Activation of peroxisome proliferator-activated receptor-γ potentiates pro-inflammatory cytokine production, and adrenal and somatotropic changes of weaned pigs after Escherichia coli lipopolysaccharide challenge

Innate Immunity

Volumn 15, Issue 3, 2009, Pages 169-178

  Liu, Yulan ^a   Shi, Junxia ^a   Lu, Jing ^a   Meng, Guoquan ^a   Zhu, Huiling ^a   Hou, Yongqing ^a   Yin, Yulong ^a,b   Zhao, Shengjun ^a   Ding, Binying ^a  

^a WUHAN POLYTECHNIC UNIVERSITY   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Bisphenol A diglycidyl ether; Lipopolysaccharide; Peroxisome proliferator activated receptor ; Pro inflammatory cytokines; Rosiglitazone; Weaned pigs

Indexed keywords

CYTOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; GROWTH HORMONE; HYDROCORTISONE; INTERLEUKIN 6; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN E2; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA;

ADRENAL FUNCTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HYDROCORTISONE BLOOD LEVEL; IMMUNE RESPONSE; IMMUNOMODULATION; INFLAMMATION; LEUKOCYTE; MALE; MESENTERY LYMPH NODE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN LOCALIZATION; SPLEEN; THYMUS;

ANIMALS; CYTOKINES; DIMETHYL SULFOXIDE; DINOPROSTONE; EPOXY COMPOUNDS; ESCHERICHIA COLI; FREE RADICAL SCAVENGERS; HYDROCORTISONE; INFLAMMATION; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MALE; PPAR GAMMA; SWINE; THIAZOLIDINEDIONES; TUMOR NECROSIS FACTOR-ALPHA; WEANING;

ESCHERICHIA COLI; SUIDAE;

EID: 66149165911     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425908102014     Document Type: Article

References (47)

