메뉴 건너뛰기




Volumn 62, Issue 12, 2013, Pages 4132-4143

Programmed cell death-4 deficiency prevents diet-induced obesity, adipose tissue inflammation, and insulin resistance

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; LIVER X RECEPTOR ALPHA; PROGRAMMED CELL DEATH 4 PROTEIN; TRANSLATION TERMINATION FACTOR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84886700339     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-0097     Document Type: Article
Times cited : (52)

References (47)
  • 1
    • 33846422032 scopus 로고    scopus 로고
    • Obesity and diabetes in the developing world-A growing challenge
    • Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world-a growing challenge. N Engl J Med 2007;356:213-215
    • (2007) N Engl J Med , vol.356 , pp. 213-215
    • Hossain, P.1    Kawar, B.2    El Nahas, M.3
  • 2
    • 74549140993 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2008
    • Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010;303:235-241
    • (2010) JAMA , vol.303 , pp. 235-241
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Curtin, L.R.4
  • 3
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444: 860-867
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 4
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003;112:1821-1830
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3
  • 6
    • 77249132284 scopus 로고    scopus 로고
    • Adipose tissue inflammation in obesity and metabolic syndrome
    • Nishimura S, Manabe I, Nagai R. Adipose tissue inflammation in obesity and metabolic syndrome. Discov Med 2009;8:55-60
    • (2009) Discov Med , vol.8 , pp. 55-60
    • Nishimura, S.1    Manabe, I.2    Nagai, R.3
  • 7
    • 33847280286 scopus 로고    scopus 로고
    • T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity
    • Wu H, Ghosh S, Perrard XD, et al. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 2007;115:1029-1038
    • (2007) Circulation , vol.115 , pp. 1029-1038
    • Wu, H.1    Ghosh, S.2    Perrard, X.D.3
  • 8
    • 0029595270 scopus 로고
    • Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death
    • Shibahara K, Asano M, Ishida Y, Aoki T, Koike T, Honjo T. Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. Gene 1995;166:297-301
    • (1995) Gene , vol.166 , pp. 297-301
    • Shibahara, K.1    Asano, M.2    Ishida, Y.3    Aoki, T.4    Koike, T.5    Honjo, T.6
  • 9
    • 67449104909 scopus 로고    scopus 로고
    • The tumour suppressor Pdcd4: Recent advances in the elucidation of function and regulation
    • Lankat-Buttgereit B, Göke R. The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation. Biol Cell 2009;101: 309-317
    • (2009) Biol Cell , vol.101 , pp. 309-317
    • Lankat-Buttgereit, B.1    Göke, R.2
  • 10
    • 0344035319 scopus 로고    scopus 로고
    • Programmed cell death protein 4 (pdcd4): A novel target for antineoplastic therapy?
    • Lankat-Buttgereit B, Göke R. Programmed cell death protein 4 (pdcd4): a novel target for antineoplastic therapy? Biol Cell 2003;95:515-519
    • (2003) Biol Cell , vol.95 , pp. 515-519
    • Lankat-Buttgereit, B.1    Göke, R.2
  • 11
    • 40249092910 scopus 로고    scopus 로고
    • MicroRNA-21 targets tumor suppressor genes in invasion and metastasis
    • Zhu S, Wu H, Wu F, Nie D, Sheng S, Mo YY. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res 2008;18:350-359
    • (2008) Cell Res , vol.18 , pp. 350-359
    • Zhu, S.1    Wu, H.2    Wu, F.3    Nie, D.4    Sheng, S.5    Mo, Y.Y.6
  • 12
    • 0042524204 scopus 로고    scopus 로고
    • Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis
    • Chen Y, Knösel T, Kristiansen G, et al. Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis. J Pathol 2003;200:640-646
    • (2003) J Pathol , vol.200 , pp. 640-646
    • Chen, Y.1    Knösel, T.2    Kristiansen, G.3
  • 13
    • 33749868662 scopus 로고    scopus 로고
    • Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma
