Micro- and nanobubbles: A versatile non-viral platform for gene delivery

International Journal of Pharmaceutics

Volumn 456, Issue 2, 2013, Pages 437-445

  Cavalli, Roberta ^a   Bisazza, Agnese ^a   Lembo, David ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Gene delivery; Microbubbles; Nanobubbles; Nanodroplets; Non viral carriers; Ultrasound

Indexed keywords

FLUOROCARBON; GONADORELIN ASSOCIATED PEPTIDE; LIPOPLEX; LIPOSOME; NANOBUBBLE; NUCLEASE; PERFLUTREN; POLYETHYLENEIMINE; POLYVINYL ALCOHOL; REACTIVE OXYGEN METABOLITE; VASCULOTROPIN;

ANTIGEN SPECIFICITY; BLOOD VESSEL; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE TRANSPORT; ENDOCYTOSIS; ENZYME DEGRADATION; GENE DELIVERY SYSTEM; GENE TARGETING; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; MICROBUBBLE; MOLECULAR IMAGING; NANOEMULSION; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW; STATIC ELECTRICITY; TEMPERATURE; ULTRASOUND;

GENE DELIVERY; MICROBUBBLES; NANOBUBBLES; NANODROPLETS; NON VIRAL CARRIERS; ULTRASOUND;

ANIMALS; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; HUMANS; MICROBUBBLES; NANOTECHNOLOGY;

EID: 84886716941     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.08.041     Document Type: Short Survey

References (122)

1. A. Alzaara, G. Gravante, W.Y. Chung, D. Al-Leswas, M. Bruno, A.R. Dennison, and D.M. Lloyd Targeted microbubbles in the experimental and clinical setting Am. J. Surgery 204 2012 355 366
2. S. Bao, B. Thrall, and D. Miller Transfection of a reporter plasmid into cultured cells by sonoporation in vitro Ultrasound Med. Biol. 23 1997 953 959 (Pubitemid 27349543)
3. G. Basta, L. Venneri, G. Lazzerini, E. Pasanisi, M. Pianelli, N. Vesentini, S. Del Turco, C. Kusmic, and E. Picano In vitro modulation of intracellular oxidative stress of endothelial cells by diagnostic cardiac ultrasound Cardiovasc. Res. 58 2003 156 161 (Pubitemid 36351633)
4. R. Bekeredjian, P. Grayburn, and R. Shohet Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine J. Am. Coll. Cardiol. 45 2005 329 335 (Pubitemid 40186780)
5. A. Bisazza, A. Civra, M. Donalisio, D. Lembo, and R. Cavalli The in-vitro characterization of dextran-based nanobubbles as possible DNA transfection agents Soft Matter 7 2011 10590 10593
6. A.A. Bogdanov, A.L. Klibanov, and V.P. Torchilin Protein immobilization on the surface of liposomes via carbodiimide activation in the presence of N-hydroxysulfosuccinimide FEBS Lett. 231 1988 381 384
7. D. Bokor Diagnostic efficacy of Sonovue Am. J. Cardiol. 86 2000 19 24
8. Borden, Ma, D.E. Cruse, C.E. Caskey, S.K. Zhao, P.A. Dayton, and K.W. Ferrara Influence of lipid shell: physic-chemical properties on ultrasound-induced microbubble destruction IEEE Trans. Ultrason. Ferroelectr. Freq. Control 2005 1992 2002 (Pubitemid 41812148)
9. M. Borden, E. Little, R. Gillies, and K. Ferrara DNA and polylysine adsorption and multilayer construction onto cationic lipid-coated microbubbles Langmuir 23 2007 9401 9408 (Pubitemid 47383531)
10. R.J. Browning, H. Mulvana, M.X. Tang, J.V. Hajnal, D.J. Wells, and R.J. Eckersley Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo Ultrasound Med. Biol. 38 2012 1067 1077
