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Volumn 15, Issue 1, 2013, Pages 258-266

The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistance

Author keywords

diabetes; high fat diet induced obesity; liver X receptor; nuclear receptor; T0901317

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE I; CHOLESTEROL 7ALPHA MONOOXYGENASE; FAS ANTIGEN; LIPID; LIVER X RECEPTOR; LIVER X RECEPTOR AGONIST; MESSENGER RNA; N (2,2,2 TRIFLUOROETHYL) N [4 [2,2,2 TRIFLUORO 1 HYDROXY 1 (TRIFLUOROMETHOXY)ETHYL]PHENYL]BENZENESULFONAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCOUPLING PROTEIN 1;

EID: 84871990404     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-012-9429-3     Document Type: Article
Times cited : (43)

References (33)
  • 1
    • 79952793112 scopus 로고    scopus 로고
    • Obesity prevalence in the United States - Up, down, or sideways?
    • 21410367 10.1056/NEJMp1009229 1:CAS:528:DC%2BC3MXjtlSlsb4%3D
    • Yanovski SZ, Yanovski JA. Obesity prevalence in the United States - up, down, or sideways? N Engl J Med. 2011;364(11):987-9.
    • (2011) N Engl J Med , vol.364 , Issue.11 , pp. 987-989
    • Yanovski, S.Z.1    Yanovski, J.A.2
  • 2
    • 34547227547 scopus 로고    scopus 로고
    • The obesity epidemic in the United States - Gender, age, socioeconomic, racial/ethnic, and geographic characteristics: A systematic review and meta-regression analysis
    • DOI 10.1093/epirev/mxm007
    • Wang Y, Beydoun MA. The obesity epidemic in the United States - gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev. 2007;29:6-28. (Pubitemid 47229643)
    • (2007) Epidemiologic Reviews , vol.29 , Issue.1 , pp. 6-28
    • Wang, Y.1    Beydoun, M.A.2
  • 3
    • 77953630340 scopus 로고    scopus 로고
    • The role of gut hormones and the hypothalamus in appetite regulation
    • 20424341 10.1507/endocrj.K10E-077 1:CAS:528:DC%2BC3cXhtFahsrrK
    • Suzuki K, Simpson KA, Minnion JS, Shillito JC, Bloom SR. The role of gut hormones and the hypothalamus in appetite regulation. Endocr J. 2010;57(5):359-72.
    • (2010) Endocr J , vol.57 , Issue.5 , pp. 359-372
    • Suzuki, K.1    Simpson, K.A.2    Minnion, J.S.3    Shillito, J.C.4    Bloom, S.R.5
  • 4
    • 0035856920 scopus 로고    scopus 로고
    • Global and societal implications of the diabetes epidemic
    • DOI 10.1038/414782a
    • Zimmet P, Alberti KGMM, Shaw J. Global and societal implications of the diabetes epidemic. Nature. 2001;414(6865):782-7. (Pubitemid 34000780)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 782-787
    • Zimmet, P.1    Alberti, K.G.M.M.2    Shaw, J.3
  • 5
    • 78751532080 scopus 로고    scopus 로고
    • Toward a more complete (and less controversial) understanding of energy expenditure and its role in obesity pathogenesis
    • 21193735 10.2337/db10-0909 1:CAS:528:DC%2BC3MXosVWisQ%3D%3D
    • Kaiyala KJ, Schwartz MW. Toward a more complete (and less controversial) understanding of energy expenditure and its role in obesity pathogenesis. Diabetes. 2011;60(1):17-23.
    • (2011) Diabetes , vol.60 , Issue.1 , pp. 17-23
    • Kaiyala, K.J.1    Schwartz, M.W.2
  • 6
    • 34548749230 scopus 로고    scopus 로고
    • Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis
    • DOI 10.1007/s11154-007-9049-x, Special issue on Environment and Origin on Disease