    • Zhang H, Ozaki I, Mizuta T, et al. Involvement of programmed cell death 4 in transforming growth factor-beta1-induced apoptosis in human hepatocellular carcinoma. Oncogene 2006;25:6101-6112
    • (2006) Oncogene , vol.25 , pp. 6101-6112
    • Zhang, H.1    Ozaki, I.2    Mizuta, T.3
  • 14
    • 38149139712 scopus 로고    scopus 로고
    • Frequent loss of PDCD4 expression in human glioma: Possible role in the tumorigenesis of glioma
    • Gao F, Zhang P, Zhou C, et al. Frequent loss of PDCD4 expression in human glioma: possible role in the tumorigenesis of glioma. Oncol Rep 2007;17:123-128
    • (2007) Oncol Rep , vol.17 , pp. 123-128
    • Gao, F.1    Zhang, P.2    Zhou, C.3
  • 15
    • 67650680903 scopus 로고    scopus 로고
    • PDCD4 inhibits the malignant phenotype of ovarian cancer cells
    • Wei ZT, Zhang X, Wang XY, et al. PDCD4 inhibits the malignant phenotype of ovarian cancer cells. Cancer Sci 2009;100:1408-1413
    • (2009) Cancer Sci , vol.100 , pp. 1408-1413
    • Wei, Z.T.1    Zhang, X.2    Wang, X.Y.3
  • 16
    • 75649113377 scopus 로고    scopus 로고
    • Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21
    • Sheedy FJ, Palsson-McDermott E, Hennessy EJ, et al. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol 2010;11:141-147
    • (2010) Nat Immunol , vol.11 , pp. 141-147
    • Sheedy, F.J.1    Palsson-Mcdermott, E.2    Hennessy, E.J.3
  • 17
    • 79961065195 scopus 로고    scopus 로고
    • The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death
    • Ruan Q, Wang T, Kameswaran V, et al. The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death. Proc Natl Acad Sci USA 2011;108:12030-12035
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 12030-12035
    • Ruan, Q.1    Wang, T.2    Kameswaran, V.3
  • 18
    • 0028025654 scopus 로고
    • A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily
    • Apfel R, Benbrook D, Lernhardt E, Ortiz MA, Salbert G, Pfahl M. A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily. Mol Cell Biol 1994;14:7025-7035
    • (1994) Mol Cell Biol , vol.14 , pp. 7025-7035
    • Apfel, R.1    Benbrook, D.2    Lernhardt, E.3    Ortiz, M.A.4    Salbert, G.5    Pfahl, M.6
  • 19
    • 0030747895 scopus 로고    scopus 로고
    • Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: No alteration in adipose tissue of obese and NIDDM patients
    • Auboeuf D, Rieusset J, Fajas L, et al. Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 1997;46:1319-1327
    • (1997) Diabetes , vol.46 , pp. 1319-1327
    • Auboeuf, D.1    Rieusset, J.2    Fajas, L.3
  • 20
    • 38849122775 scopus 로고    scopus 로고
    • Liver X receptors (LXRs). Part I: Structure, function, regulation of activity, and role in lipid metabolism
    • Wójcicka G, Jamroz-Wi?niewska A, Horoszewicz K, Be?towski J. Liver X receptors (LXRs). Part I: structure, function, regulation of activity, and role in lipid metabolism. Postepy Hig Med Dosw (Online) 2007;61:736-759
    • (2007) Postepy Hig Med Dosw (Online) , vol.61 , pp. 736-759
    • Wójcicka, G.1    Jamroz-Winiewska, A.2    Horoszewicz, K.3    Betowski, J.4
  • 21
    • 80051474745 scopus 로고    scopus 로고
    • Liver X receptor: An oxysterol sensor and a major player in the control of lipogenesis
    • Ducheix S, Lobaccaro JM, Martin PG, Guillou H, Liver X. Liver X receptor: an oxysterol sensor and a major player in the control of lipogenesis. Chem Phys Lipids 2011;164:500-514
    • (2011) Chem Phys Lipids , vol.164 , pp. 500-514
    • Ducheix, S.1    Lobaccaro, J.M.2    Martin, P.G.3    Guillou, H.4    Liver, X.5
  • 22
    • 77956365905 scopus 로고    scopus 로고
    • The liver X receptor: Control of cellular lipid homeostasis and beyond Implications for drug design
    • Oosterveer MH, Grefhorst A, Groen AK, Kuipers F. The liver X receptor: control of cellular lipid homeostasis and beyond Implications for drug design. Prog Lipid Res 2010;49:343-352