11. M.E. Burkard, and H.D. Van Liew Effects of physical properties of the breathing gas on decompression-sickness bubbles J. Appl. Physiol. 79 1995 1828 1836
12. S. Capece, E. Chessi, R. Cavalli, P. Giustetto, D. Grishenkov, and G. Paradossi A general strategy for the obtainment of biodegradable polymer shelled microbubbles as theranostic device Chem. Commun. 49 2013 5763 5765
13. F. Cavalieri, A. Hamassi, E. Chiessi, G. Paradossi, R. Villa, and N. Zaffaroni Ligands tethering to biocompatible ultrasound active polymeric microbubbles surface Macromol. Symp. 234 2006 94 101
14. F. Cavalieri, A. El Hamassi, E. Chiessi, G. Paradossi, R. Villa, and N. Zaffaroni Tethering functional ligands onto shell of ultrasound active polymeric microbubbles Biomacromolecules 7 2006 604 611
15. R. Cavalli, A. Bisazza, A. Rolfo, S. Balbis, D. Madonnaripa, I. Caniggia, and C. Guiot Ultrasound-mediated oxygen delivery from chitosan nanobubbles Int. J. Pharm. 378 2009 215 217
16. Cavalli, R., Bisazza, A., Giustetto, P., Cittadino, E., Torres, E., Mainini, F., Terreno, E., Aime, S., 2010. Dextran multilayer microbubbles as ultrasound-triggered doxorubicin carriers, 2nd Conference on Innovation Drug Delivery, Aix-en-Provence, France, October 3-6, 2010.
17. R. Cavalli, A. Bisazza, R. Sessa, L. Primo, F. Fenili, A. Manfredi, E. Ranucci, and P. Ferruti Amphoteric agmatine containing polyamidoamines as carriers for plasmid DNA in vitro and in vivo delivery Biomacromolecules 11 2010 2667 2674
18. R. Cavalli, A. Bisazza, M. Trotta, M. Argenziano, A. Civra, M. Donalisio, and D. Lembo New chitosan nanobubbles for ultrasound-mediated gene delivery: preparation and in vitro characterization Int. J. Nanomed. 7 2012 3309 3318
19. S. Chang, J. Guo, J. Sun, S. Zhu, Y. Yan, Y. Zhu, M. Li, Z. Wang, and R.X. Xu Targeted microbubbles for ultrasound mediated gene transfection and apoptosis induction in ovarian cancer cells Ultrason. Sonochem. 20 2013 171 179
20. C.C. Chen, S.R. Sirsi, S. Homma, and M.A. Borden Effect of surface architecture on in vivo ultrasound contrast persistence of targeted size-selected microbubbles Ultrasound Med. Biol. 38 2012 492 503
21. Y. Cheng, L. Jiang, N. Liu, Z.H. Wang, K. Hong, and Q.P. Zhang P85, Optison microbubbles and ultrasound cooperate in mediating plasmid DNA transfection in mouse skeletal muscles in vivo Ultrason. Sonochem. 18 2011 513 519
22. J.P. Christiansen, B.A. French, A.L. Klibanov, S. Kaul, and J.R. Lindner Targeted tissue transfection with ultrasound destruction of plasmid-bearing cationic microbubbles Ultrasound Med. Biol. 29 2003 1759 1767 (Pubitemid 38091725)
23. J. Dai, S. Zou, Y. Pei, D. Cheng, H. Ai, and X. Shuai Polyethylenimine-grafted copolymer of poly(l-lysine) and poly(ethylene glycol) for gene delivery Biomaterials 32 2011 1694 1705
24. S. Dang, R. Wang, M. Qin, Y. Zhang, Y.Z. Gu, M.Y. Wang, Q.L. Yang, X.R. Li, and X.G. Zhang A novel transfection method for eukaryotic cells using polyethylenimine coated albumin microbubbles Plasmid 66 2011 19 25
25. N. De Jong, L. Hoff, T. Skotland, and N. Bom Absorption and scatter of encapsulated gas filled microspheres: theoretical considerations and some measurements Ultrasonics 30 1992 95 103
26. R. Deckers, and C.T. Moonen Ultrasound triggered, image guided, local drug delivery J. Control. Rel. 148 2010 25 33
