Polyethylenimine-grafted copolymer of poly(l-lysine) and poly(ethylene glycol) for gene delivery

Biomaterials

Volumn 32, Issue 6, 2011, Pages 1694-1705

  Dai, Jian ^a   Zou, Seyin ^b   Pei, Yuanyuan ^b   Cheng, Du ^a   Ai, Hua ^c   Shuai, Xintao ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Folate targeting; Gene therapy; Linear polyethylenimine; Poly(l lysine); TRAIL gene

Indexed keywords

APOPTOSIS; BUFFERING CAPACITIES; CELL APOPTOSIS; CELL LINES; CELL VIABILITY; FOLATE RECEPTOR; FOLATE TARGETING; GENE DELIVERY; GENE DELIVERY VECTORS; GENE TRANSFECTION; GRAFTED COPOLYMERS; HUMAN HEPATOMAS; IN-VIVO; L-LYSINE; LOW MOLECULAR WEIGHT; LOW TOXICITY; MOLECULAR COMPOSITIONS; MOLECULAR DESIGN; POLY(ETHYLENIMINE); POLY-L-LYSINE; POLYETHYLENIMINES; THERAPEUTIC GENES; TRAIL GENE; TRANSGENE ACTIVITY;

AMINO ACIDS; BIODEGRADATION; BLOCK COPOLYMERS; CELL CULTURE; CELL DEATH; COPOLYMERIZATION; DYES; ETHYLENE; ETHYLENE GLYCOL; GENE TRANSFER; GRAFTING (CHEMICAL); LIGANDS; PLASTIC PRODUCTS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; PROTONS; TOXICITY;

GENE THERAPY;

COPOLYMER; FOLATE RECEPTOR; MACROGOL; PLASMID DNA; POLYETHYLENEIMINE; POLYLYSINE; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; BIODEGRADABILITY; CELL VIABILITY; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY; GENE OVEREXPRESSION; GENE TARGETING; GENE VECTOR; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER CELL CULTURE; MOLECULAR WEIGHT; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; TRANSGENE;

APOPTOSIS; CELL LINE, TUMOR; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; POLYLYSINE; POLYMERS;

EID: 78650277181     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2010.10.044     Document Type: Article

References (38)

