-
1
-
-
70350348011
-
NMR spectroscopy brings invisible protein states into focus
-
Baldwin A.J., Kay L.E. NMR spectroscopy brings invisible protein states into focus. Nat. Chem. Biol. 2009, 5:808-814.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 808-814
-
-
Baldwin, A.J.1
Kay, L.E.2
-
2
-
-
14544297527
-
From proteomic inventory to architecture
-
Baumeister W. From proteomic inventory to architecture. FEBS Lett. 2005, 579:933-937.
-
(2005)
FEBS Lett.
, vol.579
, pp. 933-937
-
-
Baumeister, W.1
-
3
-
-
0032215219
-
At sixes and sevens: characterization of the symmetry mismatch of the ClpAP chaperone-assisted protease
-
Beuron F., Maurizi M.R., Belnap D.M., Kocsis E., Booy F.P., et al. At sixes and sevens: characterization of the symmetry mismatch of the ClpAP chaperone-assisted protease. J. Struct. Biol. 1998, 123:248-259.
-
(1998)
J. Struct. Biol.
, vol.123
, pp. 248-259
-
-
Beuron, F.1
Maurizi, M.R.2
Belnap, D.M.3
Kocsis, E.4
Booy, F.P.5
-
4
-
-
31344467469
-
The asymmetry in the mature amino-terminus of ClpP facilitates a local symmetry match in ClpAP and ClpXP complexes
-
Bewley M.C., Graziano V., Griffin K., Flanagan J.M. The asymmetry in the mature amino-terminus of ClpP facilitates a local symmetry match in ClpAP and ClpXP complexes. J. Struct. Biol. 2006, 153:113-128.
-
(2006)
J. Struct. Biol.
, vol.153
, pp. 113-128
-
-
Bewley, M.C.1
Graziano, V.2
Griffin, K.3
Flanagan, J.M.4
-
5
-
-
58349103347
-
Turned on for degradation: ATPase-independent degradation by ClpP
-
Bewley M.C., Graziano V., Griffin K., Flanagan J.M. Turned on for degradation: ATPase-independent degradation by ClpP. J. Struct. Biol. 2009, 165:118-125.
-
(2009)
J. Struct. Biol.
, vol.165
, pp. 118-125
-
-
Bewley, M.C.1
Graziano, V.2
Griffin, K.3
Flanagan, J.M.4
-
6
-
-
27144460621
-
Dysregulation of bacterial proteolytic machinery by a new class of antibiotics
-
Brotz-Oesterhelt H., Beyer D., Kroll H.P., Endermann R., Ladel C., et al. Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. Nat. Med. 2005, 11:1082-1087.
-
(2005)
Nat. Med.
, vol.11
, pp. 1082-1087
-
-
Brotz-Oesterhelt, H.1
Beyer, D.2
Kroll, H.P.3
Endermann, R.4
Ladel, C.5
-
7
-
-
33645805882
-
Self-compartmentalized bacterial proteases and pathogenesis
-
Butler S.M., Festa R.A., Pearce M.J., Darwin K.H. Self-compartmentalized bacterial proteases and pathogenesis. Mol. Microbiol. 2006, 60:553-562.
-
(2006)
Mol. Microbiol.
, vol.60
, pp. 553-562
-
-
Butler, S.M.1
Festa, R.A.2
Pearce, M.J.3
Darwin, K.H.4
-
8
-
-
38749149916
-
Protein crystallization: from purified protein to diffraction-quality crystal
-
Chayen N.E., Saridakis E. Protein crystallization: from purified protein to diffraction-quality crystal. Nat. Methods 2008, 5:147-153.
-
(2008)
Nat. Methods
, vol.5
, pp. 147-153
-
-
Chayen, N.E.1
Saridakis, E.2
-
9
-
-
0032055408
-
A human homologue of Escherichia coli ClpP caseinolytic protease: recombinant expression, intracellular processing and subcellular localization
-
Corydon T.J., Bross P., Holst H.U., Neve S., Kristiansen K., et al. A human homologue of Escherichia coli ClpP caseinolytic protease: recombinant expression, intracellular processing and subcellular localization. Biochem. J. 1998, 331(Pt 1):309-316.
-
(1998)
Biochem. J.
, vol.331
, Issue.PART 1
, pp. 309-316
-
-
Corydon, T.J.1
Bross, P.2
Holst, H.U.3
Neve, S.4
Kristiansen, K.5
-
10
-
-
0024007766
-
Cryo-electron microscopy of vitrified specimens
-
Dubochet J., Adrian M., Chang J.J., Homo J.C., Lepault J., et al. Cryo-electron microscopy of vitrified specimens. Q. Rev. Biophys. 1988, 21:129-228.
