In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by Artemether-Lumefantrine (Coartem)

Journal of Infectious Diseases

Volumn 191, Issue 6, 2005, Pages 1014-1017

  Sisowath, Christin ^a   Strömberg, Johan ^a   Mårtensson, Andreas ^a   Msellem, Mwinyi ^b   Obondo, Christine ^a   Björkman, Anders ^a   Gil, José P ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Zanzibar Malaria Control Programme   (Tanzania)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL;

ALLELE; ANTIBIOTIC RESISTANCE; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EXPOSURE; FOLLOW UP; HUMAN; IN VIVO STUDY; NONHUMAN; PARASITOSIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; TANZANIA; TIME SERIES ANALYSIS;

ALLELES; ANIMALS; ANTIMALARIALS; ARTEMISININS; ATP-BINDING CASSETTE TRANSPORTERS; CHILD; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; ETHANOLAMINES; FLUORENES; GENES, MDR; HUMANS; INFANT; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTOZOAN PROTEINS; SELECTION (GENETICS); SESQUITERPENES;

EID: 14844327986     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/427997     Document Type: Article

References (11)

1. White NJ. Delaying antimalarial drug resistance with combination chemotherapy. Parassitologia 1999; 41:301-8.
2. Nosten F, van Vugt M, Price R, et al. Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. Lancet 2000; 356:297-302.
3. Wongsrichanalai C, Pickard AL, Wernsdorfer WH, Meshnick SR. Epidemiology of drug-resistant malaria. Lancet Infect Dis 2002; 2:209-28.
4. Duraisingh MT, Roper C, Walliker D, Warhurst DC. Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum. Mol Microbiol 2000; 36:955-61.
5. Duraisingh MT, Jones P, Sambou I, von Seidlein L, Pinder M, Warhurst DC. The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin. Mol Biochem Parasitol 2000; 108:13-23.
6. Djimde A, Doumbo AK, Cortese JF, et al. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med 2001; 344:257-63.
7. Snounou G, Zhu X, Siripoon N, et al. Biased distribution of msp1 and msp2 allelic variants in Plasmodium falciparum populations in Thailand. Trans R Soc Trop Med Hyg 1999; 93:369-74.
8. Gardner MJ, Altman DG, eds. Statistics with confidence. London: British Medical Journal Books, 1989.
9. Schneider AG, Premji Z, Felger I, et al. A point mutation in codon 76 of pfcrt of P. falciparum is positively selected for by chloroquine treatment in Tanzania. Infect Genet Evol 2002; 1:183-9.
10. Warhurst DC, Duraisingh MT. Rational use of drugs against Plasmodium falciparum. Trans R Soc Trop Med Hyg 2001; 95:345-6.
11. Ezzet F, Mull R, Karbwang J. Population pharmacokinetics and therapeutic response of CGP 56697 (artemether + benflumetol) in malaria patients. Br J Clin Pharmacol 1998; 46:553-61.