Dietary heme iron and the risk of colorectal cancer with specific mutations in KRAS and APC

Carcinogenesis

Volumn 34, Issue 12, 2013, Pages 2757-2766

  Gilsing, Anne M J ^a   Fransen, Fiona ^a   de Kok, Theo M ^a   Goldbohm, Alexandra R ^b   Schouten, Leo J ^a   de Bruïne, Adriaan P ^a   van Engeland, Manon ^a   van den Brandt, Piet A ^a   de Goeij, Anton F P M ^a   Weijenberg, Matty P ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; CHLOROPHYLL; HEME; HEME IRON; K RAS PROTEIN; PROTEIN P53; UNCLASSIFIED DRUG;

ADENOMATOUS POLYPOSIS COLI GENE; ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; CALCIUM INTAKE; CANCER PATIENT; CANCER RISK; COHORT ANALYSIS; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; EXPOSURE; FAMILY HISTORY; FEMALE; FOLLOW UP; GENE OVEREXPRESSION; HAZARD RATIO; HUMAN; HUMAN TISSUE; IRON INTAKE; MAJOR CLINICAL STUDY; MALE; MEAT; NETHERLANDS; ONCOGENE K RAS; PHYSICAL ACTIVITY; POINT MUTATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SMOKING; TUMOR SUPPRESSOR GENE; VEGETABLE;

CASE-CONTROL STUDIES; COHORT STUDIES; COLORECTAL NEOPLASMS; FEMALE; GENES, APC; GENES, P53; GENES, RAS; HEME; HUMANS; IRON, DIETARY; MALE; MEAT; MIDDLE AGED; MUTATION; RISK; RISK FACTORS;

EID: 84886696254     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt290     Document Type: Article

References (63)