-
(1988)
Q. Rev. Biophys.
, vol.21
, pp. 129-228
-
-
Dubochet, J.1
Adrian, M.2
Chang, J.J.3
Homo, J.C.4
Lepault, J.5
-
11
-
-
77951980628
-
Binding of the CLP-A unfoldase opens the axial gate of CLP-P peptidase
-
Effantin G., Maurizi M.R., Steven A.C. Binding of the CLP-A unfoldase opens the axial gate of CLP-P peptidase. J. Biol. Chem. 2010, 285:14834-14840.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 14834-14840
-
-
Effantin, G.1
Maurizi, M.R.2
Steven, A.C.3
-
12
-
-
0030936847
-
Protein quality control: triage by chaperones and proteases
-
Gottesman S., Wickner S., Maurizi M.R. Protein quality control: triage by chaperones and proteases. Genes Dev. 1997, 11:815-823.
-
(1997)
Genes Dev.
, vol.11
, pp. 815-823
-
-
Gottesman, S.1
Wickner, S.2
Maurizi, M.R.3
-
13
-
-
18144426344
-
The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formation
-
Gribun A., Kimber M.S., Ching R., Sprangers R., Fiebig K.M., et al. The ClpP double ring tetradecameric protease exhibits plastic ring-ring interactions, and the N termini of its subunits form flexible loops that are essential for ClpXP and ClpAP complex formation. J. Biol. Chem. 2005, 280:16185-16196.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 16185-16196
-
-
Gribun, A.1
Kimber, M.S.2
Ching, R.3
Sprangers, R.4
Fiebig, K.M.5
-
14
-
-
0032524297
-
Enzymatic and structural similarities between the Escherichia coli ATP-dependent proteases, ClpXP and ClpAP
-
Grimaud R., Kessel M., Beuron F., Steven A.C., Maurizi M.R. Enzymatic and structural similarities between the Escherichia coli ATP-dependent proteases, ClpXP and ClpAP. J. Biol. Chem. 1998, 273:12476-12481.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 12476-12481
-
-
Grimaud, R.1
Kessel, M.2
Beuron, F.3
Steven, A.C.4
Maurizi, M.R.5
-
15
-
-
0032514746
-
The role of the ClpA chaperone in proteolysis by ClpAP
-
Hoskins J.R., Pak M., Maurizi M.R., Wickner S. The role of the ClpA chaperone in proteolysis by ClpAP. Proc. Natl. Acad. Sci. USA 1998, 95:12135-12140.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 12135-12140
-
-
Hoskins, J.R.1
Pak, M.2
Maurizi, M.R.3
Wickner, S.4
-
16
-
-
33846654174
-
Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1
-
Ingvarsson H., Mate M.J., Hogbom M., Portnoi D., Benaroudj N., et al. Insights into the inter-ring plasticity of caseinolytic proteases from the X-ray structure of Mycobacterium tuberculosis ClpP1. Acta Crystallogr. D Biol. Crystallogr. 2007, 63:249-259.
-
(2007)
Acta Crystallogr. D Biol. Crystallogr.
, vol.63
, pp. 249-259
-
-
Ingvarsson, H.1
Mate, M.J.2
Hogbom, M.3
Portnoi, D.4
Benaroudj, N.5
-
17
-
-
0035836749
-
Translocation pathway of protein substrates in ClpAP protease
-
Ishikawa T., Beuron F., Kessel M., Wickner S., Maurizi M.R., et al. Translocation pathway of protein substrates in ClpAP protease. Proc. Natl. Acad. Sci. USA 2001, 98:4328-4333.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4328-4333
-
-
Ishikawa, T.1
Beuron, F.2
Kessel, M.3
Wickner, S.4
Maurizi, M.R.5
-
18
-
-
54349084780
-
The ClpP N-terminus coordinates substrate access with protease active site reactivity
-
Jennings L.D., Bohon J., Chance M.R., Licht S. The ClpP N-terminus coordinates substrate access with protease active site reactivity. Biochemistry 2008, 47:11031-11040.
