Development and functional anatomy of the spine

The Genetics and Development of Scoliosis

Volumn , Issue , 2010, Pages 21-46

  Rawls, Alan ^a,b   Fisher, Rebecca E ^a,b  

^a ARIZONA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84886269451     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4419-1406-4_2     Document Type: Chapter

References (140)

1. Afonin, B., Ho, M., Gustin, J. K., Meloty-Kapella, C., and Domingo, C. R. 2006. Cell behaviors associated with somite segmentation and rotation in Xenopus laevis. Dev Dyn. 235:3268-3279.
2. Alexander, M. A. and Season, E. H. 1978. Idiopathic scoliosis: an electromyographic study. Arch. Phys. Med. Rehabil. 59:314-315.
3. Alvares, L. E., Schubert, F. R., Thorpe, C., Mootoosamy, R. C., Cheng, L., Parkyn, G., Lumsden, A., and Dietrich, S. 2003. Intrinsic, Hox-dependent cues determine the fate of skeletal muscle precursors. Dev. Cell 5:379-390.
4. Aoyama, H. and Asamoto, K. 1988. Determination of somite cells: independence of cell differentiation and morphogenesis. Development. 104:15-28.
5. Aoyama, H. and Asamoto, K. 2000. The developmental fate of the rostral/caudal half of a somite for vertebra and rib formation: experimental confirmation of the resegmentation theory using chick-quail chimeras. Mech. Dev. 99:71-82.
6. Arnold, H. H. and Braun, T. 2000. Genetics of muscle determination and development. Curr. Top. Dev. Biol. 48:129-164.
7. Ashby, P., Chinnah, T., Zakany, J., Duboule, D., and Tickle, C. 2002. Muscle and tendon pattern is altered independently of skeletal pattern in HoxD mutant limbs. J. Anat. 201:422.
8. Baffi, M. O., Moran, M. A., and Serra, R. 2006. Tgfbr2 regulates the maintenance of boundaries in the axial skeleton. Dev. Biol. 296:363-374.
9. Barrallo-Gimeno, A., and Nieto, M. A. 2005. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 132:3151-3161.
10. Barrantes, I. B., Elia, A. J., Wünsch, K., Hrabe De Angelis, M. H., Mak, T. W., Rossant, J., Conlon, R. A., Gossler, A., and De La Pompa, J. L. 1999. Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr Biol. 9:470-480.
11. Batlle, E., Sancho, E., Franci, C., Dominguez, D., Monfar, M., Baulida, J., and Garcia De Herreros, A. 2000. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat. Cell Biol. 2:84-89.
12. Berkes, C. A., Bergstrom, D. A., Penn, B. H., Seaver, K. J., Knoepfler, P. S., and Tapscott, S. J. 2004. Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential. Mol. Cell 14:465-477.
13. Borello, U., Berarducci, B., Murphy, P., Bajard, L., Buffa, V., Piccolo, S., Buckingham, M., and Cossu, G. 2006. The Wnt/beta-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. Development 133:3723-3732.
14. Borycki, A., Brown, A. M., and Emerson, C. P. Jr. 2000. Shh and Wnt signaling pathways converge to control Gli gene activation in avian somites. Development 127:2075-2087.
15. Borycki, A. G., Brunk, B., Tajbakhsh, S., Buckingham, M., Chiang, C., and Emerson, C. P. Jr. 1999. Sonic hedgehog controls epaxial muscle determination through Myf5 activation. Development 126:4053-4063.
16. Brand-Saberi, B., and Christ, B. 2000. Evolution and development of distinct cell lineages derived from somites. Curr. Topics Dev. Biol. 48:1-42.
17. Brent, A. E., Braun, T., and Tabin, C. J. 2005. Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Development 132:515-528.
18. Brent, A. E., Schweitzer, R., and Tabin, C. J. 2003. A somitic compartment of tendon progenitors. Cell 113:235-248.
19. Brent, A. E. and Tabin, C. J. 2004. FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression. Development 131:3885-3896.
20. Buchberger, A., Seidl, K., Klein, C., Eberhardt, H., and Arnold, H. H. 1998. cMeso-1, a novel bHLH transcription factor, is involved in somite formation in chicken embryos. Dev. Biol. 199:201-215.
21. Burgess, R., Cserjesi, P., Ligon, K. L., and Olson, E. N. 1995. Paraxis: a basic helix-loop-helix protein expressed in paraxial mesoderm and developing somites. Dev. Biol. 168:296-306.