1. World Cancer Research Fund/American Institute for Cancer Research. (2007) Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. AICR, Washington, DC.
2. Larsson,S.C. et al. (2006) Meat consumption and risk of colorectal cancer: a meta-analysis of prospective studies. Int. J. Cancer, 119, 2657-2664.
3. Chan,D.S. et al. (2011) Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies. PLoS One, 6, e20456.
4. Service., U.S.D.o.A.a.A.R. USDA National Nutrient Database for Standard Reference, Release 21. Internet: Nutrient Data Laboratory Home Page, http://www.ars.usda.gov/nutrientdata (22 November 2011, date last accessed).
5. Larsson,S.C. et al. (2005) Re: heme iron, zinc, alcohol consumption, and risk of colon cancer. J. Natl. Cancer Inst., 97, 232-233; author reply 233-234.
6. Lee,D.H. et al. (2004) Heme iron, zinc, alcohol consumption, and colon cancer: Iowa Women's Health Study. J. Natl. Cancer Inst., 96, 403-407.
7. Balder,H.F. et al. (2006) Heme and chlorophyll intake and risk of colorectal cancer in the Netherlands cohort study. Cancer Epidemiol. Biomarkers Prev., 15, 717-725.
8. Kabat,G.C. et al. (2007) A cohort study of dietary iron and heme iron intake and risk of colorectal cancer in women. Br. J. Cancer, 97, 118-122.
9. Cross,A.J. et al. (2010) A large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this association. Cancer Res., 70, 2406-2414.
10. Zhang,X. et al. (2011) A prospective study of intakes of zinc and heme iron and colorectal cancer risk in men and women. Cancer Causes Control, 22, 1627-1637.
11. Bastide,N.M. et al. (2011) Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved. Cancer Prev. Res., 4, 177-184.
12. Fearon,E.R. (2011) Molecular genetics of colorectal cancer. Annu. Rev. Pathol., 6, 479-507.
13. Cross,A.J. et al. (2003) Haem, not protein or inorganic iron, is responsible for endogenous intestinal N-nitrosation arising from red meat. Cancer Res., 63, 2358-2360.
14. Hebels,D.G. et al. (2010) Radical mechanisms in nitrosamine- and nitrosamide- induced whole-genome gene expression modulations in Caco-2 cells. Toxicol. Sci., 116, 194-205.
15. Shuker,D.E. et al. (1997) Nitrosated glycine derivatives as a potential source of O6-methylguanine in DNA. Cancer Res., 57, 366-369.
16. Saffhill,R. et al. (1985) Mechanisms of carcinogenesis induced by alkylating agents. Biochim. Biophys. Acta, 823, 111-145.
17. Jacoby,R.F. et al. (1992) K-ras oncogene mutations in rat colon tumors induced by N-methyl-N-nitrosourea. Carcinogenesis, 13, 45-49.
18. Gottschalg,E. et al. (2007) Potassium diazoacetate-induced p53 mutations in vitro in relation to formation of O6-carboxymethyl- and O6-methyl- 2'-deoxyguanosine DNA adducts: relevance for gastrointestinal cancer. Carcinogenesis, 28, 356-362.
19. Tappel,A. (2007) Heme of consumed red meat can act as a catalyst of oxidative damage and could initiate colon, breast and prostate cancers, heart disease and other diseases. Med. Hypotheses, 68, 562-564.
20. Shibutani,S. et al. (1991) Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature, 349, 431-434.
21. Sesink,A.L. et al. (1999) Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme. Cancer Res., 59, 5704-5709.
22. Sesink,A.L. et al. (2000) Red meat and colon cancer: dietary haem, but not fat, has cytotoxic and hyperproliferative effects on rat colonic epithelium. Carcinogenesis, 21, 1909-1915.
23. IJssennagger,N. et al. (2012) Dietary haem stimulates epithelial cell turnover by downregulating feedback inhibitors of proliferation in murine colon. Gut, 61, 1041-1049.
24. Ahearn,T.U. et al. (2012) Markers of the APC/ß-catenin signaling pathway as potential treatable, preneoplastic biomarkers of risk for colorectal neoplasms. Cancer Epidemiol. Biomarkers Prev., 21, 969-979.
25. Naguib,A. et al. (2010) Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study. BMC Cancer, 10, 99.
26. Gay,L.J. et al. (2012) Dietary, lifestyle and clinicopathological factors associated with APC mutations and promoter methylation in colorectal cancers from the EPIC-Norfolk study. J. Pathol., 228, 405-415.
27. Brink,M. et al. (2005) Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study. Br. J. Cancer, 92, 1310-1320.
28. Lüchtenborg,M. et al. (2005) Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: a prospective cohort study (The Netherlands). Cancer Causes Control, 16, 1041-1054.
29. Park,J.Y. et al. (2010) Lifestyle factors and p53 mutation patterns in colorectal cancer patients in the EPIC-Norfolk study. Mutagenesis, 25, 351-358.
30. Freedman,A.N. et al. (1996) Familial and nutritional risk factors for p53 overexpression in colorectal cancer. Cancer Epidemiol. Biomarkers Prev., 5, 285-291.
31. Voskuil,D.W. et al. (1999) p53 over-expression and p53 mutations in colon carcinomas: relation to dietary risk factors. Int. J. Cancer, 81, 675-681.