    • Grun F, Blumberg B. Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis. Rev Endocr Metab Disord. 2007;8(2):161-71. (Pubitemid 47434649)
    • (2007) Reviews in Endocrine and Metabolic Disorders , vol.8 , Issue.2 , pp. 161-171
    • Grun, F.1    Blumberg, B.2
  • 7
    • 27544448347 scopus 로고    scopus 로고
    • Nuclear receptor regulation of lipid metabolism: Potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases
    • Chiang JY. Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases. Curr Opin Investig Drugs. 2005;6(10):994-1001. (Pubitemid 41535783)
    • (2005) Current Opinion in Investigational Drugs , vol.6 , Issue.10 , pp. 994-1001
    • Chiang, J.Y.L.1
  • 8
    • 77949329263 scopus 로고    scopus 로고
    • Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation
    • 20015660 10.1016/j.tem.2009.11.004 1:CAS:528:DC%2BC3cXis1Shur8%3D
    • Liu YY, Brent GA. Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation. Trends Endocrinol Metab. 2010;21(3):166-73.
    • (2010) Trends Endocrinol Metab , vol.21 , Issue.3 , pp. 166-173
    • Liu, Y.Y.1    Brent, G.A.2
  • 9
    • 84863609131 scopus 로고    scopus 로고
    • Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor gamma-sparing thiazolidinedione
    • 22621923 10.1074/jbc.M112.363960 1:CAS:528:DC%2BC38XpvVejt7k%3D
    • Chen Z, Vigueira PA, Chambers KT, Hall AM, Mitra MS, Qi N, et al. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor gamma-sparing thiazolidinedione. J Biol Chem. 2012;287(28):23537-48.
    • (2012) J Biol Chem , vol.287 , Issue.28 , pp. 23537-23548
    • Chen, Z.1    Vigueira, P.A.2    Chambers, K.T.3    Hall, A.M.4    Mitra, M.S.5    Qi, N.6
  • 10
    • 78049233793 scopus 로고    scopus 로고
    • Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ss-cells
    • 20798333 10.2337/db09-1897 1:CAS:528:DC%2BC3cXhsV2nsb%2FE
    • Miyazaki S, Taniguchi H, Moritoh Y, Tashiro F, Yamamoto T, Yamato E, et al. Nuclear hormone retinoid X receptor (RXR) negatively regulates the glucose-stimulated insulin secretion of pancreatic ss-cells. Diabetes. 2010;59(11):2854-61.
    • (2010) Diabetes , vol.59 , Issue.11 , pp. 2854-2861
    • Miyazaki, S.1    Taniguchi, H.2    Moritoh, Y.3    Tashiro, F.4    Yamamoto, T.5    Yamato, E.6
  • 11
    • 78149496368 scopus 로고    scopus 로고
    • Molecular biology and functional genomics of liver X receptors (LXR) in relationship to metabolic diseases
    • 20829110 10.1016/j.coph.2010.07.003 1:CAS:528:DC%2BC3cXhsVals7rP
    • Faulds MH, Zhao C, Dahlman-Wright K. Molecular biology and functional genomics of liver X receptors (LXR) in relationship to metabolic diseases. Curr Opin Pharmacol. 2010;10(6):692-7.
    • (2010) Curr Opin Pharmacol , vol.10 , Issue.6 , pp. 692-697
    • Faulds, M.H.1    Zhao, C.2    Dahlman-Wright, K.3
  • 12
    • 0036164154 scopus 로고    scopus 로고
    • BAREing it all: The adoption of LXR and FXR and their roles in lipid homeostasis
    • Edwards PA, Kast HR, Anisfeld AM. BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. J Lipid Res. 2002;43(1):2-12. (Pubitemid 34117211)
    • (2002) Journal of Lipid Research , vol.43 , Issue.1 , pp. 2-12
    • Edwards, P.A.1    Kast, H.R.2    Anisfeld, A.M.3
  • 13
    • 33751210100 scopus 로고    scopus 로고
    • Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice
    • DOI 10.1210/en.2006-0243
    • Liu Y, Yan C, Wang Y, Nakagawa Y, Nerio N, Anghel A, et al. Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Endocrinology. 2006;147(11):5061-8. (Pubitemid 44790557)