27. A. Delalande, M.F. Bureau, P. Midoux, A. Bouakaz, and C. Pichon Ultrasound-assisted microbubbles gene transfer in tendons for gene therapy Ultrasonics 50 2010 269 272
28. A. Delalande, S. Kotopoulis, C. Rovers, and C. Pinchon Sonoporation at low mechanical index Bubble Sci. Eng. Technol. 3 2011 2 11
29. A. Delalande, M. Postema, N. Mignet, p. Midoux, and C. Pinchon Ultrasound and microbubbles-assisted gene delivery: recent advances and ongoing challenges Ther. Del. 3 2012 1199 1215
30. P.A. Dijkmans, L.J.M. Juffermans, R.J.P. Musters, A. van Wamel, F.J. ten Cate, W. van Gilst, C.A. Visser, N. de Jong, and O. Kamp Microbubbles and ultrasound: from diagnosis to therapy Eur. J. Echocardiogr. 5 2004 245 256 (Pubitemid 38950150)
31. K.L. Dittmar, J. Xie, F. Hunter, C. Trimble, M. Bur, V. Frenkel, and K.C. Li Pulsed high-intensity focused ultrasound enhances systemic administration of naked DNA in squamous cell carcinoma model: initial experience Radiology 235 2005 541 546 (Pubitemid 40571094)
32. L.C. Du Toit, T. Govender, V. Pillay, Y.E. Choonara, and T. Kodama Investigating the effect of polymeric approaches on circulation time and physical properties of nanobubbles Pharm. Res. 28 2011 494 504
33. M. Duvshani-Eshet, L. Baruch, E. Kesselman, E. Shimoni, and M. Machluf Therapeutic ultrasound-mediated DNA to cell and nucleus: bioeffects revealed by confocal and atomic-force microscopy Gene Ther. 13 2006 163 172 (Pubitemid 43039908)
34. M. Duvshani-Eshet, D. Adam, and M. Machluf The effects of albumin-coated microbubbles in DNA delivery mediated by therapeutic ultrasound J. Control. Rel. 112 2006 156 166
35. J. Escoffre, K. Kaddur, M. Rols, and A. Bouakaz In vitro gene transfer by electro-sonoporation Ultrasound Med. Biol. 36 2010 1746 1755
36. M. Fechheimer, J.F. Boylan, S. Parker, J.E. Sisken, G.L. Patel, and S.G. Zimmer Transfection of mammalian cells with plasmid DNA by scrape loading and sonication loading Proc. Natl. Acad. Sci. U. S. A. 84 1987 8463 8467
37. P.L. Felgner, T.R. Gadek, M. Holm, R. Roman, H.W. Chan, M. Wenz, and J.P. Northrop Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure Proc. Natl. Acad. Sci. U. S. A. 84 1987 7413 7417
38. L.B. Feril Jr., R. Ogawa, K. Tachibana, and T. Kondo Optimized ultrasound-mediated gene transfection in cancer cells Cancer Sci. 97 2006 1111 1114 (Pubitemid 44322562)
39. E.A. Ferrante, J.E. Pickard, J. Rychak, A. Klibanov, and K. Ley Dual targeting improves microbubble contrast agent adhesion to VCAM-1 and P-selectin under flow J. Control. Rel. 140 2009 100 107
40. K.W. Ferrara Driving delivery vehicles with ultrasound Adv. Drug Deliv. Rev. 60 2008 1097 1102
41. S. Fokong, B. Theek, Z. Wu, P. Koczera, L. Appold, S. Jorge, U. Resch-Genger, M. Van Zandvoort, G. Storm, F. Kiessling, and T. Lammers Image-guided, targeted and triggered drug delivery to tumors using polymer-based microbubbles J. Control. Rel. 163 2012 75 81
42. F. Forsberg, J.D. Lathia, D.A. Merton, J.B. Liu, N.T. Le, B.B. Goldberg, and M.A. Wheatley Effect of shell type on the in-vivo backscatter from polymer encapsulated microbubbles Ultrasound Med. Biol. 30 2004 1281 1287 (Pubitemid 39576179)