22. Burgess, R., Rawls, A., Brown, D., Bradley, A., and Olson, E. N. 1996. Requirement of the paraxis gene for somite formation and musculoskeletal patterning. Nature 384:570-573.
23. Butterworth, T. R. and James, C. 1969. Electromyographic studies in idiopathic scoliosis. South Med. J. 62:1008-1010.
24. Buxton, D. F. and Peck, D. 1989. Neuromuscular spindles relative to joint movement complexities. Clin. Anat. 2:211-224.
25. Bylund, P., Jansson, E., Dahlberg, E., and Eriksson, E. 1987. Muscle fiber types in thoracic erector spinae muscles. Clin. Orthop. 214:222-228.
26. Cailliet, R. 1988. Low Back Pain Syndrome. Fourth Edition. Philadelphia: FA Davis Company.
27. Cano, A., Perez-Moreno, M. A., Rodrigo, I., Locascio, A., Blanco, M. J., Del Barrio, M. G., Portillo, F., and Nieto, M. A. 2000. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2:76-83.
28. Capellini, T. D., Di Giacomo, G., Salsi, V., Brendolan, A., Ferretti, E., Srivastava, D., Zappavigna, V., and Selleri, L. 2006. Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Development 133:2263-2273.
29. Capellini, T. D., Zewdu, R., Di Giacomo, G., Asciutti, S., Kugler, J. E., Di Gregorio, A., and Selleri, L. 2008. Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pa x1/Pax 9 in sclerotome. Dev. Biol. 321:500-514.
30. Chan, Y. L., Cheng, J. C. Y., Guo, X., King, A. D., Griffith, J. F., and Metreweli, C. 1999. MRI evaluation of multifidus muscles in adolescent idiopathic scoliosis. Pediatr. Radiol. 29:360-363.
31. Chen, F., Greer, J., and Capecchi, M. R. 1998. Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of different sets of vertebrae. Mech. Dev. 77:49-57.
32. Condie, B. G. and Capecchi, M. R. 1994. Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions. Science 370:304-307.
33. Conlon, R. A., Reaume, A. G., and Rossant, J. 1995. Notch1 is required for the coordinate segmentation of somites. Development. 121:1533-1545.
34. Correia, K. M. and Conlon, R. A. 2000. Surface ectoderm is necessary for the morphogenesis of somites. Mech. Dev. 91:19-30.
35. Cossu, G. and Borello, U. 1999. Wnt signaling and the activation of myogenesis in mammals. EMBO J. 18:6867-6872.
36. Dale, J. K., Malapert, P., Chal, J., Vilhais-Neto, G., Maroto, M., Johnson, T., Jayasinghe, S., Trainor, P., Herrmann, B., and Pourquié, O. 2006. Oscillations of the snail genes in the presomitic mesoderm coordinate segmental patterning and morphogenesis in vertebrate somitogenesis. Dev. Cell 10:355-366.
37. De La Pompa, J. L., Wakeham, A., Correia, K. M., Samper, E., Brown, S., Aguilera, R. J., Nakano, T., Honjo, T., Mak, T. W., Rossant, J., and Conlon, R. A. 1997. Conservation of the Notch signalling pathway in mammalian neurogenesis. Development 124:1139-1148.
38. Denetclaw, W. F. Jr., Christ, B., and Ordahl, C. P. 1997. Location and growth of epaxial myotome precursor cells. Development 124:1601-1610.
39. Denetclaw, W. F. and Ordahl, C. P. 2000. The growth of the dermomyotome and formation of early myotome lineages in thoracolumbar somites of chicken embryos. Development 127:893-905.
40. Dockter, J. L. 2000. Sclerotome induction and differentiation. Curr. Top. Dev. Biol. 48:77-127.
41. Duband, J. L., Dufour, S., Hatta, K., Takeichi, M., Edelman, G. M., and Thiery, J. P. 1987. Adhesion molecules during somitogenesis in the avian embryo. J. Cell Biol. 104:1361-1374.
42. Dubrulle, J., and Pourquié, O. 2004. Coupling segmentation to axis formation. Development 131:5783-5793.
43. Dunwoodie, S. L., Clements, M., Sparrow, D. B., Sa, X., Conlon, R. A., and Beddington, R. S. 2002. Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. Development 129:1795-1806.