-
(2008)
Biochemistry
, vol.47
, pp. 11031-11040
-
-
Jennings, L.D.1
Bohon, J.2
Chance, M.R.3
Licht, S.4
-
19
-
-
55249118150
-
ClpP hydrolyzes a protein substrate processively in the absence of the ClpA ATPase: mechanistic studies of ATP-independent proteolysis
-
Jennings L.D., Lun D.S., Medard M., Licht S. ClpP hydrolyzes a protein substrate processively in the absence of the ClpA ATPase: mechanistic studies of ATP-independent proteolysis. Biochemistry 2008, 47:11536-11546.
-
(2008)
Biochemistry
, vol.47
, pp. 11536-11546
-
-
Jennings, L.D.1
Lun, D.S.2
Medard, M.3
Licht, S.4
-
20
-
-
7444254844
-
Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP
-
Kang S.G., Maurizi M.R., Thompson M., Mueser T., Ahvazi B. Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP. J. Struct. Biol. 2004, 148:338-352.
-
(2004)
J. Struct. Biol.
, vol.148
, pp. 338-352
-
-
Kang, S.G.1
Maurizi, M.R.2
Thompson, M.3
Mueser, T.4
Ahvazi, B.5
-
21
-
-
0023184358
-
A multiple-component, ATP-dependent protease from Escherichia coli
-
Katayama-Fujimura Y., Gottesman S., Maurizi M.R. A multiple-component, ATP-dependent protease from Escherichia coli. J Biol Chem 1987, 262:4477-4485.
-
(1987)
J Biol Chem
, vol.262
, pp. 4477-4485
-
-
Katayama-Fujimura, Y.1
Gottesman, S.2
Maurizi, M.R.3
-
22
-
-
14844361989
-
NMR studies of protein structure and dynamics
-
Kay L.E. NMR studies of protein structure and dynamics. J. Magn. Reson. 2005, 173:193-207.
-
(2005)
J. Magn. Reson.
, vol.173
, pp. 193-207
-
-
Kay, L.E.1
-
23
-
-
0029126356
-
Homology in structural organization between E. coli ClpAP protease and the eukaryotic 26S proteasome
-
Kessel M., Maurizi M.R., Kim B., Kocsis E., Trus B.L., et al. Homology in structural organization between E. coli ClpAP protease and the eukaryotic 26S proteasome. J. Mol. Biol. 1995, 250:587-594.
-
(1995)
J. Mol. Biol.
, vol.250
, pp. 587-594
-
-
Kessel, M.1
Maurizi, M.R.2
Kim, B.3
Kocsis, E.4
Trus, B.L.5
-
24
-
-
44149116183
-
The structural basis for the activation and peptide recognition of bacterial ClpP
-
Kim D.Y., Kim K.K. The structural basis for the activation and peptide recognition of bacterial ClpP. J. Mol. Biol. 2008, 379:760-771.
-
(2008)
J. Mol. Biol.
, vol.379
, pp. 760-771
-
-
Kim, D.Y.1
Kim, K.K.2
-
25
-
-
0035122947
-
Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase
-
Kim Y.I., Levchenko I., Fraczkowska K., Woodruff R.V., Sauer R.T., et al. Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase. Nat. Struct. Biol. 2001, 8:230-233.
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 230-233
-
-
Kim, Y.I.1
Levchenko, I.2
Fraczkowska, K.3
Woodruff, R.V.4
Sauer, R.T.5
-
26
-
-
71749110235
-
The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease
-
Kirstein J., Hoffmann A., Lilie H., Schmidt R., Rubsamen-Waigmann H., et al. The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease. EMBO Mol. Med. 2009, 1:37-49.
-
(2009)
EMBO Mol. Med.
, vol.1
, pp. 37-49
-
-
Kirstein, J.1
Hoffmann, A.2
Lilie, H.3
Schmidt, R.4
Rubsamen-Waigmann, H.5
-
27
-
-
84859926157
-
Structural insights into the conformational diversity of ClpP from Bacillus subtilis
-
Lee B.G., Kim M.K., Song H.K. Structural insights into the conformational diversity of ClpP from Bacillus subtilis. Mol. Cells 2011, 32:589-595.
-
(2011)
Mol. Cells
, vol.32
, pp. 589-595
-
-
Lee, B.G.1
Kim, M.K.2
Song, H.K.3
-
28
-
-
77950519954
-
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
-
Lee B.G., Park E.Y., Lee K.E., Jeon H., Sung K.H., et al. Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Nat. Struct. Mol. Biol. 2010, 17:471-478.
-
(2010)
Nat. Struct. Mol. Biol.
