pfmdr1 amplification associated with clinical resistance to mefloquine in West Africa: Implications for efficacy of artemisinin combination therapies

Journal of Clinical Microbiology

Volumn 48, Issue 10, 2010, Pages 3797-3799

  Witkowski, Benoit ^a,b,c   Iriart, Xavier ^a,b   Soh, Patrice Njomnang ^a,b,c   Menard, Sandie ^a,b   Alvarez, Muriel ^a   Naneix Laroche, Veronique ^a   Marchou, Bruno ^a   Magnaval, Jean François ^b   Benoit Vical, Françoise ^a,b,c   Berry, Antoine ^a,b  

^a TOULOUSE UNIVERSITY HOSPITAL   (France)

^b UNIVERSITÉ PAUL SABATIER   (France)

^c LCC LABORATOIRE DE CHIMIE DE COORDINATION   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; ARTESUNATE; CHLOROQUINE; HEMOGLOBIN; HISTIDINE; MEFLOQUINE; PARASITE ANTIGEN; PFMDR1 PROTEIN; QUININE; UNCLASSIFIED DRUG;

ADULT; AFRICA; ANEMIA; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; BLOOD SMEAR; CASE REPORT; CHILL; CHROMATOGRAPHY; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; COPY NUMBER VARIATION; DRUG EFFICACY; DRUG SUBSTITUTION; DRUG TREATMENT FAILURE; FEVER; GENE AMPLIFICATION; GENOTYPE; HEMOGLOBIN BLOOD LEVEL; HUMAN; IC 50; IN VITRO STUDY; MALARIA FALCIPARUM; MALE; NAUSEA; PARASITEMIA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERODIAGNOSIS; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

ADULT; AFRICA, WESTERN; ARTEMISININS; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; GENE DOSAGE; HUMANS; INHIBITORY CONCENTRATION 50; MALARIA, FALCIPARUM; MALE; MEFLOQUINE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; TREATMENT FAILURE;

EID: 77957785508     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.01057-10     Document Type: Article

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