44. Fan, C. M., and Tessier-Lavigne, M. 1994. Patterning of mammalian somites by surface ectoderm and notochord: evidence for sclerotome induction by a hedgehog homolog. Cell 79:1175-1186.
45. Fidler, M. W. and Jowett, R. L. 1976. Muscle imbalance in the aetiology of scoliosis. J. Bone Joint Surg. 58-B: 200-201.
46. Ford, D. M., Bagnall, K. M., McFadden, K. D., Greenhill, B. J., and Raso, V. J. 1984. Paraspinal muscle imbalance in adolescent idiopathic scoliosis. Spine 9:373-376.
47. Furumoto, T. A., Miura, N., Akasaka, T., Mizutanikoseki, Y., Sudo, H., Fukuda, K., Maekawa, M., Yuasa, S., Fu, Y., Moriya, H., Taniguchi, M., Imai, K., Dahl, E., Balling, R., Pavlova, M., Gossler, A., and Koseki, H. 1999. Notochord-dependent expression of MFH1 and PAX1 cooperates maintain the proliferation of sclerotome cells during the vertebral column development. Dev. Biol. 210:15-29.
48. Geetha-Loganathan, P., Nimmagadda, S., Huang, R., Christ, B., and Scaal, M. 2006. Regulation of ectodermal Wnt6 expression by the neural tube is transduced by dermomyotomal Wnt11: a mechanism of dermomyotomal lip sustainment. Development 133:2897-2904.
49. Goldstein, R. S. and Kalcheim, C. 1992. Determination of epithelial half-somites in skeletal morphogenesis. Development 116:441-445.
50. Henry, C. A., Hall, L. A., Burr Hille, M., Solnica-Krezel, L., and Cooper, M. S. 2000. Somites in zebrafish doubly mutant for knypek and trilobite form without internal mesenchymal cells or compaction. Curr. Biol. 10:1063-1066.
51. Horikawa, K., Radice, G., Takeichi, M., and Chisaka, O. 1999. Adhesive subdivisions intrinsic to the epithelial somites. Dev. Biol. 215:182-189.
52. Hrab De Angelis, M., McIntyre, J., 2nd, and Gossler, A. 1997. Maintenance of somite borders in mice requires the Delta homologue DII1. Nature 386:717-721.
53. Huang, R., Zhi, Q., Neubuser, A., Muller, T. S., Brand-Saberi, B., Christ, B., and Wilting, J. 1996. Function of somite and somitocoele cells in the formation of the vertebral motion segment in avian embryos. Acta Anat. (Basel) 155:231-241.
54. Jacob, H. J. and Christ, B. 1980. On the formation of muscular pattern in the chick limb. In Teratology of the Limbs. pp. 89-97. Berlin: Walter de Gruyter and Co.
55. Jiang, Y. J., Aerne, B. L., Smithers, L., Haddon, C., Ish-Horowicz, D., and Lewis, J. 2000. Notch signaling and the synchronization of the somite segmentation clock. Nature 408:475-479.
56. Johnson, J., Rhee, J., Parsons, S. M., Brown, D., Olson, E. N., and Rawls, A. 2001. The anterior/posterior polarity of somites is disrupted in paraxis-deficient mice. Dev. Biol. 229:176-187.
57. Kahane, N., Cinnamon, Y., and Kalcheim, C. 1998. The cellular mechanism by which the dermomyotome contributes to the second wave of myotome development. Development 125:4259-4271.
58. Kardon, G., Harfe, B. D., and Tabin, C. T. 2003. A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning. Dev. Cell 5:937-944.
59. Keynes, R. J. and Stern, C. D. 1988. Mechanisms of vertebrate segmentation. Development 103:413-429.
60. Khosla, S., Tredwell, S. J., Day, B., Shinn, S. L., and Ovalle, W. K. 1980. An ultrastructural study of multifidus muscle in progressive idiopathic scoliosis-changes resulting from a sarcolemmal defect of the myotendinous junction. J. Neurol. Sci. 46:13-31.
61. Kim, D. J., Moon, S. H., Kim, H., Kwon, U. H., Park, M. S., Han, K. J., Hahn, S. B., and Lee, H. M. 2003. Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells. Spine 28:2679-2684.
62. Kim, S. Y., Paylor, S. W., Magnuson, T., and Schumacher, A. 2006. Juxtaposed Polycomb complexes co-regulate vertebral identity. Development 133:4957-4968.