, vol.17
, pp. 471-478
-
-
Lee, B.G.1
Park, E.Y.2
Lee, K.E.3
Jeon, H.4
Sung, K.H.5
-
29
-
-
77953694169
-
Control of substrate gating and translocation into ClpP by channel residues and ClpX binding
-
Lee M.E., Baker T.A., Sauer R.T. Control of substrate gating and translocation into ClpP by channel residues and ClpX binding. J. Mol. Biol. 2010, 399:707-718.
-
(2010)
J. Mol. Biol.
, vol.399
, pp. 707-718
-
-
Lee, M.E.1
Baker, T.A.2
Sauer, R.T.3
-
30
-
-
80053133921
-
Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease
-
Leung E., Datti A., Cossette M., Goodreid J., McCaw S.E., et al. Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease. Chem. Biol. 2011, 18:1167-1178.
-
(2011)
Chem. Biol.
, vol.18
, pp. 1167-1178
-
-
Leung, E.1
Datti, A.2
Cossette, M.3
Goodreid, J.4
McCaw, S.E.5
-
31
-
-
77956947687
-
Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: a model for the ClpX/ClpA-bound state of ClpP
-
Li D.H., Chung Y.S., Gloyd M., Joseph E., Ghirlando R., et al. Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: a model for the ClpX/ClpA-bound state of ClpP. Chem. Biol. 2010, 17:959-969.
-
(2010)
Chem. Biol.
, vol.17
, pp. 959-969
-
-
Li, D.H.1
Chung, Y.S.2
Gloyd, M.3
Joseph, E.4
Ghirlando, R.5
-
32
-
-
34250850205
-
Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease
-
Martin A., Baker T.A., Sauer R.T. Distinct static and dynamic interactions control ATPase-peptidase communication in a AAA+ protease. Mol. Cell 2007, 27:41-52.
-
(2007)
Mol. Cell
, vol.27
, pp. 41-52
-
-
Martin, A.1
Baker, T.A.2
Sauer, R.T.3
-
33
-
-
0025358672
-
Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli
-
Maurizi M.R., Clark W.P., Katayama Y., Rudikoff S., Pumphrey J., et al. Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli. J. Biol. Chem. 1990, 265:12536-12545.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 12536-12545
-
-
Maurizi, M.R.1
Clark, W.P.2
Katayama, Y.3
Rudikoff, S.4
Pumphrey, J.5
-
34
-
-
0037119954
-
Alternating translocation of protein substrates from both ends of ClpXP protease
-
Ortega J., Lee H.S., Maurizi M.R., Steven A.C. Alternating translocation of protein substrates from both ends of ClpXP protease. EMBO J. 2002, 21:4938-4949.
-
(2002)
EMBO J.
, vol.21
, pp. 4938-4949
-
-
Ortega, J.1
Lee, H.S.2
Maurizi, M.R.3
Steven, A.C.4
-
35
-
-
1642369829
-
ClpA and ClpX ATPases bind simultaneously to opposite ends of ClpP peptidase to form active hybrid complexes
-
Ortega J., Lee H.S., Maurizi M.R., Steven A.C. ClpA and ClpX ATPases bind simultaneously to opposite ends of ClpP peptidase to form active hybrid complexes. J. Struct. Biol. 2004, 146:217-226.
-
(2004)
J. Struct. Biol.
, vol.146
, pp. 217-226
-
-
Ortega, J.1
Lee, H.S.2
Maurizi, M.R.3
Steven, A.C.4
-
36
-
-
0034502532
-
Visualization of substrate binding and translocation by the ATP-dependent protease
-
Ortega J., Singh S.K., Ishikawa T., Maurizi M.R., Steven A.C. Visualization of substrate binding and translocation by the ATP-dependent protease. ClpXP. Mol. Cell 2000, 6:1515-1521.
-
(2000)
ClpXP. Mol. Cell
, vol.6
, pp. 1515-1521
-
-
Ortega, J.1
Singh, S.K.2
Ishikawa, T.3
Maurizi, M.R.4
Steven, A.C.5
-
37
-
-
80054829705
-
Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ
-
Sass P., Josten M., Famulla K., Schiffer G., Sahl H.G., et al. Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Proc. Natl. Acad. Sci. USA 2011, 108:17474-17479.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 17474-17479
-
-
Sass, P.1
Josten, M.2
Famulla, K.3
Schiffer, G.4
Sahl, H.G.5
-
38
-
-
79959389010
-
AAA+ proteases: ATP-fueled machines of protein destruction
-
Sauer R.T., Baker T.A. AAA+ proteases: ATP-fueled machines of protein destruction. Annu. Rev. Biochem. 2011, 80:587-612.