43. V. Frenkel Ultrasound mediated delivery of drugs and genes to solid tumors Adv. Drug Deliv. Rev. 60 2008 1193 1208
44. P. Frenkel, S. Chen, T. Thai, R.V. Shohet, and P.A. Grayburn DNA-loaded albumin microbubbles enhance ultrasound-mediated transfection in-vitro Ultrasound Med. Biol. 28 2002 817 822 (Pubitemid 34756815)
45. W.J. Greenleaff, M.E. Bolander, G. Sarkar, M.B. Goldring, and J.F. Greenleaf Artificial cavitation nuclei significantly enhance acoustically induced cell transfection Ultrasound Med. Biol. 24 1998 587 595 (Pubitemid 28252453)
46. D. Grishenkov, L. Kari, L.A. Brodin, T.B. Brismar, and G. Paradossi In vitro contrast-enhanced ultrasound measurements of capillary microcirculation: comparison between polymerand phospholipid-shelled microbubbles Ultrasonics 51 2011 40 48
47. C. Guiot, G. Pastore, M. Napoleone, P. Gabriele, M. Trotta, and R. Cavalli Thermal response of contrast agent microbubbles: preliminary results from physico-chemical and US-imaging characterization Ultrasonics 44 2006 e127 e130
48. H.R. Guzmán, D.X. Nguyen, S. Khan, and M.R. Prausnitz Ultrasound-mediated disruption of cell membranes. II. Heterogeneous effects on cells J. Acoust. Soc. Am. 110 2001 597 606 (Pubitemid 32642596)
49. H.R. Guzmán, D.X. Nguyen, S. Khan, and M.R. Prausnitz Ultrasound-mediated disruption of cell membranes. I. Quantification of molecular uptake and cell viability J. Acoust. Soc. Am. 110 2001 588 596 (Pubitemid 32642595)
50. H.R. Guzmán, D.X. Nguyen, A.J. McNamara, and M.R. Prausnitz Equilibrium loading of cells with macromolecules by ultrasound: effects of molecular size and acoustic energy J. Pharm. Sci. 91 2002 1693 1701 (Pubitemid 34680232)
51. S. Horie, Y. Watanabe, R. Chen, S. Mori, Y. Matsumura, and T. Kodama Development of localized gene delivery using a dual-intensity ultrasound system in the bladder Ultrasound Med. Biol. 36 2010 1867 1875
52. M. Javadi, W.G. Pitt, C.M. Tracy, J.R. Barrow, B.M. Willardson, J.M. Hartley, and N.H. Tsosie Ultrasonic gene and drug delivery using eLiposomes J. Control. Rel. 167 2013 92 100
53. A. Kabalnov, J. Bradley, S. Flaim, D. Klein, T. Pelura, B. Peters, S. Otto, J. Reynolds, E. Schutt, and J. Weers Dissolution of multicomponent microbubbles in the bloodstream: 2. Experiment Ultrasound Med. Biol. 24 1998 751 760 (Pubitemid 28285211)
54. G. Kantarci, and R. Cavalli Non viral systems for gene delivery: up to date Nanotechnology in Progress: Pharmaceutical Applications 2012 Research SignPost Kerala, India
55. R. Karshafian, P.D. Bevan, R. Williams, S. Samac, and P.N. Burns Sonoporation by ultrasound-activated microbubble contrast agents: effect of acoustic exposure parameters on cell membrane permeability and cell viability Ultrasound Med. Biol. 35 2009 847 860
56. Z. Kauerova, R. Lukac, P. Kohout, J. Mašek, Š. Koudelka, J. Plocková, M. Vašíčková, M. Vlašín, and J. Turánek A prototype 'Infucon' device for continuous infusion of microbubbles in vivo Int. J. Pharm. 441 2013 92 98
57. H.J. Kim, J.F. Greenleaf, R.R. Kinnick, J.T. Bronk, and M.E. Bolander Ultrasoundmediated transfection of mammalian cells Hum. Gene Ther. 7 1996 1339 1346
58. D.H. Kim, M.J. Costello, P.B. Duncan, and D. Needham Mechanical properties and microstructure of polycrystalline phospholipids monolayer shells Langmuir 19 2003 8455 8466
