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Volumn 2, Issue 3, 2012, Pages

Leucine-rich repeat kinase 2 for beginners: Six key questions

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; LEUCINE RICH REPEAT KINASE 2; LRRK2 PROTEIN, HUMAN; PARKIN; PROTEIN SERINE THREONINE KINASE; TAU PROTEIN; UBIQUITIN PROTEIN LIGASE;

EID: 84886642469     PISSN: None     EISSN: 21571422     Source Type: Journal    
DOI: 10.1101/cshperspect.a009407     Document Type: Article
Times cited : (31)

References (73)
  • 1
    • 70349991886 scopus 로고    scopus 로고
    • LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
    • Alegre-Abarrategui J, Christian H, Lufino MM, Mutihac R, Venda LL, AnsorgeO, Wade-Martins R. 2009. LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum Mol Genet 18: 4022-4034.
    • (2009) Hum Mol Genet , vol.18 , pp. 4022-4034
    • Alegre-Abarrategui, J.1    Christian, H.2    Lufino, M.M.3    Mutihac, R.4    Venda, L.L.5    Ansorge, O.6    Wade-Martins, R.7
  • 5
    • 33644877400 scopus 로고    scopus 로고
    • 14-3-3 Proteins: A number of functions for a numbered protein
    • Bridges D, Moorhead GB. 2005. 14-3-3 Proteins: A number of functions for a numbered protein. Sci STKE 2005: re10.
    • (2005) Sci STKE , vol.2005
    • Bridges, D.1    Moorhead, G.B.2
  • 6
    • 21544458763 scopus 로고    scopus 로고
    • Axonal dynactin p150Glued transports caspase-8 to drive retrograde olfactory receptor neuron apoptosis
    • Carson C, Saleh M, Fung FW, Nicholson DW, Roskams AJ. 2005. Axonal dynactin p150Glued transports caspase-8 to drive retrograde olfactory receptor neuron apoptosis. J Neurosci 25: 6092-6104.
    • (2005) J Neurosci , vol.25 , pp. 6092-6104
    • Carson, C.1    Saleh, M.2    Fung, F.W.3    Nicholson, D.W.4    Roskams, A.J.5
  • 9
    • 40349101849 scopus 로고    scopus 로고
    • Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
    • Deng J, Lewis PA, Greggio E, Sluch E, Beilina A, Cookson MR. 2008. Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proc Natl Acad Sci 105: 1499-1504.
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 1499-1504
    • Deng, J.1    Lewis, P.A.2    Greggio, E.3    Sluch, E.4    Beilina, A.5    Cookson, M.R.6
  • 10
    • 77956655427 scopus 로고    scopus 로고
    • Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization
    • Dzamko N, Deak M, Hentati F, Reith AD, Prescott AR, Alessi DR, Nichols RJ. 2010. Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization. Biochem J 430: 405-413.
    • (2010) Biochem J , vol.430 , pp. 405-413
    • Dzamko, N.1    Deak, M.2    Hentati, F.3    Reith, A.D.4    Prescott, A.R.5    Alessi, D.R.6    Nichols, R.J.7
  • 12
    • 0036196860 scopus 로고    scopus 로고
    • A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11. 2-q13. 1
    • Funayama M, Hasegawa K, Kowa H, Saito M, Tsuji S, Obata F. 2002. A new locus for Parkinson's disease (PARK8) maps to chromosome 12p11. 2-q13. 1. Ann Neurol 51: 296-301.
    • (2002) Ann Neurol , vol.51 , pp. 296-301
    • Funayama, M.1    Hasegawa, K.2    Kowa, H.3    Saito, M.4    Tsuji, S.5    Obata, F.6
  • 15
    • 84897585636 scopus 로고    scopus 로고
    • G2019S LRRK2 mutation causing Parkinson's disease without Lewy bodies
    • doi: 10. 1136/bcr. 08. 2008. 0632
    • Gaig C, Marti MJ, Ezquerra M, Cardozo A, Rey MJ, Tolosa E. 2009. G2019S LRRK2 mutation causing Parkinson's disease without Lewy bodies. BMJ Case Reports doi: 10. 1136/bcr. 08. 2008. 0632.