    • (2010) Prog Lipid Res , vol.49 , pp. 343-352
    • Oosterveer, M.H.1    Grefhorst, A.2    Groen, A.K.3    Kuipers, F.4
  • 23
    • 84858796689 scopus 로고    scopus 로고
    • Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR
    • Calkin AC, Tontonoz P. Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR. Nat Rev Mol Cell Biol 2012;13:213-224
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 213-224
    • Calkin, A.C.1    Tontonoz, P.2
  • 24
    • 79957605136 scopus 로고    scopus 로고
    • Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
    • Fu S, Yang L, Li P, et al. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature 2011;473:528-531
    • (2011) Nature , vol.473 , pp. 528-531
    • Fu, S.1    Yang, L.2    Li, P.3
  • 26
    • 71549152580 scopus 로고    scopus 로고
    • Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis
    • Erbay E, Babaev VR, Mayers JR, et al. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med 2009;15:1383-1391
    • (2009) Nat Med , vol.15 , pp. 1383-1391
    • Erbay, E.1    Babaev, V.R.2    Mayers, J.R.3
  • 28
    • 78650637747 scopus 로고    scopus 로고
    • A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice
    • Gao Q, Jiang Y, Ma T, et al. A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice. J Immunol 2010;185:5820-5827
    • (2010) J Immunol , vol.185 , pp. 5820-5827
    • Gao, Q.1    Jiang, Y.2    Ma, T.3
  • 29
    • 84863297431 scopus 로고    scopus 로고
    • Local gene silencing of monocyte chemoattractant protein-1 prevents vulnerable plaque disruption in apolipoprotein E-knockout mice
    • Liu XL, Zhang PF, Ding SF, et al. Local gene silencing of monocyte chemoattractant protein-1 prevents vulnerable plaque disruption in apolipoprotein E-knockout mice. PLoS ONE 2012;7:e33497
    • (2012) PLoS ONE , vol.7
    • Liu, X.L.1    Zhang, P.F.2    Ding, S.F.3
  • 30
    • 42449104952 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes
    • discussion 94-88, 162-163, 196-203
    • Hotamisligil GS. Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes. Novartis Found Symp 2007;286:86-94; discussion 94-88, 162-163, 196-203
    • (2007) Novartis Found Symp , vol.286 , pp. 86-94
    • Hotamisligil, G.S.1
  • 31
    • 77957078371 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and inflammation in obesity and diabetes
    • Hummasti S, Hotamisligil GS. Endoplasmic reticulum stress and inflammation in obesity and diabetes. Circ Res 2010;107:579-591
    • (2010) Circ Res , vol.107 , pp. 579-591
    • Hummasti, S.1    Hotamisligil, G.S.2
  • 32
    • 52749091008 scopus 로고    scopus 로고
    • Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulinresistant individuals
    • Boden G, Duan X, Homko C, et al. Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulinresistant individuals. Diabetes 2008;57:2438-2444
    • (2008) Diabetes , vol.57 , pp. 2438-2444
    • Boden, G.1    Duan, X.2    Homko, C.3
  • 33
    • 79251508007 scopus 로고    scopus 로고
    • Measurement of the increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulinresistant individuals
    • Boden G, Merali S. Measurement of the increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulinresistant individuals. Methods Enzymol 2011;489:67-82
    • (2011) Methods Enzymol , vol.489 , pp. 67-82
    • Boden, G.1    Merali, S.2
  • 34
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004;306:457-461
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3
  • 35
    • 82955203485 scopus 로고    scopus 로고
    • Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation
    • Singh P, Wedeken L, Waters LC, Carr MD, Klempnauer KH. Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation. Oncogene 2011;30:4864-4873
    • (2011) Oncogene , vol.30 , pp. 4864-4873
    • Singh, P.1    Wedeken, L.2    Waters, L.C.3    Carr, M.D.4    Klempnauer, K.H.5
  • 36
    • 83355169699 scopus 로고    scopus 로고
    • Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA
    • Wedeken L, Singh P, Klempnauer KH. Tumor suppressor protein Pdcd4 inhibits translation of p53 mRNA. J Biol Chem 2011;286:42855-42862
    • (2011) J Biol Chem , vol.286 , pp. 42855-42862
    • Wedeken, L.1    Singh, P.2    Klempnauer, K.H.3
  • 37
    • 58149484392 scopus 로고    scopus 로고
    • Inflammation and endoplasmic reticulum stress in obesity and diabetes
    • Hotamisligil GS. Inflammation and endoplasmic reticulum stress in obesity and diabetes. Int J Obes (Lond) 2008;32(Suppl. 7):S52-S54
    • (2008) Int J Obes (Lond) , vol.32 , Issue.SUPPL. 7
    • Hotamisligil, G.S.1
  • 38
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010;140:900-917
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 39
    • 63149189738 scopus 로고    scopus 로고
    • Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway
    • Awazawa M, Ueki K, Inabe K, et al. Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway. Biochem Biophys Res Commun 2009;382:51-56
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 51-56
    • Awazawa, M.1    Ueki, K.2    Inabe, K.3
  • 40
    • 4644289020 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid regulation of gene expression
    • Sampath H, Ntambi JM. Polyunsaturated fatty acid regulation of gene expression. Nutr Rev 2004;62:333-339
    • (2004) Nutr Rev , vol.62 , pp. 333-339
    • Sampath, H.1    Ntambi, J.M.2
  • 41
    • 38649116056 scopus 로고    scopus 로고
    • Selective versus total insulin resistance: A pathogenic paradox
    • Brown MS, Goldstein JL. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab 2008;7:95-96
    • (2008) Cell Metab , vol.7 , pp. 95-96
    • Brown, M.S.1    Goldstein, J.L.2
  • 42
    • 0033636780 scopus 로고    scopus 로고
    • Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
    • Shimomura I, Matsuda M, Hammer RE, Bashmakov Y, Brown MS, Goldstein JL. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol Cell 2000;6:77-86
    • (2000) Mol Cell , vol.6 , pp. 77-86
    • Shimomura, I.1    Matsuda, M.2    Hammer, R.E.3    Bashmakov, Y.4    Brown, M.S.5    Goldstein, J.L.6
  • 43
    • 84871023781 scopus 로고    scopus 로고
    • Liver X receptors and fat cell metabolism
    • Laurencikiene J, Rydén M. Liver X receptors and fat cell metabolism. Int J Obes (Lond) 2012;36:1494-1502
    • (2012) Int J Obes (Lond) , vol.36 , pp. 1494-1502
    • Laurencikiene, J.1    Rydén, M.2
  • 44
    • 84871990404 scopus 로고    scopus 로고
    • The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistance
    • Gao M, Liu D. The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistance. AAPS J 2013;15:258-266
    • (2013) AAPS J , vol.15 , pp. 258-266
    • Gao, M.1    Liu, D.2
  • 45
    • 84876789513 scopus 로고    scopus 로고
    • High-fructose diet downregulates longchain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway
    • Dong B, Kan CF, Singh AB, Liu J. High-fructose diet downregulates longchain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway. J Lipid Res 2013;54:1241-1254
    • (2013) J Lipid Res , vol.54 , pp. 1241-1254
    • Dong, B.1    Kan, C.F.2    Singh, A.B.3    Liu, J.4
  • 46
    • 79959578732 scopus 로고    scopus 로고
    • Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice
    • Korach-André M, Archer A, Gabbi C, et al. Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice. Am J Physiol Endocrinol Metab 2011;301:E210-E222
    • (2011) Am J Physiol Endocrinol Metab , vol.301
    • Korach-André, M.1    Archer, A.2    Gabbi, C.3
  • 47
    • 0036188910 scopus 로고    scopus 로고
    • Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism
    • Li Y, Bolten C, Bhat BG, et al. Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism. Mol Endocrinol 2002;16:506-514
    • (2002) Mol Endocrinol , vol.16 , pp. 506-514
    • Li, Y.1    Bolten, C.2    Bhat, B.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.