59. A.L. Klibanov Ligand-carrying gas-filled microbubbles: ultrasound contrast agents for targeted molecular imaging Bioconj. Chem. 16 2005 9 17 (Pubitemid 40129671)
60. A.L. Klibanov Preparation of targeted microbubbles: ultrasound contrast agents for molecular imaging Med. Biol. Eng. Comput. 47 2009 875 882
61. A.L. Klibanov, T.J. Shevchenko, B.L. Raju, L. Seip, and C.T. Chin Ultrasound-triggered release of materials entrapped in microbubble-liposome constructs: a tool for targeted drug delivery J. Control. Rel. 148 2010 13 17
62. O.D. Kripfgans, M.L. Fabilli, P.L. Carson, and J.B. Fowlkes On the acoustic vaporization of micrometer-sized droplets J. Acoust. Soc. Am. 116 2004 272 281 (Pubitemid 38916005)
63. T.M. Krupka, L. Solorio, R.E. Wilson, H. Wu, N. Azar, and A.A. Exner Formulation and characterization of echogenic lipid-Pluronic nanobubbles Mol. Pharmacol. 7 2010 49 59
64. J.J. Kwan, and M.A. Borden Lipid monolayer collapse and microbubble stability Adv. Colloids Interface Sci. 183-184 2012 82 99
65. A. Lawrie, A.F. Brisken, S.E. Francis, D.I. Tayler, J. Chamberlain, D. Crossman, Cumberland, and C.M. Newman Ultrasound enhance reporter gene expression after transfection of vascular cells in vitro Circulation 99 1999 2617 2620 (Pubitemid 29237446)
66. A. Lawrie, A.F. Brisken, S.E. Francis, S.E. Francis, D. Wyllie, E. Kiss-toth, E.E. Qwarnstrom, S.K. Dower, D.C. Crossman, and C.M. Newman Ultrasound-enhanced transgene expression in vascular cells is not dependent upon cavitation-induced free radicals Ultrasound Med. Biol. 29 2003 1453 1461 (Pubitemid 37345158)
67. H. Lee, and R.W. Pastor Corse-grained model for PEGylated lipids: effect of PEGylation on the size and shape of self-assembled structures J. Phys. Chem. B 115 2001 7830 7837
68. T.G. Leighton What is ultrasound? Prog. Biophys. Mol. Biol. 3 2007 3 83 (Pubitemid 44809380)
69. I. Lentacker, B.G. De Geest, R.E. Vandenbroucke, I. Peeters, J. Demeester, S.C. De Smedt, and N.N. Sanders Ultrasound-responsive polymer-coated microbubbleto bind and protect DNA Langmuir 22 2006 7273 7278 (Pubitemid 44366426)
70. I. Lentacker, S.C. De Smedt, J. Demeester, V. Van Marck, M. Bracke, and N.N. Sanders Lipoplex-loaded microbubbles for gene delivery: a Trojan horse controlled by ultrasound Adv. Funct. Mater. 17 2007 1910 1916 (Pubitemid 47291238)
71. H. Leong-Poi, J. Song, S.J. Rim, J. Christiansen, S. Kaul, and J.R. Lindner Influence of microbubble shell properties on ultrasound signal: implications for low-power perfusion imaging J. Am. Soc. Echocardiogr. 15 2002 1269 1276 (Pubitemid 36528736)
72. T. Li, K. Tachibana, M. Kuroki, and M. Kuroki Gene transfer with echo-enhanced contrast agents: comparison between Albunex, Optison, and Levovist in mice - initial results Radiology 229 2003 423 428 (Pubitemid 37310829)
73. X.H. Li, Z. Ping, L.H. Wang, S.M. Tian, Y. Qian, L.R. Chen, and P. Zhang The targeted gene (KDRP-CD/TK) therapy of breast cancer mediated by SonoVue and ultrasound irradiation in vitro Ultrasonics 52 2012 186 191
74. J.R. Lindner, M.P. Coggins, S. Kaul, A.L. Klibanov, G.H. Brandenburger, and K. Ley Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes Circulation 101 2000 668 675 (Pubitemid 30094739)