1. Anderson D.G., Peng W.D., Akinc A., Hossain N., Kohn A., Padera R., et al. A polymer library approach to suicide gene therapy for cancer. Proc Natl Acad Sci USA 2004, 101:16028-16033.
2. Merdan T., Kopeček J., Kissel T. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv Drug Deliv Rev 2002, 54:715-758.
3. Allen T.M., Cullis P.R. Drug delivery systems: entering the mainstream. Science 2004, 303:1818-1822.
4. Kichler A., Leborgne C., Coeytaux E., Danos O. Polyethylenimine-mediated gene delivery: a mechanistic study. J Gene Med 2001, 3:135-144.
5. Wagner E., Ogris M., Zauner W. Polylysine-based transfection systems utilizing receptor-mediated delivery. Adv Drug Deliv Rev 1998, 30:97-113.
6. Köping-Höggard M., Tubulekas I., Guan H., Edwards K., Nilsson M., Vårum K.M., et al. Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo. Gene Ther 2001, 8:1108-1121.
7. Akinc A., Lynn D.M., Anderson D.G., Langer R. Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery. J Am Chem Soc 2003, 125:5316-5323.
8. Tang M.X., Redemann C.T., Szoka F.C. In vitro gene delivery by degraded polyamidoamine dendrimers. Bioconjug Chem 1996, 7:703-714.
9. Katayose S., Kataoka K. Water-soluble polyion complex associates of DNA and poly(ethylene glycol)-poly(l-lysine) block copolymer. Bioconjug Chem 1997, 8:702-707.
10. Putnam D., Gentry C., Pack D.W., Langer R. Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini. Proc Natl Acad Sci USA 2001, 98:1200-1205.
11. Meyer M., Philipp A., Oskuee R., Schmidt C., Wagner E. Breathing life into polycations: functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery. J Am Chem Soc 2008, 130:3272-3273.
12. Fischer D., Bieber T., Li Y., Elsasser H.P., Kissel T. A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res 1999, 8:1273-1279.
13. Wightman L., Kircheis R., Rossler V., Carotta S., Ruzicka R., Kursa M., et al. Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo. J Gene Med 2001, 3:362-372.
14. Weitman S.D., Lark R.H., Coney L.R., Fort D.W., Frasca V., Zurawski V.R.J., et al. Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues. Cancer Res 1992, 52:3396-3401.
15. Ross J.F., Chaudhuri P.K., Ratnam M. Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines physiologic and clinical implications. Cancer 1994, 73:2432-2443.
16. Liang B., He M.L., Chan C., Chen Y., Li X.P., Li Y., et al. The use of folate-PEG-grafted-hybranched-PEI nonviral vector for the inhibition of glioma growth in the rat. Biomaterials 2009, 30:4014-4020.
17. Naumann U., Waltereit R., Schulz J.B., Weller M. Adenoviral (full-length) Apo2L/TRAIL gene transfer is an ineffective treatment strategy for malignant glioma. J Neuro-Oncol 2003, 61:7-15.
18. Cho K.C., Jeong J.H., Chung H.J., Joe C.O., Kim S.W., Park T.G. Folate receptor-mediated intracellular delivery of recombinant caspase-3 for inducing apoptosis. J Control Release 2005, 108:121-131.
19. Bikram M., Ahn C.H., Chae S.Y., Lee M., Yockman J.W., Kim S.W. Biodegradable poly(ethylene glycol)-co-poly(L-lysine)-g-histidine multiblock copolymers for nonviral gene delivery. Macromolecules 2004, 37:1903-1916.
20. Neal J.C., Stolnik S., Schacht E., Kenawy E.R., Garnett M.C., Davis S.S., et al. In vitro displacement by rat serum of adsorbed radiolabeled poloxamer and poloxamine copolymers from model and biodegradable nanospheres. J Pharm Sci 1998, 87:1242-1248.
21. Aoi K., Okada M. Polymerization of oxazolines. Prog Polym Sci 1996, 21:151-208.
22. Harada A., Kataoka K. Formation of polyion complex micelles in an aqueous milieu from a pair of oppositely-charged block copolymers with poly(ethylene glycol) segments. Macromolecules 1995, 28:5294-5299.
23. Nasongkla N., Shuai X., Ai H., Weinberg B.D., Pink J., Boothman D.A., et al. cRGD-functionalized polymer micelles for targeted doxorubicin delivery. Angew Chem Int Ed Engl 2004, 43:6323-6327.
24. Shuai X., Merdan T., Unger F., Matthias W., Kissel T. Novel biodegradable ternary copolymers hy-PEI-g-PCL-b-PEG: synthesis, characterization and potential as efficient non-viral gene delivery vectors. Macromolecules 2003, 36:5751-5759.
25. Morille M., Passirani C., Vonarbourg A., Clavreul A., Benoit J.P. Progress in developing cationic vectors for non-viral systemic gene therapy against cancer. Biomaterials 2008, 29:3477-3496.
26. Boussif O., Lezoualčh F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethyleneimine. Proc Natl Acad Sci USA 1995, 92:7297-7301.
27. Wang D.A., Narang A.S., Kotb M., Gaber A.O., Miller D.D., Kim S.W., et al. Novel branched poly(ethylenimine)-cholesterol water-soluble lipopolymers for gene delivery. Biomacromolecules 2002, 3:1197-1207.
28. Volcke C., Pirotton S., Ch G.r.a.n.d.f.i.l.s., Humbert C., Thiry P.A., Ydens I., et al. Influence of DNA condensation state on transfection efficiency in DNA/polymer complexes: an AFM and DLS comparative study. J Biotechnol 2006, 125:11-21.
29. Zhong Z.Y., Feijen J., Lok M.C., Hennink W.E., Christensen L.V., Yockman J.W., et al. Low molecular weight linear polyethylenimine-b-poly(ethylene glycol)-b-polyethylenimine triblock copolymers: synthesis, characterization, and in vitro gene transfer properties. Biomacromolecules 2005, 6:3440-3448.
30. Zhang M., Liu M., Xue Y.N., Huang S.W., Zhuo R.X. Polyaspartamide-based oligo-ethylenimine brushes with high buffer capacity and low cytotoxicity for highly efficient gene delivery. Bioconjug Chem 2009, 20:440-446.
31. Wang C.F., Lin Y.X., Jiang T., He F., Zhuo R.X. Polyethylenimine-grafted polycarbonates as biodegradable polycations for gene delivery. Biomaterials 2009, 30:4824-4832.
32. Liu X.Y., Ho W.Y., Hung W.J., Shau M.D. The characteristics and transfection efficiency of cationic poly(ester-co-urethane)-short chain PEI conjugates self-assembled with DNA. Biomaterials 2009, 30:6665-6673.
33. Sun Y.X., Xiao W., Cheng S.X., Zhang X.Z., Zhuo R.X. Synthesis of (Dex-HMDI)-g-PEIs as effective and low cytotoxic nonviral gene vectors. J Control Release 2008, 128:171-178.
34. Benns J.M., Choi J.S., Mahato R.I., Park J.S., Kim S.W. pH-sensitive cationic polymer gene delivery vehicle: N-Ac-poly(L-histidine)-graft-poly(L-lysine) comb shaped polymer. Bioconjug Chem 2000, 11:637-645.
35. Brissault B., Kichler A., Guis C., Leborgne C., Danos O., Cheradame H. Synthesis of linear polyethylenimine derivatives for DNA transfection. Bioconjug Chem 2003, 14:581-587.
36. Zhang S., Li J., Lykotrafitis G., Bao G., Suresh S. Size-dependent endocytosis of nanoparticles. Adv Mater 2009, 21:419-424.
37. Pack D.W., HoffmanAS P.u.n.S., Stayton P.S. Design and development of polymers for gene delivery. Nat Rev Drug Discov 2005, 4:581-593.
38. Chen G., Chen W., Wu Z., Yuan R., Li H., Gao J., et al. MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression. Biomaterials 2009, 30:1962-1970.