63. Koizumi, K., Nakajima, M., Yuasa, S., Saga, Y., Sakai, T., Kuriyama, T., Shirasawa, T., and Koseki, H. 2001. The role of presenilin 1 during somite segmentation. Development 128:1391-1402.
64. Kulesa, P. M. and Fraser, S. E. 2002. Cell dynamics during somite boundary formation revealed by time-lapse analysis. Science 298:991-995.
65. Kulesa, P. M., Schnell, S., Rudloff, S., Baker, R. E., and Maini, P. K. 2007. From segment to somite: segmentation epithelialization analyzed within quantitative frameworks. Dev. Dyn. 236:1392-1402.
66. Kusumi, K., Sun, E. S., Kerrebrock, A. W., Bronson, R. T., Chi, D. C., Bulotsky, M. S., Spencer, J. B., Birren, B. W., Frankel, W. N., and Lander, E. S. 1998. The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nat. Genet. 19(3):274-278.
67. Lewis, E. B. 1978. A gene complex controlling segmentation in Drosophila. Nature 276:565-570.
68. Li, J., Yoon, S. T., and Hutton, W. C. 2004. Effect of bone morphogenetic protein-2 (BMP-2) on matrix production, other BMPs, and BMP receptors in rat intervertebral disc cells. J. Spinal Disord. Tech. 17:423-428.
69. Linker, C., Lesbros, C., Gros, J., Burrus, L. W., Rawls, A., and Marcelle, C. 2005. Beta-Catenindependent Wnt signalling controls the epithelial organisation of somites through the activation of paraxis. Development 132:3895-3905.
70. Mackie, E. J., Ahmed, Y. A., Tatarczuch, L., Chen, K. S., and Mirams, M. 2008. Endochondral ossification: how cartilage is converted into bone in the developing skeleton. Int. J. Biochem. Cell Biol. 40:46-62.
71. Maconochie, M. K., Nonchev, S., Studer, M., Chan, S. K., Popperl, H., Sham, M. H., Mann, R. S., and Krumlauf, R. 1997. Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1. Genes Dev. 11:1885-1895.
72. Mankoo, B. S., Skuntz, S., Harrigan, I., Grigorieva, E., Candia, A., Wright, C. V., Arnheiter, H., and Pachnis, V. 2003. The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites. Development 130:4655-4664.
73. Mannion, A. F., Meier, M., Grob, D., and Müntener, M. 1998. Paraspinal muscle fibre type alterations associated with scoliosis: an old problem revisited with new evidence. Eur. Spine J. 7:289-293.
74. McDermott, A., Gustafsson, M., Elsam, T., Hui, C. C., Emerson, C. P. Jr., and Borycki, A. G. 2005. Gli2 and Gli3 have redundant and context-dependent function in skeletal muscle formation. Development 132:345-357.
75. McIntyre, D. M., Rakshit, S., Yallowitz, A. R., Loken, L., Jeannotte, L., Capecchi, M. R., and Wellik, D. M. 2007. Hox Patterning of the vertebrate rib cage. Development 134:2981-2989.
76. McKinsey, T. A., Zhang, C. L., Lu, J., and Olson, E. N. 2000. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature 408:106-111.
77. McKinsey, T. A., Zhang, C. L., and Olson, E. N. 2001. Control of muscle development by dueling HATs and HDACs. Curr. Opin. Genet. Dev. 11:497-504.
78. McMahon, J. A., Takada, S., Zimmerman, L. B., and McMhaon, A. P. 1998. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 12:1438-1452.
79. Meier, M. P., Klein, M. P., Krebs, D., Grob, D., and Müntener, M. 1997. Fiber transformations in multifidus muscle of young patients with idiopathic scoliosis. Spine 22:2357-2364.
80. Mittapalli, V. R., Huang, R., Patel, K., Christ, B., and Scaal, M. 2005. Arthrotome: a specific joint forming compartment in the avian somite. Dev. Dyn. 234:48-53.
81. Moens, C. B. and Selleri, L. 2006. Hox cofactors in vertebrate development. Dev. Biol. 291:193-206.
82. Molkentin, J. D. and Olson, E. N. 1996. Defining the regulatory networks for muscle development. Curr. Opin. Genet. Dev. 6:445-453.