    • (2009) BMJ Case Reports
    • Gaig, C.1    Marti, M.J.2    Ezquerra, M.3    Cardozo, A.4    Rey, M.J.5    Tolosa, E.6
  • 16
    • 45549085874 scopus 로고    scopus 로고
    • The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules
    • Gandhi PN, Wang X, Zhu X, Chen SG, Wilson-Delfosse AL. 2008. The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules. J Neurosci Res 86: 1711-1720.
    • (2008) J Neurosci Res , vol.86 , pp. 1711-1720
    • Gandhi, P.N.1    Wang, X.2    Zhu, X.3    Chen, S.G.4    Wilson-Delfosse, A.L.5
  • 19
    • 68949218403 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 phosphorylates brain tubulin-βisoforms and modulates microtubule stability-A point of convergence in parkinsonian neurodegeneration?
    • Gillardon F. 2009. Leucine-rich repeat kinase 2 phosphorylates brain tubulin-βisoforms and modulates microtubule stability-A point of convergence in parkinsonian neurodegeneration? J Neurochem 110: 1514-1522.
    • (2009) J Neurochem , vol.110 , pp. 1514-1522
    • Gillardon, F.1
  • 22
    • 47749114984 scopus 로고    scopus 로고
    • The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
    • Greggio E, Zambrano I, Kaganovich A, Beilina A, Taymans JM, Daniels V, LewisP, Jain S, Ding J, Syed A, et al. 2008. The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation. J Biol Chem 283: 16906-16914.
    • (2008) J Biol Chem , vol.283 , pp. 16906-16914
    • Greggio, E.1    Zambrano, I.2    Kaganovich, A.3    Beilina, A.4    Taymans, J.M.5    Daniels, V.6    Lewis, P.7    Jain, S.8    Ding, J.9    Syed, A.10
  • 23
    • 34548604567 scopus 로고    scopus 로고
    • The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity
    • Guo L, Gandhi PN, Wang W, Petersen RB, Wilson-Delfosse AL, Chen SG. 2007. The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity. Exp Cell Res 313: 3658-3670.
    • (2007) Exp Cell Res , vol.313 , pp. 3658-3670
    • Guo, L.1    Gandhi, P.N.2    Wang, W.3    Petersen, R.B.4    Wilson-Delfosse, A.L.5    Chen, S.G.6
  • 27
    • 59649089328 scopus 로고    scopus 로고
    • The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration
    • Ho CC, Rideout HJ, Ribe E, Troy CM, Dauer WT. 2009. The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration. J Neurosci 29: 1011-1016.
    • (2009) J Neurosci , vol.29 , pp. 1011-1016
    • Ho, C.C.1    Rideout, H.J.2    Ribe, E.3    Troy, C.M.4    Dauer, W.T.5
  • 28
    • 51949090816 scopus 로고    scopus 로고
    • Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    • Imai Y, Gehrke S, Wang HQ, Takahashi R, Hasegawa K, Oota E, Lu B. 2008. Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J 27: 2432-2443.
    • (2008) EMBO J , vol.27 , pp. 2432-2443
    • Imai, Y.1    Gehrke, S.2    Wang, H.Q.3    Takahashi, R.4    Hasegawa, K.5    Oota, E.6    Lu, B.7
  • 29
    • 34447118788 scopus 로고    scopus 로고
    • LRRK2 phosphorylates moesin at threonine-558: Characterization of how Parkinson's disease mutants affect kinase activity
    • Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, Knebel A, Alessi DR. 2007. LRRK2 phosphorylates moesin at threonine-558: Characterization of how Parkinson's disease mutants affect kinase activity. Biochem J 405: 307-317.
    • (2007) Biochem J , vol.405 , pp. 307-317
    • Jaleel, M.1    Nichols, R.J.2    Deak, M.3    Campbell, D.G.4    Gillardon, F.5    Knebel, A.6    Alessi, D.R.7
  • 32
    • 77956521263 scopus 로고    scopus 로고
    • Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila
    • Kanao T, Venderova K, Park DS, Unterman T, Lu B, Imai Y. 2010. Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila. Hum Mol Genet 19: 3747-3758.