    • (2006) Endocrinology , vol.147 , Issue.11 , pp. 5061-5068
    • Liu, Y.1    Yan, C.2    Wang, Y.3    Nakagawa, Y.4    Nerio, N.5    Anghel, A.6    Lutfy, K.7    Friedman, T.C.8
  • 15
    • 77955654470 scopus 로고    scopus 로고
    • Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14
    • 20390404 10.1007/s00125-010-1737-5 1:CAS:528:DC%2BC3cXmsFyrt7o%3D
    • Babaya N, Fujisawa T, Nojima K, Itoi-Babaya M, Yamaji K, Yamada K, et al. Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14. Diabetologia. 2010;53(7):1362-71.
    • (2010) Diabetologia , vol.53 , Issue.7 , pp. 1362-1371
    • Babaya, N.1    Fujisawa, T.2    Nojima, K.3    Itoi-Babaya, M.4    Yamaji, K.5    Yamada, K.6
  • 16
    • 70449718904 scopus 로고    scopus 로고
    • Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice
    • 19505930 10.1093/cvr/cvp191 1:CAS:528:DC%2BD1MXhtFarsbnP
    • Hirata A, Maeda N, Hiuge A, Hibuse T, Fujita K, Okada T, et al. Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice. Cardiovasc Res. 2009;84(1):164-72.
    • (2009) Cardiovasc Res , vol.84 , Issue.1 , pp. 164-172
    • Hirata, A.1    Maeda, N.2    Hiuge, A.3    Hibuse, T.4    Fujita, K.5    Okada, T.6
  • 17
    • 34249682775 scopus 로고    scopus 로고
    • Chronic activation of liver X receptor induces β-cell apoptosis through hyperactivation of lipogenesis: Liver X receptor-mediated lipotoxicity in pancreatic β-cells
    • DOI 10.2337/db06-1059
    • Choe SS, Choi AH, Lee JW, Kim KH, Chung JJ, Park J, et al. Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis - liver X receptor-mediated lipotoxicity in pancreatic beta-cells. Diabetes. 2007;56(6):1534-43. (Pubitemid 46842606)
    • (2007) Diabetes , vol.56 , Issue.6 , pp. 1534-1543
    • Sung, S.C.1    Choi, A.H.2    Lee, J.-W.3    Kang, H.K.4    Chung, J.-J.5    Park, J.6    Lee, K.-M.7    Park, K.-G.8    Lee, I.-K.9    Jae, B.K.10
  • 19
    • 69349088117 scopus 로고    scopus 로고
    • Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex
    • 19641492 10.1038/nature08262 1:CAS:528:DC%2BD1MXpt1WhtLs%3D
    • Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, et al. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 2009;460(7259):1154-8.
    • (2009) Nature , vol.460 , Issue.7259 , pp. 1154-1158
    • Kajimura, S.1    Seale, P.2    Kubota, K.3    Lunsford, E.4    Frangioni, J.V.5    Gygi, S.P.6
  • 20
    • 77449124765 scopus 로고    scopus 로고
    • Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue
    • 19833890 10.2337/db09-0929 1:CAS:528:DC%2BC3cXmtVKgsg%3D%3D
    • Cheng Y, Meng QS, Wang CX, Li HK, Huang ZY, Chen SH, et al. Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue. Diabetes. 2010;59(1):17-25.
    • (2010) Diabetes , vol.59 , Issue.1 , pp. 17-25
    • Cheng, Y.1    Meng, Q.S.2    Wang, C.X.3    Li, H.K.4    Huang, Z.Y.5    Chen, S.H.6
  • 21
    • 46749125376 scopus 로고    scopus 로고
    • Transcriptional control of mitochondrial biogenesis: The central role of PGC-1α
    • DOI 10.1093/cvr/cvn098
    • Ventura-Clapier R, Garnier A, Veksler V. Transcriptional control of mitochondrial biogenesis: the central role of PGC-1alpha. Cardiovasc Res. 2008;79(2):208-17. (Pubitemid 351951611)
    • (2008) Cardiovascular Research , vol.79 , Issue.2 , pp. 208-217