75. J.R. Lindner, P.A. Dayton, M.P. Coggins, K. Ley, J. Song, K. Ferrara, and S. Kaul Noninvasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles Circulation 102 2000 531 538 (Pubitemid 30639971)
76. J.R. Lindner, J. Song, F. Xu, A.L. Klibanov, K. Singbartl, K. Ley, and S. Kaul Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes Circulation 102 2000 2745 2750
77. J.R. Lindner, J. Song, J. Christiansen, A.L. Klibanov, F. Xu, and K. Ley Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin Circulation 104 2001 2107 2112 (Pubitemid 33027054)
78. J.R. Lindner, J. Song, J. Sklenar, and S. Kaul Microvascular rheology of Definity microbubbles after intra-arterial and intravenous administration J. Am. Soc. Echocardiogr. 15 2002 396 403 (Pubitemid 46002653)
79. E. Lukianova-Hleb, A. Samaniego, J. Wen, L. Metelitsa, C.C. Chang, and D.O. Lapotko Selective gene transfection of individual cells in vitro with plasmonic nanobubbles J. Control. Rel. 152 2011 286 293
80. H. Maeda, and W.J.Y. Matsumura Tumor vascular permeability and EPR effect J. Control. Rel. 65 2000 271 284
81. H. Mannell, J. Pircher, F. Fochler, Y. Stampnik, T. Rathel, B. Gleich, C. Plank, O. Mykhaylyk, C. Dahmani, M. Wörnle, A. Ribeiro, U. Pohl, and F. Krötz Site directed vascular gene delivery in vivo by ultrasonic destruction of magnetic nanoparticle coated microbubbles Nanomedicine 8 2012 1309 1318
82. E.E.J. Marxer, J. Brüßler, A. Becker, J. Schümmelfeder, R. Schubert, C. Nimsky, and U. Bakowsky Development and characterization of new nanoscaled ultrasound active lipid dispersions as contrast agents Eur. J. Pharm. Biopharm. 77 2011 430 437
83. Y. Matsumura, and H. Maeda A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res. 46 1986 6387 6392 (Pubitemid 17221789)
84. D.L. Miller, and J. Quddus Lysis and sonoporation of epidermoid and phagocytic monolayer cells by diagnostic ultrasound activation of contrast agent gas bodies Ultrasound Med. Biol. 27 2001 1107 1113 (Pubitemid 32807733)
85. D.L. Miller, S. Bao, R.A. Gres, and B.D. Thrall Ultrasound enhancement of gene transfection in murine melanoma tumors Ultrasound Med. Biol. 25 1999 1425 1430
86. D.L. Miller, S. Bao, and J.E. Morris Sonoporation of cultured cells in the rotating tube exposure system Ultrasound Med. Biol. 25 1999 143 149 (Pubitemid 29013452)
87. N. Nomikou, P. Tiwari, T. Trehan, K. Gulati, and A.P. McHale Studies on neutral, cationic and biotinylated cationic microbubbles in enhancing ultrasound-mediated gene delivery in vitro and in vivo Acta Biomater. 8 2012 1273 1280
88. E. Oeffinger, and A. Wheatltley Development and characterization of a nano-scale contrast agent Ultrasonics 42 2004 343 347
89. S.V. Pislaru, C. Pislaru, R.R. Kinnick, R. Singh, R. Gulati, J.F. Greenleaf, and R.D. Simari Optimization of ultrasound-mediated gene transfer: comparison of contrast agents and ultrasound modalities Eur. Heart J. 24 2003 1690 1698 (Pubitemid 37174910)
90. W.G. Pitt, and G.A. Husseini Ultrasound in drug and gene delivery Adv. Drug Deliv. Rev. 60 2008 1095 1096
91. W.G. Pitt, D.R. Jack, G.A. Husseini, and B.V. Memmott Non-viral gene transfection with ultrasound: is 100% transfection possible? Adv. Sci. Lett. 11 2012 98 105