    • (2010) Hum Mol Genet , vol.19 , pp. 3747-3758
    • Kanao, T.1    Venderova, K.2    Park, D.S.3    Unterman, T.4    Lu, B.5    Imai, Y.6
  • 33
    • 77649328234 scopus 로고    scopus 로고
    • The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation
    • Kumar A, Greggio E, Beilina A, Kaganovich A, Chan D, Taymans JM, Wolozin B, Cookson MR. 2010. The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation. PLoS One 5: e8730.
    • (2010) PLoS One , vol.5
    • Kumar, A.1    Greggio, E.2    Beilina, A.3    Kaganovich, A.4    Chan, D.5    Taymans, J.M.6    Wolozin, B.7    Cookson, M.R.8
  • 35
    • 78650389179 scopus 로고    scopus 로고
    • LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction
    • Lee S, Liu HP, Lin WY, Guo H, Lu B. 2010b. LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. J Neurosci 30: 16959-16969.
    • (2010) J Neurosci , vol.30 , pp. 16959-16969
    • Lee, S.1    Liu, H.P.2    Lin, W.Y.3    Guo, H.4    Lu, B.5
  • 39
    • 72149087091 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant α-synuclein
    • Lin X, Parisiadou L, Gu XL, Wang L, Shim H, Sun L, Xie C, Long CX, Yang WJ, Ding J, et al. 2009. Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant α-synuclein. Neuron 64: 807-827.
    • (2009) Neuron , vol.64 , pp. 807-827
    • Lin, X.1    Parisiadou, L.2    Gu, X.L.3    Wang, L.4    Shim, H.5    Sun, L.6    Xie, C.7    Long, C.X.8    Yang, W.J.9    Ding, J.10
  • 40
    • 77957377567 scopus 로고    scopus 로고
    • LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ss
    • Lin CH, Tsai PI, Wu RM, Chien CT. 2010. LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ss. J Neurosci 30: 13138-13149.
    • (2010) J Neurosci , vol.30 , pp. 13138-13149
    • Lin, C.H.1    Tsai, P.I.2    Wu, R.M.3    Chien, C.T.4
  • 41
    • 33751256567 scopus 로고    scopus 로고
    • The familial Parkinsonism gene LRRK2 regulates neurite process morphology
    • MacLeod D, Dowman J, Hammond R, Leete T, Inoue K, Abeliovich A. 2006. The familial Parkinsonism gene LRRK2 regulates neurite process morphology. Neuron 52: 587-593.
    • (2006) Neuron , vol.52 , pp. 587-593
    • McLeod, D.1    Dowman, J.2    Hammond, R.3    Leete, T.4    Inoue, K.5    Abeliovich, A.6
  • 45
    • 79960346073 scopus 로고    scopus 로고
    • LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: Impairment of the kinase activity by Parkinson's disease-associated mutations
    • Ohta E, Kawakami F, Kubo M, Obata F. 2011. LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: Impairment of the kinase activity by Parkinson's disease-associated mutations. FEBS Lett 585: 2165-2170.
    • (2011) FEBS Lett , vol.585 , pp. 2165-2170
    • Ohta, E.1    Kawakami, F.2    Kubo, M.3    Obata, F.4
  • 48
    • 70449377127 scopus 로고    scopus 로고
    • Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis
    • Parisiadou L, Xie C, Cho HJ, Lin X, Gu XL, Long CX, Lobbestael E, Baekelandt V, Taymans JM, Sun L, et al. 2009. Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. J Neurosci 29: 13971-13980.
    • (2009) J Neurosci , vol.29 , pp. 13971-13980
    • Parisiadou, L.1    Xie, C.2    Cho, H.J.3    Lin, X.4    Gu, X.L.5    Long, C.X.6    Lobbestael, E.7    Baekelandt, V.8    Taymans, J.M.9    Sun, L.10
  • 50
    • 79959242887 scopus 로고    scopus 로고
    • Disruption of LRRK2 does not cause specific loss of dopaminergic neurons in zebrafish
    • Ren G, Xin S, Li S, Zhong H, Lin S. 2011. Disruption of LRRK2 does not cause specific loss of dopaminergic neurons in zebrafish. PLoS One 6: e20630.
