Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy

Malaria Journal

Volumn 12, Issue 1, 2013, Pages

  Duah, Nancy O ^a   Matrevi, Sena A ^a   De Souza, Dziedzom K ^a   Binnah, Daniel D ^a   Tamakloe, Mary M ^a   Opoku, Vera S ^a   Onwona, Christiana O ^a   Narh, Charles A ^a   Quashie, Neils B ^a   Abuaku, Benjamin ^a   Duplessis, Christopher ^b   Kronmann, Karl C ^b   Koram, Kwadwo A ^a  

^a UNIVERSITY OF GHANA   (Ghana)

^b US Naval Medical Research Unit No 3 Egypt   (Egypt)

Author keywords

Anti malarial drug resistance; Ghana; Molecular markers; Plasmodium falciparum chloroquine resistance transporter gene (pfcrt); Plasmodium falciparum multidrug resistance gene (pfmdr1)

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETHER PLUS BENFLUMETOL; CHLOROQUINE; MEMBRANE PROTEIN; MEROZOITE SURFACE PROTEIN 2; PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER; PLASMODIUM FALCIPARUM MULTIDRUG RESISTANCE PROTEIN 1; UNCLASSIFIED DRUG;

ALLELE; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; BLOOD SAMPLING; CHILD; CONTROLLED STUDY; GENE; GENE DOSAGE; GENE MUTATION; GENOTYPE; GHANA; HAPLOTYPE; HUMAN; INFANT; MAJOR CLINICAL STUDY; PARASITE PREVALENCE; PLASMODIUM FALCIPARUM; PRESCHOOL CHILD; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ANTIMALARIALS; CHILD, PRESCHOOL; DNA, PROTOZOAN; DRUG RESISTANCE; FEMALE; GENE DOSAGE; GENE FREQUENCY; GHANA; HEALTH POLICY; HUMANS; INFANT; MALARIA, FALCIPARUM; MALE; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION, MISSENSE; PLASMODIUM FALCIPARUM; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROTOZOAN PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84886731709     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-12-377     Document Type: Article

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