83. Monsoro-Burq, A. H., Bontoux, M., Teillet, M. A., and Le Douarin, N. M. 1994. Heterogeneity in the development of the vertebra. Proc. Natl. Acad. Sci. U. S. A. 91:10435-10439.
84. Monsoro-Burq, A. H., Duprez, D., Watanabe, Y., Bontoux, M., Vincent, C., Brickell, P., and Le Douarin, N. 1996. The role of bone morphogenetic proteins in vertebral development. Development 122:3607-3616.
85. Moore, K. L. and Dalley, A. F. 2006. Clinically Oriented Anatomy. Baltimore: Lippincott Williams and Wilkins.
86. Morimoto, M., Sasaki, N., Oginuma, M., Kiso, M., Igarashi, K., Aizaki, K., Kanno, J., and Saga, Y. 2007. The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostrocaudal patterning within a somite. Development 134:1561-1569.
87. Nakaya, Y., Kuroda, S., Katagiri, Y. T., Kaibuchi, K., and Takahashi, Y. 2004. Mesenchymalepithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1. Dev. Cell 7:425-438.
88. Oka, C., Nakano, T., Wakeham, A., De La Pompa, J. L., Mori, C., Sakai, T., Okazaki, S., Kawaichi, M., Shiota, K., Mak, T. W., and Honjo, T. 1995. Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development 121:3291-3301.
89. Ordahl, C. P., Berdougo, E., Venters, S. J., and Denetclaw, W. F. Jr. 2001. The dermomyotome dorsomedial lip drives growth and morphogenesis of both the primary myotome and dermomyotome epithelium. Development 128:1731-1744.
90. Ordahl, C. P. and Le Douarin, N. M. 1992. Two myogenic lineages within the developing somite. Development 114:339-353.
91. Paavola, L. G., Wilson, D. B., and Center, E. M. 1980. Histochemistry of the developing notochord, perichordal sheath and vertebrae in Danforth's short-tail (sd) and normal C57BL/6 mice. J. Embryol. Exp. Morphol. 55:227-245.
92. Palmeirim, I., Dubrulle, J., Henrique, D., Ish-Horowicz, D., and Pourquié, O. 1998. Uncoupling segmentation and somitogenesis in the chick presomitic mesoderm. Dev. Genet. 23:77-85.
93. Peters, H., Doll, U., and Niessing, J. 1995. Differential expression of the chicken Pax-1 and Pax-9 gene: in situ hybridization and immunohistochemical analysis. Dev. Dyn. 203:1-16.
94. Peters, H., Wilm, B., Sakai, N., Imai, K., Maas, R., and Balling, R. 1999. Pax 1 and Pa x 9 synergistically regulate vertebral column development. Development 126:5399-5408.
95. Popperl, H., Bienz, M., Studer, M., Chan, S. K., Aparicio, S., Brenner, S., Mann, R. S., and Krumlauf, R. 1995. Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx. Cell 81:1031-1042.
96. Pourquie, O., Coltey, M., Teillet, M. A., Ordahl, C., and Le Douarin, M. 1993. Control of dorsoventral patterning of somitic derivatives by notochord and floor plate. Proc. Natl. Acad. Sci. U. S. A. 90:5242-5246.
97. Puri, P. L., Sartorelli, V., Yang, X. J., Hamamori, Y., Ogryzko, V. V., Howard, B. H., Kedes, L., Wang, J. Y., Graessmann, A., Nakatani, Y., and Levrero, M. 1997. Differential roles of p300 and PCAF acetyltransferases in muscle differentiation. Mol. Cell 1:35-45.
98. Radice, G. L., Rayburn, H., Matsunami, H., Knudsen, K. A., Takeichi, M., and Hynes, R. O. 1997. Developmental defects in mouse embryos lacking N-cadherin. Dev. Biol. 181:64-78.
99. Reshef, R., Maroto, M., and Lassar, A. B. 1998. Regulation of dorsal somitic cell fates: BMPs and Noggin control the timing and pattern of myogenic regulator expression. Genes Dev. 12:290-303.
100. Reuber, M., Schultz, A., McNeill, T., and Spencer, D. 1983. Trunk muscle myoelectric activities in idiopathic scoliosis. Spine 8:447-456.
101. Saga, Y., Hata, N., Koseki, H., and Taketo, M. M. 1997. Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev. 11:1827-1839.