    • Ventura-Clapier, R.1    Garnier, A.2    Veksler, V.3
  • 23
    • 11244348954 scopus 로고    scopus 로고
    • A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats
    • DOI 10.1096/fj.04-2291fje
    • Carmiel-Haggai M, Cederbaum AI, Nieto N. A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats. FASEB J. 2005;19(1):136-8. (Pubitemid 40069943)
    • (2005) FASEB Journal , vol.19 , Issue.1 , pp. 136-138
    • Carmiel-Haggai, M.1    Cederbaum, A.I.2    Nieto, N.3
  • 24
    • 33847006599 scopus 로고    scopus 로고
    • The Liver X Receptor (LXR) and hepatic lipogenesis: The carbohydrate-response element-binding protein is a target gene of LXR
    • DOI 10.1074/jbc.M605023200
    • Cha JY, Repa JJ. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem. 2007;282(1):743-51. (Pubitemid 47076632)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.1 , pp. 743-751
    • Cha, J.-Y.1    Repa, J.J.2
  • 27
    • 0348111308 scopus 로고    scopus 로고
    • Expression of the Insulin-responsive Glucose Transporter GLUT4 in Adipocytes Is Dependent on Liver X Receptor α
    • DOI 10.1074/jbc.M302287200
    • Dalen KT, Ulven SM, Bamberg K, Gustafsson JA, Nebb HI. Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. J Biol Chem. 2003;278(48):48283-91. (Pubitemid 37526713)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.48 , pp. 48283-48291
    • Dalen, K.T.1    Ulven, S.M.2    Bamberg, K.3    Gustafsson, J.-A.4    Nebb, H.I.5
  • 28
    • 0345461478 scopus 로고    scopus 로고
    • Putative metabolic effects of the liver X receptor (LXR)
    • 14749264 10.2337/diabetes.53.2007.S36 1:CAS:528:DC%2BD2cXhtlGqsLc%3D
    • Steffensen KR, Gustafsson JA. Putative metabolic effects of the liver X receptor (LXR). Diabetes. 2004;53 Suppl 1:S36-42.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Steffensen, K.R.1    Gustafsson, J.A.2
  • 30
    • 84861842833 scopus 로고    scopus 로고
    • Changes in glucose tolerance and leptin responsiveness of rats offered a choice of lard, sucrose, and chow
    • 10.1152/ajpregu.00477.2011 1:CAS:528:DC%2BC38XhtVGnsbbN
    • Harris RBS, Apolzan JW. Changes in glucose tolerance and leptin responsiveness of rats offered a choice of lard, sucrose, and chow. Am J Physiol Regul Integr. 2012;302(11):R1327-39.
    • (2012) Am J Physiol Regul Integr , vol.302 , Issue.11
    • Harris, R.B.S.1    Apolzan, J.W.2
  • 31
    • 4544235732 scopus 로고    scopus 로고
    • The role of uncoupling protein 1 in the metabolism and adiposity of RIIβ-protein kinase A-deficient mice
    • DOI 10.1210/me.2004-0194
    • Nolan MA, Sikorski MA, McKnight GS. The role of uncoupling protein 1 in the metabolism and adiposity of RII beta-protein kinase A-deficient mice. Mol Endocrinol. 2004;18(9):2302-11. (Pubitemid 39215258)
    • (2004) Molecular Endocrinology , vol.18 , Issue.9 , pp. 2302-2311
    • Nolan, M.A.1    Sikorski, M.A.2    McKnight, G.S.3
  • 32
    • 0345098365 scopus 로고    scopus 로고
    • The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse
    • DOI 10.1194/jlr.M300135-JLR200
    • Chisholm JW, Hong J, Mills SA, Lawn RM. The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. J Lipid Res. 2003;44(11):2039-48. (Pubitemid 37509619)
    • (2003) Journal of Lipid Research , vol.44 , Issue.11 , pp. 2039-2048
    • Chisholm, J.W.1    Hong, J.2    Mills, S.A.3    Lawn, R.M.4


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