Activation of ClpP protease by ADEP antibiotics: Insights from hydrogen exchange mass spectrometry

Journal of Molecular Biology

Volumn 425, Issue 22, 2013, Pages 4508-4519

  Sowole, Modupeola A ^a   Alexopoulos, John A ^b   Cheng, Yi Qiang ^c   Ortega, Joaquin ^b   Konermann, Lars ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

caseinolytic protease P; conformational dynamics; electrospray ionization; hydrophobic clustering; ligand binding

Indexed keywords

ACYLDEPSIPEPTIDE; ANTIBIOTIC AGENT; BACTERIAL ENZYME; DEUTERIUM; ENDOPEPTIDASE CLP; HYDROGEN; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BACTERIAL OUTER MEMBRANE; CRYOELECTRON MICROSCOPY; ENZYME ACTIVATION; ENZYME STRUCTURE; ENZYME SUBUNIT; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HYDROGEN BOND; HYDROGEN DEUTERIUM EXCHANGE MASS SPECTROMETRY; HYDROPHOBICITY; KINETICS; LIGAND BINDING; MASS SPECTROMETER; MASS SPECTROMETRY; MEASUREMENT; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS;

BACTERIA (MICROORGANISMS);

EID: 84886642731     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.08.005     Document Type: Article

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