32. Sesink,A.L. et al. (2001) Red meat and colon cancer: dietary haem-induced colonic cytotoxicity and epithelial hyperproliferation are inhibited by calcium. Carcinogenesis, 22, 1653-1659.
33. de Vogel,J. et al. (2005) Green vegetables, red meat and colon cancer: chlorophyll prevents the cytotoxic and hyperproliferative effects of haem in rat colon. Carcinogenesis, 26, 387-393.
34. van den Brandt,P.A. et al. (1990) A large-scale prospective cohort study on diet and cancer in The Netherlands. J. Clin. Epidemiol., 43, 285-295.
35. Goldbohm,R.A. et al. (1994) Estimation of the coverage of Dutch municipalities by cancer registries and PALGA based on hospital discharge data. Tijdschrift Soc Gezondheidsz, 72, 80-84.
36. (1986) Nevo Table: Dutch Food Composition Table 1986-1987 (in Dutch). Voorlichtingsbureau voor de voeding, The Hague, The Natherlands.
37. Goldbohm,R.A. et al. (1994) Validation of a dietary questionnaire used in a large-scale prospective cohort study on diet and cancer. Eur. J. Clin. Nutr., 48, 253-265.
38. Goldbohm,R.A. et al. (1995) Reproducibility of a food frequency questionnaire and stability of dietary habits determined from five annually repeated measurements. Eur. J. Clin. Nutr., 49, 420-429.
39. Brink,M. et al. (2003) K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study. Carcinogenesis, 24, 703-710.
40. Lüchtenborg,M. et al. (2004) APC mutations in sporadic colorectal carcinomas from The Netherlands Cohort Study. Carcinogenesis, 25, 1219-1226.
41. Bongaerts,B.W. et al. (2007) Alcohol consumption and distinct molecular pathways to colorectal cancer. Br. J. Nutr., 97, 430-434.
42. Schouten,L.J. et al. (1993) Quality of cancer registry data: a comparison of data provided by clinicians with those of registration personnel. Br. J. Cancer, 68, 974-977.
43. Volovics,A. et al. (1997) Methods for the analysis of case-cohort studies. Biom. J., 39, 195-214.
44. Lin,D.Y. et al. (1989) The robust inference for the Cox proportional hazards model. J. AM Stat. Assoc., 1074-1078.
45. Wacholder,S. et al. (1989) Alternative variance and efficiency calculations for the case-cohort design. Biometrika, 76, 117-123.
46. de Vogel,S. et al. (2008) Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer. Carcinogenesis, 29, 1765-1773.
47. Willett,W. (1998) Nutritional Epidemiology. Oxford University Press, New York, NY.
48. Lewin,M.H. et al. (2006) Red meat enhances the colonic formation of the DNA adduct O6-carboxymethyl guanine: implications for colorectal cancer risk. Cancer Res., 66, 1859-1865.
49. Horsfall,M.J. et al. (1990) Mutational specificity of alkylating agents and the influence of DNA repair. Environ. Mol. Mutagen., 15, 107-122.
50. Bartsch,H. et al. (1989) Carcinogenic nitrosamines: free radical aspects of their action. Free Radic. Biol. Med., 7, 637-644.
51. Diergaarde,B. et al. (2005) Dietary factors and truncating APC mutations in sporadic colorectal adenomas. Int. J. Cancer, 113, 126-132.
52. Diergaarde,B. et al. (2003) Dietary factors and the occurrence of truncating APC mutations in sporadic colon carcinomas: a Dutch population-based study. Carcinogenesis, 24, 283-290.
53. Fearon,E.R. et al. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
54. Dix,B. et al. (1994) Comparison of p53 gene mutation and protein overexpression in colorectal carcinomas. Br. J. Cancer, 70, 585-590.
55. Cripps,K.J. et al. (1994) A study of stabilisation of p53 protein versus point mutation in colorectal carcinoma. Oncogene, 9, 2739-2743.
56. Povey,A.C. et al. (2000) Elevated levels of the pro-carcinogenic adduct, O(6)-methylguanine, in normal DNA from the cancer prone regions of the large bowel. Gut, 47, 362-365.
57. Ferrucci,L.M. et al. (2009) Dietary meat intake in relation to colorectal adenoma in asymptomatic women. Am. J. Gastroenterol., 104, 1231-1240.
58. Cross,A. et al. (2012) Developing a heme iron database for meats according to meat type, cooking method and doneness level. Food Nutr. Sci.., 3, 905-913.
59. Cross,A.J. et al. (2004) Meat-related mutagens/carcinogens in the etiology of colorectal cancer. Environ. Mol. Mutagen., 44, 44-55.
60. Sinha,R. et al. (2005) Development of a food frequency questionnaire module and databases for compounds in cooked and processed meats. Mol. Nutr. Food Res., 49, 648-655.
61. Dingley,K.H. et al. (1999) DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relevant dose of 2-amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Epidemiol. Biomarkers Prev., 8, 507-512.
62. Turteltaub,K.W. et al. (1999) Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses. Cancer Lett., 143, 149-155.
63. Hebels,D.G. et al. (2012) Red meat intake-induced increases in fecal water genotoxicity correlate with pro-carcinogenic gene expression changes in the human colon. Food Chem. Toxicol., 50, 95-103.