92. T.R. Porter, P.L. Iversen, S. Li, and F. Xie 1996, Interaction of diagnostic ultrasound with synthetic oligonucleotide-labeled perfluorocarbon-exposed sonicated dextrose albumin microbubbles J. Ultrasound Med. 15 1996 577 584 (Pubitemid 26250646)
93. Y. Qiu, Y. Luo, Y. Zhang, W. Cui, D. Zhang, J. Wu, J. Zhang, and J. Tu The correlation between acoustic cavitation and sonoporation involved in ultrasound-mediated DNA transfection with polyethylenimine (PEI) in vitro J. Control. Rel. 145 2010 40 48
94. N. Rapoport, K.H. Nam, R. Gupta, Z. Gao, P. Mohan, A. Payne, N. Todd, X. Liu, T. Kim, J. Shea, C. Scaife, D.L. Parker, E.K. Jeong, and A.M. Kennedy Ultrasound-mediated tumor imaging and nanotherapy using drug-loaded block copolymer stabilized perfluorocarbon nanoemulsions J. Control. Rel. 153 2011 4 15
95. J. Ren, Z. Whang, Y. Zhang, Y.Y. Zheng, X.S. Li, Q.X. Zhang, Z.X. Wang, and C.S. Xu Transfection efficiency of TDL compound in HUVEC enhanced by ultrasound-targeted microbubble destruction Ultrasound Med. Biol. 34 2008 1857 1867
96. J. Ren, C. Xu, Z. Zhou, Y. Zhang, X. Li, Y. Zheng, H. Ran, and Z. Wang A novel ultrasound microbubble carrying gene and Tat peptide: preparation and characterization Acad. Radiol. 16 2009 1457 1465
97. E.G. Schutt, D.H. Klein, R.M. Mattrey, and J.G. Riess Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: the key role of perfluorochemicals Angew. Chem. Int. Ed. 42 2003 3218 3235 (Pubitemid 36917164)
98. M. Shimamura, N. Sato, Y. Taniyama, H. Kurinami, H. Tanaka, T. Takami, T. Ogihara, M. Tohyama, Y. Kaneda, and R. Morishita Gene transfer into adult rat spinal cord using naked plasmid DNA and ultrasound microbubble J. Gene Med. 7 2005 1468 1474 (Pubitemid 41672405)
99. R.V. Shohet, S. Chen, Y.T. Zhou, Z. Wang, R.S. Meidell, R.H. Unger, and P.A. Grayburn Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium Circulation 101 22 2000 2554 2556 (Pubitemid 30350631)
100. S. Sirsi, and M. Borden Microbubble compositions, properties and biomedical applications Bubble Sci. Eng. Technol. 1 2009 3 17
101. S.R. Sirsi, S.L. Hernandez, L. Zielinski, H. Blomback, A. Koubaa, M. Synder, S. Homma, J.J. Kandel, D.J. Yamashiro, and M.A. Borden Polyplex-microbubble hybrids for ultrasound-guided plasmid DNA delivery to solid tumors J. Control. Rel. 157 2012 224 234
102. S.A. Skinner, P.J. Tutton, and P.E. O'Brien Microvascular architecture of experimental colon tumors in the rat Cancer Res. 50 1990 2411 2417 (Pubitemid 20134503)
103. E. Stride, and M. Edirisinghe Novel microbubble preparation technologies Soft Matter 4 2008 2350 2359
104. E. Stride, and N. Saffari On the destruction of microbubbles ultrasound contrast agents Ultrasound Med. Biol. 29 2003 563 573 (Pubitemid 36561424)
105. R. Suzuki, T. Takizawa, Y. Negishi, N. Utoguchi, K. Sawamura, K. Tanaka, E. Namai, Y. Oda, Y. Matsumura, and K. Maruyama Tumor specific ultrasound enhanced gene transfer in vivo with novel liposomal bubbles J. Control. Rel. 125 2008 137 144 (Pubitemid 350299602)
106. R. Suzuki, T. Takizawa, Y. Negishi, N. Utoguchi, and K. Maruyama Effective gene delivery with novel liposomal bubbles and ultrasonic destruction technology Int. J. Pharm. 354 2008 49 55
