Activators of Cylindrical Proteases as Antimicrobials: Identification and Development of Small Molecule Activators of ClpP Protease

Chemistry and Biology

Volumn 18, Issue 9, 2011, Pages 1167-1178

  Leung, Elisa ^a   Datti, Alessandro ^b,c   Cossette, Michele ^d   Goodreid, Jordan ^d   McCaw, Shannon E ^a   Mah, Michelle ^a   Nakhamchik, Alina ^a   Ogata, Koji ^e,h   El Bakkouri, Majida ^a   Cheng, Yi Qiang ^f   Wodak, Shoshana J ^a,e   Eger, Bryan T ^a,g   Pai, Emil F ^a,g   Liu, Jun ^a   Gray Owen, Scott ^a   Batey, Robert A ^d   Houry, Walid A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF PERUGIA   (Italy)

^d UNIVERSITY OF TORONTO   (Canada)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

^f UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^g PRINCESS MARGARET HOSPITAL   (Canada)

^h RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; CHAPERONE; ENDOPEPTIDASE CLP; ESCHERICHIA COLI PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; BINDING SITE; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; ESCHERICHIA COLI; GENETICS; METABOLISM; MICROBIOLOGICAL EXAMINATION; MOLECULAR LIBRARY; PROTEIN TERTIARY STRUCTURE;

ANTI-BACTERIAL AGENTS; BINDING SITES; COMPUTER SIMULATION; ENDOPEPTIDASE CLP; ENZYME ACTIVATION; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MICROBIAL SENSITIVITY TESTS; MOLECULAR CHAPERONES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 80053133921     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2011.07.023     Document Type: Article

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