1. Johnson RW Inhibition of growth by pro-inflammatory cytokines: An integrated view. J Anim Sci 1997; 75: 1244-1255.
2. Jacobi SK, Gabler NK, Ajuwon KM, Davis JE, Spurlock ME Adipocytes, myofibers, and cytokine biology: New horizons in the regulation of growth and body composition. J Anim Sci 2006; 84(E Suppl): E140-E149.
3. Gabler NK, Spurlock ME Integrating the immune system with the regulation of growth and efficiency. J Anim Sci 2008; 86(E Suppl): E64-E74.
4. Liu YL, Li DF, Gong LM, Yi GF, Gaines AM, Carroll JA Effects of fish oil supplementation on the performance and the immunological, adrenal, and somatotropic responses of weaned pigs after an Escherichia coli lipopolysaccharide challenge. J Anim Sci 2003; 81: 2758-2765.
5. Issemann I., Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 1990; 347: 645-650.
6. Dreyer C., Krey G., Keller F., Givel H., Helftenbein G., Wahli W. Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 1992; 68: 879-887.
7. Tontonoz P., Hu E., Graves RA, Budavari AI, Spiegelman BM mPPAR gamma2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 1994; 158: 1224-1234.
8. Spiegelman BM PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor. Diabetes 1998; 47: 507-514.
9. Moraes LA, Piqueras L., Bishop-Bailey D. Peroxisome proliferator-activated receptors and inflammation. Pharmacol Ther 2006; 110: 371-385.
10. Dubuquoy L., Rousseaux C., Thuru X. et al. PPARg as a new therapeutic target in inflammatory bowel diseases. Gut 2006; 55: 1341-1349.
11. Straus DS, Glass CK Anti-inflammatory actions of PPAR ligands: New insights on cellular and molecular mechanisms. Trends Immunol 2007; 28: 551-558.
12. Chung JH, Seo AY, Chung SW et al. Molecular mechanism of PPAR in the regulation of age-related inflammation. Ageing Res Rev 2008; 7: 126-136.
13. Lewis JD, Lichtenstein GR, Stein RB et al. An open-label trial of the PPAR-gamma ligand rosiglitazone for active ulcerative colitis. Am J Gastroenterol 2001; 96: 3323-3328.
14. Kawahito Y., Kondo M., Tsubouchi Y. et al. 15-Deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats. J Clin Invest 2000; 106: 189-197.
15. Lee S., Kim W., Kang KP et al. Agonist of peroxisome proliferator-activated receptor-gamma, rosiglitazone, reduces renal injury and dysfunction in a murine sepsis model. Nephrol Dial Transplant 2005; 20: 1057-1065.
16. Birrell MA, Patel HJ, McCluskie K. et al. PPAR-gamma agonists as therapy for diseases involving airway neutrophilia. Eur Respir J 2004; 24: 18-23.
17. Jeon EJ, Lee SK, Park YS, Kim DH, Yum JH, Park CS The effects of peroxisome proliferator-activated receptor-g agonist on a murine model of experimental allergic rhinitis. Otolaryngol Head Neck Surg 2008; 139: 124-130.
18. Delerive P., Fruchart JC, Staels B. Peroxisome proliferator-activated receptors in inflammation control. J Endocrinol 2001; 169: 453-459.
19. Chinetti G., Fruchart JC, Staels B. Peroxisome proliferators-activated receptors and inflammation: From basic science to clinical applications. Int J Obesity 2003; 27: S41-S45.
20. Johnson RW, von Borell E. Lipopolysaccharide-induced sickness behavior in pigs is inhibited by pretreatment with indomethacin. J Anim Sci 1994; 72: 309-314.
21. Liu YL, Huang JJ, Hou YQ et al. Dietary arginine supplementation alleviates intestinal mucosal disruption induced by Escherichia coli lipopolysaccharide in weaned pigs. Br J Nutr 2008; 100: 552-560.
22. Liu YL, Lu J., Shi JX et al. Increased expression of the peroxisome proliferator-activated receptor g in the immune system of weaned pigs after Escherichia coli lipopolysaccharide challenge. Vet Immunol Immunopathol 2008; 124: 82-92.
23. Cuzzocrea S., Pisano B., Dugo L. et al. Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-g, reduces acute inflammation. Eur J Pharmacol 2004; 483: 79-93.
24. Guo GL, Liu YL, Fan W. et al. Effects of Achyranthes bidentata polysaccharide on growth performance, immunological, adrenal, and somatotropic responses of weaned pigs challenged with Escherichia coli lipopolysaccharide. Asian-Aust J Anim Sci 2008; 21: 1189-1195.
25. T method. Methods 2001; 25: 402-408.
26. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ Protein measurement with Folin phenol reagent. J Biol Chem 1951; 193: 265-275.
27. Ghose R., Mulder J., von Furstenberg RJ, Thevananther S., Kuipers F., Karpen SJ Rosiglitazone attenuates suppression of RXRα-dependent gene expression in inflamed liver. J Hepatol 2007; 46: 115-123.
28. Webel DM, Finck BN, Baker DH, Johnson RW Time course of increased plasma cytokines, cortisol, and urea nitrogen in pigs following intraperitoneal injection of lipopolysaccharide. J Anim Sci 1997; 75: 1514-1520.
29. Wright KJ, Balaji R., Hill CM, Dritz SS, Knoppel EL, Minton JE Integrated adrenal, somatotropic, and immune responses of growing pigs to treatment with lipopolysaccharide. J Anim Sci 2000; 78: 1892-1899.
30. Carroll JA, Gaines AM, Spencer JD et al. Effect of menhaden fish oil supplementation and lipopolysaccharide exposure on nursery pigs I. Effects on the immune axis when fed diets containing spray-dried plasma. Domest Anim Endocrinol 2003; 24: 341-351.
31. Gaines AM, Carroll JA, Yi GF, Allee GL, Zannelli ME Effect of menhaden fish oil supplementation and lipopolysaccharide exposure on nursery pigs II. Effects on the immune axis when fed simple or complex diets containing no spray-dried plasma. Domest Anim Endocrinol 2003; 24: 353-365.
32. Li J., Li DF, Xing JJ, Cheng ZB, Lai CH Effects of β-glucan extracted from Saccharomyces cerevisiae on growth performance, and immunological and somatotropic responses of pigs challenged with Escherichia coli lipopolysaccharide. J Anim Sci 2006; 84: 2374-2381.
33. Lai CH, Yin JD, Li DF, Zhao LD, Qiao SY, Xing JJ Conjugated linoleic acid attenuates the production and gene expression of proinflammatory cytokines in weaned pigs challenged with lipopolysaccharide. J Nutr 2005; 135: 239-244.
34. Turrin NP, Gayle D., Ilyin SE et al. Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide. Brain Res Bull 2001; 54: 443-453.
35. Lang CH, Silvis C., Deshpande N., Nystrom G., Frost RA Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1β, -6, and high-mobility-group protein-1 in skeletal muscle. Shock 2003; 19: 538-546.
36. Zhou HR, Islam Z., Pestka JJ Kinetics of lipopolysaccharide-induced transcription factor activation/inactivation and relation to proinflammatory gene expression in the murine spleen. Toxicol Appl Pharmacol 2003; 187: 147-161.
37. Wright HM, Clish CB, Mikami T. et al. A synthetic antagonist for the peroxisome proliferator-activated receptor g inhibits adipocyte differentiation. J Biol Chem 2000; 275: 1873-1877.
38. 2. J Neuroimmunol 2006; 178: 76-86.
39. Shu H., Wong B., Zhou G. et al. Activation of PPARα or g reduces secretion of matrix metalloproteinase 9 but not interleukin 8 from human monocytic THP-1 cells. Biochem Biophys Res Commun 2000; 267: 345-349.
40. Thieringer R., Fenyk-Melody JE, Grand CBL et al. Activation of peroxisome proliferator-activated receptor g does not inhibit IL-6 or TNF-a responses of macrophages to lipopolysaccharide in vitro or in vivo. J Immunol 2000; 164: 1046-1054.
41. 2. J Immunol 2001; 166: 7104-7111.
42. 2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-g-independent mechanism. Biochem Biophys Res Commun 2003; 302: 415-420.
43. 2 on acute lung injury induced by lipopolysaccharide in mice. Eur J Pharmacol 2003; 481: 261-269.
44. Hellerstein MK, Meydani SN, Meydani M., Wu K., Dinarello CA Interleukin-1 induced anorexia in the rat. Influence of prostaglandins. J Clin Invest 1989; 84: 228-235.
45. 2 influence rate of protein turnover in skeletal and cardiac muscle. J Biol Chem 1982; 257: 1632-1638.
46. Perlstein RS, Whitnall MH, Abrams JS, Mougey EH, Neta R. Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo. Endocrinology 1993; 132: 946-952.
47. George P., Chrousos MD The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 1995; 332: 1351-1363.