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 587-612
-
-
Sauer, R.T.1
Baker, T.A.2
-
39
-
-
5344269437
-
Sculpting the proteome with AAA(+) proteases and disassembly machines
-
Sauer R.T., Bolon D.N., Burton B.M., Burton R.E., Flynn J.M., et al. Sculpting the proteome with AAA(+) proteases and disassembly machines. Cell 2004, 119:9-18.
-
(2004)
Cell
, vol.119
, pp. 9-18
-
-
Sauer, R.T.1
Bolon, D.N.2
Burton, B.M.3
Burton, R.E.4
Flynn, J.M.5
-
40
-
-
0033539690
-
ClpA and ClpP remain associated during multiple rounds of ATP-dependent protein degradation by ClpAP protease
-
Singh S.K., Guo F., Maurizi M.R. ClpA and ClpP remain associated during multiple rounds of ATP-dependent protein degradation by ClpAP protease. Biochemistry 1999, 38:14906-14915.
-
(1999)
Biochemistry
, vol.38
, pp. 14906-14915
-
-
Singh, S.K.1
Guo, F.2
Maurizi, M.R.3
-
41
-
-
0034254908
-
Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP
-
Singh S.K., Grimaud R., Hoskins J.R., Wickner S., Maurizi M.R. Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP. Proc. Natl. Acad. Sci. USA 2000, 97:8898-8903.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8898-8903
-
-
Singh, S.K.1
Grimaud, R.2
Hoskins, J.R.3
Wickner, S.4
Maurizi, M.R.5
-
42
-
-
28044440088
-
Quantitative NMR spectroscopy of supramolecular complexes: dynamic side pores in ClpP are important for product release
-
Sprangers R., Gribun A., Hwang P.M., Houry W.A., Kay L.E. Quantitative NMR spectroscopy of supramolecular complexes: dynamic side pores in ClpP are important for product release. Proc. Natl. Acad. Sci. USA 2005, 102:16678-16683.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 16678-16683
-
-
Sprangers, R.1
Gribun, A.2
Hwang, P.M.3
Houry, W.A.4
Kay, L.E.5
-
43
-
-
33749247217
-
Crystal structure at 1.9A of E. coli ClpP with a peptide covalently bound at the active site
-
Szyk A., Maurizi M.R. Crystal structure at 1.9A of E. coli ClpP with a peptide covalently bound at the active site. J. Struct. Biol. 2006, 156:165-174.
-
(2006)
J. Struct. Biol.
, vol.156
, pp. 165-174
-
-
Szyk, A.1
Maurizi, M.R.2
-
44
-
-
0028365133
-
Processive degradation of proteins by the ATP-dependent Clp protease from Escherichia coli. Requirement for the multiple array of active sites in ClpP but not ATP hydrolysis
-
Thompson M.W., Singh S.K., Maurizi M.R. Processive degradation of proteins by the ATP-dependent Clp protease from Escherichia coli. Requirement for the multiple array of active sites in ClpP but not ATP hydrolysis. J. Biol. Chem. 1994, 269:18209-18215.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 18209-18215
-
-
Thompson, M.W.1
Singh, S.K.2
Maurizi, M.R.3
-
45
-
-
0030691115
-
The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysis
-
Wang J., Hartling J.A., Flanagan J.M. The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysis. Cell 1997, 91:447-456.
-
(1997)
Cell
, vol.91
, pp. 447-456
-
-
Wang, J.1
Hartling, J.A.2
Flanagan, J.M.3
-
46
-
-
0033520987
-
Posttranslational quality control: folding, refolding, and degrading proteins
-
Wickner S., Maurizi M.R., Gottesman S. Posttranslational quality control: folding, refolding, and degrading proteins. Science 1999, 286:1888-1893.
-
(1999)
Science
, vol.286
, pp. 1888-1893
-
-
Wickner, S.1
Maurizi, M.R.2
Gottesman, S.3
-
47
-
-
0024552829
-
Protease Ti from Escherichia coli requires ATP hydrolysis for protein breakdown but not for hydrolysis of small peptides
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Woo K.M., Chung W.J., Ha D.B., Goldberg A.L., Chung C.H. Protease Ti from Escherichia coli requires ATP hydrolysis for protein breakdown but not for hydrolysis of small peptides. J. Biol. Chem. 1989, 264:2088-2091.
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(1989)
J. Biol. Chem.
, vol.264
, pp. 2088-2091
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Woo, K.M.1
Chung, W.J.2
Ha, D.B.3
Goldberg, A.L.4
Chung, C.H.5
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