107. R. Suzuki, Y. Oda, N. Utoguchi, and K. Maruyama Progress in the development of ultrasound-mediated gene delivery systems utilizing nano- and microbubbles J. Control. Rel. 149 2011 36 41
108. D.B. Tata, F. Dunn, and D.J. Tindall Selective clinical ultrasound signals mediate differential gene transfer and expression in two human prostate cancer cell lines: LnCap and PC-3 Biochem. Biophys. Res. Commun. 234 1997 64 67 (Pubitemid 27267532)
109. C. Tilcock Delivery of contrast agents for magnetic resonance imaging, computed tomography, nuclear medicine and ultrasound Adv. Drug Deliv. Rev. 37 1999 33 51 (Pubitemid 29164498)
110. S. Tinkov, R. Bekeredjian, G. Winter, and C. Coester Microbubbles as ultrasound rug carriers J. Pharm. Sci. 90 2009 1035 1961
111. J.L. Tlaxca, C.R. Anderson, A.L. Klibanov, B. Lowrey, J.A. Hossack, J.S. Alexander, M.B. Lawrence, and J.J. Rychak Analysis of in vitro transfection by sonoporation using cationic and neutral microbubbles Ultrasound Med. Biol. 36 2010 1907 1918
112. E. Unger, T. Porter, W. Culp, R. Labell, T. Matsunaga, and R. Zutshi Therapeutic applications of lipid-coated microbubbles Adv. Drug Deliv. Rev. 56 2004 1291 1314 (Pubitemid 38510475)
113. F.S. Villanueva, R.J. Jankowski, S. Klibanov, M.L. Pina, S.M. Alber, S.C. Watkins, G.H. Brandenburger, and W.R. Wagner Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells Circulation 98 1998 1 5 (Pubitemid 28312070)
114. W. Wei, B. Zheng-zhong, W. Yong-jie, Z. Qing-wu, and M. Ya-lin Bioeffects of low-frequency ultrasonic gene delivery and safety on cell membrane permeability control J. Ultrasound Med. 23 12 2004 1569 1582 (Pubitemid 39586862)
115. J. Wu Temperature rise generated by ultrasound in the presence of a contrast agent Ultrasound Med. Biol. 24 1998 267 274
116. A. Xie, T. Belcik, Y. Qi, T.K. Morgan, S.A. Champaneri, S. Taylor, B.P. Davidson, Y. Zhao, A.L. Klibanov, M.A. Kuliszewski, H. Leong-Poi, A. Ammi, and J.R. Lindner Ultrasound-mediated vascular gene transfection by cavitation of endothelial-targeted cationic microbubbles JACC Cardiovasc. Imaging 5 2012 1253 1262
117. Z.W. Xing, H.T. Ke, S.Q. Liu, Z.F. Dail, J.R. Wang, and J.B. Liu Preparation of polyelectrolyte multilayer coated microbubbles for use as ultrasound contrast agents Chin. Med. Sci. J. 2008
118. X. Yang, B. Zhu, T. Dong, P. Pan, X. Shuai, and Y. Inoue Interactions between an anticancer drug and polymeric micelles based on biodegradable polyesters Macromol. Biosci. 8 2008 1116 1125
119. T. Yin, P. Wang, and R. Zheng Nanobubbles for enhanced ultrasound imaging of tumors Int. J. Nanomed. 7 2012 895 904
120. T. Yu, S.L. Li, J.Z. Zhao, and T.J. Mason Ultrasound: a chemotherapy sensitizer Technol. Cancer Res. Treat. 5 2006 51 60 (Pubitemid 43278318)
121. C. Zhang, H. Cao, Q. Li, J. Tu, X. Guo, Z. Liu, and D. Zhang Enhancement effect of ultrasound-induced microbubble cavitation on branched polyethylenimine-mediated VEGF165 transfection with varied N/P ratio Ultrasound Med. Biol. 39 2013 161 171
122. L. Zhao, and C. Lu Factors that affect the efficiency of antisense oligodeoxyribonucleotide transfection by insonated gas-filled lipid microbubbles J. Nanopart. Res. 10 2008 449 454