    • (2011) PLoS One , vol.6
    • Ren, G.1    Xin, S.2    Li, S.3    Zhong, H.4    Lin, S.5
  • 53
    • 33947663512 scopus 로고    scopus 로고
    • LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins
    • Sakaguchi-Nakashima A, Meir JY, Jin Y, Matsumoto K, Hisamoto N. 2007. LRK-1, a C. elegans PARK8-related kinase, regulates axonal-dendritic polarity of SV proteins. Curr Biol 17: 592-598.
    • (2007) Curr Biol , vol.17 , pp. 592-598
    • Sakaguchi-Nakashima, A.1    Meir, J.Y.2    Jin, Y.3    Matsumoto, K.4    Hisamoto, N.5
  • 60
    • 32044458576 scopus 로고    scopus 로고
    • LRRK2: A common pathway for parkinsonism, pathogenesis and prevention?
    • Taylor JP, Mata IF, Farrer MJ. 2006. LRRK2: A common pathway for parkinsonism, pathogenesis and prevention? Trends Mol Med 12: 76-82.
    • (2006) Trends Mol Med , vol.12 , pp. 76-82
    • Taylor, J.P.1    Mata, I.F.2    Farrer, M.J.3
  • 61
    • 77953090478 scopus 로고    scopus 로고
    • Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
    • Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher R Jr., Shen J. 2010. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci 107: 9879-9884.
    • (2010) Proc Natl Acad Sci , vol.107 , pp. 9879-9884
    • Tong, Y.1    Yamaguchi, H.2    Giaime, E.3    Boyle, S.4    Kopan, R.5    Kelleher Jr., R.6    Shen, J.7
  • 62
    • 0036479325 scopus 로고    scopus 로고
    • 14-3-3 proteins: Active cofactors in cellular regulation by serine/threonine phosphorylation
    • Tzivion G, Avruch J. 2002. 14-3-3 proteins: Active cofactors in cellular regulation by serine/threonine phosphorylation. J Biol Chem 277: 3061-3064.
    • (2002) J Biol Chem , vol.277 , pp. 3061-3064
    • Tzivion, G.1    Avruch, J.2
  • 63
    • 77957283003 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease
    • Vitte J, Traver S, De Paula AM, Lesage S, Rovelli G, Corti O, Duyckaerts C, BriceA. 2010. Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease. J Neuropathol Exp Neurol 69: 959-972.
    • (2010) J Neuropathol Exp Neurol , vol.69 , pp. 959-972
    • Vitte, J.1    Traver, S.2    De Paula, A.M.3    Lesage, S.4    Rovelli, G.5    Corti, O.6    Duyckaerts, C.7    Brice, A.8
  • 64
    • 41549124987 scopus 로고    scopus 로고
    • Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons
    • Wang D, Tang B, Zhao G, Pan Q, Xia K, Bodmer R, Zhang Z. 2008. Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons. Mol Neurodegener 3: 3.
    • (2008) Mol Neurodegener , vol.3 , pp. 3
    • Wang, D.1    Tang, B.2    Zhao, G.3    Pan, Q.4    Xia, K.5    Bodmer, R.6    Zhang, Z.7
  • 65
    • 84860389765 scopus 로고    scopus 로고
    • Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities
    • Webber PJ, Smith AD, Sen S, Renfrow MB, Mobley JA, West AB. 2011. Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities. J Mol Biol 412: 94-110.
    • (2011) J Mol Biol , vol.412 , pp. 94-110
    • Webber, P.J.1    Smith, A.D.2    Sen, S.3    Renfrow, M.B.4    Mobley, J.A.5    West, A.B.6
  • 68
    • 40949145205 scopus 로고    scopus 로고
    • Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease
    • Westerlund M, Belin AC, Anvret A, Bickford P, Olson L, Galter D. 2008. Developmental regulation of leucine-rich repeat kinase 1 and 2 expression in the brain and other rodent and human organs: Implications for Parkinson's disease. Neuroscience 152: 429-436.
    • (2008) Neuroscience , vol.152 , pp. 429-436
    • Westerlund, M.1    Belin, A.C.2    Anvret, A.3    Bickford, P.4    Olson, L.5    Galter, D.6


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