102. Sahgal, V., Shah, A., Flanagan, N., Schaffer, M., Kane, W., Subramani, V., and Singh, H. 1983. Morphologic and morphometric studies of muscle in idiopathic scoliosis. Acta Orthop. 54:242-251.
103. Sartorelli, V., Puri, P. L., Hamamori, Y., Ogryzko, V., Chung, G., Nakatani, Y., Wang, J. Y., and Kedes, L. 1999. Acetylation of MyoD directed by PCAF is necessary for the execution of the muscle program. Mol. Cell 4:725-734.
104. Sato, Y. and Takahashi, Y. 2005. A novel signal induces a segmentation fissure by acting in a ventral-to-dorsal direction in the presomitic mesoderm. Dev. Biol. 282:183-191.
105. Sato, Y., Yasuda, K., and Takahashi, Y. 2002. Morphological boundary forms by a novel inductive event mediated by Lunatic fringe and Notch during somitic segmentation. Development 129:3633-3644.
106. Schmidt, C., Stoeckelhuber, M., McKinnell, I., Putz, R., Christ, B., and Patel, K. 2004. Wnt 6 regulates the epithelialisation process of the segmental plate mesoderm leading to somite formation. Dev. Biol. 271:198-209.
107. Schubert, F. R., Tremblay, P., Mansouri, A., Faisst, A. M., Kammandel, B., Lumsden, A., Gruss, P., and Dietrich, S. 2001. Early mesodermal phenotypes in splotch suggest a role for Pa x3 in the formation of epithelial somites. Dev. Dyn. 222:506-521.
108. Schuster-Gossler, K., Harris, B., Johnson, R., Serth, J., and Gossler, A. 2009. Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut 1 levels during early mouse development. BMC Dev. Biol. 9:6.
109. Skuntz, S., Mankoo, B., Nguyen, M. T., Hustert, E., Nakayama, A., Tournier-Lasserve, E., Wright, C. V., Pachnis, V., Bharti, K., and Arnheiter, H. 2009. Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton. Dev. Biol. 2009 Aug. 15; 332(2):383-95.
110. Smith, T. G., Sweetman, D., Patterson, M., Keyse, S. M., and Münsterberg, A. 2005. Feedback interactions between MKP3 and ERK MAP kinase control scleraxis expression and the specification of rib progenitors in the developing chick somite. Development 132:1305-1314.
111. Smits, P. and Lefebvre, V. 2003. Sox5 and Sox6 are required for notochord extracellular matrix sheath formation, notochord cell survival and development of the nucleus pulposus of intervertebral discs. Development 130:1135-1148.
112. Sosić, D., Brand-Saberi, B., Schmidt, C., Christ, B., and Olson, E. N. 1997. Regulation of paraxis expression and somite formation by ectoderm- and neural tube-derived signals. Dev. Biol. 185:229-243.
113. Sparrow, D. B., Chapman, G., Turnpenny, P. D., and Dunwoodie, S. L. 2007. Disruption of the somitic molecular clock causes abnormal vertebral segmentation. Birth Defects Res. C Embryo Today 81:93-110.
114. Spencer, G. S. and Zorab, P. A. 1976. Spinal muscle in scoliosis. Part 1: histology and histochemistry. J. Neurol. Sci. 30:127-142.
115. Summerbell, D., Ashby, P. R., Coutelle, O., Cox, D., Yee, S., and Rigby, P. W. 2000. The expression of Myf5 in the developing mouse embryo is controlled by discrete and dispersed enhancers specific for particular populations of skeletal muscle precursors. Development 127:3745-3757.
116. Swiatek, P. J., Lindsell, C. E., Del Amo, F. F., Weinmaster, G., and Gridley, T. 1994. Notch1 is essential for postimplantation development in mice. Genes Dev. 8:707-719.
117. Tajbakhsh, S., Borello, U., Vivarelli, E., Kelly, R., Papkoff, J., Duprez, D., Buckingham, M., and Cossu, G. 1998. Differential activation of Myf5 and MyoD by different Wnts in explants of mouse paraxial mesoderm and the later activation of myogenesis in the absence of Myf5. Development 125:4155-4162.
118. Takahashi, Y., Inoue, T., Gossler, A., and Saga, Y. 2003. Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites. Development 130:4259-4268.
119. Takahashi, Y., Koizumi, K., Takagi, A., Kitajima, S., Inoue, T., Koseki, H., and Saga, Y. 2000. Mesp2 initiates somite segmentation through the Notch signalling pathway. Nat. Genet. 25:390-396.
