The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic β cell death

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 29, 2011, Pages 12030-12035

  Ruan, Qingguo ^a   Wang, Ting ^a,b   Kameswaran, Vasumathi ^a   Wei, Qin ^a   Johnson, Derek S ^a   Matschinsky, Franz ^a   Shi, Weiyun ^b   Chen, Youhai H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b SHANDONG EYE INSTITUTE   (China)

Author keywords

Autoimmunity

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEMBRANE PROTEIN; MICRORNA 21; PROGRAMMED CELL DEATH PROTEIN 4; PROTEIN BAX; STREPTOZOCIN; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DEATH; CONTROLLED STUDY; GENE ACTIVATION; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; STREPTOZOCIN DIABETES; T LYMPHOCYTE;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CELL DEATH; DIABETES MELLITUS, TYPE 1; DNA PRIMERS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; INSULIN-SECRETING CELLS; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICRORNAS; NF-KAPPA B; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA-BINDING PROTEINS;

MUS;

EID: 79961065195     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101450108     Document Type: Article

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