Arch. Surg. 127:170-174.