120. Takahashi, Y. and Sato, Y. 2008. Somitogenesis as a model to study the formation of morphological boundaries and cell epithelialization. Develop. Growth Differ. 50:S149-S155.
121. Takahashi, Y., Takagi, A., Hiraoka, S., Koseki, H., Kanno, J., Rawls, A., and Saga, Y. 2007. Transcription factors Mesp2 and Pa rax i s have critical roles in axial musculoskeletal formation. Dev. Dyn. 236:1484-1494.
122. Tam, P. P. and Trainor, P. A. 1994. Specification and segmentation of the paraxial mesoderm. Anat. Embryol. 189:275-305.
123. Tanaka, M. and Tickle, C. 2004. Tbx18 and boundary formation in chick somite and wing development. Dev. Biol. 268:470-480.
124. Teboul, L., Summerbell, D., and Rigby, P. W. 2003. The initial somitic phase of Myf5 expression requires neither Shh signaling nor Gli regulation. Genes Dev. 17:2870-2874.
125. Teppner, I., Becker, S., De Angelis, M. H., Gossler, A., and Beckers, J. 2007. Compartmentalised expression of Delta-like 1 in epithelial somites is required for the formation of intervertebral joints. BMC Dev. Biol. 7:68.
126. Tonegawa, A., Funayama, N., Ueno, N., and Takahashi, Y. 1997. Mesodermal subdivision along the mediolateral axis in chicken controlled by different concentrations of BMP-4. Development 124:1975-1984.
127. Tozer, S. and Duprez, D. 2005. Tendon and ligament: development, repair and disease. Birth Defects Res. C Embryo Today 75:226-236.
128. Van Den Akker, E., Fromental-Ramain, C., De Graaf, W., Le Mouellic, H., Brulet, P., Chambon, P., and Deschamps, J. 2001. Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes. Development 128:1911-1921.
129. Venters, S. J., Thorsteinsdottir, S., and Duxson, M. J. 1999. Early development of the myotome in the mouse. Dev. Dyn. 216:219-232.
130. Wagner, J., Schmidt, C., Nikowits, W. Jr., and Christ, B. 2000. Compartmentalization of the somite and myogenesis in chick embryos are influenced by wnt expression. Dev. Biol. 228:86-94.
131. Watanabe, Y., Duprez, D., Monsoro-Burq, A. H., Vincent, C., and Le Douarin, N. M. 1998. Two domains in vertebral development: antagonistic regulation by SHH and BMP4 proteins. Development 125:2631-2639.
132. Wellik, D. M. 2007. Hox patterning of the vertebrate axial skeleton. Dev. Dyn. 236:2454-2463.
133. Wellik, D. M. and Capecchi, M. R. 2003. Hox10 and Hox11 genes are required to globally pattern the mammalian skeleton. Science 301:363-366.
134. Wood, A. and Thorogood, P. 1994. Patterns of cell behavior underlying somitogenesis and notochord formation in intact vertebrate embryos. Dev. Dyn. 201:151-167.
135. Yang, X., Arber, S., William, C., Li, L., Tanabe, Y., Jessell, T. M., Birchmeier, C., and Burden, S. J. 2001. Patterning of muscle acetylcholine receptor gene expression in the absence of motor innervation. Neuron 30:399-410.
136. Yarom, R. and Robin, G. C. 1979. Studies on spinal and peripheral muscles from patients with scoliosis. Spine 4:12-21.
137. Yasuhiko, Y., Haraguchi, S., Kitajima, S., Takahashi, Y., Kanno, J., and Saga, Y. 2006. Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression. Proc. Natl. Acad. Sci. U. S. A. 103:3651-3656.
138. Yoon, S. T., Su Kim, K., Li, J., Soo Park, J., Akamaru, T., Elmer, W. A., and Hutton, W. C. 2003. The effect of bone morphogenetic protein-2 on rat intervertebral disc cells in vitro. Spine 28:1773-1780.
139. Zetterberg, C., Aniansson, A., and Grimby, G. 1983. Morphology of the paravertebral muscles in adolescent idiopathic scoliosis. Spine 8:457-462.
140. Zuk, T. 1962. The role of spinal and abdominal muscles in the pathogenesis of scoliosis. J. Bone Joint Surg. Br. 44:102-105.